scholarly journals Association between the chronology of gestation and the morphometrical skin characteristics at childbirth: a development of predictive model

2021 ◽  
Vol 28 (1) ◽  
pp. e100476
Author(s):  
Ingrid Michelle Fonseca de Souza ◽  
Gabriela Luiza Nogueira Vitral ◽  
Marcelo Vidigal Caliari ◽  
Zilma Silveira Nogueira Reis
Keyword(s):  
Gestational Age ◽  
Fibrous Tissue ◽  
The Body ◽  
Skin Thickness ◽  
Cross Sectional ◽  
Potential Marker ◽  
Multivariate Modelling ◽  
Histological Images ◽  
Pregnancy Dating ◽  
Gestational Age At Birth

ObjectiveThe structural maturation of the skin is considered a potential marker of pregnancy dating. This study investigated the correlation between the morphometrical skin characteristics with the pregnancy chronology to propose models for predicting gestational age.MethodsA cross-sectional analysis selected 35 corpses of newborns. The biopsy was performed up to 48 hours after death in the periumbilical abdomen, palm and sole regions. Pregnancy chronology was based on the obstetric ultrasound before 14 weeks. The dimensions of the skin layers, area of glands and connective fibrous tissue were measured with imaging software support. Univariate and multivariate regression models on morphometric values were used to predict gestational age.ResultsGestational age at birth ranged from 20.3 to 41.2 weeks. Seventy-one skin specimens resulted in the analysis of 1183 digital histological images. The correlation between skin thickness and gestational age was positive and strong in both regions of the body. The highest univariate correlation between gestational age and skin thickness was using the epidermal layer dimensions, in palm (r=0.867, p<0.001). The multivariate modelling with the thickness of the abdominal epidermis, the dermis and the area of the sebaceous glands adjusted had the highest correlation with gestational age (r=0.99, p<0.001).ConclusionThe thickness of the protective epidermal barrier is, in itself, a potential marker of pregnancy dating. However, sets of values obtained from skin morphometry enhanced the estimation of the gestational age. Such findings may support non-invasive image approaches to estimate pregnancy dating with various clinical applications.

scholarly journals Skin thickness as a potential marker of gestational age at birth despite different fetal growth profiles: A feasibility study

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0196542 ◽  
Author(s):  
Gabriela Luiza Nogueira Vitral ◽  
Regina Amélia P. Lopes Aguiar ◽  
Ingrid Michelle Fonseca de Souza ◽  
Maria Albertina Santiago Rego ◽  
Rodney Nascimento Guimarães ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Fetal Growth ◽  
Gestational Age ◽  
Skin Thickness ◽  
Potential Marker ◽  
Growth Profiles ◽  
Gestational Age At Birth ◽  
Age At Birth

scholarly journals Blood serum myokine irisin and adipocytokine levels in newborns small for gestational age at birth

2021 ◽  
Vol 18 (4) ◽  
pp. 402-412
Author(s):  
V. A. Prylutskaya ◽  
A. V. Sukalo ◽  
A. V. Goncharik
Keyword(s):  
Blood Serum ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
The Body ◽  
Delivery Mode ◽  
Gestational Age At Birth ◽  
Age At Birth

In recent years, a number of the studies of myokine irisin in adults and isolated in newborns have been carried out. The role of adipocytokines in the growth and development of the fetus and children has been shown.The aim of the study was to assess the levels of myokine irisin and adipocytokines in newborns small for gestational age at birth and to analyze the relationship between the parameters of the hormonal status of children and their mothers.49 newborns and their mothers were examined. Two groups were identified: group 1 (Gr1) – newborns small for gestational age (n = 24), group 2 (Gr2) – newborns appropriate for gestational age (n = 25). The levels of irisin and adipocytokines in the blood serum were determined by the enzyme immunoassay.Newborns small for gestational age had significantly lower levels of leptin and IGF-1 in the umbilical cord blood compared to children with physical development corresponding to the gestational age. There were no significant differences in the irisin content of cord blood serum in newborn Gr1 compared with Gr2. The presence of significant positive correlations between the level of irisin in the umbilical cord blood of newborns small for gestational age and the body weight at birth was established. In Gr1, a positive relationship was found between the irisin levels of mothers and newborns (r = 0.518, p = 0.028). The differences in the irisin content between the groups were established, taking into account the delivery mode (p = 0.0104).The revealed statistically significant differences in the concentrations of the analyzed metabolic markers in mother–child pairs, their relationship with clinical and anthropometric parameters substantiate the possibility of using irisin and adipocytokines as predictors in predicting the formation of metabolic disorders of infants small for gestational age.

scholarly journals Comparison of absolute neutrophil count between premature and term infants

2016 ◽  
Vol 44 (5) ◽  
pp. 197
Author(s):  
Ahmad Faisal ◽  
Guslihan D Tjipta ◽  
Bidasari Lubis ◽  
Dachrul Aldy
Keyword(s):  
Premature Infants ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Gestational Age ◽  
Early Onset ◽  
Complete Blood Count ◽  
Newborn Infants ◽  
The Body ◽  
Term Infants ◽  
Cross Sectional

