scholarly journals Hypoxia, depression of testosterone, and impotence in pickwickian syndrome reversed by weight reduction.

BMJ ◽  
1984 ◽  
Vol 289 (6448) ◽  
pp. 801-802 ◽  
Author(s):  
P A Semple ◽  
A Graham ◽  
Y Malcolm ◽  
G H Beastall ◽  
W S Watson
Keyword(s):  
Weight Reduction ◽  
Pickwickian Syndrome

CARDIORESPIRATORY SYNDROME OF OBESITY (PICKWICKIAN SYNDROME) IN CHILDREN

PEDIATRICS ◽  
1961 ◽  
Vol 27 (2) ◽  
pp. 237-245
Author(s):  
Glen G. Cayler ◽  
James Mays ◽  
Harris D. Riley
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Weight Reduction ◽  
Practical Importance ◽  
Right Atrial ◽  
Oxygen Administration ◽  
Pulmonary Arterial ◽  
Pickwickian Syndrome

The clinical, pulmonary and hemodynamic findings in two boys with the Pickwickian syndrome are presented. In contrast to adults with this syndrome, all four children thus far reported have been mentally retarded. Both of our cases were cyanotic, lethargic and in congestive heart failure at the time of admission. They both exhibited polycythemia, cardiac enlargement, electrocardiographic evidence of right atrial and right ventricular hypertrophy, decreased pulmonary function without evidence of obstructive pulmonary disease and pulmonary arterial hypertension. Symptoms of cardiorespiratory disease subsided following weight reduction. The pathophysiologic mechanisms of alveolar hypoventilation, pulmonary arterial hypertension, and congestive heart failure in patients with this disease complex are discussed. The clinical recognition of this syndrome is of practical importance because: 1) it is a preventable disease, 2) the changes are reversible following weight reduction and 3) because of the dangers of oxygen administration.

Approach to Automotive Weight Reduction

1992 ◽  
Vol 78 (10) ◽  
pp. 1512-1516
Author(s):  
Shinji SHIBATA
Keyword(s):  
Weight Reduction

The Weight Reduction of Charged Capacitors, Charge-Mass Interaction, and Einstein's Unification

2015 ◽  
Vol 7 (3) ◽  
pp. 1959-1969 ◽  
Author(s):  
C. Y. Lo
Keyword(s):  
General Relativity ◽  
Weight Reduction ◽  
Gravitational Force ◽  
Gravitational Energy ◽  
Repulsive Force ◽  
Mass Force ◽  
Charge Mass ◽  
Energy Stress ◽  
Current Mass ◽  
Photonic Energy

The Biefeld-Brown (B-B) effect consists of two parts: 1) the initial thrust is due to the electric potential that moves the electrons to the positive post; and 2) the subsequent lift is due to the separate concentration of the positive and the negative charges. The weight reduction of a charged capacitor is due to a repulsive charge-mass interaction, which is normally cancelled by the attractive current-mass interaction. In a charged capacitor, some electrons initially moving in the orbits become statically concentrated and thus a net repulsive force is exhibited. Based on observations, it is concluded that a repulsive charge-mass interaction is proportional to the charge density square and diminishes faster than the attractive gravitational force, and that the current-mass force is perpendicular to the current. This charge-mass interaction is crucial to establish the unification of electromagnetism and gravitation. To confirm general relativity further, experimental verification of the details of this mass-charge repulsive force is recommended. Moreover, general relativity implies that the photons must include gravitational energy and this explains that experiments show that the photonic energy is equivalent to mass although the electromagnetic energy-stress tensor is traceless. In general relativity,it is crucial to understandnon-linear mathematics and that the Einstein equation has no bounded dynamic solutions. However, due to following Einstein's errors, theorists failed in understanding these and ignored experimental facts on repulsive gravitation. Since the charge-mass interaction occurs in many areas of physics, Einstein's unification is potentially another revolution in physics. Moreover, the existence of a repulsive gravitation implies the necessity of re-justifying anew the speculation of black holes.

Do the Natural Chemical Compounds Interact with the Same Targets of Current Pharmacotherapy for Weight Management?-A Review

2019 ◽  
Vol 20 (4) ◽  
pp. 399-411 ◽  
Author(s):  
Shiqi Luo ◽  
George Binh Lenon ◽  
Harsharn Gill ◽  
Heidi Yuen ◽  
Angela Wei Hong Yang ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Management ◽  
Pancreatic Lipase ◽  
Weight Reduction ◽  
Chemical Compounds ◽  
Alpha Amylase ◽  
Melanocortin Receptor ◽  
Health Concern ◽  
European Medicines Agency ◽  
Ppar Γ

Background: Obesity has become a worldwide health concern. Pharmacotherapies are now being introduced because lifestyle modifications alone are insufficient for weight management. The treatment outcomes of current approved anti-obesity agents are not satisfying due to drug-related intolerances. And so natural therapies including herbal medicines are popular alternatives for weight reduction; however, there are limited studies about their mechanism of actions. Methods: Five databases (PubMed, Scopus, Google Scholar, Science Direct, Proquest) were searched to investigate the targets and safety profiles of the current and past anti-obesity drugs that have been approved by the Food and Drug Administration (FDA) or the European Medicines Agency (EMA) as well as the commonly used off-label agents. The targets for weight-loss natural products and their principle bioactive components have also been searched. Only articles in English were included. Results: The targets for current anti-obesity single agents include pancreatic lipase, Glucagon Like Peptide-1(GLP-1) receptor, and serotonin 2C (5-HT2C) receptor. Potential targets such as amylin, pancreatic alpha amylase, leptin receptor, melanocortin receptor 4 receptor (MC4R), Peroxisome Proliferator- Activated Receptors gamma (PPAR γ), endocannabinoid 1 (CB1) receptor and Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) were discussed in various studies. Natural compounds have been found to interact with targets like pancreatic lipase, pancreatic alpha amylase, AMPK and PPAR γ to achieve weight reduction. Conclusion: Current pharmacotherapies and natural chemical compounds do act on same targets. Further investigations on the interactions between herbal compounds and the above targets are essential for the development of novel weight-loss therapies.

Association of Components of Metabolic Syndrome with Depression and Anxiety in Patients Undergoing Weight Reduction Surgery~!2009-09-21~!2009-12-23~!2010-08-27~!

2010 ◽  
Vol 2 (1) ◽  
pp. 125-131
Author(s):  
Jillian B. Kallman ◽  
Angela Wheeler ◽  
Husam K. Alathari ◽  
Yun Fang ◽  
Maria Stepanova ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Weight Reduction ◽  
Depression And Anxiety
Sign in / Sign up

Export Citation Format

Share Document