Gentamicin

1967 ◽  
Vol 5 (10) ◽  
pp. 39-40
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Staph Aureus ◽  
E Coli ◽  
Gentamicin Sulphate

Gentamicin sulphate (Cidomycin - Roussel; Genticin - British Schering) is an antibiotic related to the kanamycin group. It is produced by fermentation from an actinomycete, Micromonospora purpurea, and has a wide and unusual range of antibacterial activity.1 2 Most strains of E. coli, the Klebsiella-Aerobacter group, and all species of Proteus are highly or moderately susceptible to the drug, as are the smaller number of Shigella and Salmonella species so far tested. In this respect its range resembles that of kanamycin but, in addition, gentamicin is active against most strains of Pseudomonas aeruginosa (pyocyanea), thus combining the antibacterial activity of kanamycin with that of the polymyxins (to which Proteus is resistant). Gentamicin is also active against Staph. aureus, but streptococci are only moderately sensitive, and enterococci are often resistant.

scholarly journals The role of Biofilm for Pseudomonas aeruginosa to resistance ultraviolet and MIC concentration for antibiotics

2012 ◽  
Vol 36 (0A) ◽  
pp. 13-19
Author(s):  
احمد محمد تركي
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
High Resistance ◽  
The Other ◽  
Bacterial Isolates ◽  
Staph Aureus ◽  
E Coli ◽  
The Impact ◽  
And Staphylococcus Aureus

The present study is conducted to in restigate the bacteria Pseudomonas aeruginosa, the impact of ultraviolet on the bacterial isolates under study and the resistance of these isolates to ultraviolet are studied in comparison to two standard isolates ( E . coli and Staphylococcus aureus ) which are considered sensitive to ultraviolet . The natures of the resistance of the isolates, under study, are also being investigated against the different antibiotics. The isolates are subjected to a test to examine their sensitivity to (12) types of antibiotics used routinely in the treatment of various infection of these bacteria. They are (streptomycin , cephalothin ,Gentamycin , cefotaxime ,nitrofurantion ,ampicillin, amoxicillin, rifampin, lincomycin, tetracycline, erythromycin and ciprofloxacin ).The lowest concentration installer ( MIC ) is also testified in accordance with six types of antibiotics (streptomycin, cefotaxime , rifampin , nitrofurantion , Gentamycin , amoxicillin ).The biologic effectiveness of the overlap between the bacterial isolates , under study, is examined against four bacteria (klebseilla pneumonia , Staphylococcus aureus , Enterobacter , Proteus ) The result of using the ultraviolet with different wavelength show the ability of the five local isolates used to resistance of ultraviolet reaching (180 s.) in comparison to the isolates E.coli and staph. aureus in which the ratio of killing is %100 at a time of exposing 40 , 60 sec. respectively. The results indicated that the five local bacterial isolates have high resistance to the most tested antibiotics, It is shouted that all of them have resistance to (erythromycin , tetracycline , lincomycin , Gentamycin ) but they are sensitive towards antibiotic streptomycin . as for the other antibiotics , over can find that the isolates are varied of them for being resisting or sensitive towards them .The results of testing the inhabited effectiveness of the five bacterial isolates towards some other bacterial isolates show the efficiency of the five local isolates in the inhabitation of growth of the five studied bacterial isolates.

scholarly journals Portrayal of Punica granatum L. peel extract through High Performance Liquid Chromatography and antimicrobial activity evaluation

2023 ◽  
Vol 83 ◽  
Author(s):  
M.S. Mahmood ◽  
A. Ashraf ◽  
S. Ali ◽  
A.B. Siddique ◽  
F. Asad ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Methanolic Extract ◽  
Punica Granatum ◽  
Diffusion Method ◽  
Staph Aureus ◽  
E Coli ◽  
Peel Extract

