scholarly journals Faster and Slower Posttraining Recovery in Futsal: Multifactorial Classification of Recovery Profiles

2019 ◽  
Vol 14 (8) ◽  
pp. 1089-1095 ◽  
Author(s):  
Carolina F. Wilke ◽  
Felipe Augusto P. Fernandes ◽  
Flávio Vinícius C. Martins ◽  
Anísio M. Lacerda ◽  
Fabio Y. Nakamura ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Time Course ◽  
Maximal Oxygen Consumption ◽  
Area Under The Curve ◽  
Hierarchical Cluster ◽  
Total Quality ◽  
Countermovement Jump ◽  
Quality Of Recovery ◽  
Physical Abilities ◽  
Mood Scale

Purpose: To investigate the existence of faster vs slower recovery profiles in futsal and factors distinguishing them. Methods: 22 male futsal players were evaluated in countermovement jump, 10-m sprint, creatine kinase, total quality of recovery (TQR), and Brunel Mood Scale (fatigue and vigor) before and immediately and 3, 24, and 48 h posttraining. Hierarchical cluster analysis allocated players to different recovery profiles using the area under the curve (AUC) of the percentage differences from baseline. One-way ANOVA compared the time course of each variable and players’ characteristics between clusters. Results: Three clusters were identified and labeled faster recovery (FR), slower physiological recovery (SLphy), and slower perceptual recovery (SLperc). FR presented better AUC in 10-m sprint than SLphy (P = .001) and SLperc (P = .008), as well as better TQR SLphy (P = .018) and SLperc (P = .026). SLperc showed better AUC in countermovement jump than SLphy (P = .014) but presented worse fatigue AUC than SLphy (P = .014) and FR (P = .008). AUC of creatine kinase was worse in SLphy than in FR (P = .001) and SLperc (P < .001). The SLphy players were younger than SLperc players (P = .027), whereas FR were slower 10-m sprinters than SLphy players (P = .003) and SLperc (P = .013) and tended to have higher maximal oxygen consumption than SLphy (effect size =1.13). Conclusion: Different posttraining recovery profiles exist in futsal players, possibly influenced by their physical abilities and age/experience.

Preseason Training Improves Perception of Fatigue and Recovery From a Futsal Training Session

2020 ◽  
pp. 1-8
Author(s):  
Carolina Franco Wilke ◽  
Samuel P. Wanner ◽  
Eduardo M. Penna ◽  
André Maia-Lima ◽  
Weslley H.M. Santos ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
High Intensity ◽  
Aerobic Power ◽  
Training Session ◽  
Maximal Aerobic Power ◽  
Total Quality ◽  
Perception Of Effort ◽  
Recovery Profile ◽  
Tactical Training ◽  
Mood Scale

Purpose: To compare the posttraining recovery timeline of elite Brazilian futsal athletes before (Pre-PS) and after 10 weeks of the preseason (Post-PS) period of high-intensity technical–tactical training. Methods: At the start (n = 13) and at the end of the preseason (n = 7), under-20 male futsal players undertook fitness testing for maximal aerobic power, the countermovement jump (CMJ), and the 10-m sprint with change of direction. Furthermore, at both Pre-PS and Post-PS, the players participated in a training session where performance and psychophysiological measures were recorded before, immediately, 3, 24, and 48 hours postsession. The measures included CMJ, 10-m sprint, creatine kinase, Total Quality Recovery Scale, and Brunel Mood Scale. Effect size (ES) analyses compared fitness and posttraining recovery values for each parameter at Pre-PS versus Post-PS. Results: Only trivial ES (−0.02 to 0.11) was evident in maximal aerobic power, CMJ, and 10-m sprint at Post-PS compared with Pre-PS. For the timeline of recovery, only trivial and small ESs were evident for the 10-m sprint (−0.12 to 0.49), though CMJ recovery was improved at 3 hours (0.87) and 48 hours (1.27) at Post-PS and creatine kinase was lower at 48 hours (−1.33) at Post-PS. Perception of recovery was improved in Post-PS at 3 hours (1.50) and 24 hours postsession (0.92). Furthermore, perception of effort was lower immediately after the session (−0.29), fatigue was lower at 3 hours (−0.63), and vigor responses were improved in all postseason assessments (0.59 to 1.13). Conclusion: Despite minimal changes in fitness, preseason training attenuated players’ perception of effort and fatigue and improved their recovery profile following a high-intensity technical–tactical training session.

