Intervention analysis and classification: key to health outcomes optimization

2019 ◽  
Vol 32 (2) ◽  
pp. 347-359
Author(s):  
Oguchi Nkwocha

PurposeMeasures are important to healthcare outcomes. Outcome changes result from deliberate selective intervention introduction on a measure. If measures can be characterized and categorized, then the resulting schema may be generalized and utilized as a framework for uniquely identifying, packaging and comparing different interventions and probing target systems to facilitate selecting the most appropriate intervention for maximum desired outcomes. Measure characterization was accomplished with multi-axial statistical analysis and measure categorization by logical tabulation. The measure of interest is a key provider productivity index: “patient visits per hour,” while the specific intervention is “patient schedule manipulation by overbooking.” The paper aims to discuss these issues.Design/methodology/approachFor statistical analysis, interrupted time series (ITS), robust-ITS and outlier detection models were applied to an 18-month data set that included patient visits per hour and intervention introduction time. A statistically significant change-point was determined, resulting in pre-intervention, transitional and post-effect segmentation. Linear regression modeling was used to analyze pre-intervention and post-effect mean change while a triangle was used to analyze the transitional state. For categorization, an “intervention moments” table was constructed from the analysis results with: time-to-effect, pre- and post-mean change magnitude and velocity; pre- and post-correlation and variance; and effect decay/doubling time. The table included transitional parameters such as transition velocity and transition footprint visualization represented as a triangle.FindingsThe intervention produced a significant change. The pre-intervention and post-effect means for patient visits per hour were statistically different (0.38,p=0.0001). The pre- and post-variance change (0.23,p=0.01) was statistically significant (variance was higher post-intervention, which was undesirable). Post-intervention correlation was higher (desirable). Decay time for the effect was calculated as 11 months post-effect. Time-to-effect was four months; mean change velocity was +0.094 visits per h/month. A transition triangular footprint was produced, yielding 0.35 visits per hr/month transition velocity. Using these results, the intervention was fully profiled and thereby categorized as an intervention moments table.Research limitations/implicationsOne limitation is sample size for this time series, 18 monthly cycles’ analysis. However, interventions on measures in healthcare demand short time cycles (hence necessarily yielding fewer data points) for practicality, meaningfulness and usefulness. Despite this shortcoming, the statistical processes applied such as outliers detection,t-test for mean difference,F-test for variances and modeling, all consider the small sample sizes. Seasonality, which usually affects time series, was not detected and even if present, was also considered by modeling.Practical implicationsObtaining an intervention profile, made possible by multidimensional analysis, allows interventions to be uniquely classified and categorized, enabling informed, comparative and appropriate selective deployment against health measures, thus potentially contributing to outcomes optimization.Social implicationsThe inevitable direction for healthcare is heavy investment in measures outcomes optimization to improve: patient experience; population health; and reduce costs. Interventions are the tools that change outcomes. Creative modeling and applying novel methods for intervention analysis are necessary if healthcare is to achieve this goal. Analytical methods should categorize and rank interventions; probe the measures to improve future selection and adoption; reveal the organic systems’ strengths and shortcomings implementing the interventions for fine-tuning for better performance.Originality/valueAn “intervention moments table” is proposed, created from a multi-axial statistical intervention analysis for organizing, classifying and categorizing interventions. The analysis-set was expanded with additional parameters such as time-to-effect, mean change velocity and effect decay time/doubling time, including transition zone analysis, which produced a unique transitional footprint; and transition velocity. The “intervention moments” should facilitate intervention cross-comparisons, intervention selection and optimal intervention deployment for best outcomes optimization.

2020 ◽  
Vol 60 (2) ◽  
pp. 182-193
Author(s):  
Kacem Abdelhadi ◽  
Houar Abdelatif ◽  
Zerf Mohamed ◽  
Bengoua Ali

SummaryThis study tests the impact of COVID-19 on sleep of Algerian population before and during the COVID-19 quarantine by an estimated online survey, adapted from the PSQI Italian version. Including 1210 participants (age between 18-60 years old). The statistical analysis was carried out using SPSS version 22.0 software. Our results showed a significant change in sleeping quality during quarantine, the sleep timing markedly changed, we also noticed additional use of sleeping medications. Algerian scientists recommend to build public awareness and to provide necessary information regarding Algerian sleep quality, especially for Algerian adults.


