Molecular factors involved in the hypolipidemic- and insulin-sensitizing effects of a ginger (Zingiber officinale Roscoe) extract in rats fed a high-fat diet

2017 ◽  
Vol 42 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Natalia de las Heras ◽  
María Valero-Muñoz ◽  
Beatriz Martín-Fernández ◽  
Sandra Ballesteros ◽  
Antonio López-Farré ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Plasma Levels ◽  
High Fat Diet ◽  
Tissue Growth ◽  
Collagen I ◽  
Metabolic Effects ◽  
Control Group ◽  
Standard Diet ◽  
High Fat ◽  
Glucose Transporter 2

Hypolipidemic and hypoglycemic properties of ginger in animal models have been reported. However, information related to the mechanisms and factors involved in the metabolic effects of ginger at a hepatic level are limited. The aim of the present study was to investigate molecular factors involved in the hypoglycemic and hypolipidemic effects of a hydroethanolic ginger extract (GE) in the liver of rats fed a high-fat diet (HFD). The study was conducted in male Wistar rats divided into the following 3 groups: (i) Rats fed a standard diet (3.5% fat), the control group; (ii) rats fed an HFD (33.5% fat); and (iii) rats fed an HFD treated with GE (250 mg·kg−1·day−1) for 5 weeks (HFD+GE). Plasma levels of glucose, insulin, lipid profile, leptin, and adiponectin were measured. Liver expression of glycerol phosphate acyltransferase (GPAT), cholesterol 7 alpha-hydroxylase, peroxisome proliferator-activated receptors (PPAR), PPARα and PPARγ, glucose transporter 2 (GLUT-2), liver X receptor, sterol regulatory element-binding protein (SREBP1c), connective tissue growth factor (CTGF), and collagen I was measured. Data were analyzed using a 1-way ANOVA, followed by a Newman−Keuls test if differences were noted. The study showed that GE improved lipid profile and attenuated the increase of plasma levels of glucose, insulin, and leptin in HFD rats. This effect was associated with a higher liver expression of PPARα, PPARγ, and GLUT-2 and an enhancement of plasma adiponectin levels. Furthermore, GE reduced liver expression of GPAT, SREBP1c, CTGF, and collagen I. The results suggest that GE might be considered as an alternative therapeutic strategy in the management of overweight and hepatic and metabolic−related alterations.

Swimming training combined with chitosan supplementation reduces the development of obesity and oxidative stress in high fat diet fed mice

2021 ◽  
pp. 1-31
Author(s):  
Zahra Zalaqi ◽  
Farshad Ghazalian ◽  
Mohammad Javad Khodayar ◽  
Atefeh Raesi Vanani ◽  
Layasadat Khorsandi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Dietary Intervention ◽  
The Body ◽  
Control Group ◽  
Standard Diet ◽  
High Fat ◽  
Swimming Training ◽  
Fat Diets

Abstract Obesity is often introduced as one of the metabolic disorders caused by imbalance between energy consumption and metabolisable energy intake. Experts in the field considered obesity as one of the robust risk factors for the life-style associated diseases. The present research examined interventional effects of marine chitosan (CS), swimming training (ST) and combination of CS and ST (CS+ST) in the mice fed with high fat diets (HFD). In this study, sample size was considered more than 3 in groups. Forty mice were randomly divided into 5 groups (n = 8 per group) including control group (received the standard diet), HFD group (received high fat food with 20% fat), HFD+CS group (treated with high fat food with 5% CS), HFD+ST group (treated with high fat diet and ST) and HFD+CS+ST group (treated with high fat food with 5% CS & ST). After 8 weeks the blood glucose, oxidative stress (OS), and lipid profile were measured. Results showed more efficiency of CS+ST in the control of body weight with the increased concentration of HDL-C, OS inhibition via enhancing the body antioxidant capacity in comparison to the ST or CS alone in obese mice. Moreover, lipid profile was improved in CS + ST-treated mice compared with HFD-treated mice, and OS inhibition correlated to the greater activities of the antioxidant enzyme, enhance the lipid oxidation, cholesterol and fatty acid homeostasis. The results suggested that a dietary intervention with a combined ST and CS can be a feasible supplementary for human prevention of obesity.