scholarly journals 5-HT1A Serotonergic, α-Adrenergic and Opioidergic Receptors Mediate the Analgesic Efficacy of Vortioxetine in Mice

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3242
Author(s):  
Nazlı Turan Yücel ◽  
Ümmühan Kandemir ◽  
Ümide Demir Özkay ◽  
Özgür Devrim Can
Keyword(s):  
Analgesic Activity ◽  
Time Course ◽  
Motor Coordination ◽  
Antidepressant Drug ◽  
Area Under The Curve ◽  
Analgesic Efficacy ◽  
Synthesis Inhibitor ◽  
Tail Immersion ◽  
Adrenoceptor Blocker ◽  
The Central Nervous System

Vortioxetine is a multimodal antidepressant drug that affects several brain neurochemicals and has the potential to induce various pharmacological effects on the central nervous system. Therefore, we investigated the centrally mediated analgesic efficacy of this drug and the mechanisms underlying this effect. Analgesic activity of vortioxetine (5, 10 and 20 mg/kg, p.o.) was examined by tail-clip, tail-immersion and hot-plate tests. Motor performance of animals was evaluated using Rota-rod device. Time course measurements (30–180 min) showed that vortioxetine (10 and 20 mg/kg) administrations significantly increased the response latency, percent maximum possible effect and area under the curve values in all of the nociceptive tests. These data pointed out the analgesic effect of vortioxetine on central pathways carrying acute thermal and mechanical nociceptive stimuli. Vortioxetine did not alter the motor coordination of mice indicating that the analgesic activity of this drug was specific. In mechanistic studies, pre-treatments with p-chlorophenylalanine (serotonin-synthesis inhibitor), NAN-190 (serotonin 5-HT1A receptor antagonist), α-methyl-para-tyrosine (catecholamine-synthesis inhibitor), phentolamine (non-selective α-adrenoceptor blocker), and naloxone (non-selective opioid receptor blocker) antagonised the vortioxetine-induced analgesia. Obtained findings indicated that vortioxetine-induced analgesia is mediated by 5-HT1A serotonergic, α-adrenergic and opioidergic receptors, and contributions of central serotonergic and catecholaminergic neurotransmissions are critical for this effect.

scholarly journals Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease

2019 ◽  
Vol 14 ◽  
pp. 117727191987047 ◽  
Author(s):  
Hiroshi Furukawa ◽  
Shomi Oka ◽  
Kota Shimada ◽  
Atsushi Hashimoto ◽  
Akiko Komiya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Stable State ◽  
Area Under The Curve ◽  
Stable Condition ◽  
Hierarchical Cluster ◽  
Acute Onset ◽  
Serum Samples ◽  
Drug Induced

Objective: Acute-onset diffuse interstitial lung disease (AoDILD) includes acute exacerbation of interstitial lung disease (ILD), drug-induced ILD, and Pneumocystis pneumonia, and frequently occurs in patients with rheumatoid arthritis (RA). Since AoDILD causes a poor prognosis in RA, biomarkers for AoDILD were eagerly desired. Metabolomic analyses were extensively performed in cancer patients and successfully generated better diagnostic biomarkers. In the present study, serum metabolomic profiles of AoDILD in RA were investigated to generate better potential metabolomic biomarkers. Methods: Serum samples of 10 RA patients with AoDILD were collected on admission and in a stable state, more than 3 months before the admission. Serum metabolomic analyses were conducted on the samples from these RA patients with AoDILD. Results: Apparently distinct serum metabolomic profiles in AoDILD were not observed in univariate or hierarchical cluster analyses. Partial least squares-discriminant analysis (PLS-DA) was performed to select candidate metabolites based on variable importance in projection (VIP) scores. The PLS-DA model generated from the four metabolites with VIP scores more than 2.25 (mannosamine, alliin, kynurenine, and 2-hydroxybutyric acid) could successfully discriminate AoDILD from the stable condition (area under the curve: 0.962, 95% confidence interval: 0.778–1.000). Conclusion: It was demonstrated that metabolomic profiling was useful to generate better biomarkers in AoDILD.

