Local cold acclimation during exercise and its effect on neuromuscular function of the hand

Most acclimation research is performed on resting individuals, whereas in real life, cold exposure is often accompanied by physical activity. We examined the effects of 2 weeks of repeated cold exposure of the hand with or without an elevated core temperature from exercise on neuromuscular function of the first dorsal interosseus (FDI) muscle and manual performance of the hand. The experimental group (4 female, 6 male; age, 25.1 ± 6.9 y) cooled their hands in 8 °C water for 30 min daily while cycling (50% of heart rate reserve); the control group (4 female, 4 male; age, 25.1 ± 5.7 y) remained still. Manual function testing consisted of tactile sensitivity, grip strength, manual dexterity, and evoked twitch force in a custom-made myograph. Thermal sensation, skin temperature of index finger (Tif) and hand (Tfdi), as well as rectal temperature (Tre), were recorded daily. Tre increased significantly during bicycling, by 0.6 ± 0.2 °C. Minimal Tif and Tfdi of the groups combined increased significantly during exposure days from 8.7 ± 0.7 °C and 12.4 ± 2.8 °C to 10.1 ± 1.3 °C and 15.0 ± 3.0 °C, respectively (p = 0.04), with no significant difference between groups. Thermal ratings improved significantly on exposure days. Manual function was impaired with cooling, but with no significant difference between groups or across time. Deterioration of twitch characteristics with cooling did not change with repeated cold exposure. Although the increasing core temperature during cold water immersion changed the acute temperature response and thermal ratings, it had no effect on local cold acclimation or manual function.

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Effect of cold acclimation on neuromuscular function of the hand

Applied Physiology Nutrition and Metabolism ◽

10.1139/h06-013 ◽

2006 ◽

Vol 31 (4) ◽

pp. 480-481

Author(s):

Carla L.M. Geurts

Keyword(s):

Cold Stress ◽

Cold Acclimation ◽

Cold Exposure ◽

Force Control ◽

Cold Water ◽

Water Immersion ◽

Temperature Response ◽

Neuromuscular Function ◽

Cold Water Immersion ◽

Hand Temperature

The research in this thesis investigated the effects of cold stress on neuromuscular function with the main focus on cold acclimation. In total, 6 studies, 1 field study and 5 experiments, were conducted. The field study showed that during manual work in cold weather, finger and hand temperature can drop to levels that may impair manual function. The first 2 experiments were conducted to investigate the effect of acute local cold stress on force control and to investigate the effect of cold-induced vasodilatation (CIVD) on neuromuscular function. In experiment 1, it was found that cooling of the hand in 10 °C cold water for 10 min did not improve force control, although neuromuscular function was significantly impaired after cooling. In experiment 2, cold-induced vasodilatation, occurring after 20 min of 8 °C cold-water immersion of the hand, was confined to the finger tip and had no effect on the temperature of the first dorsal interosseus (FDI) muscle or its neuromuscular function. A series of cold acclimation studies was conducted to investigate the effect of repeated cold-water hand immersions on neuromuscular function. In these experiments, neuromuscular function was tested before and after 2–3 weeks of daily hand immersion in 8 °C cold water for 30 min. In experiment 3, it was found that 3 weeks of cold-water immersion resulted in a decrease in minimum and mean index finger temperature and CIVD was attenuated. Neuromuscular function was not affected by this change in temperature response. In experiment 4, one hand was exposed daily to cold water and compared with the opposite control hand. Blood plasma catecholamine concentrations were increased after 2 weeks in the cold-exposed hand, but no changes in temperature response or neuromuscular function were found after repeated cold exposure. Thermal comfort after 30 min of cold-water immersion significantly improved after repeated cold exposure causing a discrepancy between actual and perceived temperature and it was suggested that this may impose a greater risk of cold injury owing to a change in behavioural thermoregulation. In the last experiment, core temperature was elevated by bicycling at a submaximal level during the cold hand immersion. Exercise had a direct effect on the temperature response during cold-water immersion, decreasing the minimum FDI temperature and slowing down the deteriorating effect of cold on neuromuscular function; however, exercise showed was no effect on local cold acclimation. It is concluded that local repeated cold exposures may improve finger and hand temperature and subjective thermal ratings, but that these changes are too small to improve neuromuscular function. The best remedy to maintain manual function is to limit or avoid cold stress as much as possible. If sufficient protection of the hands is impossible, core heating through exercise or passive heating may be a solution.

