ASSESSMENT OF PARAMETER UNCERTAINTY IN RIGID MUSCULOSKELETAL SIMULATION USING A PROBABILISTIC APPROACH

Experimental investigation coupled with numerical simulations is commonly used for solving multi-physical problems. In the field of biomechanics, in which the aim is to understand the mechanics of living system, the main difficulties are to provide experimental data reflecting the multi-physical behavior of the system of interest. These experimental data are used as input data for numerical simulations to quantify output responses through physical and/or biological laws expressed by constitutive mathematical equations. However, uncertainties on the experimentally available data exist from factors such as human variability and differences in protocols parameters and techniques. Thus, the true values of these data could never be experimentally measured. The objective of this study was to develop a modeling workflow to assess and account for the parameter uncertainty in rigid musculoskeletal simulation. A generic musculoskeletal model was used. Data uncertainties of the right thigh mass, physiological cross-sectional area (pCSA) and muscle tension coefficient of the rectus femoris were accounted to estimate their effect on the joint moment and muscle force computing, respectively. A guideline was developed to fuse data from multiple sources into a sample variation space leading to establish input data distribution. Uncertainty propagation was performed using Monte Carlo and most probable point methods. A high degree of sensitivity of 0.98 was noted for the effect of thigh mass uncertainty on the hip joint moment using inverse dynamics method. A strong deviation of rectus femoris muscle force (around 260 N) was found under effect of pCSA and muscle tension coefficient on the force estimation using static optimization method. Accounting parameter uncertainty into rigid musculoskeletal simulation plays an essential role in the evaluation of the confidence in the model outputs. Thus, simulation outcome may be computed and represented in a more reliable manner with a global range of plausible values.