scholarly journals Anaerobic Production of Isoprene by Engineered Methanosarcina Species Archaea

2021 ◽  
Vol 87 (6) ◽  
Author(s):  
Jared Aldridge ◽  
Sean Carr ◽  
Karrie A. Weber ◽  
Nicole R. Buan
Keyword(s):  
Lipid Synthesis ◽  
Production Costs ◽  
Total Carbon ◽  
High Yield ◽  
Extraction And Purification ◽  
Engineered Yeast ◽  
High Production ◽  
The Cost ◽  
Isoprene Synthesis ◽  
Anaerobic Production

ABSTRACT Isoprene is a valuable petrochemical used for a wide variety of consumer goods, such as adhesives and synthetic rubber. We were able to achieve a high yield of renewable isoprene by taking advantage of the naturally high-flux mevalonate lipid synthesis pathway in anaerobic methane-producing archaea (methanogens). Our study illustrates that by genetically manipulating Methanosarcina species methanogens, it is possible to create organisms that grow by producing the hemiterpene isoprene. Mass balance measurements show that engineered methanogens direct up to 4% of total carbon flux to isoprene, demonstrating that methanogens produce higher isoprene yields than engineered yeast, bacteria, or cyanobacteria, and from inexpensive feedstocks. Expression of isoprene synthase resulted in increased biomass and changes in gene expression that indicate that isoprene synthesis depletes membrane precursors and redirects electron flux, enabling isoprene to be a major metabolic product. Our results demonstrate that methanogens are a promising engineering chassis for renewable isoprene synthesis. IMPORTANCE A significant barrier to implementing renewable chemical technologies is high production costs relative to those for petroleum-derived products. Existing technologies using engineered organisms have difficulty competing with petroleum-derived chemicals due to the cost of feedstocks (such as glucose), product extraction, and purification. The hemiterpene monomer isoprene is one such chemical that cannot currently be produced using cost-competitive renewable biotechnologies. To reduce the cost of renewable isoprene, we have engineered methanogens to synthesize it from inexpensive feedstocks such as methane, methanol, acetate, and carbon dioxide. The “isoprenogen” strains we developed have potential to be used for industrial production of inexpensive renewable isoprene.

scholarly journals USE OF ZEOLITE IS ACTIVATED AS SUBSTITUTION OF CEMENT FOR PRICE AND COST

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Ahmad Nurfiki Alwi ◽  
Arif Rahman Setiaji ◽  
Abdurrohim Kurnia Agung ◽  
Abdul Halim
Keyword(s):  
Compressive Strength ◽  
Fly Ash ◽  
Hypothesis Testing ◽  
Building Materials ◽  
Production Costs ◽  
Light Weight ◽  
Residential Community ◽  
High Production ◽  
The Cost ◽  
Cement Compounds

The number of economic needs is one of the fundamental aspects to support the survival of every individual in an area.  If seen in general, the cost of building the building and residential community still use building materials and installation costs are relatively higher.  With the advancement of technology has found a lightweight brick that has better strength, lighter, faster installation and environmentally friendly, so many people began to switch to using lightweight bricks.  For now the price of lightweight brick is still expensive, but this deficiency is covered with the speed of mounting and light weight so overall lightweight brick usage on certain patterns is very profitable.  The use of cement on lightweight bricks leads to high production costs.  With the above problems we have a breakthrough to replace the cement by using zeozolites containing silica compounds that resemble one of the cement compounds.  In this research, cement replacement with Zeolite is 20%, 40% and 60%.  Before use Zeolite was first activated using Fly Ash ratio of 65% Zeolite: 35% Fly Ash and 50% Zeolite: 50% Fly Ash, also activated using Ca (OH) 2 ratio 65% Zeolite: 35% Ca (OH) 2  And 50% Zeolite: 50% Ca (OH) 2.  Thus, there are 15 compositions including the control composition, each composition will be made up of 10 specimens.  Hypothesis testing using two way anova, tested is the effect of cement change treatment with Zeolite and comparison of Zeolite composition with Fly Ash and Ca (OH) 2 to compressive strength, absorption and cost. Keywords: Zeolite, Cement, compressive strength, Cost

scholarly journals ANALISIS DETERMINASI BIAYA PRODUKSI DENGAN PENDEKATAN ACTIVITY BASED COSTING SYSTEM (ABC SYSTEM) (STUDI KASUS DI UD. PRIMA BHAKTI KARAWANG)

BUANA ILMU ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Ade Suhara ◽  
Bona Herman Sianturi
Keyword(s):  
Food Industry ◽  
Production Costs ◽  
Activity Based Costing ◽  
Cost Drivers ◽  
System Method ◽  
Production Activity ◽  
High Production ◽  
Cost Of Production ◽  
Costing System ◽  
The Cost