2020 ◽  
Vol 27 (3) ◽  
pp. 755-770
Author(s):  
Maria Krambia-Kapardis

Purpose The purpose of this study is to develop a profile of whistleblowers and to determine whether whistleblowing legislation would encourage those individuals to bring to light some illegal or unethical behaviour that otherwise would remain in the shadows. Design/methodology/approach Having identified whistleblowing correlation, a survey was carried out in Cyprus of actual whistleblowers and could-have-been whistleblowers. Findings Males between 46 and55 years of age, regardless of whether they have dependents or hold senior positions in organizations are significantly more likely to blow the whistle. However, could-have-been whistleblowers did not go ahead because they felt that the authorities would not act on their information. Research limitations/implications Because of the sensitive nature of the research topic and the fact that only whistleblowers or intended whistleblowers could participate in the study, the sample size is limited as a result. This, in turn, limits both the number of respondents in each category (actual and intended) as well as constrains the statistical analysis that could be carried out on the data. Practical implications It remains to be seen whether EU Member States shall implement the European Directive 2019/1937 on the protection of persons who report breaches of Union Law, in its entirety by the due date, namely December 2021. Originality/value This study provides a literature review of whistleblowing and reports an original survey against the backdrop of the European Directive.


2019 ◽  
Vol 15 (2) ◽  
pp. 647-659 ◽  
Author(s):  
Zahra Moeini Najafabadi ◽  
Mehdi Bijari ◽  
Mehdi Khashei

Purpose This study aims to make investment decisions in stock markets using forecasting-Markowitz based decision-making approaches. Design/methodology/approach The authors’ approach offers the use of time series prediction methods including autoregressive, autoregressive moving average and artificial neural network, rather than calculating the expected rate of return based on distribution. Findings The results show that using time series prediction methods has a significant effect on improving investment decisions and the performance of the investments. Originality/value In this study, in contrast to previous studies, the alteration in the Markowitz model started with the investment expected rate of return. For this purpose, instead of considering the distribution of returns and determining the expected returns, time series prediction methods were used to calculate the future return of each asset. Then, the results of different time series methods replaced the expected returns in the Markowitz model. Finally, the overall performance of the method, as well as the performance of each of the prediction methods used, was examined in relation to nine stock market indices.


Buildings ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 21
Author(s):  
Thomas Danel ◽  
Zoubeir Lafhaj ◽  
Anand Puppala ◽  
Sophie Lienard ◽  
Philippe Richard

This article proposes a methodology to measure the productivity of a construction site through the analysis of tower crane data. These data were obtained from a data logger that records a time series of spatial and load data from the lifting machine during the structural phase of a construction project. The first step was data collection, followed by preparation, which consisted of formatting and cleaning the dataset. Then, a visualization step identified which data was the most meaningful for the practitioners. From that, the activity of the tower crane was measured by extracting effective lifting operations using the load signal essentially. Having used such a sampling technique allows statistical analysis on the duration, load, and curvilinear distance of every extracted lifting operation. The build statistical distribution and indicators were finally used to compare construction site productivity.


