This article analyzes the main factors of anthropological crisis, its attributes, impact upon the worldview, psychological, and cultural characteristics of the modern global network generation of Millennials and Centennials. An overview is given to the sources, in which the authors raise the problems of personal crisis, its causes, as well as the prospects for further development of humanity. Analysis is conducted on key traits in communication of collective society, peculiarities of behavioral communication strategy in the conditions of Informatization of the society. The article provides the results of modern research of R. Jenkins and the agency PBN H+K jointly with Magram MR, as well as “Tomsk initiative” project on the representatives of Millennials – “generation Y” and Centennials – “generation Z”; comparative characteristics of their value orientations and life strategies is given. The current formation and development of the new cultural space with the specific features of global, universal, technologized, virtual nature is demonstrated. The role of Net-technologies is revealed; being the key factor of the transformation of modern space, change the forms of sociocultural interaction, production techniques, transformation and conveyance of information, require elaboration of the special forms of spiritual and practical mastering of the reality and self-reflection of the individuals. An assumption is made that due to the technologies of globalization and ideology of postmodernism, takes place the uniformity of social and political structures, destruction of the forms of human identification – cultural, historical and spiritual, as well as destruction of the worldview foundations of personal becoming. Deidentification of a person becomes the key reason of the anthropological crisis.