Effect of, hexylresorcinol, a chemical analogue of bacterial anabiosis autoinducers on the stability of membrane structures

2009 ◽  
Vol 45 (2) ◽  
pp. 162-168 ◽  
Author(s):  
N. G. Loiko ◽  
A. L. Mulyukin ◽  
A. N. Kozlova ◽  
A. P. Kaplun ◽  
V. V. Sorokin ◽  
...  
Keyword(s):  
Membrane Structures ◽  
The Stability ◽  
Chemical Analogue

scholarly journals Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xiao-Huan Tang ◽  
Ting Guo ◽  
Xiang-Yu Gao ◽  
Xiao-Long Wu ◽  
Xiao-Fang Xing ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Noncoding Rnas ◽  
Tumour Microenvironment ◽  
Clinical Applications ◽  
Biological Molecules ◽  
Biological Functions ◽  
Membrane Structures ◽  
Chemical Substances ◽  
Expression Levels ◽  
The Stability

AbstractExosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs play crucial roles in the tumorigenesis, progression and drug resistance of gastric cancer (GC). In addition, regulating the expression levels of exosomal ncRNAs can promote or suppress GC progression. Moreover, the membrane structures of exosomes protect ncRNAs from degradation by enzymes and other chemical substances, significantly increasing the stability of exosomal ncRNAs. Specific hallmarks within exosomes that can be used for exosome identification, and specific contents can be used to determine their origin. Therefore, exosomal ncRNAs are suitable for use as diagnostic and prognostic biomarkers or therapeutic targets. Regulating the biogenesis of exosomes and the expression levels of exosomal ncRNAs may represent a new way to block or eradicate GC. In this review, we summarized the origins and characteristics of exosomes and analysed the association between exosomal ncRNAs and GC development.

scholarly journals Enhanced Stability of Lipid Structures by Dip-Pen Nanolithography on Block-Type MPC Copolymer

Molecules ◽  
2020 ◽  
Vol 25 (12) ◽  
pp. 2768
Author(s):  
Hui-Yu Liu ◽  
Ravi Kumar ◽  
Madoka Takai ◽  
Michael Hirtz
Keyword(s):  
Lipid Membranes ◽  
Silicon Oxide ◽  
Lipid Membrane ◽  
Block Type ◽  
Membrane Structures ◽  
Solid Supports ◽  
Biomedical Sensing ◽  
The Stability ◽  
Lipid Structures ◽  
Dip Pen Nanolithography

Biomimetic lipid membranes on solid supports have been used in a plethora of applications, including as biosensors, in research on membrane proteins or as interfaces in cell experiments. For many of these applications, structured lipid membranes, e.g., in the form of arrays with features of different functionality, are highly desired. The stability of these features on a given substrate during storage and in incubation steps is key, while at the same time the substrate ideally should also exhibit antifouling properties. Here, we describe the highly beneficial properties of a 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer for the stability of supported lipid membrane structures generated by dip-pen nanolithography with phospholipids (L-DPN). The MPC copolymer substrates allow for more stable and higher membrane stack structures in comparison to other hydrophilic substrates, like glass or silicon oxide surfaces. The structures remain highly stable under immersion in liquid and subsequent incubation and washing steps. This allows multiplexed functionalization of lipid arrays with antibodies via microchannel cantilever spotting (µCS), without the need of orthogonal binding tags for each antibody type. The combined properties of the MPC copolymer substrate demonstrate a great potential for lipid-based biomedical sensing and diagnostic platforms.

scholarly journals Wind-Load Response and Evacuation Efficiency Analysis of Marine Evacuation Inflatable Slide

2019 ◽  
Vol 10 (1) ◽  
pp. 21
Author(s):  
Fankai Kong ◽  
Hengxu Liu ◽  
Binghan Wang ◽  
Huaqiu Ding ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Internal Pressure ◽  
Wind Load ◽  
Membrane Structures ◽  
Double Standards ◽  
Wind Resistance ◽  
Wind Speeds ◽  
Load Response ◽  
The Stability ◽  
Dangerous Condition ◽  
The Ideal