scholarly journals Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Lovisa Heyman ◽  
Ulrika Axling ◽  
Narda Blanco ◽  
Olov Sterner ◽  
Cecilia Holm ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Inflammatory Marker ◽  
Metabolic Effects ◽  
Control Group ◽  
High Fat ◽  
Hepatic Lipid Accumulation ◽  
Positive Effects ◽  
Low Fat Diet ◽  
Body Fat Content ◽  
Quercetin Glycosides

Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes.Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (20%) with lingonberry, blackcurrant, bilberry, raspberry, açai, crowberry, prune or blackberry.Results. The groups receiving a high-fat diet supplemented with lingonberries, blackcurrants, raspberries or bilberries gained less weight and had lower fasting insulin levels than the control group receiving high-fat diet without berries. Lingonberries, and also blackcurrants and bilberries, significantly decreased body fat content, hepatic lipid accumulation, and plasma levels of the inflammatory marker PAI-1, as well as mediated positive effects on glucose homeostasis. The group receiving açai displayed increased weight gain and developed large, steatotic livers. Quercetin glycosides were detected in the lingonberry and the blackcurrant diets.Conclusion. Lingonberries were shown to fully or partially prevent the detrimental metabolic effects induced by high-fat diet. Blackcurrants and bilberries had similar properties, but to a lower degree. We propose that the beneficial metabolic effects of lingonberries could be useful in preventing obesity and related disorders.

scholarly journals The Efficacy of Seluang Fish Oil (Rasbora agrotynea) Related Body Weight, Lipid Profile, Adiponectin and Leptin in Wistar Rats-Induced High Fat Diet

2018 ◽  
Vol 2 (2) ◽  
pp. 25-30
Author(s):  
Fatmawati Karim ◽  
Rachmat Hidayat ◽  
Erizka Rivani ◽  
Husnul Khotimah ◽  
Ester G Pansserga
Keyword(s):  
Body Weight ◽  
Fish Oil ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Adiponectin Level ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Reduce Body Weight

Background Rasbora agrotynea (local name : Seluang ) is a fish native to Sumatera, Malaya and Borneo. This fish has a potential as a local wisdom for supplementation of omega 3 and omega 6. In Sumatera, Seluang fish was used as traditional food.   Aim of Study Aim of this study to explore the efficacy of seluang fish oil in body weight, lipid profile, adiponectin and leptin level in Wistar Rats-Induced High Fat Diet   Methods This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and seluang fish oil  at dose of 0,1 , 0,2  and 0,4 mL/200 gr BW/day for 2 weeks. Seluang fish oil was extracted by distilation methods. The results of this study were assayed by SPSS 18.   Results Seluang fish oil 0,4 mL/200 gr BW  was more potent to reduce body weight gain, triglyseride level,  leptin and increase adiponectin level than seluang fish oil 0,1 mL/200 gr BW, 0,2 mL/200 gr BW, negative control and positive control.   Conclusion Seluang fish oil had a potention to reduce body weight, triglyceride, leptin and increase adiponectin level.   Keywords: Seluang fish Oil – body weight- triglyserida – leptin - adiponectin  

scholarly journals Influence of α-lipoic acid on morphology of organs of rabbits fed a high fat diet with the addition of oxidised rapeseed oil

2017 ◽  
Vol 61 (4) ◽  
pp. 517-525
Author(s):  
Barbara Stawiarska-Pięta ◽  
Jolanta Zalejska-Fiolka ◽  
Magdalena Wyszyńska ◽  
Anna Kleczka ◽  
Beata Janiga ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
High Fat Diet ◽  
Rapeseed Oil ◽  
Mononuclear Cells ◽  
Fat Content ◽  
Control Group ◽  
Atherosclerotic Plaques ◽  
Standard Diet ◽  
High Fat ◽  
Group I

