Bone and Joint Disease in the Elderly

OBJECTIVE: to identify the prevalence and intensity of chronic pain among elderly people of the community and to analyze associations with the self-perceived health status.METHOD: cross-sectional study with a populational sample (n=934), conducted through household interviews in the city of Goiânia, Brazil. The intensity of chronic pain (existing for 6 months or more) was measured using a numerical scale (0-10) and the self-perceived health through a verbal scale (very good, good, fair, poor, very poor). For the statistical analysis, the absolute frequency and percentage, CI (95%), Chi-square test, Odds ratio, and regression analysis were used. Significance of 5%.RESULTS: The prevalence of chronic pain was 52.8% [CI (95%):49.4-56.1]; most frequently located in the lower limbs (34.5%) and lumbar region (29.5%); with high or the worst possible intensity for 54.6% of the elderly people. The occurrence of chronic pain was associated with (p<0.0001) a worse self-perception of health (OR=4.2:2.5-7.0), a greater number of chronic diseases (OR=1.8:1.2-2.7), joint disease (OR=3.5:2.4-5.1) and the female gender (OR=2.3:1.7-3.0). A lower intensity of chronic pain was associated with a better self-perception of health (p<0.0001).CONCLUSION: the majority of the elderly people of the community reported chronic pain, of a severe intensity, and located in areas related to movement activities, thus influencing the morbidity and mortality of this population.

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Correlation between histopathologic and radiological changes in articular cartilage of the knee joint with degenerative joint disease

International Surgery Journal ◽

10.18203/2349-2902.isj20164795 ◽

2017 ◽

Vol 4 (2) ◽

pp. 450

Author(s):

Hakan Cift ◽

Ali Seker ◽

Bulent Kilic ◽

Murat Demiroglu ◽

Asli Erdogan Cakir ◽

...

Keyword(s):

Subchondral Bone ◽

The Elderly ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Lateral Condyle ◽

Replacement Procedure ◽

Tibial Condyle ◽

Stage 4 ◽

Significant Difference ◽

The Difference

Background: Osteoarthritis (OA) of the knee is among the most common disabling diseases which may cause pain and decrease in functional status. It is the commonest form of arthritis and is most prevalent in the elderly, with 50% of adults aged 65-75 years and almost 70% of those 75+ years suffer from this disease. The aim of this study was to investigate consistency of radiologic findings with histomorphologic structure of bone in patients with severe gonarthrosis.Methods: 62 knees of 57 patients over 60 years old who had stage 3-4 gonarthrosis according to Kellgren-Lawrence classification were included in the study. Patients were separated into two groups as having stage 3 or stage 4 gonarthrosis. All the patients underwent total knee replacement procedure. During the operation distal femoral medial/lateral condyle and proximal tibial medial/lateral plateau were removed and sent to histologic examination for the measurement of thickness of cartilage layer and subchondral bone, number and thickness of trabeculae, space between two trabeculae.Results: Average thickness of subchondral bone was measured at stage 3 gonarthrosis and at stage 4 gonarthrosis. Only the difference between medial tibial condyle values of two groups was statistically significant. Average trabecula thickness was measured both at stage 3 and at stage 4 gonarthrosis. Only the difference between lateral tibial condyle values of two groups was statistically significant. Furthermore, as for the number of trabeculas and cavity between trabeculae, a significant difference couldn’t be found.Conclusions: Despite having radiological differences two groups can be said to show similar histopathological characteristics.