Flexible inflatable membrane structure has the characteristics of light weight, large span, and small stiffness, and it is very sensitive to wind load. Aiming at the dynamic response of marine evacuation inflatable slides under complex and changeable wind loads at sea, the response law of the inflatable slide under different wind directions, wind speeds, and internal pressure conditions is studied by using fluid–solid coupling theory. The most dangerous conditions of evacuation system installation and the ideal internal pressure of the inflatable slide meeting the stability requirements are deduced. The LS-DYNA module is used to simulate the inflation process of the slide. The evacuation sliding is rationally simplified. By changing the inflatable internal pressure of the slide, the variation law of displacement, deformation, and sliding speed of the slide is obtained, and the optimal inflation internal pressure satisfying the evacuation efficiency requirement is obtained. The results show that the inflow wind direction angle of 30° is the most dangerous condition for slideway installation, and the internal pressure of 4000 Pa is the ideal internal pressure to meet the double standards of stability and evacuation efficiency. The numerical results obtained are valuable for analyzing wind resistance of offshore inflatable membrane structures and their practical design and application in evacuation systems.

On the role of membrane anisotropy and BAR proteins in the stability of tubular membrane structures

2012 ◽  
Vol 45 (2) ◽  
pp. 231-238 ◽  
Author(s):  
Doron Kabaso ◽  
Nataliya Bobrovska ◽  
Wojciech Góźdź ◽  
Nir Gov ◽  
Veronika Kralj-Iglič ◽  
...  
Keyword(s):  
Membrane Structures ◽  
Tubular Membrane ◽  
The Stability

Residual stress and microstructural evolution in thin film materials for a micro solid oxide fuel cell (SOFC).

2004 ◽  
Vol 854 ◽  
Author(s):  
David Quinn ◽  
S. Mark Spearing ◽  
Brian L. Wardle
Keyword(s):  
Residual Stress ◽  
Stress Component ◽  
Solid Oxide ◽  
Intrinsic Stress ◽  
Oxide Fuel ◽  
X Ray Diffraction ◽  
Membrane Structures ◽  
X Ray ◽  
Sputter Deposited ◽  
The Stability

ABSTRACTThe stability of multilayered membrane structures is a major challenge in the development of microfabricated solid oxide fuel cells (SOFC). The work presented here explores residual stress in sputter-deposited yttria stabilized zirconia (YSZ) thin films (5nm – 1000nm thickness) as a function of deposition pressure and substrate temperature. The results indicate variations in intrinsic stress from ∼0.5GPa compressive to mildly tensile (∼50 MPa). Microstructure is characterized by x-ray diffraction (XRD). The evolution of intrinsic stress with temperature is investigated by thermally cycling YSZ films deposited on silicon wafers. Observed changes of 100s of MPa in the intrinsic stress component of the film serve as indicators of possible changes in microstructure. Such changes in microstructure are subsequently characterized using x-ray diffraction of as-deposited and annealed films. Correlations with relevant mechanisms and models of residual stress evolution are discussed. Finally, use of such residual stress data in the fabrication and design of mechanically stable multilayered membranes for micro SOFC devices is discussed.

Open discussion

1982 ◽  
Vol 99 ◽  
pp. 605-613
Author(s):  
P. S. Conti
Keyword(s):  
Buenos Aires ◽  
Large Mass ◽  
List Type ◽  
Common Phenomenon ◽  
Open Discussion ◽  
The Stability ◽  
Ring Nebulae

Conti: One of the main conclusions of the Wolf-Rayet symposium in Buenos Aires was that Wolf-Rayet stars are evolutionary products of massive objects. Some questions:–Do hot helium-rich stars, that are not Wolf-Rayet stars, exist?–What about the stability of helium rich stars of large mass? We know a helium rich star of ∼40 MO. Has the stability something to do with the wind?–Ring nebulae and bubbles : this seems to be a much more common phenomenon than we thought of some years age.–What is the origin of the subtypes? This is important to find a possible matching of scenarios to subtypes.

