scholarly journals Hantavirus outbreaks in the American Southwest: Propagation and retraction of rodent and virus diffusion waves from sky-island refugia

2021 ◽  
Author(s):  
Robert R. Parmenter ◽  
Gregory E. Glass
Keyword(s):  
Wave Propagation ◽  
Wave Velocity ◽  
Disease Risk ◽  
Deer Mouse ◽  
Temporal Analysis ◽  
American Southwest ◽  
Infection Prevalence ◽  
Mouse Population ◽  
Diffusion Wave ◽  
Diffusion Waves

Hantavirus outbreaks in the American Southwest are hypothesized to be driven by episodic seasonal events of high precipitation, promoting rapid increases in virus-reservoir rodent species that then move across the landscape from high quality montane forested habitats (refugia), eventually over-running human residences and increasing disease risk. In this study, the velocities of rodents and virus diffusion wave propagation and retraction were documented and quantified in the sky-islands of northern New Mexico and related to rodent-virus relationships in refugia versus nonrefugia habitats. Deer mouse (Peromyscus maniculatus) refugia populations exhibited higher Sin Nombre Virus (SNV) infection prevalence than nonrefugia populations. The velocity of propagating diffusion waves of Peromyscus from montane to lower grassland habitats was measured at [Formula: see text] m/day (SE), with wave retraction velocities of [Formula: see text] m/day. SNV infection diffusion wave propagation velocity within a deer mouse population averaged [Formula: see text] m/day, with a faster retraction wave velocity of [Formula: see text] m/day. A spatio-temporal analysis of human Hantavirus Pulmonary Syndrome (HPS) cases during the initial 1993 epidemic revealed a positive linear relationship between the time during the epidemic and the distance of human cases from the nearest deer mouse refugium, with a landscape diffusion wave velocity of [Formula: see text] m/day ([Formula: see text]). These consistent diffusion propagation wave velocity results support the traveling wave component of the HPS outbreak theory and can provide information on space–time constraints for future outbreak forecasts.

scholarly journals Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Delia Taverner ◽  
Dídac Llop ◽  
Roser Rosales ◽  
Raimon Ferré ◽  
Luis Masana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Epigenetic Biomarkers

AbstractTo validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. Multivariate analyses adjusted for traditional confounders and treatments showed that decreased expression of microRNA-425-5p in men and decreased expression of microRNA-451 in women were significantly associated with increased (β = 0.072; p = 0.017) and decreased carotid intima-media thickness (β = −0.05; p = 0.013), respectively. MicroRNA-425-5p and microRNA-451 also increased the accuracy to discriminate patients with pathological carotid intima-media thickness by 1.8% (p = 0.036) in men and 3.5% (p = 0.027) in women, respectively. In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p = 0.008). Additionally, decreased expression of microRNA-451 was significantly associated with decreased pulse wave velocity (β = −0.72; p = 0.035) in overall rheumatoid arthritis population. Distensibility showed no significant association with expression levels of the microRNAs studied. We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.

scholarly journals Normal and reference values for cardiovascular magnetic resonance-based pulse wave velocity in the middle-aged general population

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Max J. van Hout ◽  
Ilona A. Dekkers ◽  
Jos J. Westenberg ◽  
Martin J. Schalij ◽  
Ralph L. Widya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
General Population ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Reference Values ◽  
Pulse Wave ◽  
Disease Risk ◽  
Cardiovascular Disease Risk

