POSITIVE FEEDBACK-ASSISTED SHORT/LONG-RANGE CELL SIGNALINGS IN MAPK CASCADES

2009 ◽  
Vol 20 (11) ◽  
pp. 1769-1787
Author(s):  
YANBIN ZHANG ◽  
KENIAN CHEN ◽  
JUNWEI WANG ◽  
AIMIN CHEN ◽  
TIANSHOU ZHOU
Keyword(s):  
Long Range ◽  
Positive Feedback ◽  
Information Transfer ◽  
Spatial Information ◽  
Signal Propagation ◽  
Large Cell ◽  
Long Distance ◽  
Mapk Cascades ◽  
Range Cell ◽  
Living Organisms

In this paper, we study potentials of positive feedback in spatial phosphoprotein signal propagation. For this, we consider a signaling pathway of four-tiered protein kinase cascades with each tier involving single (de)phosphorylation reactions only. In the case of a small cell, we propose a short positive feedback for short-range cell signaling, which can generate bistability to facilitate the phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. In contrast, in the case of a large cell for which the long-range signaling cannot be achieved by the short feedback, we propose a long positive feedback, and find that it can facilitate the propagation of phosphoprotein signal over a long distance. These results imply that positive-feedback mechanisms would be employed by living organisms for spatial information transfer and cellular decision-making processing.

CROSSTALK FACILITATES SPATIAL SIGNAL PROPAGATION THROUGH MAPK CASCADES

2009 ◽  
Vol 17 (03) ◽  
pp. 461-477
Author(s):  
YANBIN ZHANG ◽  
KENIAN CHEN ◽  
JUNWEI WANG ◽  
AIMIN CHEN ◽  
MEICHUN ZHAO ◽  
...  
Keyword(s):  
Information Transfer ◽  
Spatial Information ◽  
Signal Propagation ◽  
Mitogen Activated Protein Kinase ◽  
Spatial Gradients ◽  
Cell Compartments ◽  
Mapk Cascades ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Living Organisms

In intracellular mitogen-activated protein kinase (MAPK) cascades, it has been shown that signals can be propagated across the cell cytosol in the form of phosphoprotein waves arising from the bistable response of MAPK to active MAPK kinase. Without such a bistable response, however, they can not propagate into distant cell compartments, although a long positive feedback endows a mechanistically-distinct bistable response of MAPK to extracellular signal. Here we provide a compensate means that uses crosstalk between parallel identical pathways of MAPK cascades. For a spherical cell, we find that both unidirectional and bidirectional crosstalk with enhancement of phosphorylation can facilitate phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. Moreover, different shallow spatial gradients of biphosphorylated MAPK occur in the cytosol under different strengths of pathway interactions. These results suggest that crosstalk would be utilized by living organisms for spatial information transfer and cellular decision-making processing.

scholarly journals A Long-Distance Communication Architecture for Medical Devices Based on LoRaWAN Protocol

Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 940
Author(s):  
Nicoleta Cristina Gaitan
Keyword(s):  
Energy Consumption ◽  
Long Range ◽  
Medical Devices ◽  
Low Energy ◽  
Area Network ◽  
Wide Area Network ◽  
Long Distance ◽  
Communication Architecture ◽  
Low Energy Consumption ◽  
Distance Communication

Recent market studies show that the market for remote monitoring devices of different medical parameters will grow exponentially. Globally, more than 4 million individuals will be monitored remotely from the perspective of different health parameters by 2023. Of particular importance is the way of remote transmission of the information acquired from the medical sensors. At this time, there are several methods such as Bluetooth, WI-FI, or other wireless communication interfaces. Recently, the communication based on LoRa (Long Range) technology has had an explosive development that allows the transmission of information over long distances with low energy consumption. The implementation of the IoT (Internet of Things) applications using LoRa devices based on open Long Range Wide-Area Network (LoRaWAN) protocol for long distances with low energy consumption can also be used in the medical field. Therefore, in this paper, we proposed and developed a long-distance communication architecture for medical devices based on the LoRaWAN protocol that allows data communications over a distance of more than 10 km.

scholarly journals A Robust Lane Detection Model Using Vertical Spatial Features and Contextual Driving Information

Sensors ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 708
Author(s):  
Wenbo Liu ◽  
Fei Yan ◽  
Jiyong Zhang ◽  
Tao Deng
Keyword(s):  
Information Exchange ◽  
Information Transfer ◽  
Spatial Information ◽  
Contextual Information ◽  
Great Influence ◽  
Light Condition ◽  
Lane Detection ◽  
Detection Model ◽  
Spatial Features ◽  
Proposed Model