2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S590-S590
Author(s):  
Lorena Guerrero-Torres ◽  
Isaac Núñez-Saavedra ◽  
Yanink Caro-Vega ◽  
Brenda Crabtree-Ramírez

Abstract Background Among 230,000 people living with HIV in Mexico, 24% are unaware of their diagnosis, and half of newly diagnosed individuals are diagnosed with advanced disease. Early diagnosis is the goal to mitigate HIV epidemic. Missed opportunities may reflect a lack of clinicians’ consideration of HIV screening as part of routine medical care. We assessed whether an educational intervention on residents was effective to 1) improve the knowledge on HIV screening; 2) increase the rate of HIV tests requested in the hospitalization floor (HF) and the emergency department (ED); and 3) increase HIV diagnosis in HF and ED. Methods Internal Medicine and Surgery residents at a teaching hospital were invited to participate. The intervention occurred in August 2018 and consisted in 2 sessions on HIV screening with an expert. A questionnaire was applied before (BQ) and after (AQ) the intervention, which included HIV screening indications and clinical cases. The Institutional Review Board approved this study. Written informed consent was obtained from all participants. BQ and AQ scores were compared with a paired t-test. To evaluate the effect on HIV test rate in the HF and ED, an interrupted time series analysis was performed. Daily rates of tests were obtained from September 2016 to August 2019 and plotted along time. Restricted cubic splines (RCS) were used to model temporal trends. HIV diagnosis in HF and ED pre- and post-intervention were compared with a Fisher’s exact test. A p< 0.05 was considered significant. Results Among 104 residents, 57 participated and completed both questionnaires. BQ score was 79/100 (SD±12) and AQ was 85/100 (SD±8), p< .004. Time series of HIV testing had apparent temporal trends (Fig 1). HIV test rate in the HF increased (7.3 vs 11.1 per 100 episodes) and decreased in the ED (2.6 vs 2.3 per 100 episodes). HIV diagnosis increased in the HF, from 0/1079 (0%) pre-intervention to 5/894 (0.6%) post-intervention (p< .018) (Table 1). Fig 1. HIV test rates. Gray area represents post-intervention period. Table 1. Description of episodes, HIV tests and rates pre- and post-intervention in the Emergency Department and Hospitalization Floor. Conclusion A feasible educational intervention improved residents’ knowledge on HIV screening, achieved maintenance of a constant rate of HIV testing in the HF and increased the number of HIV diagnosis in the HF. However, these results were not observed in the ED, where administrative barriers and work overload could hinder HIV screening. Disclosures All Authors: No reported disclosures


Radiocarbon ◽  
2001 ◽  
Vol 43 (2B) ◽  
pp. 843-855 ◽  
Author(s):  
John M Kalish ◽  
Reidar Nydal ◽  
Kjell H Nedreaas ◽  
George S Burr ◽  
Gro L Eine

Radiocarbon measured in seawater dissolved inorganic carbon (DIC) can be used to investigate ocean circulation, atmosphere/ocean carbon flux, and provide powerful constraints for the fine-tuning of general circulation models (GCMs). Time series of 14C in seawater are derived most frequently from annual bands of hermatypic corals. However, this proxy is unavailable in temperate and polar oceans. Fish otoliths, calcium carbonate auditory, and gravity receptors in the membranous labyrinths of teleost fishes, can act as proxies for 14C in most oceans and at most depths. Arcto-Norwegian cod otoliths are suited to this application due to the well-defined distribution of this species in the Barents Sea, the ability to determine ages of individual Arcto-Norwegian cod with a high level of accuracy, and the availability of archived otoliths collected for fisheries research over the past 60 years. Using measurements of 14C derived from Arcto-Norwegian cod otoliths, we present the first pre- and post-bomb time series (1919–1992) of 14C from polar seas and consider the significance of these data in relation to ocean circulation and atmosphere/ocean flux of 14C. The data provide evidence for a minor Suess effect of only 0.2‰ per year between 1919 and 1950. Bomb 14C was evident in the Barents Sea as early as 1957 and the highest 14C value was measured in an otolith core from a cod with a birth date of 1967. The otolith 14C data display key features common to records of 14C obtained from a Georges Bank mollusc and corals from the tropical and subtropical North Atlantic.


2011 ◽  
Vol 56 (2) ◽  
pp. 989-994 ◽  
Author(s):  
C. Plüss-Suard ◽  
A. Pannatier ◽  
C. Ruffieux ◽  
A. Kronenberg ◽  
K. Mühlemann ◽  
...  