AbstractIntroduction:The aim of the study was to assess the influence of α-lipoic acid (ALA) on the morphology of the aorta and liver of rabbits fed high fat diet with addition of oxidised (ORO) and non-oxidised rapeseed oil (N-ORO).Material and Methods:The study was conducted on male chinchilla rabbits divided into six groups. The control group (C) was fed a breeding standard diet (BSD), group I received BSD with the addition of ALA in the dose of 10 mg/kg b.w., groups II and III received BSD enriched with 10% addition of N-ORO or ORO, whereas rabbits from groups IV and V received BSD with 10% addition of N-ORO or ORO and ALA.Results:Addition of ORO caused necrosis and steatosis of hepatocytes, as well as atherosclerotic plaques of various intensification in the aorta. In the liver of rabbits from group II (N-ORO) infiltrations of mononuclear cells was observed in the area of liver triads and between liver lobules. The beneficial influence of ALA was demonstrated in rabbits fed a diet containing N-ORO or ORO. In case of ORO, the activity of ALA was not fully effective.Conclusion:Diet supplementation with ALA counteracts the changes generated in the liver and aorta under increased exposure to higher fat content in diet, in particular thermally treated fats.

scholarly journals Prostatic Adenocarcinoma Progression Delay After Brazilian Berry Extract Intake in Transgenic Mice (Tramp) Submitted to a High- Fat Diet (P05-016-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Valeria Cagnon ◽  
Ellen Lima ◽  
Celina Lamas ◽  
Andressa Baseggio ◽  
Larissa Kido ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Diet Group ◽  
Control Group ◽  
Standard Diet ◽  
High Fat ◽  
Well Differentiated ◽  
Diet Intake ◽  
Old Mice ◽  
Tramp Mice ◽  
Peel Extract

Abstract Objectives Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present a high polyphenol concentration in the peel, showing an antioxidative property. The aim herein was to evaluate the antiangiogenic, antioxidant and proliferative effects of the Jaboticaba peel extract (patent BR 1020170054624) in early adenocarcinoma development in association with high-fat diet intake Methods Tramp mice were divided into 5 groups: Control group 8 (C8): 8 week-old mice; Control group 16 (C16): 16 week-old mice, standard diet; High-fat diet group (CH16): 16 week-old mice, high-fat diet; Jaboticaba standard diet group (JC): 16 week-old mice, standard diet and Jaboticaba intake; Jaboticaba high-fat diet group (HF): 16 week-old mice, high-fat diet and Jaboticaba intake. The 5.8 g Jaboticaba/Kg/body weight dose was administered five days per week for 2 months. The prostate was evaluated for proliferative, antiangiogenic and antioxidative markers, using morphology, immunohistochemistry and Western Blotting analyses. Results The prostate showed increased high grade prostatic intraepithelial neoplasia (HGPIN) and well-differentiated adenocarcinoma in the CH16 group. The Jaboticaba peel (JH group) led to decreased HGPIN. In both the JC and JH groups, a frequency increase of healthy prostatic epithelium was verified. A well-differentiated adenocarcinoma decrease was seen in the JC group. PCNA showed an increase in the CH16 group and a decrease in the JH group. VEGF had an increase in the CH16 group and a decrease after Jaboticaba peel extract intake. Catalase, SOD2, GR and 4HNE showed an increase in the CH16 group and all these molecules presented a decrease after Jaboticaba peel intake in the JH group. The TGFα protein level increased in the C16 and CH16 groups and decreased in the JC and JH groups. Conclusions To conclude, the high-fat diet intake intensified the severity of prostatic lesions. The Jaboticaba peel extract was effective in delaying prostatic adenocarcinoma progression, when administered at the early grades of cancer and considering the lesion severity. Jaboticaba peel intake showed antiangiogenic and antioxidant effects in the prostate, especially, after high-fat diet intake in Tramp mice, indicating a possible coadjuvant role of this natural compound in prostatic cancer therapy. Funding Sources Fapesp 18 045797.