ABSTRACT UD. Prima Bhakti is a food industry that is engaged in processing cassava into cassava chips which are located at Jalan Kemuning, Karangligar Village, West Telukjambe District, Karawang District, West Java. This factory experienced problems in the system of controlling high production costs which impacted on rising selling prices. The occurrence of production costs swelling due to the lack of good cost management. The costing used by the company is currently based on past cost data which is then made an estimated cost that will occur. From the above problems carried out a study of the design of the cost of production through the approach of Activity Based Costing (ABC). Activity Based Costing method is a method of calculating costs that imposes first costs on activities, then on products based on the use of activity by each product. Activity Based Costing System method identifies the activities carried out, tracing the costs to these activities and then using various cost drivers to trace costs, activities to cost objects. Key words: Cassava chips, cost of production, activity based costing ABSTRAK UD. Prima Bhakti merupakan industri makanan yang bergerak di bidang pengolahan singkong menjadi keripik singkong yang beralamat di Jalan Kemuning Desa Karangligar Kecamatan Telukjambe Barat Kabupaten Karawang Jawa Barat. Pabrik ini mengalami permasalahan pada sistem pengendalian biaya produksi yang tinggi yang berimbas pada naiknya harga jual. Terjadinya pembengkakan biaya produksi dikarenakan belum adanya manajemen biaya yang baik. Penetapan biaya yang dipakai perusahaan saat ini didasarkan pada data biaya masa lalu yang kemudian dibuat taksiran biaya yang akan terjadi. Dari permasalahan di atas dilakukan suatu penelitian mengenai rancangan harga pokok produksi melalui pendekatan Activity Based Costing (ABC). Metode Activity Based Costing adalah metode kalkulasi biaya yang membebankan biaya pertama-tama pada aktivitas, lalu pada produk berdasarkan penggunaan aktivitas oleh setiap produk. Metode Activity Based Costing System mengidentifikasikan aktivitas yang dilaksanakan, menelusuri biaya keaktivatas tersebut dan kemudian menggunakan berbagai pemicu biaya (cost drivers) untuk menelusuri biaya, aktivitas ke objek biaya. Kata kunci : Keripik singkong, harga pokok produksi, activity based costing

Improving Design of Cricoid Plastic Gating System Based on Moldflow

2012 ◽  
Vol 472-475 ◽  
pp. 2264-2269
Author(s):  
Dong Po Yang ◽  
Jian Min Han
Keyword(s):  
Weight Ratio ◽  
Economic Benefits ◽  
Production Costs ◽  
Gating System ◽  
Molding Process ◽  
The Poor ◽  
Design And Manufacturing ◽  
High Production ◽  
Poor Ventilation ◽  
The Cost

To solve the problems such as poor ventilation and high production costs in the production of cricoid plastics, we analysis the reasons and look for solutions with Moldflow software to guide the new design and manufacturing of the mould. The poor ventilated structure is changed into a ventilation structure. A poor ventilation structure is changed to a good ventilation structure. Injection weight ratio was reduced from 35% to 15% - 20%, the gating system was improved, the molding process was optimized, ensuring product quality and save the cost, produced good economic benefits.

scholarly journals Life Cycle Cost Analysis and Optimization of Modular Substation

2019 ◽  
Vol 136 ◽  
pp. 01049
Author(s):  
Li Jun ◽  
Zhang Fan ◽  
Li Yinyuan ◽  
Zhang Beibei
Keyword(s):  
Life Cycle ◽  
Life Cycle Cost ◽  
Cost Optimization ◽  
Production Costs ◽  
Life Cycle Cost Analysis ◽  
Production Scale ◽  
Literature Reading ◽  
High Production ◽  
Cost Breakdown Structure ◽  
The Cost

Due to the lack of high standardization and specialization, the production scale of modular substation is difficult to meet the established requirements. Compared with traditional substation construction, there are still practical problems such as high production costs. Therefore, it is still difficult to promote modular substation. Considering the life cycle of modular substation project, Cost Breakdown Structure (CBS) and Engineering Breakdown Structure (EBS) of the modular substation were defined through literature reading and data analysis. Then use the life cycle cost mapping model to further determine the mapping relationship between CBS and EBS. Finally, the connotation and goal of the life cycle cost optimization of modular substation were proposed, which can effectively promote the cost management of modular substation projects and optimization.