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Differences in Predictive Factors for Sustained Clinical Remission with Abatacept Between Younger and Elderly Patients with Biologic-naive Rheumatoid Arthritis: Results from the ABROAD Study

The Journal of Rheumatology ◽

10.3899/jrheum.160051 ◽

2016 ◽

Vol 43 (11) ◽

pp. 1974-1983 ◽

Cited By ~ 13

Author(s):

Masahiro Sekiguchi ◽

Takao Fujii ◽

Kiyoshi Matsui ◽

Kosaku Murakami ◽

Satoshi Morita ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Elderly Patients ◽

Disease Activity ◽

Predictive Factors ◽

Clinical Remission ◽

Health Assessment ◽

The Elderly ◽

Joint Disease ◽

Younger Patients ◽

Reactive Protein

Objective.To differentiate predictive factors for sustained clinical remission between elderly and younger patients with rheumatoid arthritis (RA) receiving abatacept (ABA) as an initial biological disease-modifying antirheumatic drug.Methods.The study involved 277 biologic-naive patients with RA with high or moderate disease activity, who were treated with intravenous ABA and evaluated for 48 weeks in 43 Japanese hospitals and rheumatology clinics (the ABatacept Research Outcomes as a First-line Biological Agent in the Real WorlD study: UMIN000004651). Predictive factors associated with sustained clinical remission defined by the 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP) during the 24–48–week or 36–48–week periods were determined in elderly (≥ 65 yrs, n = 148) and younger patient groups (< 65 yrs, n = 129) using logistic regression analysis.Results.Clinical remission was achieved at 24 and 48 weeks in 35.1% and 36.5% of patients in the elderly group and 34.9% and 43.4% in the younger group, respectively. In elderly patients, anticitrullinated protein antibody (ACPA) positivity and a lower DAS28-CRP score were significantly associated with sustained clinical remission; however, a lower Health Assessment Questionnaire-Disability Index (HAQ-DI) score was not related to sustained clinical remission. In younger patients, lower DAS28-CRP and HAQ-DI scores were predictive factors for sustained clinical remission, whereas ACPA positivity was not a useful predictive factor for sustained clinical remission.Conclusion.Although the effectiveness of ABA in biologic-naive patients with RA was equally recognized in elderly and younger patients, the baseline clinical characteristics associated with sustained clinical remission were substantially different.

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Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes

Food & Function ◽

10.1039/c7fo00823f ◽

2017 ◽

Vol 8 (10) ◽

pp. 3737-3744 ◽

Cited By ~ 26

Author(s):

Zhenhua Feng ◽

Xiaobin Li ◽

Jian Lin ◽

Wenhao Zheng ◽

Zhichao Hu ◽

...

Keyword(s):

Articular Cartilage ◽

Subchondral Bone ◽

Inflammatory Mediators ◽

Elderly Population ◽

The Elderly ◽

Joint Disease ◽

Induced Expression ◽

Bone Sclerosis ◽

Osteoarthritis Chondrocytes

Osteoarthritis (OA) is the most common form of joint disease and is widespread in the elderly population and is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis.

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Bone and Joint Disease in the Elderly

Medical Clinics of North America ◽

10.1016/s0025-7125(16)31218-4 ◽

1983 ◽

Vol 67 (2) ◽

pp. 517-530 ◽

Cited By ~ 8

Author(s):

Kenneth P. Scileppi

Keyword(s):

The Elderly ◽

Joint Disease

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Bone and Joint Disease in the Elderly

Postgraduate Medical Journal ◽

10.1136/pgmj.60.703.380 ◽

1984 ◽

Vol 60 (703) ◽

pp. 380-380

Author(s):

G. S. Rai

Keyword(s):

The Elderly ◽

Joint Disease

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Serum Metabolites as Potential Biomarkers for Diagnosis of Knee Osteoarthritis

Disease Markers ◽

10.1155/2015/684794 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 13

Author(s):

Qingmeng Zhang ◽

Heng Li ◽

Zhendong Zhang ◽

Fan Yang ◽

Jiying Chen

Keyword(s):

Knee Osteoarthritis ◽

Metabolic Profile ◽

Elderly Population ◽

The Elderly ◽

Ultra Performance Liquid Chromatography ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Healthy Controls ◽

Knee Oa ◽

Potential Biomarkers

Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.