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Seven days of cold acclimation substantially reduces shivering intensity and increases nonshivering thermogenesis in adult humans

Journal of Applied Physiology ◽

10.1152/japplphysiol.01133.2018 ◽

2019 ◽

Vol 126 (6) ◽

pp. 1598-1606 ◽

Cited By ~ 6

Author(s):

Kyle Gordon ◽

Denis P. Blondin ◽

Brian J. Friesen ◽

Hans Christian Tingelstad ◽

Glen P. Kenny ◽

...

Keyword(s):

Cold Acclimation ◽

Core Temperature ◽

Heat Production ◽

Cold Exposure ◽

Cold Water ◽

Water Immersion ◽

Cold Water Immersion ◽

Metabolic Changes ◽

Whole Body ◽

Nonshivering Thermogenesis

Daily compensable cold exposure in humans reduces shivering by ~20% without changing total heat production, partly by increasing brown adipose tissue thermogenic capacity and activity. Although acclimation and acclimatization studies have long suggested that daily reductions in core temperature are essential to elicit significant metabolic changes in response to repeated cold exposure, this has never directly been demonstrated. The aim of the present study is to determine whether daily cold-water immersion, resulting in a significant fall in core temperature, can further reduce shivering intensity during mild acute cold exposure. Seven men underwent 1 h of daily cold-water immersion (14°C) for seven consecutive days. Immediately before and following the acclimation protocol, participants underwent a mild cold exposure using a novel skin temperature clamping cold exposure protocol to elicit the same thermogenic rate between trials. Metabolic heat production, shivering intensity, muscle recruitment pattern, and thermal sensation were measured throughout these experimental sessions. Uncompensable cold acclimation reduced total shivering intensity by 36% ( P = 0.003), without affecting whole body heat production, double what was previously shown from a 4-wk mild acclimation. This implies that nonshivering thermogenesis increased to supplement the reduction in the thermogenic contribution of shivering. As fuel selection did not change following the 7-day cold acclimation, we suggest that the nonshivering mechanism recruited must rely on a similar fuel mixture to produce this heat. The more significant reductions in shivering intensity compared with a longer mild cold acclimation suggest important differential metabolic responses, resulting from an uncompensable compared with compensable cold acclimation. NEW & NOTEWORTHY Several decades of research have been dedicated to reducing the presence of shivering during cold exposure. The present study aims to determine whether as little as seven consecutive days of cold-water immersion is sufficient to reduce shivering and increase nonshivering thermogenesis. We provide evidence that whole body nonshivering thermogenesis can be increased to offset a reduction in shivering activity to maintain endogenous heat production. This demonstrates that short, but intense cold stimulation can elicit rapid metabolic changes in humans, thereby improving our comfort and ability to perform various motor tasks in the cold. Further research is required to determine the nonshivering processes that are upregulated within this short time period.

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Inflammatory and oxidative alterations of water immersion and epidural analgesia during the labor

Medical Science and Discovery ◽

10.36472/msd.v7i8.407 ◽

2020 ◽

Vol 7 (8) ◽

pp. 598-602

Author(s):

Ümit Yasemin Sert ◽

Özlem Uzunlar ◽

Nezaket Kadıoğlu ◽

Tuba Candar ◽

Yaprak Engin Üstün

Keyword(s):