Abstract Background Aortic stiffness, assessed through pulse wave velocity (PWV), is an independent predictor for cardiovascular disease risk. However, the scarce availability of normal and reference values for cardiovascular magnetic resonance imaging (CMR) based PWV is limiting clinical implementation. The aim of this study was to determine normal and reference values for CMR assessed PWV in the general population. Methods From the 2,484 participants of the Netherlands Epidemiology of Obesity (NEO) study that have available CMR-PWV data, 1,394 participants free from cardiovasculard disease, smokers or treatment for diabetes, hypertension or dyslipidaemia were selected (45–65 years, 51% female). Participants were divided into sex, age and blood pressure (BP) subgroups. Normal values were specified for participants with a BP < 130/80 mmHg and reference values for elevated BP subgroups (≥ 130/80 and < 140/90 mmHg; and ≥ 140/90 mmHg). Differences between groups were tested with independent samples t-test or ANOVA. Due to an oversampling of obese individuals in this study, PWV values are based on a weighted analysis making them representative of the general population. Results Normal mean PWV was 6.0 m/s [95% CI 5.8–6.1]. PWV increased with advancing age and BP categories (both p < 0.001). There was no difference between sex in normal PWV, however in the BP > 140/90 mmHg women had a higher PWV (p = 0.005). The interpercentile ranges were smaller for participants < 55 years old compared to participants ≥ 55 years, indicating an increasing variability of PWV with age. PWV upper limits were particularly elevated in participants ≥ 55 years old in the high blood pressure subgroups. Conclusion This study provides normal and reference values for CMR-assessed PWV per sex, age and blood pressure category in the general population.

scholarly journals Impact of the experimental removal of lizards on Lyme disease risk

2011 ◽  
Vol 278 (1720) ◽  
pp. 2970-2978 ◽  
Author(s):  
Andrea Swei ◽  
Richard S. Ostfeld ◽  
Robert S. Lane ◽  
Cheryl J. Briggs
Keyword(s):  
Lyme Disease ◽  
Disease Ecology ◽  
Disease Risk ◽  
Large Fraction ◽  
Host Community ◽  
Deer Mice ◽  
Infection Prevalence ◽  
Alternate Host ◽  
Experimental Removal ◽  
Tick Infection

The distribution of vector meals in the host community is an important element of understanding and predicting vector-borne disease risk. Lizards (such as the western fence lizard; Sceloporus occidentalis ) play a unique role in Lyme disease ecology in the far-western United States. Lizards rather than mammals serve as the blood meal hosts for a large fraction of larval and nymphal western black-legged ticks ( Ixodes pacificus —the vector for Lyme disease in that region) but are not competent reservoirs for the pathogen, Borrelia burgdorferi . Prior studies have suggested that the net effect of lizards is to reduce risk of human exposure to Lyme disease, a hypothesis that we tested experimentally. Following experimental removal of lizards, we documented incomplete host switching by larval ticks (5.19%) from lizards to other hosts. Larval tick burdens increased on woodrats, a competent reservoir, but not on deer mice, a less competent pathogen reservoir. However, most larvae failed to find an alternate host. This resulted in significantly lower densities of nymphal ticks the following year. Unexpectedly, the removal of reservoir-incompetent lizards did not cause an increase in nymphal tick infection prevalence. The net result of lizard removal was a decrease in the density of infected nymphal ticks, and therefore a decreased risk to humans of Lyme disease. Our results indicate that an incompetent reservoir for a pathogen may, in fact, increase disease risk through the maintenance of higher vector density and therefore, higher density of infected vectors.

Diversifying forest communities may change Lyme disease risk: extra dimension to the dilution effect in Europe

Parasitology ◽  
2016 ◽  
Vol 143 (10) ◽  
pp. 1310-1319 ◽  
Author(s):  
SANNE C. RUYTS ◽  
EVY AMPOORTER ◽  
ELENA C. COIPAN ◽  
LANDER BAETEN ◽  
DIETER HEYLEN ◽  
...  
Keyword(s):  
North America ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Disease Risk ◽  
Severe Disease ◽  
Dilution Effect ◽  
Ixodid Ticks ◽  
Infection Prevalence ◽  
Host Diversity ◽  
Pine Stands

SUMMARYLyme disease is caused by bacteria of theBorrelia burgdorferigenospecies complex and transmitted by Ixodid ticks. In North America only one pathogenic genospecies occurs, in Europe there are several. According to the dilution effect hypothesis (DEH), formulated in North America, nymphal infection prevalence (NIP) decreases with increasing host diversity since host species differ in transmission potential. We analysedBorreliainfection in nymphs from 94 forest stands in Belgium, which are part of a diversification gradient with a supposedly related increasing host diversity: from pine stands without to oak stands with a shrub layer. We expected changing tree species and forest structure to increase host diversity and decrease NIP. In contrast with the DEH, NIP did not differ between different forest types. Genospecies diversity however, and presumably also host diversity, was higher in oak than in pine stands. Infected nymphs tended to harbourBorrelia afzeliiinfection more often in pine stands whileBorrelia gariniiandBorrelia burgdorferiss. infection appeared to be more prevalent in oak stands. This has important health consequences, since the latter two cause more severe disease manifestations. We show that the DEH must be nuanced for Europe and should consider the response of multiple pathogenic genospecies.