Symmetric Multistep Methods Revisited: II. Numerical Experiments

1999 ◽  
Vol 173 ◽  
pp. 309-314 ◽  
Author(s):  
T. Fukushima
Keyword(s):  
Multistep Methods ◽  
Computational Time ◽  
Integration Time ◽  
Implicit Methods ◽  
Symmetric Methods ◽  
Celestial Bodies ◽  
The Stability ◽  
Predictor Corrector ◽  
Symmetric Multistep Methods ◽  
Integration Errors

AbstractBy using the stability condition and general formulas developed by Fukushima (1998 = Paper I) we discovered that, just as in the case of the explicit symmetric multistep methods (Quinlan and Tremaine, 1990), when integrating orbital motions of celestial bodies, the implicit symmetric multistep methods used in the predictor-corrector manner lead to integration errors in position which grow linearly with the integration time if the stepsizes adopted are sufficiently small and if the number of corrections is sufficiently large, say two or three. We confirmed also that the symmetric methods (explicit or implicit) would produce the stepsize-dependent instabilities/resonances, which was discovered by A. Toomre in 1991 and confirmed by G.D. Quinlan for some high order explicit methods. Although the implicit methods require twice or more computational time for the same stepsize than the explicit symmetric ones do, they seem to be preferable since they reduce these undesirable features significantly.

Uniformity of Magnification from Different Electron Microscopes

1967 ◽  
Vol 25 ◽  
pp. 32-33
Author(s):  
Godfrey C. Hoskins ◽  
V. Williams ◽  
V. Allison
Keyword(s):  
Diffraction Grating ◽  
The Other ◽  
Carbon Replica ◽  
Electron Microscopes ◽  
The Stability

The method demonstrated is an adaptation of a proven procedure for accurately determining the magnification of light photomicrographs. Because of the stability of modern electrical lenses, the method is shown to be directly applicable for providing precise reproducibility of magnification in various models of electron microscopes.A readily recognizable area of a carbon replica of a crossed-line diffraction grating is used as a standard. The same area of the standard was photographed in Phillips EM 200, Hitachi HU-11B2, and RCA EMU 3F electron microscopes at taps representative of the range of magnification of each. Negatives from one microscope were selected as guides and printed at convenient magnifications; then negatives from each of the other microscopes were projected to register with these prints. By deferring measurement to the print rather than comparing negatives, correspondence of magnification of the specimen in the three microscopes could be brought to within 2%.

Effect of Improved ThO2 Particle Dispersion in Nickel on High-Temperature Strength

1970 ◽  
Vol 28 ◽  
pp. 444-445
Author(s):  
E. R. Kimmel ◽  
H. L. Anthony ◽  
W. Scheithauer
Keyword(s):  
High Temperature ◽  
Metal Matrix ◽  
Oxide Particle ◽  
Oxide Phase ◽  
Dislocation Motion ◽  
Particle Dispersion ◽  
High Temperature Strength ◽  
Strengthening Effect ◽  
Oxide Particles ◽  
The Stability

The strengthening effect at high temperature produced by a dispersed oxide phase in a metal matrix is seemingly dependent on at least two major contributors: oxide particle size and spatial distribution, and stability of the worked microstructure. These two are strongly interrelated. The stability of the microstructure is produced by polygonization of the worked structure forming low angle cell boundaries which become anchored by the dispersed oxide particles. The effect of the particles on strength is therefore twofold, in that they stabilize the worked microstructure and also hinder dislocation motion during loading.

An Analysis of Dissociation of Molecules in a High Resolution Electron Microscope

1973 ◽  
Vol 31 ◽  
pp. 486-487
Author(s):  
Mihir Parikh
Keyword(s):  
Electron Microscope ◽  
High Resolution ◽  
Cross Sections ◽  
Resolving Power ◽  
Peak Intensity ◽  
Molecular Film ◽  
Resolution Electron ◽  
Dissociation Cross Section ◽  
High Resolution Electron Microscope ◽  
The Stability

It is well known that the resolution of bio-molecules in a high resolution electron microscope depends not just on the physical resolving power of the instrument, but also on the stability of these molecules under the electron beam. Experimentally, the damage to the bio-molecules is commo ly monitored by the decrease in the intensity of the diffraction pattern, or more quantitatively by the decrease in the peaks of an energy loss spectrum. In the latter case the exposure, EC, to decrease the peak intensity from IO to I’O can be related to the molecular dissociation cross-section, σD, by EC = ℓn(IO /I’O) /ℓD. Qu ntitative data on damage cross-sections are just being reported, However, the microscopist needs to know the explicit dependence of damage on: (1) the molecular properties, (2) the density and characteristics of the molecular film and that of the support film, if any, (3) the temperature of the molecular film and (4) certain characteristics of the electron microscope used

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