Epidural Analgesia ◽

Water Immersion ◽

Demographic Data ◽

Total Serum ◽

Control Group ◽

Epidural Group ◽

Birth Process ◽

Apgar Scores ◽

Significant Difference ◽

And Control

Objective: Water immersion and epidural analgesia are both pain relief methods used to perceive less pain during the labor process. There are concerns about the maternal and fetal outcomes, although studies presented no significant complication directly related to these methods. We aimed to compare the IL-1 and 6 levels, Total serum oxidant (TOS), antioxidant (TAS) and catalase levels of births with epidural analgesia, water immersion and conventional birth without analgesia. Material and Methods: A total of 88 patients were included in the study (The water immersion group included 29 patients, while the epidural analgesia and control group included 30 and 29 patients respectively). Umblical cord IL-1, IL-6, catalase, TAS, TOS levels, neonatal Apgar scores, duration of birth process and demographic data were compared between three groups Results: There was no significant difference between the three groups in terms of age, Body mass index (BMI), gravidity, parity, gestational week, and birth weight (p>0.05). TOS and IL-6 levels were significantly lower in epidural group than others (p=0.031, p=0.019 respectively). Apgar scores were significantly lower in epidural group (p<0.001). Conclusion: The water immersion and epidural analgesia were found to have no adverse effect on oxidative status and infection parameters of women.

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Comparative evaluation of postoperative pain intensity after single-visit and multiple-visit retreatment cases: a prospective randomized clinical trial

Brazilian Dental Science ◽

10.14295/bds.2018.v21i1.1515 ◽

2018 ◽

Vol 21 (1) ◽

pp. 26 ◽

Cited By ~ 3

Author(s):

Hatice Miray Uyan ◽

Keziban Olcay ◽

Mutlu Özcan

Keyword(s):

Postoperative Pain ◽

Repeated Measures ◽

Control Group ◽

Periapical Lesions ◽

Single Visit ◽

Group 4 ◽

Multiple Visit ◽

Significant Difference ◽

Group 3 ◽

Group 2

Objective: This study was designed to evaluate postoperative pain after endodontic retreatment. Material and Methods: Asymptomatic, multi-rooted molar & premolar teeth requiring retreatment with 2–5 mm periapical lesions were included. Seventy-eight teeth were randomly placed in four groups (n=20): single-visit (control, group 1), Ledermix (group 2), metronidazole, ciprofloxacin, minocycline mixture (group 3), calcium hydroxide (group 4). The postoperative pain was recorded using a VAS at 6, 12, 24, and 48 h after retreatment. Statistical evaluation was performed using Two-Way Repeated Measures ANOVA and Tukey test. Results: Mild pain occurred in 67.5%, moderate in 30%, and flare-ups in 2.5%, and there was a significant difference between the groups (p<0.01). Significantly lower postoperative pain was observed in TAP and CaOH2 groups(p<0.05). In the 6, 12, and 24 h intervals, there was a significant difference in the pain levels (p<0.05). Conclusion: TAP and CaOH2 are effective for reducing postoperative pain after retreatment.KeywordsIntracanal medicaments; Multiple-visit; Postoperative pain; Retreatment; Single-visit.

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Evaluation of Effect by Different Surface Treatment Agents on Retention of Custom Made Cast Metal Post and Prefabricated Glass Fibre Post-A Comparative Study

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672007 ◽

2015 ◽

Vol 03 (01) ◽

pp. 007-011

Author(s):

Sunny Panthi ◽

Kusum Dutta ◽

Gaurav Singla ◽

Keyword(s):