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Efektivitas Kompres Bawang Merah terhadap Nyeri Sendi pada Lansia

Jurnal Kesehatan ◽

10.26630/jk.v9i2.867 ◽

2018 ◽

Vol 9 (2) ◽

pp. 177

Author(s):

Siti Fadlilah ◽

Ririn Wahyu Widayati

Keyword(s):

Joint Pain ◽

Measurement Instrument ◽

Sampling Technique ◽

The Elderly ◽

Complementary Therapy ◽

Pain Scale ◽

Joint Disease ◽

Rank Test ◽

P Value ◽

Quasi Experimental

One of the changes in the musculoskeletal system such as changes in muscles and joint bones is the most common among the elderly aged > 60 years. The percentage of the joint pain among the elderly in the special region of Yogyakarta is 25.4%. If not treated immediately the incidence rate of the joint disease will increase significantly. This can be overcome by providing an intervention in the form of onion compress. The result of a preliminary study indicated that 22 elderly people experienced the joint pain. The objective is to investigate the effectiveness of onion compress in the joint pain among the elderly in Sanggrahan Hamlet, Wedomartani, Ngemplak, Sleman, Yogyakarta. Research Method is this was a quantitative study, namely a quasi-experimental study. The sample consisted of 15 people. The sampling technique was the purposive sampling technique. The measurement instrument was the pain ratio scale. The statistical test was the Wilcoxon signed rank test. Results are The mean scores of the pain scale before and after onion compress were 5.2 and 2.4 with a mean difference of 2.8. The bivariate test yielded p-value=0.001. Conclusion and Suggestion are Onion compress is effective to decrease the joint pain among the elderly in Sanggrahan Hamlet, Wedomartani, Ngemplak, Sleman, Yogyakarta. The respondents are expected to be able to apply an onion compress as a complementary therapy for the joint pain.<strong></strong>

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Targeting Nerve Growth Factor, a new option for treatment of osteoarthritis: A Network meta-analysis of comparative efficacy and safety with traditional drugs

10.21203/rs.3.rs-28823/v1 ◽

2020 ◽

Author(s):

Ziqin Cao ◽

Pengcheng Dou ◽

Zeling Long ◽

Yihan Li ◽

Jingjing Sun ◽

...

Keyword(s):

Pain Relief ◽

Meta Analysis ◽

The Elderly ◽

Joint Disease ◽

Efficacy And Safety ◽

Relieve Pain ◽

Inflammatory Drugs ◽

Meta Analyses ◽

And Function ◽

Efficacious Drug

Abstract BACKGROUND: Osteoarthritis (OA) is the most common joint disease and leading cause of pain and disability in the elderly population. Most guidelines recommend the use non-steroidal anti-inflammatory drugs (NSAIDs) and opioids for the non-operative treatment of OA. Monoclonal NGF antibodies are potential for pain relief and function improvement of OA. We conducted this network meta-analysis to comprehensively compare the efficacy and safety of monoclonal NGF antibodies with NSAIDs and opioids for OA. METHODS: Relevant studies, published up to January 2020, were included from PubMed, CKNI and Web of Science databases. Bayesian network and conventional meta-analyses were conducted. Pain relief, function improvement and risk of adverse effects (AEs) were assessed. RESULTS: 38 articles, comprising 41 trials (20489 patients with OA) were included. Overall, Anti-NGF was the most efficacious drug for pain relief (SMD compared with placebo 4.25, 95% CIs [2.87 to 5.63], SUCRA=93.7%) and (SMD 4.90, 95% CIs [3.46 to 6.33], SUCRA=98.3%). Although Anti-NGF was associated with higher risk of peripheral sensation abnormality (paresthesia and pruritus), it was not associated with higher withdrawal rates due to AEs and ohter AEs. CONCLUSIONS: The results show that monoclonal NGF antibodies significantly relieve pain due to OA and improve function, compared to selective cox-2 inhibitions, NSAIDs, and opioids. The monoclonal NGF antibodies are not associated with severe AEs. However, there is need to conduct more studies to confirm the findings of this study.