SELISIH BIAYA PRODUKSI SEBAGAI ALAT PENGENDALIAN MANAJEMEN PT INDO PUSAKA BERAU

2019 ◽  
Vol 3 (02) ◽  
pp. 397
Author(s):  
SAFITRI NURHIDAYATI ◽  
RIZKI AMELYA SYAM
Keyword(s):  
Raw Materials ◽  
Field Research ◽  
Analytical Tool ◽  
Production Costs ◽  
Raw Material ◽  
Labor Costs ◽  
Material Costs ◽  
Library Research ◽  
The Difference ◽  
The Cost

This study aims to analyze whether the difference that occurs in the cost of raw materials, direct labor, and factory overhead costs between the standard costs and the actual costs in PLTU LATI is a difference that is favorable or unfavorable. Data collection techniques with field research and library research. The analytical tool used is the analysis of the difference in raw material costs, the difference in direct labor costs and the difference in factory overhead costs. The hypothesis in this study is that the difference allegedly occurs in the cost of raw materials, direct labor costs, and factory overhead costs at PT Indo Pusaka Berau Tanjung Redeb is a favorable difference. The results showed that the difference in the cost of producing MWh electricity at PT Indo Pusaka Berau Tanjung Redeb in 2018, namely the difference in the price of raw material costs Rp. 548,029.80, - is favorable, the difference in quantity of raw materials is Rp. 957,216,602, - is (favorable) , the difference in direct labor costs Rp 2,602,642,084, - is (unfavorable), and the difference in factory overhead costs Rp 8,807,051,422, - is (favorable) This shows that the difference in the overall production cost budget is favorable or profitable. This beneficial difference shows that the company is really able to reduce production costs optimally in 2018.  

AN ECONOMICAL STUDY TO MEASUREMENT OF MARKETING EFFICIENCY IN CALF FATTENING FIELDS IN NINEVEH GOVERNORATE(2018)

2020 ◽  
Vol 51 (4) ◽  
Author(s):  
Abdullah & Al-Taye
Keyword(s):  
Commodity Prices ◽  
Red Meat ◽  
Production Costs ◽  
Meat Production ◽  
Marketing Efficiency ◽  
Basic Source ◽  
Essential Nutrient ◽  
High Production ◽  
Marketing Costs ◽  
Marketing Margins

This study was aimed at assessing marketing efficiency in the main sites of meat production of calf fattening fields in the private sector due to the importance of meat, especially red meat, which has essential nutrient for human body growth and high commodity prices depending on the measurement indicators used to suit the nature of the research conducted in calves fattening production fields in Gogjali region- Nineveh  (2018). The basic source data of the study is obtained from sources on the ongoing ground- marketing questionnaire of three levels, the producer, the wholesaler, the retailer and two fields groups of caste random sample. The first group included (100) fields with imported calves class. The second included (51) fields with local calves class. Whereas, according to the production and marketing costs indicator, the average of marketing efficiency (ME1 ) of marketed meat in both groups of claves fattening fields amounted (92.47, 93.39%) respectively for a kilogram which is a sign of high production costs and, according to the marketing margins indicator, the average of marketing efficiency (ME2 ) of marketed meat in both groups of claves fattening fields amounted (86.89,79.13 %) for per kg which is a sign of high marketing margins. Thus the study concluded a high value of marketing efficiency using the first scale with the fattening period time for both groups while marketing efficiency by using the second scale was characterized by the gradual decline in the imported fattening fields and a gradual rise in the local fattening fields.  The study recommends supporting production inputs (fodder, treatment), unifying markets and limiting the    importation of red meat importation  in order to obtain a good production and currency policy by which the production costs could be reduced to the minimum .

scholarly journals Monitoring the technological processes in the wood industry in order to make them more efficient through technical overhauling

2019 ◽  
Vol 290 ◽  
pp. 02007
Author(s):  
Radu Dan Paltan ◽  
Cristina Biriş ◽  
Loredana Anne-Marie Rădulescu
Keyword(s):  
Automotive Industry ◽  
Operating Mode ◽  
Solid Wood ◽  
Production Costs ◽  
Operating Costs ◽  
Future Research ◽  
Wood Industry ◽  
Research Article ◽  
State Of Research ◽  
The Cost

Of many techniques that are used to optimize production and costs, the studies conducted within a profile company lead to our choice for testing the 6Sigma method (the most used method in the automotive industry) in view of the economic efficiency applied in the wood Industry company. This method measures how many flaws exist in a process and determines in a systematic way how to improve it by technical overhauling and eliminating or minimizing the process for efficiency. This research article aims to study the state of research on the optimization of the production process through technical overhauling for panels reconstituted from solid wood and ways to make production more efficient by cutting costs through technical overhauling. From preliminary research, we estimate that all the items founded and others that will result from further research will result in a significant decrease in production costs that are reflected in the cost of the finished product and consequently in increasing the yield of the company by maximizing its profit. At the same time it may be the basis of future research studies in the field. The easier it is to maximize profits, the lower the operating costs are and the higher recovery rate of investments are, that will result a change in the operating mode: “working smarter not harder”.