Wave Propagation in a Piezoelectric Coupled Solid Medium

2002 ◽  
Vol 69 (6) ◽  
pp. 819-824 ◽  
Author(s):  
Q. Wang
Keyword(s):  
Wave Propagation ◽  
Wave Velocity ◽  
Electric Potential ◽  
Solid Medium ◽  
Electric Displacement ◽  
Piezoelectric Medium ◽  
Wave Number ◽  
Mode Shapes ◽  
Coupled Structures ◽  
Shear Horizontal

Shear horizontal (SH) wave propagation in a semi-infinite solid medium surface bonded by a layer of piezoelectric material abutting the vacuum is investigated in this paper. The dispersive characteristics and the mode shapes of the deflection, the electric potential, and the electric displacements in the thickness direction of the piezoelectric layer are obtained theoretically. Numerical simulations show that the asymptotic phase velocities for different modes are the Bleustein surface wave velocity or the shear horizontal wave velocity of the pure piezoelectric medium. Besides, the mode shapes of the deflection, electric potential, and electric displacement show different distributions for different modes and different wave number. These results can be served as a benchmark for further analyses and are significant in the modeling of wave propagation in the piezoelectric coupled structures.

scholarly journals Simulation of the effect of stress-induced anisotropy on borehole compressional wave propagation

Geophysics ◽  
2014 ◽  
Vol 79 (4) ◽  
pp. D205-D216 ◽  
Author(s):  
Xinding Fang ◽  
Michael C. Fehler ◽  
Arthur Cheng
Keyword(s):  
Wave Propagation ◽  
Stress Concentration ◽  
Elastic Properties ◽  
Wave Velocity ◽  
Wave Amplitude ◽  
P Wave ◽  
Azimuthal Variation ◽  
P Wave Velocity ◽  
Velocity Region

Formation elastic properties near a borehole may be altered from their original state due to the stress concentration around the borehole. This can lead to an incorrect estimation of formation elastic properties measured from sonic logs. Previous work has focused on estimating the elastic properties of the formation surrounding a borehole under anisotropic stress loading. We studied the effect of borehole stress concentration on sonic logging in a moderately consolidated Berea sandstone using a two-step approach. First, we used an iterative approach, which combines a rock-physics model and a finite-element method, to calculate the stress-dependent elastic properties of the rock around a borehole subjected to an anisotropic stress loading. Second, we used the anisotropic elastic model obtained from the first step and a finite-difference method to simulate the acoustic response of the borehole. Although we neglected the effects of rock failure and stress-induced crack opening, our modeling results provided important insights into the characteristics of borehole P-wave propagation when anisotropic in situ stresses are present. Our simulation results were consistent with the published laboratory measurements, which indicate that azimuthal variation of the P-wave velocity around a borehole subjected to uniaxial loading is not a simple cosine function. However, on field scale, the azimuthal variation in P-wave velocity might not be apparent at conventional logging frequencies. We found that the low-velocity region along the wellbore acts as an acoustic focusing zone that substantially enhances the P-wave amplitude, whereas the high-velocity region caused by the stress concentration near the borehole results in a significantly reduced P-wave amplitude. This results in strong azimuthal variation of P-wave amplitude, which may be used to infer the in situ stress state.

Effects of ellipsoidal heterogeneities on wave propagation in partially saturated double-porosity rocks

Geophysics ◽  
2018 ◽  
Vol 83 (3) ◽  
pp. WC71-WC81 ◽  
Author(s):  
Weitao Sun ◽  
Fansheng Xiong ◽  
Jing Ba ◽  
José M. Carcione
Keyword(s):  
Wave Propagation ◽  
Aspect Ratio ◽  
Wave Velocity ◽  
Velocity Dispersion ◽  
Laboratory Data ◽  
P Wave ◽  
Lagrange Equations ◽  
Wave Dissipation ◽  
P Wave Velocity ◽  
The Impact