Background Neutrophils are very important in the body defenseagainst bacterial infection. Absolute neutrophil count (ANC) couldbe used for the recognition of early-onset bacterial sepsis inneonates.Objective The aim of this study was to compare the value of ANCbetween premature and term infants, to assess the prevalence ofearly-onset neutropenia in premature infants and its relationshipwith prematurity, and to find out the correlation between gesta-tional age and ANC.Methods A cross-sectional study was conducted during Februaryto May 2003. Subjects were newborn infants with gestational ageof less than 37 weeks who were born in Adam Malik and PirngadiHospitals, Medan. Newborn infants with severe asphyxia (5-minuteApgar score of less than 4), fever, seizure, and maternalhypertension were excluded. Complete blood count was done bymeans of automatic cell counter (Micros (R) , Germany). Term healthyinfants were used as control subjects.Results ANC differed significantly between both groups (p=0.0001).The prevalence of early-onset neutropenia in premature infantswas 9% (95%CI 0.065;0.21). Prematurity was related with theincidence of neutropenia with a prevalence ratio of 1.1. Therewas a weak positive correlation between gestational age andANC with an r-value of 0.49 (p=0.0001).Conclusions ANC in premature infants differs from that in terminfants. The prevalence of early-onset neutropenia in prematureinfants was 9% (95%CI 0.065;0.21). Prematurity is related with theincidence of early-onset neutropenia in newborn infants. There isa correlation between gestational age and ANC

scholarly journals Compliance of iron tablets consumption related to anemia status in pregnant women in Cikarang Health Center Bekasi

2019 ◽  
Vol 3 (2) ◽  
pp. 80-90
Author(s):  
Fiqriah Ayu Awalamaroh ◽  
Leni Sri Rahayu ◽  
Indah Yuliana
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Significant Relationship ◽  
Statistical Tests ◽  
The Body ◽  
Food Sources ◽  
Cross Sectional ◽  
Diet Compliance ◽  
Cross Sectional Design ◽  
Iron Folic Acid

Anemia in pregnancy is one of the national problems that reflects the value of the socio-economic welfare of the community which also influences the quality of human resources. Factors that can influence the emergence of anemia among pregnant women include socioeconomic, knowledge, frequency of antenatal care visits, maternal age, distance of pregnancy, parity, infectious diseases, lack of consumption of iron, folic acid, vitamin B12, chronic bleeding, nutritional status, diet, compliance to consume Fe tablets, impaired absorption of iron in the body, and gestational age. The purpose of this study was to determine the association of food sources of Fe consumption, compliance to consume Fe Tablets and knowledge about anemia with anemia status in pregnant women. This research used cross sectional design. The number of samples in this study were 51 pregnant women with gestational age ≥ 36 weeks. Analysis of this research data used Fisher’s Exact. The results of statistical tests showed that there was a significant relationship between compliance to consume Fe tablet adherence to taking Fe tablets (p=0,000) and anemia status in pregnant women gestational age ≥ 36 weeks. Meanwhile, the consumption of Fe (p > 0,05) and knowledge about anemia (p > 0,05) had no significant relationship with anemia status in pregnant women ≥ 36 weeks. Thus, the level of compliance with Fe tablet consumption needs to be maintained and improved. Pregnant women still need to be educated about anemia, the effects and food sources of Fe that should be consumed during pregnancy, so that the level of knowledge can increase. Keywords: Anemia, Compliance of Iron Tablet Consumption, Knowledge, Pregnant Women

Combination of Fundal Height and Ultrasound to Predict Small for Gestational Age at Birth

2021 ◽  
Author(s):  
Katherine L. Grantz ◽  
Ana M. Ortega-Villa ◽  
Sarah J. Pugh ◽  
Alaina Bever ◽  
William Grobman ◽  
...  
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Predictive Value ◽  
Secondary Analysis ◽  
Cross Sectional ◽  
Cut Points ◽  
Key Points ◽  
Novel Method ◽  
Sensitivity Specificity ◽  
Gestational Age At Birth