Surface Treatment ◽

Ethyl Alcohol ◽

Glass Fibre ◽

Control Group ◽

Sand Blasting ◽

Cast Metal ◽

Custom Made ◽

Significant Difference ◽

Glass Fibre Posts ◽

Metal Post

AbstractPosts are widely used for restoring endodontically treated teeth with insufficient coronal tooth structure. Custom made cast metal post and core systems have a long history of successful use due to their superior physical properties. Prefabricated post systems have recently become more popular because they can provide satisfactory results, while saving time and reducing costs. Materials and Method: Post spaces were prepared in 60 extracted caries free teeth, and divided into two main groups of 30 teeth each for cast metal and glass fibre posts. These groups were further divided into 3 subgroups of 10 specimens each I) Control group without any surface treatment, II) Specimens treated with 57% ethanol, III) Specimens air abraded with 50um air borne alumina particles. Teeth were mounted in acrylic blocks prepared from a specially fabricated metal device. Posts were luted in the prepared post spaces with glass ionomer luting cement. Retentive strength was tested by Universal testing machine at 2mm/min crosshead speed. Results: Sand blasting of cast metal posts showed more significant improvement in retention compared to both control group and ethyl alcohol treated groups. In case of glass fibre posts, sand blasting significantly improved its retention compared to control group but no significant difference was observed between control and ethyl alcohol treated groups. There was also no significant difference between ethyl alcohol treated and sand blasted group. Conclusion: It was concluded that, sand blasting is an effective method to improve retention of both cast metal and glass fibre posts.

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Do cigarette and alcohol affect semen analysis?

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2016.1.56 ◽

2016 ◽

Vol 88 (1) ◽

pp. 56 ◽

Cited By ~ 3

Author(s):

Mehmet Zeynel Keskin ◽

Salih Budak ◽

Saim Gubari ◽

Kalender Durmaz ◽

Mehmet Yoldas ◽

...

Keyword(s):

Alcohol Use ◽

Semen Analysis ◽

Threshold Value ◽

Semen Parameters ◽

Control Group ◽

Cigarette Use ◽

Group 4 ◽

Semen Volume ◽

Significant Difference ◽

The Relationship

Objectives: There are a number of studies about the effect of cigarette and alcohol on semen parameters in the literature. There is not a consensus on the relationship between use of cigarette and alchol and semen parameters in those studies. The number of studies in which cigarette and alcohol use are evaluated together is limited. This study was aimed to analyze the effect of cigarette and/or alcohol use on semen parameters. Methods: In this prospective study, 762 patients who applied to an hospital urology polyclinic between January 2015 and March 2015 due to infertility, were questioned for alcohol and cigarette use in anamnesis. The remaining 356 patients were included in our study. Then, semen analysis of the patients was performed. The patients were divided into five groups according to cigarette use, into five groups according to alcohol use and into four groups according to cigarette and/or alcohol use. Significant differences were analyzed between the groups in terms of semen volume, semen concentration, total motility, forward motility and morphological (normality, head anomaly, neck anomaly, tail anomaly) values. Results: According to cigarette use, only in group 4 (who use more than 20 package-years cigarette) semen volume was significantly lower than the control group (Mann-Whitney U, p = 0.009). There was no significant difference in any of the other parameters and groups compared with the control group (Mann-Whitney U, p > 0,05) Conclusion:According to our study, using more than 20 package- years cigarette decreases semen volume. The reason of this result might be the fact that the threshold value, from which the effect of cigarette and alcohol use on the semen parameters has to be determined.

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Efficacy of Double Manual Cleaning Versus Automated Cleaning for Removal of Biofilm of Hinged Surgical Instruments

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.1200 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s518-s519

Author(s):

Dayane Costa ◽

Roel Castillo ◽

Lillian Kelly Lopes ◽

Anaclara Tipple ◽

Honghua Hu ◽

...

Keyword(s):