The quality of detected lane lines has a great influence on the driving decisions of unmanned vehicles. However, during the process of unmanned vehicle driving, the changes in the driving scene cause much trouble for lane detection algorithms. The unclear and occluded lane lines cannot be clearly detected by most existing lane detection models in many complex driving scenes, such as crowded scene, poor light condition, etc. In view of this, we propose a robust lane detection model using vertical spatial features and contextual driving information in complex driving scenes. The more effective use of contextual information and vertical spatial features enables the proposed model more robust detect unclear and occluded lane lines by two designed blocks: feature merging block and information exchange block. The feature merging block can provide increased contextual information to pass to the subsequent network, which enables the network to learn more feature details to help detect unclear lane lines. The information exchange block is a novel block that combines the advantages of spatial convolution and dilated convolution to enhance the process of information transfer between pixels. The addition of spatial information allows the network to better detect occluded lane lines. Experimental results show that our proposed model can detect lane lines more robustly and precisely than state-of-the-art models in a variety of complex driving scenarios.

scholarly journals Variation of Low-Frequency Time-Code Signal Field Strength during the Annular Solar Eclipse on 21 June 2020: Observation and Analysis

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1216
Author(s):  
Xin Wang ◽  
Bo Li ◽  
Fan Zhao ◽  
Xinyu Luo ◽  
Luxi Huang ◽  
...  
Keyword(s):  
Field Strength ◽  
Solar Eclipse ◽  
Low Frequency ◽  
Signal Propagation ◽  
Normal Operation ◽  
Time Code ◽  
Long Distance ◽  
Time Service ◽  
Annular Solar Eclipse ◽  
Signal Field

Due to the occlusion of the moon, an annular solar eclipse will have an effect on the ionosphere above the earth. The change of the ionosphere, for the low-frequency time-code signal that relies on it as a reflection medium for long-distance propagation, the signal field strength, and other parameters will also produce corresponding changes, which will affect the normal operation of the low-frequency time-code time service system. This paper selects the solar eclipse that occurred in China on 21 June 2020, and uses the existing measurement equipment to carry out experimental research on the low-frequency time-code signal. We measured and analyzed the signal field strength from 20 June 2020 to 23 June 2020, and combined solar activity data, ionospheric data, and geomagnetic data, and attempted to explore the reasons and rules of the change of signal parameters. The results showed that the field strength of the low-frequency time-code signal changed dramatically within a short time period, the max growth value can reach up to 17 dBμV/m and the variation trend yielded ‘three mutations’. This change in signal field strength is probably due to the occurrence of a solar eclipse that has an effect on the ionosphere. When the signal propagation conditions change, the signal strength will also change accordingly.

scholarly journals Deep brain stimulation of the subthalamic nucleus reestablishes neuronal information transmission in the 6-OHDA rat model of parkinsonism

2014 ◽  
Vol 111 (10) ◽  
pp. 1949-1959 ◽  
Author(s):  
Alan D. Dorval ◽  
Warren M. Grill
Keyword(s):  
Deep Brain Stimulation ◽  
Basal Ganglia ◽  
Information Transmission ◽  
Brain Stimulation ◽  
Rat Model ◽  
Information Transfer ◽  
Firing Pattern ◽  
Signal Propagation ◽  
Neuronal Firing ◽  
Deep Brain

Pathophysiological activity of basal ganglia neurons accompanies the motor symptoms of Parkinson's disease. High-frequency (>90 Hz) deep brain stimulation (DBS) reduces parkinsonian symptoms, but the mechanisms remain unclear. We hypothesize that parkinsonism-associated electrophysiological changes constitute an increase in neuronal firing pattern disorder and a concomitant decrease in information transmission through the ventral basal ganglia, and that effective DBS alleviates symptoms by decreasing neuronal disorder while simultaneously increasing information transfer through the same regions. We tested these hypotheses in the freely behaving, 6-hydroxydopamine-lesioned rat model of hemiparkinsonism. Following the onset of parkinsonism, mean neuronal firing rates were unchanged, despite a significant increase in firing pattern disorder (i.e., neuronal entropy), in both the globus pallidus and substantia nigra pars reticulata. This increase in neuronal entropy was reversed by symptom-alleviating DBS. Whereas increases in signal entropy are most commonly indicative of similar increases in information transmission, directed information through both regions was substantially reduced (>70%) following the onset of parkinsonism. Again, this decrease in information transmission was partially reversed by DBS. Together, these results suggest that the parkinsonian basal ganglia are rife with entropic activity and incapable of functional information transmission. Furthermore, they indicate that symptom-alleviating DBS works by lowering the entropic noise floor, enabling more information-rich signal propagation. In this view, the symptoms of parkinsonism may be more a default mode, normally overridden by healthy basal ganglia information. When that information is abolished by parkinsonian pathophysiology, hypokinetic symptoms emerge.