Amino Acid Mixture Enriched With Arginine, Alanine, and Phenylalanine Stimulates Fat Metabolism During Exercise

2016 ◽  
Vol 26 (1) ◽  
pp. 46-54 ◽  
Author(s):  
Keisuke Ueda ◽  
Yutaka Nakamura ◽  
Makoto Yamaguchi ◽  
Takeshi Mori ◽  
Masayuki Uchida ◽  
...  
Keyword(s):  
Fat Metabolism ◽  
Maximal Oxygen Consumption ◽  
Area Under The Curve ◽  
Oral Intake ◽  
Glucagon Secretion ◽  
Free Fatty Acid Level ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Double Blind ◽  
Maximum Serum

Although there have been many investigations of the beneficial effects of both exercise and amino acids (AAs), little is known about their combined effects on the single-dose ingestion of AAs for lipid metabolism during exercise. We hypothesize that taking a specific combination of AAs implicated in glucagon secretion during exercise may increase fat metabolism. We recently developed a new mixture, d–AA mixture (D-mix), that contains arginine, alanine, and phenylalanine to investigate fat oxidation. In a double-blind, placebo-controlled crossover study, 10 healthy male volunteers were randomized to ingest either D-mix (3 g/dose) or placebo. Subjects in each condition subsequently performed a physical task that included workload trials on a cycle ergometer at 50% of maximal oxygen consumption for 1 hr. After oral intake of D-mix, maximum serum concentrations of glycerol (9.32 ± 6.29 mg/L and 5.22 ± 2.22 mg/L, respectively; p = .028), free fatty acid level (0.77 ± 0.26 mEq/L and 0.63 ± 0.28 mEq/L, respectively; p = .022), and acetoacetic acid levels (37.9 ± 17.7 μmol/L and 30.3 ± 13.9 μmol/L, respectively; p = .040) were significantly higher than in the placebo groups. The area under the curve for glucagon during recovery was numerically higher than placebo (6.61 ± 1.33 μg/L • min and 6.06 ± 1.23 μg/L • min, respectively; p = .099). These results suggest that preexercise ingestion of D-mix may stimulate fat metabolism. Combined with exercise, the administration of AA mixtures could prove to be a useful nutritional strategy to maximize fat metabolism.

Acute and Short-Term Response to Different Loading Conditions During Resisted Sprint Training

2020 ◽  
Vol 15 (7) ◽  
pp. 997-1004
Author(s):  
Beatriz Bachero-Mena ◽  
Miguel Sánchez-Moreno ◽  
Fernando Pareja-Blanco ◽  
Borja Sañudo
Keyword(s):  
Creatine Kinase ◽  
Blood Lactate ◽  
Physical Performance ◽  
Metabolic Response ◽  
Training Session ◽  
Sprint Performance ◽  
Loading Conditions ◽  
Sprint Training ◽  
Countermovement Jump ◽  
Short Term

Purpose: To analyze the acute and short-term physical and metabolic responses to resisted sprint training with 5 different loading conditions (0%, 20%, 40%, 60%, and 80% body mass). Methods: Fifteen male participants performed 8 × 20-m sprints with 2-minute rests between sprints with 5 different loading conditions. Subjects performed a battery of tests (creatine kinase and lactate concentrations, countermovement jump, 20-m sprint, and isokinetic knee extension and flexion contractions) at 3 different time points (preexercise [PRE], postexercise [POST], and 24-h postexercise [POST24H]). Results: Results revealed significant increases in blood lactate for all loading conditions; however, as sled loadings increased, higher blood lactate concentrations and increments in sprint times during the training session were observed. Significant increases in creatine kinase concentration were observed from PRE to POST24H for all loading conditions. Concerning physical performance, significant decreases in countermovement-jump height from PRE to POST were found for all loading conditions. In addition, significant decreases in 20-m sprint performance from PRE to POST were observed for 0% (P = .05) and 80% (P = .02). No significant differences with PRE were observed for the physical-performance variables at POST24H, except for 20% load, which induced a significant decrease in mean power during knee flexion (P = .03). Conclusions: These results suggest that the higher the load used during resisted sprint training, the higher the physical-performance impairments and metabolic response produced, although all loading conditions led to a complete recovery of sprint performance at POST24H.

scholarly journals Molecular Insight into the Anti-Inflammatory Effects of the Curcumin Ester Prodrug Curcumin Diglutaric Acid In Vitro and In Vivo