Protein Level ◽

Positive Control ◽

Surgical Instruments ◽

Microbial Load ◽

Positive Control Group ◽

Control Group ◽

Group 4 ◽

Significant Difference ◽

Group 3 ◽

Group 2

Objectives: To evaluate the efficacy of double manual cleaning (DMC) with enzymatic followed by alkaline detergent for removing biofilm on hinged surgical instruments compared to automated cleaning by the washer-disinfector. Methods: Biofilm of Staphylococcus aureus (ATCC 25923) was formed in vitro on hemostatic forceps (Fig. 1). Biofilm-covered forceps were rinsed in distilled water and subjected to one of the following cleaning regimes (n = 5 forceps each): Group 1 forceps were soaked in sterile water for 5 minutes. Group 2-DMC forceps were soaked in enzymatic detergent, brushed 5 times on each face, rinsed with filtrated water (0.2 µm), soaked in alkaline detergent, brushed 5 times each face, rinsed with filtrated water (0.2 µm), and dried with sterile cloth. For group 3-DMC plus hinge inner brushing (n = 5), the forceps were soaked in detergents and brushed as in group 2, including hinge inner brushing (2-mm lumen brush) (Fig. 1). In group 4 (automated cleaning in a washer/disinfector), forceps were prewashed, washed once, washed again, rinsed, thermally rinsed, and dried. After the treatments, forceps were evaluated for microbial load (counting of colony-forming units), residual protein (BCA protein assay kit), and biofilm (scanning electron microscopy). Results: There was no statistically significant differences between the microbial load and protein level contaminating the forceps subjected to DMC (group 2) and the positive control group. The DMC with hinge inner brushing group (group 3) and the automated cleaning group (group 4) demonstrated a significantly reduced microbial load: reduction averages of 2.8 log 10 (P = .038) and 7.6 log10 (P ≤ .001), respectively. The protein level remaining on the forceps also significantly decreased: 2.563 μg (P = .016) and 1,453 μg (P = .001), respectively, compared to the positive control group. There was no statistically significant difference between DMC with hinge inner brushing and automated cleaning (groups 3 and 4) for all of the tests performed. None of the cleaning methods completely removed biofilm and/or soil from the forceps hinge internal region (Fig. 1). Conclusions: Automated cleaning had the best efficacy for removing biofilm. However, DMC with hinge inner brushing was an acceptable alternative cleaning method for sterilizing service units with only manual cleaning available, as is the case in most low- and middle-income countries. Neither automated nor any manual cleaning regimes were able to completely remove biofilm and soil from the forceps hinged area, and the amount of protein left after automated and DMC plus hinge brushing was higher than the recommended. Cleaning is the most important step for the reprocessing of reusable medical devices; thus, efforts must be undertaken to improve cleaning in different social and economic realities and scenarios.Funding: This study was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.Disclosures: None

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Effect of Different Finishing and Polishing Methods for Color Stability of the E-Max Dental Ceramics: In vitro Study

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/14.4.21 ◽

2021 ◽

Vol 14 (4) ◽

pp. 1508-1513

Author(s):

Ibraheem F Alshiddi

Keyword(s):

Surface Brightness ◽

Color Stability ◽

Color Measurement ◽

Control Group ◽

Group 4 ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

Group 1

In order to assess the influence of finishing and polishing on the surface brightness and color stability of the ceramic veneer, fifty specimens were fabricated with 10 mm diameter and 2 mm thickness using IPS E-Max Ceramic. After glazing, 10 specimens were untouched as control group, and the other 40 specimens were abraded using 125µm diamond bur to create surface roughness. Forty specimens were divided into four groups (n=10), in group 1: specimens were finished using diamond point, in group 2 specimens’ surface was polished with a polishing kit, Group 3: Each specimen surface was polished with the polishing kit as in protocol 2 and was polished a polishing past and group 4 Each specimen was glazed by heating at 621℃ for 3 minutes followed by a temperature increase of 83℃/min up to 918℃ for 30 seconds. Color measurement was performed using spectrophotometer. Color stability data were analyzed using two-way ANOVA and Tukey’s HSD test (α=0.05). For Ra values, paired-samples t-tests were used to analyze the data and compare groups. The change in L and E showed a significant difference among the study groups; (group 1, group 2, group 3 and group 4) with respect to three variables L, a and b. A significant difference was noted when compared each group with the control; however, only group 2 showed a significant difference from group 4; the remaining groups demonstrated similar findings for all three variables. The study displayed a significant impact of the finishing and polishing technique on the surface brightness and color stability of ceramic restoration. However, it was evident that combination of two or three polishing techniques which includes polish kit and glaze enhances the surface finish and adds color stability by alternating the yellow – blue axis (increase in b) and red- green axis (decrease in a).