scholarly journals Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat

2011 ◽  
Vol 106 (12) ◽  
pp. 1810-1813 ◽  
Author(s):  
Jason K. Higa ◽  
Wanyu Liu ◽  
Marla J. Berry ◽  
Jun Panee
Keyword(s):  
Body Weight ◽  
Visceral Fat ◽  
High Fat Diet ◽  
Water Extract ◽  
Control Group ◽  
Standard Diet ◽  
High Fat ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated the inhibitory effect of an ethanol–water extract from bamboo (BEX,Phyllostachys edulis) on the blood concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A total of ten mice were used in each group. Body weight and food consumption were measured weekly. After euthanisation, the weight of visceral fat and circulating MCP-1 concentration were measured. In comparison with the standard control group, the high-fat control group had increased body weight, abdominal fat storage and serum MCP-1 concentration by 60 % (P < 0·001), 266 % (P < 0·001) and 180 % (P < 0·01), respectively. In comparison with the high-fat control group, the high-fat BEX group showed a 3 % decrease in body weight (P < 0·01), 24 % decrease in mesenteric fat depot (P < 0·01) and 49 % decrease in serum MCP-1 concentration (P < 0·05). The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied.

scholarly journals The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet

2017 ◽  
Vol 1 (1) ◽  
pp. 8-13
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Yeni Agustin ◽  
Mgs Irsan Saleh ◽  
Nita Parisa ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Fruit Extract ◽  
Reduce Body Weight

Background Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing.   Aim of Study Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet   Methods This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract  at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18.   Results Lerek fruit extract 100 mg/kgBW  was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control.   Conclusion Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level.   Keywords: Lerek fruit extract – body weight- triglyserida - leptin

scholarly journals Effect of Citrus Limon Essential Oil on Lipid Profile and Obesity in Wistar Rats

2021 ◽  
pp. 1-5
Author(s):  
Souhaila Benchaoui ◽  
Meriem Gueracheha ◽  
Asma Boutebsou
Keyword(s):  
Body Weight ◽  
Essential Oil ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Intraperitoneal Administration ◽  
Female Rats ◽  
Abdominal Circumference ◽  
Citrus Limon ◽  
Standard Diet ◽  
High Fat

Obesity causes many pathologies; no therapeutic axis has provided an effective solution to this problem. The use of herbal medicine with healthy food and physical activity is recommended, and essential oils are the best known of these natural substances. The objective of this study is to evaluate the effect of Citrus limon essential oil on body weight and lipid profile. The plant material is the lemon; the extraction method is hydrodistillation. The experiment lasted 20 days and involved 15 female rats (2 to 3 months old) weighing between 160g and 230g. The rats were divided into 3 groups: the first receiving a standard diet, the second receiving a high-fat diet, and the third receiving a high-fat diet and treated with essential oil. The extraction yield is 1.69%. The physicochemical characteristics comply with AFNOR. This study shows that a high-lipid diet induces obesity characterized by hyperlipidemia. Intraperitoneal administration of the essential oil caused a decrease in body weight, abdominal circumference, plasma total cholesterol, and triglycerides and an increase in HDL-cholesterol. Considering this study, we found that lemon essential oil has beneficial effects on metabolic alterations. Its inclusion in the diet may help improve the metabolic profile and reduce the incidence of obesity and its long-term complications.

scholarly journals Reduced Body Fat and Epididymal Adipose Apelin Expression Associated With Raspberry Ketone [4-(4-Hydroxyphenyl)-2-Butanone] Weight Gain Prevention in High-Fat-Diet Fed Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Lihong Hao ◽  
Nicholas T. Bello
Keyword(s):  
Gene Expression ◽  
Weight Gain ◽  
High Fat Diet ◽  
The United States ◽  
Metabolic Effects ◽  
Control Group ◽  
Oral Glucose ◽  
High Fat ◽  
Oral Gavage ◽  
Raspberry Ketone

Raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] is a natural aromatic compound found in raspberries and other fruits. Raspberry ketone (RK) is synthetically produced for use as a commercial flavoring agent. In the United States and other markets, it is sold as a dietary supplement for weight control. The potential of RK to reduce or prevent excessive weight gain is unclear and could be a convergence of several different actions. This study sought to determine whether acute RK can immediately delay carbohydrate hyperglycemia and reduce gastrointestinal emptying. In addition, we explored the metabolic signature of chronic RK to prevent or remedy the metabolic effects of diet-induced weight gain. In high-fat diet (HFD; 45% fat)-fed male mice, acute oral gavage of RK (200 mg/kg) reduced hyperglycemia from oral sucrose load (4 g/kg) at 15 min. In HFD-fed female mice, acute oral RK resulted in an increase in blood glucose at 30 min. Chronic daily oral gavage of RK (200 mg/kg) commencing with HFD access (HFD_RK) for 11 weeks resulted in less body weight gain and reduced fat mass compared with vehicle treated (HFD_Veh) and chronic RK starting 4 weeks after HFD access (HFD_RKw4) groups. Compared with a control group fed a low-fat diet (LFD; 10% fat) and dosed with vehicle (LFD_Veh), glucose AUC of an oral glucose tolerance test was increased with HFD_Veh, but not in HFD_RK or HFD_RKw4. Apelin (Apln) gene expression in epididymal white adipose tissue was increased in HFD_Veh, but reduced to LFD_Veh levels in the HFD_RK group. Peroxisome proliferator activated receptor alpha (Ppara) gene expression was increased in the hepatic tissue of HFD_RK and HFD_RKw4 groups. Overall, our findings suggest that long term daily use of RK prevents diet-induced weight gain, normalizes high-fat diet-induced adipose Apln, and increases hepatic Ppara expression.

scholarly journals 3,5-Diiodo-L-Thyronine (T2) Administration Affects Visceral Adipose Tissue Inflammatory State in Rats Receiving Long-Lasting High-Fat Diet

2021 ◽  
Vol 12 ◽  
Author(s):  
Giuseppe Petito ◽  
Federica Cioffi ◽  
Elena Silvestri ◽  
Rita De Matteis ◽  
Davide Lattanzi ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Adverse Effects ◽  
High Fat Diet ◽  
Expression Profiles ◽  
Metabolic Effects ◽  
Daily Injection ◽  
Standard Diet ◽  
High Fat ◽  
Inflammatory Status ◽  
Inflammatory State

3,5-diiodo-thyronine (T2), an endogenous metabolite of thyroid hormones, exerts beneficial metabolic effects. When administered to overweight rats receiving a high fat diet (HFD), it significantly reduces body fat accumulation, which is a risk factor for the development of an inflammatory state and of related metabolic diseases. In the present study, we focused our attention on T2 actions aimed at improving the adverse effects of long-lasting HFD such as the adipocyte inflammatory response. For this purpose, three groups of rats were used throughout: i) receiving a standard diet for 14 weeks; ii) receiving a HFD for 14 weeks, and iii) receiving a HFD for 14 weeks with a simultaneous daily injection of T2 for the last 4 weeks. The results showed that T2 administration ameliorated the expression profiles of pro- and anti-inflammatory cytokines, reduced macrophage infiltration in white adipose tissue, influenced their polarization and reduced lymphocytes recruitment. Moreover, T2 improved the expression of hypoxia markers, all altered in HFD rats, and reduced angiogenesis by decreasing the pro-angiogenic miR126 expression. Additionally, T2 reduced the oxidative damage of DNA, known to be associated to the inflammatory status. This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.

Sign in / Sign up

Export Citation Format

Share Document