Field Study of Low-Energy Long-Distance Wireless Communication for IoT Application in Remote Areas

Mekatronika ◽  
2020 ◽  
Vol 2 (1) ◽  
pp. 52-62
Author(s):  
Kwai Yang Sak ◽  
Ahmad Najmuddin Ibrahim
Keyword(s):  
Radio Frequency ◽  
Long Range ◽  
Essential Element ◽  
Low Energy ◽  
Line Of Sight ◽  
Area Network ◽  
Structural Elements ◽  
Wide Area Network ◽  
Residential Areas ◽  
Long Distance

Long Range (LoRa) is a wireless radio frequency technology under the Low Power Wide Area Network (LPWAN). LoRa is able to communicate long range and low energy consumption. The communication range has become an essential element in the wireless radio frequency technology in the Internet of Things (IoT). The presence of LoRa is able IoT application performs in long communication distances with high noise sensitivity ability. People can operate, monitor, and do a variety of tasks from a remote distance. Therefore, this research aims to evaluate the performance of the LoRa connection between radio transceivers in remote locations. The different environment and structural elements affect the LoRa performance. This thesis will be supported by the experiment that LoRa communication in different environments and tests. This experiment tests in line of sight (LOS) and non-line of sight (NLOS). Two sets of LoRa parameters, including Spreading Factor (SF), Bandwidth, and coding rate, are tested in different environments. The experiment tests the LoRa performance in various aspects: received signal strength indicator (RSSI) and packet received ratio (PPR) at different coverage ranges. In addition, the LoRa performance is evaluated in university, residential areas and vegetation areas under similar temperature, weather, and time. The LoRa coverage distance in the vegetation area and university area is reached 900 meters in the LOS test. Still, the vegetation area's signal is more stable and able to receive weaker RSSI signals. The LoRa coverage distance in the NLOS test is shorter compared to the LOS test. NLOS test has only one-third of the LOS LoRa communication distance. It is due to the signal penetration on structural elements such as buildings and woods cause the signal power loss and only transmitting a shorter distance. The LoRa parameter with SF9, 31.25kHz bandwidth and 4/8 coding rate has a better coverage range and stable connection.

scholarly journals Hierarchical coupling between ATP hydrolysis and Hsp90’s client binding site

2020 ◽  
Author(s):  
Steffen Wolf ◽  
Benedikt Sohmen ◽  
Björn Hellenkamp ◽  
Johann Thurn ◽  
Gerhard Stock ◽  
...  
Keyword(s):  
Binding Site ◽  
Single Molecule ◽  
Information Transfer ◽  
Atp Hydrolysis ◽  
Structural Information ◽  
Substrate Binding ◽  
Signal Propagation ◽  
Nonequilibrium Molecular Dynamics ◽  
Time Resolved ◽  
Substrate Binding Site

I.ABSTRACTSeveral indicators for a signal propagation from a binding site to a distant functional site have been found in the Hsp90 dimer. Here we determined a time-resolved pathway from ATP hydrolysis to changes in a distant folding substrate binding site. This was possible by combining single-molecule fluorescence-based methods with extensive atomistic nonequilibrium molecular dynamics simulations. We find that hydrolysis of one ATP effects a structural asymmetry in the full Hsp90 dimer that leads to the collapse of a central folding substrate binding site. Arg380 is the major mediator in transferring structural information from the nucleotide to the substrate binding site. This allosteric process occurs via hierarchical dynamics that involve timescales from picoto milliseconds and length scales from Ångstroms to several nanometers. We presume that similar hierarchical mechanisms are fundamental for information transfer through many other proteins.

scholarly journals Identification of miRNA precursors in the phloem of Cucurbita maxima

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e8269 ◽  
Author(s):  
Eugeny Tolstyko ◽  
Alexander Lezzhov ◽  
Andrey Solovyev
Keyword(s):  
Cell Fate ◽  
Positional Information ◽  
Mature Mirnas ◽  
Inorganic Phosphorus ◽  
Pcr Analysis ◽  
Cucurbita Maxima ◽  
Phloem Exudate ◽  
Long Distance ◽  
Long Distance Transport ◽  
Range Cell

Plant development and responses to environmental cues largely depend on mobile signals including microRNAs (miRNAs) required for post-transcriptional silencing of specific genes. Short-range cell-to-cell transport of miRNA in developing tissues and organs is involved in transferring positional information essential for determining cell fate. Among other RNA species, miRNAs are found in the phloem sap. Long-distance transport of miRNA via the phloem takes a part in regulation of physiological responses to changing environmental conditions. As shown for regulation of inorganic phosphorus and sulfate homeostasis, mature miRNAs rather than miRNAs precursors are transported in the phloem as signaling molecules. Here, a bioinformatics analysis of transcriptomic data for Cucurbita maxima phloem exudate RNAs was carried out to elucidate whether miRNA precursors could also be present in the phloem. We demonstrated that the phloem transcriptome contained a subset of C. maxima pri-miRNAs that differed from a subset of pri-miRNA sequences abundant in a leaf transcriptome. Differential accumulation of pri-miRNA was confirmed by PCR analysis of C. maxima phloem exudate and leaf RNA samples. Therefore, the presented data indicate that a number of C. maxima pri-miRNAs are selectively recruited to the phloem translocation pathway. This conclusion was validated by inter-species grafting experiments, in which C. maxima pri-miR319a was found to be transported across the graft union via the phloem, confirming the presence of pri-miR319a in sieve elements and showing that phloem miRNA precursors could play a role in long-distance signaling in plants.

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