Abstract Increasing trend in antimicrobial resistance and failure of chemically synthesized antibiotics lead to discover alternative methods for the treatment of bacterial infections. Various medicinal plants are in use traditionally and their active compounds can be further applied for treatment of bacterial diseases. This study was designed to determine the antibacterial activity of Punica granatum (P. granatum L.) (pomegranate) peel extract against Enterobacteriaceae [Escherichia coli (E. coli), Salmonella Typhimurium (S. Typhimurium) and Shigella Dysenteriae (S. Dysenteriae)] and gram-positive bacterium [Staphylococcus aureus (Staph aureus)]. Methanolic extract of P. granatum L. peel was prepared by Soxhlet apparatus method. Total flavonoid and phenolic contents from the extract were determined by High Performance Liquid Chromatography (HPLC). The antibacterial activity of P. granatum L. peel extract was evaluated through agar well diffusion method. HPLC showed the range of phenolics (gallic acid, caffeic acid, benzoic acid, cinnamic acid) and flavonoid compounds. The chemical structures of flavonoid and phenolics found in the methanolic extract of P. granatum L. peel have been reported for the first time. The methanolic peel extract (50 ul) of yellow P. granatum L. showed 26, 10, 10 and 9mm zones of inhibition (ZOI) against S. aureus, S. Typhimurium, S. Dysenteriae and E. coli, respectively. The methanolic extract of red P. granatum L. (100 ul) showed 27, 8, 12 and 15 mm ZOI against Staph. aureus, S. Typhimurium, S. Dysenteriae and E. coli, respectively. Highest ZOI was observed against Staph. aureus. Many of the bacteria studied in the present work may cause serious gastrointestinal infections, which can lead to hemorrhagic diarrhea in children. These infections can be life-threatening to young children and the elderly. There is an incentive to find alternative control measures, such as plant and herbal extracts, especially in lesser-developed countries where traditional antibiotics may not be readily available.

scholarly journals ETIOLOGICAL AND PATHOLOGICAL STUDY OF EPIDEDE/lY'I‘IS IN GOATS IN BAGHDAD CITY

2022 ◽  
Vol 21 (1) ◽  
pp. 44-60
Author(s):  
Amir S.R. Al-Obaidil ◽  
Mohammed J. Alwan ◽  
Bushrah ‘ I. Al-Khaisi
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Staphylococcus Epidermidis ◽  
Histopathological Examination ◽  
Pathological Study ◽  
Staph Aureus ◽  
E Coli ◽  
Campylobacter Fetus ◽  
Gross Lesions ◽  
Acute Epididymitis ◽  
Actinomyces Pyogenes

Testes from 700 male goats aged l - 3 years , slaughtered at Baghdad abatteir, were examined during 6 months period. Histological and bacteriological examinations were done when gross lesions were observed. The results revealed that epidedimytis was observed in 21 (3%) of the examined animals ; 16 (2.3%) cases were unilaterally affected and S (0.7%) cases were bilaterally affected. Bacteriological isolations from infected organs included : Corynebacterium ovis (6 isolates) and Actinomyces pyogenes (3 isolates) both constituted the majonty of isolates ; as well as E. coli (4 iso-lates), and Pseudomonas aeruginosa , Staphylococcus epidermidis, Cory. bovis., Staph. aureus, Cory , ulcerams &. Yersinia pseuclotuberculosis ( 2 isolates of each ) and Campylobacter fetus (1 isolate). Histopathological examination showed 6 pathological patterns of epididmytis including acute epididymitis (14.2% of infected cases ) , subacute nomsuppurative epididymilis (9.5% od cases ) , chronic suppurative epididymitisd (28.5% of cases ), chronic non—suppurative epididymitis (19% of cases) and spermatic granuloma (14.2% of cases ).

scholarly journals Synthesis, Characterization and Biological Activity of Mn2+, Co2+, Ni2+and Cu2+Complexes of Benzoic Acid Ligand

2009 ◽  
Vol 6 (3) ◽  
pp. 743-746 ◽  
Author(s):  
T. Arunachalam ◽  
R. Bhakyaraj ◽  
A. K. Sasi
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Magnetic Susceptibility ◽  
Biological Activity ◽  
Benzoic Acid ◽  
Conductivity Measurements ◽  
Octahedral Structure ◽  
E Coli ◽  
Acid Ligand

Metal complex of Mn(II), Co(II), Ni(II) and Cu(II) with benzoic acid have been prepared and characterized by physiochemical methods. On the basis of electronic spectra and magnetic susceptibility measurement in conjunction with infrared spectra, six coordinated octahedral structure have been proposed to all the complexes. The benzoic acid and their complexes have been tested for their antibacterial activity against the bacteriaE. coli,Bacillus subtilis,Pseudomonas aeruginosaandStaphylococcus aureus. Further, the non electrolytic nature of all the synthesized complexes was identified from conductivity measurements.

scholarly journals Antibacterial Activity of Cu Nanoparticles against E. coli, Staphylococcus aureus and Pseudomonas aeruginosa