ABSTRACTThe original cefepime product was withdrawn from the Swiss market in January 2007 and replaced by a generic 10 months later. The goals of the study were to assess the impact of this cefepime shortage on the use and costs of alternative broad-spectrum antibiotics, on antibiotic policy, and on resistance ofPseudomonas aeruginosatoward carbapenems, ceftazidime, and piperacillin-tazobactam. A generalized regression-based interrupted time series model assessed how much the shortage changed the monthly use and costs of cefepime and of selected alternative broad-spectrum antibiotics (ceftazidime, imipenem-cilastatin, meropenem, piperacillin-tazobactam) in 15 Swiss acute care hospitals from January 2005 to December 2008. Resistance ofP. aeruginosawas compared before and after the cefepime shortage. There was a statistically significant increase in the consumption of piperacillin-tazobactam in hospitals with definitive interruption of cefepime supply and of meropenem in hospitals with transient interruption of cefepime supply. Consumption of each alternative antibiotic tended to increase during the cefepime shortage and to decrease when the cefepime generic was released. These shifts were associated with significantly higher overall costs. There was no significant change in hospitals with uninterrupted cefepime supply. The alternative antibiotics for which an increase in consumption showed the strongest association with a progression of resistance were the carbapenems. The use of alternative antibiotics after cefepime withdrawal was associated with a significant increase in piperacillin-tazobactam and meropenem use and in overall costs and with a decrease in susceptibility ofP. aeruginosain hospitals. This warrants caution with regard to shortages and withdrawals of antibiotics.


2011 ◽  
Vol 78 (5) ◽  
pp. 1397-1403 ◽  
Author(s):  
Anthony G. Dodge ◽  
Lawrence P. Wackett ◽  
Michael J. Sadowsky

ABSTRACTRhodococcussp. strain Mel was isolated from soil by enrichment and grew in minimal medium with melamine as the sole N source with a doubling time of 3.5 h. Stoichiometry studies showed that all six nitrogen atoms of melamine were assimilated. The genome was sequenced by Roche 454 pyrosequencing to 13× coverage, and a 22.3-kb DNA region was found to contain a homolog to the melamine deaminase genetrzA. Mutagenesis studies showed that the cyanuric acid hydrolase and biuret hydrolase genes were clustered together on a different 17.9-kb contig. Curing and gene transfer studies indicated that 4 of 6 genes required for the complete degradation of melamine were located on an ∼265-kb self-transmissible linear plasmid (pMel2), but this plasmid was not required for ammeline deamination. TheRhodococcussp. strain Mel melamine metabolic pathway genes were located in at least three noncontiguous regions of the genome, and the plasmid-borne genes encoding enzymes for melamine metabolism were likely recently acquired.


2017 ◽  
Vol 24 (6) ◽  
pp. 1337-1349 ◽  
Author(s):  
Atilla Damci ◽  
David Arditi ◽  
Gul Polat

Purpose The purpose of this paper is to explore the relationship between civil engineers’ demographics (e.g. age, marital status, education, work experience) and their personal values. The objective was to predict civil engineers’ personal values based on their demographics. Design/methodology/approach A questionnaire survey was administered to civil engineers to collect data on their demographics and their personal values. Statistical analysis was performed to verify whether a significant statistical relationship exists between civil engineers’ demographics and their personal values. Findings The most important and the least important personal values were identified for civil engineers. Statistical analysis indicated that civil engineers’ values do vary based on their demographics. Research limitations/implications The results of this study cannot be generalized, because individuals’ personal values and demographics are, by definition, local. Location and culture may affect the personal values of civil engineers. Practical implications Team leaders normally have access to information about the demographics of the engineers they employ; based on the results of this study, they should be able to predict their personal values, and to make more informed decisions when appointing them to particular positions on project teams. Originality/value The research presented in this paper, establishes for the first time, that a linkage exists between civil engineers’ personal values and their demographics, and makes it easier for team leaders to make assignment decisions.


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