scholarly journals Predictive models of medication non-adherence risks of patients with T2D based on multiple machine learning algorithms

2020 ◽  
Vol 8 (1) ◽  
pp. e001055
Author(s):  
Xing-Wei Wu ◽  
Heng-Bo Yang ◽  
Rong Yuan ◽  
En-Wu Long ◽  
Rong-Sheng Tong

ObjectiveMedication adherence plays a key role in type 2 diabetes (T2D) care. Identifying patients with high risks of non-compliance helps individualized management, especially for China, where medical resources are relatively insufficient. However, models with good predictive capabilities have not been studied. This study aims to assess multiple machine learning algorithms and screen out a model that can be used to predict patients’ non-adherence risks.MethodsA real-world registration study was conducted at Sichuan Provincial People’s Hospital from 1 April 2018 to 30 March 2019. Data of patients with T2D on demographics, disease and treatment, diet and exercise, mental status, and treatment adherence were obtained by face-to-face questionnaires. The medication possession ratio was used to evaluate patients’ medication adherence status. Fourteen machine learning algorithms were applied for modeling, including Bayesian network, Neural Net, support vector machine, and so on, and balanced sampling, data imputation, binning, and methods of feature selection were evaluated by the area under the receiver operating characteristic curve (AUC). We use two-way cross-validation to ensure the accuracy of model evaluation, and we performed a posteriori test on the sample size based on the trend of AUC as the sample size increase.ResultsA total of 401 patients out of 630 candidates were investigated, of which 85 were evaluated as poor adherence (21.20%). A total of 16 variables were selected as potential variables for modeling, and 300 models were built based on 30 machine learning algorithms. Among these algorithms, the AUC of the best capable one was 0.866±0.082. Imputing, oversampling and larger sample size will help improve predictive ability.ConclusionsAn accurate and sensitive adherence prediction model based on real-world registration data was established after evaluating data filling, balanced sampling, and so on, which may provide a technical tool for individualized diabetes care.

Sensors ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 1806
Author(s):  
Silvio Semanjski ◽  
Ivana Semanjski ◽  
Wim De Wilde ◽  
Sidharta Gautama

Global Navigation Satellite System (GNSS) meaconing and spoofing are being considered as the key threats to the Safety-of-Life (SoL) applications that mostly rely upon the use of open service (OS) signals without signal or data-level protection. While a number of pre and post correlation techniques have been proposed so far, possible utilization of the supervised machine learning algorithms to detect GNSS meaconing and spoofing is currently being examined. One of the supervised machine learning algorithms, the Support Vector Machine classification (C-SVM), is proposed for utilization at the GNSS receiver level due to fact that at that stage of signal processing, a number of measurements and observables exists. It is possible to establish the correlation pattern among those GNSS measurements and observables and monitor it with use of the C-SVM classification, the results of which we present in this paper. By adding the real-world spoofing and meaconing datasets to the laboratory-generated spoofing datasets at the training stage of the C-SVM, we complement the experiments and results obtained in Part I of this paper, where the training was conducted solely with the use of laboratory-generated spoofing datasets. In two experiments presented in this paper, the C-SVM algorithm was cross-fed with the real-world meaconing and spoofing datasets, such that the meaconing addition to the training was validated by the spoofing dataset, and vice versa. The comparative analysis of all four experiments presented in this paper shows promising results in two aspects: (i) the added value of the training dataset enrichment seems to be relevant for real-world GNSS signal manipulation attempt detection and (ii) the C-SVM-based approach seems to be promising for GNSS signal manipulation attempt detection, as well as in the context of potential federated learning applications.


2021 ◽  
Vol 186 (Supplement_1) ◽  
pp. 445-451
Author(s):  
Yifei Sun ◽  
Navid Rashedi ◽  
Vikrant Vaze ◽  
Parikshit Shah ◽  
Ryan Halter ◽  
...  