Objective The objective of the study was to determine whether adding longitudinal measures of fundal height (FH) to the standard cross-sectional FH to trigger third trimester ultrasound estimated fetal weight (EFW) would improve small for gestational age (SGA) prediction. Study Design We developed a longitudinal FH calculator in a secondary analysis of a prospective cohort study of 1,939 nonobese pregnant women who underwent serial FH evaluations at 12 U.S. clinical sites. We evaluated cross-sectional FH measurement ≤ –3 cm at visit 3 (mean: 32.0 ± 1.6 weeks) versus the addition of longitudinal FH up to and including visit 3 to trigger an ultrasound to diagnose SGA defined as birthweight <10th percentile. If the FH cut points were not met, the SGA screen was classified as negative. If FH cut points were met and EFW was <10th percentile, the SGA screen was considered positive. If EFW was ≥10th percentile, the SGA screen was also considered negative. Sensitivity, specificity, and positive predictive value (PPV) and negative predictive value (NPV) were computed. Results In a comparison of methods, 5.8% of women were classified as at risk of SGA by both cross-sectional and longitudinal classification methods; cross-sectional FH identified an additional 4.0%, and longitudinal fundal height identified a separate, additional 4.5%.Using cross-sectional FH as an ultrasound trigger, EFW had a PPV and NPV for SGA of 69 and 92%, respectively. After adding longitudinal FH, PPV increased to 74%, whereas NPV of 92% remained unchanged; however, the number of women who underwent triggered EFW decreased from 9.7 to 5.7%. Conclusion An innovative approach for calculating longitudinal FH to the standard cross-sectional FH improved identification of SGA birthweight, while simultaneously reducing the number of triggered ultrasounds. As an essentially free-of-charge screening test, our novel method has potential to decrease costs as well as perinatal morbidity and mortality (through better prediction of SGA). Key Points

scholarly journals A quantitative cross‐sectional analysis of the melanin index in the skin of preterm newborns and its association with gestational age at birth

2019 ◽  
Vol 26 (3) ◽  
pp. 356-361
Author(s):  
Paola Conceição Silva ◽  
Rodney Nascimento Guimarães ◽  
Rayner Guilherme Souza ◽  
Zilma Silveira Nogueira Reis
Keyword(s):  
Gestational Age ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Melanin Index ◽  
Gestational Age At Birth ◽  
Sectional Analysis ◽  
Preterm Newborns ◽  
Age At Birth

scholarly journals The Anxiety in Primigravida about Adaptation to Physiological Changes During Pregnancy

2021 ◽  
Vol 10 (1) ◽  
pp. 43-49
Author(s):  
Erma Herdyana ◽  
Betristasia Puspitasari
Keyword(s):  
Mental Health ◽  
Data Analysis ◽  
Pregnant Women ◽  
Gestational Age ◽  
The Body ◽  
Quantitative Approach ◽  
Physiological Changes ◽  
Physical And Mental Health ◽  
Cross Sectional ◽  
Research Show

Pregnancy causes major changes in the mother's body that is less understandable to be considered mysterious and anxiety. Changes in the body of pregnant women Primigravida occur as a result of an imbalance of the hormones progesterone and estrogen. Necessary adaptation to reduce the anxiety of the changes that occur during pregnancy to maintain physical and mental health. Scientists found more than half (54%) mothers have a sense of anxious and more than a third (37%) showed signs of depression at a certain period in the period of pregnancy. This research uses Descriptive with Cross Sectional approach. This study was conducted in January 2020. Population and Sample in this study were 22 respondents Primigravida in  BPM Ny. Ani., sub District Baron,  District of Nganjuk. Data analysis using quantitative approach. The results of the research show the characteristics of gestational age from 13 to 28 weeks as many as 13 respondents (59%) and the characteristics of the gestational age 29-40 weeks as much as 9 respondents (41%). After analysis with a quantitative approach using the percentage obtained results of the 22 respondents (100%) primigravida with mild anxiety

scholarly journals Newborn skin reflection: Proof of concept for a new approach for predicting gestational age at birth. A cross-sectional study

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184734 ◽  
Author(s):  
Zilma Silveira Nogueira Reis ◽  
Gabriela Luiza Nogueira Vitral ◽  
Ingrid Michelle Fonseca de Souza ◽  
Maria Albertina Santiago Rego ◽  
Rodney Nascimento Guimaraes
Keyword(s):  
Gestational Age ◽  
Cross Sectional Study ◽  
Proof Of Concept ◽  
Sectional Study ◽  
Cross Sectional ◽  
New Approach ◽  
Gestational Age At Birth ◽  
Age At Birth

X-ray micro tomography in the scanning electron microscope

1978 ◽  
Vol 36 (1) ◽  
pp. 106-107 ◽  
Author(s):  
W. Brünger
Keyword(s):  
Electron Beam ◽  
Electron Microscope ◽  
Scanning Electron Microscope ◽  
Target Surface ◽  
The Body ◽  
X Rays ◽  
Cross Sectional ◽  
X Ray ◽  
Micro Tomography ◽  
Scanning Electron

Reconstructive tomography is a new technique in diagnostic radiology for imaging cross-sectional planes of the human body /1/. A collimated beam of X-rays is scanned through a thin slice of the body and the transmitted intensity is recorded by a detector giving a linear shadow graph or projection (see fig. 1). Many of these projections at different angles are used to reconstruct the body-layer, usually with the aid of a computer. The picture element size of present tomographic scanners is approximately 1.1 mm2.Micro tomography can be realized using the very fine X-ray source generated by the focused electron beam of a scanning electron microscope (see fig. 2). The translation of the X-ray source is done by a line scan of the electron beam on a polished target surface /2/. Projections at different angles are produced by rotating the object.During the registration of a single scan the electron beam is deflected in one direction only, while both deflections are operating in the display tube.

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