Reservoir rocks are heterogeneous porous media saturated with multiphase fluids, in which strong wave dissipation and velocity dispersion are closely associated with fabric heterogeneities and patchy saturation at different scales. The irregular solid inclusions and fluid patches are ubiquitous in nature, whereas the impact of geometry on wave dissipation is still not well-understood. We have investigated the dependence of wave attenuation and velocity on patch geometry. The governing equations for wave propagation in a porous medium, containing fluid/solid heterogeneities of ellipsoidal triple-layer patches, are derived from the Lagrange equations on the basis of the potential and kinetic energies. Harmonic functions describe the wave-induced local fluid flow of an ellipsoidal patch. The effects of the aspect ratio on wave velocity are illustrated with numerical examples and comparisons with laboratory measurements. The results indicate that the P-wave velocity dispersion and attenuation depend on the aspect ratio of the ellipsoidal heterogeneities, especially in the intermediate frequency range. In the case of Fort Union sandstone, the P-wave velocity increases toward an upper bound as the aspect ratio decreases. The example of a North Sea sandstone clearly indicates that introducing ellipsoidal heterogeneities gives a better description of laboratory data than that based on spherical patches. The unexpected high-velocity values previously reported and ascribed to sample heterogeneities are explained by varying the aspect ratio of the inclusions (or patches).

Computational poroelasticity — A review

Geophysics ◽  
2010 ◽  
Vol 75 (5) ◽  
pp. 75A229-75A243 ◽  
Author(s):  
José M. Carcione ◽  
Christina Morency ◽  
Juan E. Santos
Keyword(s):  
Porous Media ◽  
Wave Propagation ◽  
Rock Physics ◽  
Spectral Element ◽  
Seismic Modeling ◽  
Loss Mechanism ◽  
Diffusion Wave ◽  
Interface Waves ◽  
Element Technique

Computational physics has become an essential research and interpretation tool in many fields. Particularly in reservoir geophysics, ultrasonic and seismic modeling in porous media is used to study the properties of rocks and to characterize the seismic response of geologic formations. We provide a review of the most common numerical methods used to solve the partial differential equations describing wave propagation in fluid-saturated rocks, i.e., finite-difference, pseudospectral, and finite-element methods, including the spectral-element technique. The modeling is based on Biot-type theories of dynamic poroelasticity, which constitute a general framework to describe the physics of wave propagation. We explain the various techniques and discuss numerical implementation aspects for application to seismic modeling and rock physics, as, for instance, the role of the Biot diffusion wave as a loss mechanism and interface waves in porous media.

Magneto-thermo-elastic plane waves

1965 ◽  
Vol 61 (4) ◽  
pp. 939-944 ◽  
Author(s):  
C. M. Purushothama
Keyword(s):  
Magnetic Field ◽  
Wave Propagation ◽  
Shear Wave ◽  
Wave Velocity ◽  
Compression Wave ◽  
Thermal Field ◽  
Plane Waves ◽  
Elastic Plane ◽  
Magnetic Diffusivity ◽  
The Magnetic Field

AbstractThe combined effects of uniform thermal and magnetic fields on the propagation of plane waves in a homogeneous, initially unstressed, electrically conducting elastic medium have been investigated.When the magnetic field is parallel to the direction of wave propagation, the compression wave is purely thermo-elastic and the shear wave is purely magneto-elastic in nature. For a transverse magnetic field, the shear waves remain elastic whereas the compression wave assumes magneto-thermo-elastic character due to the coupling of all the three fields—mechanical, magnetic and thermal. In the general case, the waves polarized in the plane of the direction of wave propagation and the magnetic field are not only coupled but are also influenced by the thermal field, once again exhibiting the coupling of the three fields. The shear wave polarized transverse to the plane retains its magneto-elastic character.Notation.Hi = primary magnetic field components,ht = induced magnetic field components,To = initial thermal field,θ = induced thermal field,C = compression wave velocity.S = shear wave velocity,ui = displacement components,cv = specific heat at constant volume,k = thermal conductivity,η = magnetic diffusivity,μe = magnetic permeability,λ, μ = Lamé's constants,β = ratio of coefficient of volume expansion to isothermal compressibility.

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