2020 ◽  
Vol 21 (16) ◽  
pp. 5700 ◽  
Author(s):  
Rianthong Phumsuay ◽  
Chawanphat Muangnoi ◽  
Peththa Wadu Dasuni Wasana ◽  
Hasriadi Hasriadi ◽  
Opa Vajragupta ◽  
...  
Keyword(s):  
Time Course ◽  
Area Under The Curve ◽  
Dependent Manner ◽  
Paw Edema ◽  
Inflammatory Agent ◽  
Potent Inhibition ◽  
Anti Inflammatory ◽  
Ester Prodrug

Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be developed as an anti-inflammatory agent due to its improved solubility and stability. In this study, the anti-inflammatory effects of CurDG were evaluated. The effects of CurDG on inflammatory mediators were evaluated in LPS-stimulated RAW 264.7 macrophage cells. CurDG reduced the increased levels of NO, IL-6, and TNF- α, as well as iNOS and COX-2 expression in cells to a greater extent than those of curcumin, along with the potent inhibition of MAPK (ERK1/2, JNK, and p38) activity. The anti-inflammatory effects were assessed in vivo by employing a carrageenan-induced mouse paw edema model. Oral administration of CurDG demonstrated significant anti-inflammatory effects in a dose-dependent manner in mice. The effects were significantly higher compared to those of curcumin at the corresponding doses (p < 0.05). Moreover, 25 mg/kg curcumin did not exert a significant anti-inflammatory effect for the overall time course as indicated by the area under the curve data, while the equimolar dose of CurDG produced significant anti-inflammatory effects comparable with 50, 100, and 200 mg/kg curcumin (p < 0.05). Similarly, CurDG significantly reduced the proinflammatory cytokine expression in paw edema tissues compared to curcumin (p < 0.05). These results provide the first experimental evidence for CurDG as a promising anti-inflammatory agent.

Increased activity of creatine kinase isoenzyme MB in a theophylline-intoxicated patient.

1985 ◽  
Vol 31 (10) ◽  
pp. 1741-1742 ◽  
Author(s):  
R H Ng ◽  
C Roe ◽  
D Funt ◽  
B E Statland
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Time Course ◽  
Clinical Findings ◽  
Creatine Kinase Isoenzyme ◽  
Increased Activity ◽  
Theophylline Intoxication ◽  
Creatine Kinase Isoenzyme Mb

Abstract A 78-year-old woman had increased activities of creatine kinase (CK; EC 2.7.3.2) and CK-MB isoenzyme in her serum, associated with severe theophylline intoxication. The time course for CK-MB activity was similar to that from an acute myocardial infarction. Clinical findings, however, including electrocardiograms, did not support the diagnosis of myocardial infarction. We suggest caution in interpreting CK-MB results in severe theophylline intoxication.

Chronic levothyroxine and acute T3 treatments enhance the amplitude and time course of uterine contractions in human

2013 ◽  
Vol 304 (5) ◽  
pp. E478-E485 ◽  
Author(s):  
Stéphanie Corriveau ◽  
Jean-Charles Pasquier ◽  
Simon Blouin ◽  
Diego Bellabarba ◽  
Éric Rousseau
Keyword(s):  
Pregnant Women ◽  
Time Course ◽  
Area Under The Curve ◽  
Isometric Tension ◽  
Control Group ◽  
Clinical Practices ◽  
Time To Peak ◽  
Uterine Contractions ◽  
Reduced Frequency

This study compares the functional consequences of levothyroxine (T4) treatment during pregnancy as well as the acute affects of triiodothyronine (T3) on spontaneous uterine contractile activities observed in vitro. Uterine biopsies were obtained from consenting women undergoing elective caesarean at term ( n = 28). Spontaneous contractile activities from T4-treated pregnant women ( n = 8) were compared with control patients ( n = 20) by isometric tension measurements. Effects of acute T3 and T4 on control tissues were also monitored. Area under the curve, amplitude, time to peak, duration, and frequency were quantified. In uterine strips from women treated for hypothyroidism, phasic uterine contractions of larger amplitude (+77%) were observed, with a prolonged duration at 90% relaxation (+138%) and reduced frequency (−55%) compared with values of the control group. The addition of exogenous T3 in vitro on control strips induced a significant increase in the duration of the contractions and a significant decrease in frequency ( P < 0.05), which partially mimics the results obtained in strips from T4-treated women. Significant modifications of contractile properties were observed in strips from pregnant women treated with levothyroxine, consistent with those observed with the addition of exogenous T3. Clinical practices of modern obstetrics should take into account the effect of thyroid hormones on uterine contractions' time course to ensure a tighter followup at the end of pregnancy to achieve safer delivery.