ABSTRACT Introduction Early prediction of the acute hypotensive episode (AHE) in critically ill patients has the potential to improve outcomes. In this study, we apply different machine learning algorithms to the MIMIC III Physionet dataset, containing more than 60,000 real-world intensive care unit records, to test commonly used machine learning technologies and compare their performances. Materials and Methods Five classification methods including K-nearest neighbor, logistic regression, support vector machine, random forest, and a deep learning method called long short-term memory are applied to predict an AHE 30 minutes in advance. An analysis comparing model performance when including versus excluding invasive features was conducted. To further study the pattern of the underlying mean arterial pressure (MAP), we apply a regression method to predict the continuous MAP values using linear regression over the next 60 minutes. Results Support vector machine yields the best performance in terms of recall (84%). Including the invasive features in the classification improves the performance significantly with both recall and precision increasing by more than 20 percentage points. We were able to predict the MAP with a root mean square error (a frequently used measure of the differences between the predicted values and the observed values) of 10 mmHg 60 minutes in the future. After converting continuous MAP predictions into AHE binary predictions, we achieve a 91% recall and 68% precision. In addition to predicting AHE, the MAP predictions provide clinically useful information regarding the timing and severity of the AHE occurrence. Conclusion We were able to predict AHE with precision and recall above 80% 30 minutes in advance with the large real-world dataset. The prediction of regression model can provide a more fine-grained, interpretable signal to practitioners. Model performance is improved by the inclusion of invasive features in predicting AHE, when compared to predicting the AHE based on only the available, restricted set of noninvasive technologies. This demonstrates the importance of exploring more noninvasive technologies for AHE prediction.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alan Brnabic ◽  
Lisa M. Hess

Abstract Background Machine learning is a broad term encompassing a number of methods that allow the investigator to learn from the data. These methods may permit large real-world databases to be more rapidly translated to applications to inform patient-provider decision making. Methods This systematic literature review was conducted to identify published observational research of employed machine learning to inform decision making at the patient-provider level. The search strategy was implemented and studies meeting eligibility criteria were evaluated by two independent reviewers. Relevant data related to study design, statistical methods and strengths and limitations were identified; study quality was assessed using a modified version of the Luo checklist. Results A total of 34 publications from January 2014 to September 2020 were identified and evaluated for this review. There were diverse methods, statistical packages and approaches used across identified studies. The most common methods included decision tree and random forest approaches. Most studies applied internal validation but only two conducted external validation. Most studies utilized one algorithm, and only eight studies applied multiple machine learning algorithms to the data. Seven items on the Luo checklist failed to be met by more than 50% of published studies. Conclusions A wide variety of approaches, algorithms, statistical software, and validation strategies were employed in the application of machine learning methods to inform patient-provider decision making. There is a need to ensure that multiple machine learning approaches are used, the model selection strategy is clearly defined, and both internal and external validation are necessary to be sure that decisions for patient care are being made with the highest quality evidence. Future work should routinely employ ensemble methods incorporating multiple machine learning algorithms.


Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4324
Author(s):  
Moaed A. Abd ◽  
Rudy Paul ◽  
Aparna Aravelli ◽  
Ou Bai ◽  
Leonel Lagos ◽  
...  

Multifunctional flexible tactile sensors could be useful to improve the control of prosthetic hands. To that end, highly stretchable liquid metal tactile sensors (LMS) were designed, manufactured via photolithography, and incorporated into the fingertips of a prosthetic hand. Three novel contributions were made with the LMS. First, individual fingertips were used to distinguish between different speeds of sliding contact with different surfaces. Second, differences in surface textures were reliably detected during sliding contact. Third, the capacity for hierarchical tactile sensor integration was demonstrated by using four LMS signals simultaneously to distinguish between ten complex multi-textured surfaces. Four different machine learning algorithms were compared for their successful classification capabilities: K-nearest neighbor (KNN), support vector machine (SVM), random forest (RF), and neural network (NN). The time-frequency features of the LMSs were extracted to train and test the machine learning algorithms. The NN generally performed the best at the speed and texture detection with a single finger and had a 99.2 ± 0.8% accuracy to distinguish between ten different multi-textured surfaces using four LMSs from four fingers simultaneously. The capability for hierarchical multi-finger tactile sensation integration could be useful to provide a higher level of intelligence for artificial hands.


Author(s):  
Pratyush Kaware

In this paper a cost-effective sensor has been implemented to read finger bend signals, by attaching the sensor to a finger, so as to classify them based on the degree of bent as well as the joint about which the finger was being bent. This was done by testing with various machine learning algorithms to get the most accurate and consistent classifier. Finally, we found that Support Vector Machine was the best algorithm suited to classify our data, using we were able predict live state of a finger, i.e., the degree of bent and the joints involved. The live voltage values from the sensor were transmitted using a NodeMCU micro-controller which were converted to digital and uploaded on a database for analysis.