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Hubungan Rasionalitas Penggunaan Obat Nyeri Terhadap Tingkat Nyeri Pada Lansia Dengan Osteoarthritis Di Panti Pelayanan Sosial Lanjut Usia Bisma Upakara Pemalang Tahun 2021

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.948 ◽

2021 ◽

Vol 1 ◽

pp. 1887-1891

Author(s):

Putri Diyah Ayu Rizkiana ◽

St Rahmatullah ◽

Nur Izzah

Keyword(s):

Health Workers ◽

Statistical Tests ◽

Cartilage Damage ◽

The Elderly ◽

Pain Medication ◽

Joint Disease ◽

Inappropriate Drug ◽

P Value ◽

Moderate Pain ◽

Kolmogorov Smirnov

AbstractOsteoarthritis is a degenerative joint disease characterized by cartilage damage and often occurs in the elderly. Diseases that are often found in the community. Management of osteoarthritis is aimed at controlling or relieving pain. Inappropriate drug selection can cause the drug to be ineffective, exacerbate a disease, and cause unwanted effects. This study aims to determine the relationship between the rationality of the use of pain medication on the level of pain in the elderly with osteoarthritis. The research design is a descriptive correlative study with a cross sectional approach. The sampling technique used was total sampling with a total of 43 respondents. Data collection tools using a questionnaire and statistical tests using the Kolmogorov Smirnov test. The results of the study found that the percentage related to rationality of rational pain medication (69.8%) was irrational (30.2%) and at the level of pain experienced mild pain (18.6%), moderate pain (67.4%), and moderate pain. weight (14.0%). Statistical test results obtained p value of 0.042 (<0.05) Ho is rejected, which means that there is a significant relationship between the rationality of pain medication use and pain levels in the elderly with osteoarthritis at the Bisma Upakara Elderly Social Service Institution, Pemalang. . The results of this study recommend for health workers to provide or improve health education related to the rationality of using pain medication.Keywords: Pain, Osteoarthritis, Rationality AbstrakOsteoarthritis adalah penyakit radang sendi degeneratif dengan di tandai dengan adanya kerusakan kartilago dan sering terjadi pada lansia .Penyakit yang sering dijumpai pada masyarakat. Penatalaksanaan osteoarthritis ditujukan pada pengendalian atau menghilangkan nyeri. Pemilihan obat yang tidak tepat dapat menyebabkan obat menjadi tidak berkhasiat, memperparah suatu penyakit, dan menimbulkan efek yang tidak diinginkan.Penelitian ini bertujuan untuk mengetahui hubungan rasionalitas penggunaan obat nyeri terhadap tingkat nyeri pada lansia dengan osteoarthritis. Desain penelitian studi deskriptif korelatif dengan pendekatancross sectional. Teknik pengambilan sampel menggunakan total samplingdengan jumlah 43 responden. Alat pengumpulan data menggunakan kuesioner dan uji statistik menggunakan uji Kolmogorov Smirnov. Hasil dari penelitiandidapatkan persentase terkait rasionalitas obat nyeri yang rasional (69,8%) tidak rasional (30,2%) dan pada tingkat nyeri yang mengalami nyeri ringan (18,6%), nyeri sedang (67,4%), dan nyeri berat (14,0%).hasil uji statistik didapatkan p value sebesar 0,042 (< 0,05) yang berarti ada hubungan yang signifikan rasionalitas penggunaan obat nyeri terhadap tingkat nyeri pada lansia dengan osteoarthritis di Panti Pelayanan Sosial Lanjut Usia Bisma Upakara Pemalang. Hasil peneltian ini merekomendasikan bagi tenaga kesehatan untuk memberikan atau meningkatkan pendidikan kesehatan terkait dengan rasionalitas penggunaan obat nyeri. Kata kunci : Nyeri; Osteoarthritis; Rasionalitas

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