scholarly journals Cost Effectiveness of Transbronchial Needle Aspiration

1999 ◽  
Vol 6 (4) ◽  
pp. 332-335 ◽  
Author(s):  
Jennifer A Crocket ◽  
Eric YL Wong ◽  
Dale C Lien ◽  
Khanh Gia Nguyen ◽  
Michelle R Chaput ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Effective ◽  
Diagnostic Procedures ◽  
Needle Aspiration ◽  
Benign Disease ◽  
University Hospital ◽  
High Yield ◽  
Transbronchial Needle Aspiration ◽  
Computed Tomographic ◽  
The Cost

OBJECTIVE: To evaluate the yield and cost effectiveness of transbronchial needle aspiration (TBNA) in the assessment of mediastinal and/or hilar lymphadenopathy.DESIGN: Retrospective study.SETTING: A university hospital.POPULATION STUDIED: Ninety-six patients referred for bronchoscopy with computed tomographic evidence of significant mediastinal or hilar adenopathy.RESULTS: Ninety-nine patient records were reviewed. Three patients had two separate bronchoscopy procedures. TBNA was positive in 42 patients (44%) and negative in 54 patients. Of the 42 patients with a positive aspirate, 40 had malignant cytology and two had cells consistent with benign disease. The positive TBNA result altered management in 22 of 40 patients with malignant disease and one of two patients with benign disease, thereby avoiding further diagnostic procedures. The cost of these subsequent procedures was estimated at $27,335. No complications related to TBNA were documented.CONCLUSIONS: TBNA is a high-yield, safe and cost effective procedure for the diagnosis and staging of bronchogenic cancer.

scholarly journals Bioethanolic yeasts from dung beetles: tapping the potential of extremophilic yeasts for improvement of lignocellulolytic feedstock fermentation

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Anita Ejiro Nwaefuna ◽  
Karl Rumbold ◽  
Teun Boekhout ◽  
Nerve Zhou
Keyword(s):  
Treatment Process ◽  
Dung Beetles ◽  
Production Costs ◽  
Industrial Wastes ◽  
Major Drawback ◽  
Renewable Fuel ◽  
Extreme Stress ◽  
Pre Treatment ◽  
The Cost ◽  
Simultaneous Saccharification

AbstractBioethanol from abundant and inexpensive agricultural and industrial wastes possesses the potential to reduce greenhouse gas emissions. Bioethanol as renewable fuel addresses elevated production costs, as well as food security concerns. Although technical advancements in simultaneous saccharification and fermentation have reduced the cost of production, one major drawback of this technology is that the pre-treatment process creates environmental stressors inhibitory to fermentative yeasts subsequently reducing bioethanol productivity. Robust fermentative yeasts with extreme stress tolerance remain limited. This review presents the potential of dung beetles from pristine and unexplored environments as an attractive source of extremophilic bioethanolic yeasts. Dung beetles survive on a recalcitrant lignocellulose-rich diet suggesting the presence of symbiotic yeasts with a cellulolytic potential. Dung beetles inhabiting extreme stress environments have the potential to harbour yeasts with the ability to withstand inhibitory environmental stresses typically associated with bioethanol production. The review further discusses established methods used to isolate bioethanolic yeasts, from dung beetles.

scholarly journals Economic and Sustainability of Biodiesel Production—A Systematic Literature Review

2021 ◽  
Vol 3 (1) ◽  
pp. 19-36
Author(s):  
Tamás Mizik ◽  
Gábor Gyarmati
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Volatile Fatty Acids ◽  
First Generation ◽  
Production Costs ◽  
Raw Material ◽  
Biodiesel Production ◽  
Important Research Topic ◽  
The Social ◽  
High Production

As Earth’s fossil energy resources are limited, there is a growing need for renewable resources such as biodiesel. That is the reason why the social, economic and environmental impacts of biofuels became an important research topic in the last decade. Depleted stocks of crude oil and the significant level of environmental pollution encourage researchers and professionals to seek and find solutions. The study aims to analyze the economic and sustainability issues of biodiesel production by a systematic literature review. During this process, 53 relevant studies were analyzed out of 13,069 identified articles. Every study agrees that there are several concerns about the first-generation technology; however, further generations cannot be price-competitive at this moment due to the immature technology and high production costs. However, there are promising alternatives, such as wastewater-based microalgae with up to 70% oil content, fat, oils and grease (FOG), when production cost is below 799 USD/gallon, and municipal solid waste-volatile fatty acids technology, where the raw material is free. Proper management of the co-products (mainly glycerol) is essential, especially at the currently low petroleum prices (0.29 USD/L), which can only be handled by the biorefineries. Sustainability is sometimes translated as cost efficiency, but the complex interpretation is becoming more common. Common elements of sustainability are environmental and social, as well as economic, issues.

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