Glutathione depletion during experimental damage to rat skeletal muscle and its relevance to Duchenne muscular dystrophy

1991 ◽  
Vol 80 (6) ◽  
pp. 559-564 ◽  
Author(s):  
M. J. Jackson ◽  
M. H. Brooke ◽  
K. Kaiser ◽  
R. H. T. Edwards
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Time Course ◽  
Contractile Activity ◽  
Calcium Ionophore ◽  
Glutathione Depletion ◽  
Ionophore A23187 ◽  
Enzyme Release

1. The release of glutathione has been studied in comparison with the release of creatine kinase from isolated rat soleus muscles subjected to certain forms of experimental damage. 2. Excessive electrically stimulated contractile activity or treatment of muscles with the mitochondrial inhibitor, 2,4-dinitrophenol, induced a substantial release of both creatine kinase and glutathione and a reduction in the total glutathione content of the muscle. The time course of this release and depletion indicates that the efflux of the two molecules is not directly related and that a reduction in muscle glutathione content does not occur before cytosolic enzyme release. 3. 2,4-Dinitrophenol-stimulated release of creatine kinase was significantly reduced by the omission of external calcium from the incubation media, but glutathione release and depletion was relatively unaffected by this. Deliberate elevation of the muscle intracellular calcium content with the calcium ionophore, A23187, induced a substantial loss of creatine kinase, but had no significant effect on the release of glutathione. 4. Muscle biopsies from patients with Duchenne muscular dystrophy were found to have an elevated content of glutathione and an equivalent protein-thiol content compared with control subjects. 5. We conclude that, although release of glutathione from skeletal muscle occurs after excessive contractile activity or inhibition of mitochondrial metabolism, this is not a key step in the damaging processes leading to cytosolic enzyme release, neither is it relevant to the ongoing damage to skeletal muscle which occurs in patients with Duchenne muscular dystrophy.

scholarly journals Comparison of the Effect of Passive and Active Recovery, and Self-Myofascial Release Exercises on Lactate Removal and Total Quality of Recovery

2018 ◽  
Vol 6 (9a) ◽  
pp. 33 ◽  
Author(s):  
İlbilge Özsu ◽  
Baris Gurol ◽  
Cem Kurt
Keyword(s):  
Strenuous Exercise ◽  
Total Quality ◽  
Active Recovery ◽  
Wingate Anaerobic Test ◽  
Subsequent Performance ◽  
Myofascial Release ◽  
Quality Of Recovery ◽  
Significant Difference ◽  
Exercise Induced

Recovery from exercise-induced fatigue is crucial for subsequent performance. Self-myofascial release (SMR) using a foam roller is an alternative to active recovery (AR). This study aims to compare the effects of passive recovery (PR), AR, and SMR on blood lactate [La-] removal and total quality of recovery (TQR). Twenty-two well trained male athletes (age: 22.6±2.9 years) underwent three testing sessions conducted 72 hours apart but at the same time of each day in a randomized order. After determining resting [La-] and heart rate (HR), the subjects completed a Wingate anaerobic test (WAnT), triggering muscular fatigue. HR and [La-] were measured threeminutes after the WAnT, following which the subjects underwent one of the three different recovery interventions over 15 minutes: PR (lying supine), AR (cycling at 40% of the estimated maximum HR of the respective subject), and SMR (using foam roller on lower extremity muscles). After each recovery intervention, [La-], HR, and TQR were measured. There was no statistically significant difference in [La-] and HR values obtained before the WAnT test (p=0.368, p=0.691, respectively) and right after the WAnT test (0.264, p=0.629) Both AR and SMR were more effective than PR for [La-] removal and obtaining a higher TQR (p<0.001). However, SMR and AR were not superior to one another for blood [La-] removal (p>0.05). In contrast, a significantly higher TQR was observed with SMR than AR and PR (p<0.001). Athletes can apply AR or SMR to recover from strenuous exercise. SMR can be an alternative to PR and AR as a recovery tool.

Sign in / Sign up

Export Citation Format

Share Document