Swimming training combined with chitosan supplementation reduces the development of obesity and oxidative stress in high fat diet fed mice
Abstract Obesity is often introduced as one of the metabolic disorders caused by imbalance between energy consumption and metabolisable energy intake. Experts in the field considered obesity as one of the robust risk factors for the life-style associated diseases. The present research examined interventional effects of marine chitosan (CS), swimming training (ST) and combination of CS and ST (CS+ST) in the mice fed with high fat diets (HFD). In this study, sample size was considered more than 3 in groups. Forty mice were randomly divided into 5 groups (n = 8 per group) including control group (received the standard diet), HFD group (received high fat food with 20% fat), HFD+CS group (treated with high fat food with 5% CS), HFD+ST group (treated with high fat diet and ST) and HFD+CS+ST group (treated with high fat food with 5% CS & ST). After 8 weeks the blood glucose, oxidative stress (OS), and lipid profile were measured. Results showed more efficiency of CS+ST in the control of body weight with the increased concentration of HDL-C, OS inhibition via enhancing the body antioxidant capacity in comparison to the ST or CS alone in obese mice. Moreover, lipid profile was improved in CS + ST-treated mice compared with HFD-treated mice, and OS inhibition correlated to the greater activities of the antioxidant enzyme, enhance the lipid oxidation, cholesterol and fatty acid homeostasis. The results suggested that a dietary intervention with a combined ST and CS can be a feasible supplementary for human prevention of obesity.