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Lalit Yadav ◽  
Ravi Mani Tripathi ◽  
Ram Prasad ◽  
Ramesh Namdeo Pudake ◽  
Jagjiwan Mittal
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Cu Nanoparticles ◽  
E Coli

scholarly journals Uji Aktivitas Antibakteri Ekstrak Sarang Lebah Hutan (Apis Dorsata) Terhadap Pertumbuhan Staphylococcus aureus, Escherichia coli Dan Pseudomonas aeruginosa

2018 ◽  
Vol 14 (1) ◽  
pp. 179
Author(s):  
Ika Prestianti ◽  
Maswati Baharuddin ◽  
Sappewali Sappewali
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Apis Dorsata ◽  
Soaking Time ◽  
E Coli ◽  
Extract Concentration ◽  
X 24 ◽  
Paper Disc

<p>Penyakit infeksi akibat bakteri merupakan masalah serius dalam kesehatan. Antibakteri alami yang dapat digunakan untuk menghambat pertumbuhan bakteri yaitu sarang lebah hutan (<em>Apis dorsata</em>) (propolis, kantong madu, kantong telur dan kantong pollen) yang mengandung senyawa metabolit sekunder seperti flavonoid, tanin dan asam fenolat.Tujuan dari penelitian ini adalah megetahui aktivitas antibakteri ekstrak sarang lebah hutan dari setiap pelarut yang digunakan dan untuk mengetahui pengaruh konsentrasi ekstrak sarang lebah hutan terhadap pertumbuhan bakteri <em>Staphylococcus aureus, Escherichia coli </em>dan<em> Pseudomonas aeruginosa</em>. Pengujian antibakteri dilakukan dengan metode difusi kertas cakram dengan lama perendaman   1 jam kemudian diinkubasi selama 3 x 24 jam. Hasil penelitian menunjukkan bahwa aktivitas antibakteri ekstrak metanol sarang lebah memiliki aktivitas tertinggi pada bakteri  <em>E. coli </em>yaitu 3,8 mm pada konsentrasi 8%, ekstrak etil asetat sarang lebah pada bakteri <em>S. a ureus </em>yaitu 3,72 mm pada konsentrasi 8% dan ekstrak n-heksan sarang lebah pada bakteri <em>E. coli </em>yaitu 16,1 mm pada konsentrasi 8%. Pengaruh konsentrasi ekstrak yaitu semakin tinggi konsentrasi ekstrak maka semakin besar pula daya hambat ekstrak terhadap pertumbuhan bakteri <em>S</em>.<em> aureus, E</em>.<em> coli </em>dan<em> P</em>.<em> aeruginosa</em>.</p><p><strong>Antibacterial Evaluation of Extract Beehive (<em>Apis dorsata</em>) on Growth <em>Staphylococcus aureus</em>, <em>Escherichia coli</em> and <em>Pseudomonas aeruginosa</em></strong>. Bacterial infectious diseases are serious health problems. One of natural antibacterial that can be used to inhibit bacterial growth is honeycomb (propolis, honey bag, egg bag and pollen bag) containing secondary metabolite compounds such as flavonoids, tannins and phenolic acids. The purpose of this research is to know the antibacterial activity of honeycomb extract from each solvent used and to know the effect of honeycomb extract concentration on the growth of <em>S</em>.<em> aureus</em>, <em>E</em>. <em>coli</em> and <em>P</em>.<em> aeruginosa</em> bacteria. Antibacterial testing was performed by the method of paper disc diffusion with soaking time 1 hour then incubated for 3 x 24 hours. The results showed that antibacterial activity of methanol honeycomb extract had the highest activity in <em>E. coli</em> bacteria i.e., 3.8 mm at 8% concentration, ethyl acetate honey extract on <em>S. aureus</em> bacteria ie 3.72 mm at 8% concentration and n extract n-hexan honeycomb in <em>E. coli</em> bacteria that is 16,1 mm at 8% concentration. The higher extract concentration the greater the inhibitory activity of extract on the growth of <em>S</em>.<em> aureus</em>, <em>E. coli</em> and <em>P</em><em>.</em><em> aeruginosa</em> bacteria.</p>

scholarly journals Antibacterial Activity of Pakistani Honey

2019 ◽  
Vol 62 (2) ◽  
pp. 97-100
Author(s):  
Taif Shah ◽  
Niyaz Ali ◽  
Zahir Shah ◽  
Azam Hayat
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Apis Mellifera ◽  
Bacterial Species ◽  
Salmonella Typhi ◽  
Stingless Bee ◽  
E Coli ◽  
Zones Of Inhibition ◽  
Khyber Pakhtunkhwa Province