2018 ◽  
Vol 7 (2.8) ◽  
pp. 684 ◽  
Author(s):  
V V. Ramalingam ◽  
Ayantan Dandapath ◽  
M Karthik Raja

Heart related diseases or Cardiovascular Diseases (CVDs) are the main reason for a huge number of death in the world over the last few decades and has emerged as the most life-threatening disease, not only in India but in the whole world. So, there is a need of reliable, accurate and feasible system to diagnose such diseases in time for proper treatment. Machine Learning algorithms and techniques have been applied to various medical datasets to automate the analysis of large and complex data. Many researchers, in recent times, have been using several machine learning techniques to help the health care industry and the professionals in the diagnosis of heart related diseases. This paper presents a survey of various models based on such algorithms and techniques andanalyze their performance. Models based on supervised learning algorithms such as Support Vector Machines (SVM), K-Nearest Neighbour (KNN), NaïveBayes, Decision Trees (DT), Random Forest (RF) and ensemble models are found very popular among the researchers.


Sensors ◽  
2018 ◽  
Vol 18 (10) ◽  
pp. 3532 ◽  
Author(s):  
Nicola Mansbridge ◽  
Jurgen Mitsch ◽  
Nicola Bollard ◽  
Keith Ellis ◽  
Giuliana Miguel-Pacheco ◽  
...  

Grazing and ruminating are the most important behaviours for ruminants, as they spend most of their daily time budget performing these. Continuous surveillance of eating behaviour is an important means for monitoring ruminant health, productivity and welfare. However, surveillance performed by human operators is prone to human variance, time-consuming and costly, especially on animals kept at pasture or free-ranging. The use of sensors to automatically acquire data, and software to classify and identify behaviours, offers significant potential in addressing such issues. In this work, data collected from sheep by means of an accelerometer/gyroscope sensor attached to the ear and collar, sampled at 16 Hz, were used to develop classifiers for grazing and ruminating behaviour using various machine learning algorithms: random forest (RF), support vector machine (SVM), k nearest neighbour (kNN) and adaptive boosting (Adaboost). Multiple features extracted from the signals were ranked on their importance for classification. Several performance indicators were considered when comparing classifiers as a function of algorithm used, sensor localisation and number of used features. Random forest yielded the highest overall accuracies: 92% for collar and 91% for ear. Gyroscope-based features were shown to have the greatest relative importance for eating behaviours. The optimum number of feature characteristics to be incorporated into the model was 39, from both ear and collar data. The findings suggest that one can successfully classify eating behaviours in sheep with very high accuracy; this could be used to develop a device for automatic monitoring of feed intake in the sheep sector to monitor health and welfare.


Author(s):  
Sandy C. Lauguico ◽  
◽  
Ronnie S. Concepcion II ◽  
Jonnel D. Alejandrino ◽  
Rogelio Ruzcko Tobias ◽  
...  

The arising problem on food scarcity drives the innovation of urban farming. One of the methods in urban farming is the smart aquaponics. However, for a smart aquaponics to yield crops successfully, it needs intensive monitoring, control, and automation. An efficient way of implementing this is the utilization of vision systems and machine learning algorithms to optimize the capabilities of the farming technique. To realize this, a comparative analysis of three machine learning estimators: Logistic Regression (LR), K-Nearest Neighbor (KNN), and Linear Support Vector Machine (L-SVM) was conducted. This was done by modeling each algorithm from the machine vision-feature extracted images of lettuce which were raised in a smart aquaponics setup. Each of the model was optimized to increase cross and hold-out validations. The results showed that KNN having the tuned hyperparameters of n_neighbors=24, weights='distance', algorithm='auto', leaf_size = 10 was the most effective model for the given dataset, yielding a cross-validation mean accuracy of 87.06% and a classification accuracy of 91.67%.


Author(s):  
Muskan Patidar

Abstract: Social networking platforms have given us incalculable opportunities than ever before, and its benefits are undeniable. Despite benefits, people may be humiliated, insulted, bullied, and harassed by anonymous users, strangers, or peers. Cyberbullying refers to the use of technology to humiliate and slander other people. It takes form of hate messages sent through social media and emails. With the exponential increase of social media users, cyberbullying has been emerged as a form of bullying through electronic messages. We have tried to propose a possible solution for the above problem, our project aims to detect cyberbullying in tweets using ML Classification algorithms like Naïve Bayes, KNN, Decision Tree, Random Forest, Support Vector etc. and also we will apply the NLTK (Natural language toolkit) which consist of bigram, trigram, n-gram and unigram on Naïve Bayes to check its accuracy. Finally, we will compare the results of proposed and baseline features with other machine learning algorithms. Findings of the comparison indicate the significance of the proposed features in cyberbullying detection. Keywords: Cyber bullying, Machine Learning Algorithms, Twitter, Natural Language Toolkit


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