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Protection of Renal Function ByHyperbaric OxygenDuring Plasmodium berghei ANKA Infection

International Journal of ChemTech Research ◽

10.20902/ijctr.2019.130108 ◽

2020 ◽

Vol 13 (1) ◽

pp. 69-74

Author(s):

Prawesty Diah Utami ◽

Herin Setianingsih

Keyword(s):

Renal Function ◽

Control Group ◽

Group 4 ◽

Wistar Strain ◽

Significant Difference ◽

Post Test ◽

Group 3 ◽

Group 5 ◽

Major Factors ◽

High Level

Background:Malaria cases have consistently increased and the number of deaths remains largely unchanged.Malaria associated renal injury has a high level of morbidity and mortality. High level of blood urea nitrogen / BUN and plasma creatinine is one of the major factors associated with mortality in humans infected with malaria, indicating that impairment of renal function. HBO is widely used as an adjunctive therapy for many diseases, it is known that HBO hasan action as antiplasmodium, antiinflammation and antioxidant effects. Objective: The aim of this study was to determine the effect of HBO on BUN and creatinine levels in rats infected with P. berghei ANKA. Methods:This research was conducted experimentally post-test only control group on six groups of rats. The samples used were 24 male Rattus norvegicus wistar strain that have been infected by Plasmodium bergheiANKA and divided into 6 groups. Group 1 was given combination artesunate and 1, 5 ATA HBO, grup 2 was given combination artesunate and 3, 0 ATA HBO, group 3 was given 1, 5 ATA HBO, group 4 was given 3, 0 ATA HBO, group 5 was given artesunate and group 6 was given aquadest. HBO therapy is carried out for 10 days and the observation of the levels of BUN and creatinine in mice after treatment on tenth day. Results:Descriptive analysis and statistical analysis (Kruskal wallis snd Mann whitney U posthoc) showed a significant difference (p < α = 0.05) on mean levels of BUN and creatinine group receiving combination of artesunate and HBO 3,0 ATA compared to other groups.Hyperbaric oxygen has the effect of reducing the levels of BUN and creatinine in rats infected by P.berghei ANKA.

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THE EFFECT OF TRACHEAL DIVERTICULUM AND CHRONIC OSTRUCTIVE LUNG DISEASE ON CHEST ANTHROPOMETRY

10.22541/au.161248656.64273199/v1 ◽

2021 ◽

Author(s):

Mine ARGALI DENIZ ◽

Hilal ER ULUBABA ◽

M. Furkan ARPACI ◽

Fatih CAVUS ◽

Gokhan DEMIRTAS ◽

...

Keyword(s):

Control Group ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Group 4 ◽

Tracheal Diverticulum ◽

Copd Patients ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

Group 1

Objective: In this study, the effect of tracheal diverticula (TD) on chest anthropometry and its relation with chronic obstructive pulmonary disease (COPD) was evaluated. Method: Between January 2019 and March 2020, 995 patients who underwent chest CT were retrospectively analyzed and TD was detected in 31 cases. Group 1 is only TD, Group 2 is TD + COPD, Group 3 is only COPD, Group 4 is defined as control group. We measured the localization, size, the distance to carina and vocal cord of TDs. In all groups chest diameters at T4 and T9 levels were measured as transverse and vertical plans. Results: TDs detected mostly at the T2 and T3 levels. In Group 1 and Group 2, there was a statistically significant difference the distance to TD of vocal chords. A statistically significant difference was found between Group 1 and Group 3 only in the vertical diameter at the T4 and T9 levels. Conclusion: We observed that COPD effect TD location and also TD had opposite effect on anteroposteriorly increasing chest parameters in COPD. Precence of TD is essential on COPD patients about thorax anthropometry. Keywords: Tracheal diverticulum; antropometry; radiology; COPD; chest diameter

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