The current study was conducted to determine the antibacterial activity of 50 crude and processed honey samples produced by Apis mellifera and stingless bee. All the honey samples were collected from different places of Districts Dir, Swat and Oghi of Khyber Pakhtunkhwa Province, Pakistan and were tested against the six ATCC bacterial species including E. coli ATCC number 25922, Pseudomonas aeruginosa ATCC number 27853, Staphylococcus aureus ATCC number 6538, Enterococcus faecalis ATCC number 19433, Salmonella typhi ATCC number 19943 and Klebsiella pneumoniae ATCC number 27736. The honey samples showed variable zones of inhibition by using Agar well plate technique. E. coli showed 17-23 mm, S. typhi 31-37 mm, E. faecalis 28 mm, P. aeruginosa 14-15 mm, K. pneumoniae 20-24 mm and Staph. aureus 19-25 mm. Most of the honey samples used in this study showed broad spectrum antibacterial activity.

scholarly journals Invitro antibacterial activity of Cassia fistula Linn methanolic leaf extracts

2019 ◽  
Vol 8 (2) ◽  
pp. 270
Author(s):  
Bindhu R. Kamath ◽  
Sabeena Kizhedath
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Cassia Fistula ◽  
Leaf Extracts ◽  
E Coli

Background: Cassia fistula Linn is a plant which is widely grown in India and is used for medicinal purposes. The study was carried out with an objective to demonstrate the antimicrobial activity of leaves of Cassia fistula Linn. The aim of the study is to assess antibacterial and antifungal activity of methanolic leaf extract of Cassia fistula Linn against selected clinical isolates.Methods: The antimicrobial activity of methanolic extract of Cassia fistula was evaluated using agar well diffusion method and to zone of inhibition of extract was determined. Clinical isolates of Staphyloccocus aureus, MRSA, Pseudomonas aeruginosa, E. coli and Proteus were screened.Results: The methanolic extracts exhibited antibacterial activity against Staphylococcus aureus. The extract was not active against E. coli, Proteus, MRSA, Pseudomonas aeruginosa. The extract also failed to demonstrate antifungal activity against Candida albicans and Aspergillus niger.Conclusions: The global emergence of multidrug resistant bacterial strains is increasing, limiting the effectiveness of current drugs and treatment failure of infections. A novel approach to the prevention of antibiotic resistance of pathogenic species is the use of new compounds that are not based on existing synthetic antimicrobial agents.

Synthesis Characterization and Antibacterial Activity of Terazosin Hydrochloride Drug and Market Formulation

2021 ◽  
pp. 4777-4782
Author(s):  
Anshul Kumar ◽  
Rajnish Kumar ◽  
Avijit Mazumdar
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Shigella Flexneri ◽  
Literature Survey ◽  
Klebsiella Pneumonia ◽  
Standard Drug ◽  
E Coli ◽  
Maximum Inhibition ◽  
Hypertensive Drug

Terazosin hydrochloride is an anti-hypertensive drug which is used to treat the diseases of hypertension. The literature survey shows the proposed synthesis of Terazosin hydrochloride derived from the starting material of 2-chloro-6, 7-dimethoxy–quinazoline-4-amine in the presence of 2-methoxy ethanol with n- benzyl piperazine to form the product. The Terazosin derivatives were prepared with the help of literature survey were 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1, 4-bis-(tertrahydrofuran-2-yl) carbonyl piperazine, and 1-(4-amino-6, 7-dimethoxy- quinazoline-2-yl)- 4-formyl- piperazine were prepared by maintaining environmental condition. The characterization done for prepared derivative was done through 1H-NMR, MASS and IR Spectroscopy. The antibacterial activity of prepared derivatives was performed on the various bacteria like E. coli, Pseudomonas aeruginosa, Shigella sonneii, Klebsiella pneumonia, Staphylococcus aureus, Shigella flexneri, Vibrio cholera, Bacillus subtilis, Pseudomonas fluorescens, Pseudomonas aeruginosa, Staphylococcus aureus. The desired derivatives shown maximum zone of inhibition using concentration prepared 100µg and 200µg using standard drug. The derivatives that shows maximum inhibition 6, 7-dimethoxy-2-piperazine-1-yl-quinazoline -4-amine and minimum was shown by 1, 4-bis-(furan-2-yl-carbonl) piperazine, 1,4-bis-(tertrahydrofuran- 2-yl) carbonyl piperazine. The result should that prepared Terazosin derivatives shows potent actively when compared with standard ciprofloxacin.

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