CORRELATIONS BETWEEN ISOMETRIC QUADRICEPS MUSCLE STRENGTH AND BONE MINERAL DENSITY

The purpose of this study was to evaluate the relationship between isometric quadriceps muscle strength and measurements of bone density (BMD), mass (BMC) and ultrasound properties. A total of 113 individuals were included, 53 men and 60 women aged 22-85 years. Isometric quadriceps muscle strength correlated significantly to BMD of the total body for both men (r=0.63, p=0.02) and women r=0.77, p=0.04) after adjustments for age, weight and height. In women, there was also an association between isometric quadriceps muscle strength and BMD of the lumbar spine (r=0.67, p=0.04). These correlations were evident in premenopausal women for BMD at the lumbar spine, femoral neck and total body whereas no significant relationships were seen in postmenopausal women or any age group of men. For isometric quadriceps muscle strength and the ultrasound measurements of the heel, a positive correlation was seen in men and women aged 41-60 years. The findings point to a role of endogenous sex steroids, primarily estrogens, in the correlation between BMD and isometric quadriceps muscle strength.

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The role of quadriceps muscle strength in the development of falls in the elderly people, a cross-sectional study

Chiropractic & Manual Therapies ◽

10.1186/s12998-018-0195-x ◽

2018 ◽

Vol 26 (1) ◽

Cited By ~ 9

Author(s):

Alijan Ahmadiahangar ◽

Yahya Javadian ◽

Mansour Babaei ◽

Behzad Heidari ◽

Seyedreza Hosseini ◽

...

Keyword(s):

Muscle Strength ◽

Elderly People ◽

The Elderly ◽

Quadriceps Muscle ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Quadriceps Muscle Strength

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Sclerostin Levels and Changes in Bone Metabolism After Bariatric Surgery

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2014-3367 ◽

2015 ◽

Vol 100 (3) ◽

pp. 891-901 ◽

Cited By ~ 49

Author(s):

Christian Muschitz ◽

Roland Kocijan ◽

Christina Marterer ◽

Arastoo Rahbar Nia ◽

Gabriela Katharina Muschitz ◽

...

Keyword(s):

Bone Metabolism ◽

Premenopausal Women ◽

Serum Levels ◽

Areal Bone Mineral Density ◽

Mineral Density ◽

Entire Study ◽

Turnover Markers ◽

Total Body ◽

Dickkopf 1

Context: The role of sclerostin as a key regulator of bone formation remains unknown after Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG). Objectives: The study objectives were evaluation of sclerostin and Dickkopf-1 (DKK-1) serum levels after surgery and correlations with bone turnover markers (P1NP, CTX), parathyroid hormone (iPTH) and areal bone mineral density (BMD), changes at total body, lumbar spine and total hip. Design and Setting: This was a prospective observational single-center two-arm study in premenopausal women with acute adipositas over 24 months. Participants: Participants were 52 premenopausal women (40 ± 8 years, BMI 43.4) after RYGB and 38 premenopausal women (41 ± 7 years, BMI 45.7) after SG. Main Outcome Measures: Prior to surgery and 1, 3, 6, 9, 12, 18, and 24 months after surgery sclerostin, DKK-1, CTX, P1NP levels and BMD were measured. Results: Sclerostin, CTX and (to a lesser extent) P1NP increased after surgery and remained elevated during the entire study period (P < 0.001). DKK-1 declined during months 3–9 (P < 0.005) and then remained unchanged, serum phosphate continuously increased (P < 0.001), iPTH remained within the upper normal limit. Sclerostin increases were significantly positively correlated with CTX and P1NP increases and negatively correlated with BMD loss. BMD independently declined regardless of RYGB and SG. Elevations of sclerostin, CTX, P1NP, and phosphate, but not DKK-1 and iPTH, were significant discriminating factors for BMD loss (AUC 0.920). Conclusion: Rapid and sustained increases of sclerostin, CTX, and to a lesser extent, P1NP cause an increase in bone metabolism and result in BMD loss at all skeletal sites.

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Changes in Bone Mineral Density Associated with Dietary-Induced Loss of Body Mass in Young Women

Clinical Science ◽

10.1042/cs0870343 ◽

1994 ◽

Vol 87 (3) ◽

pp. 343-348 ◽

Cited By ~ 58

Author(s):

S. J. Ramsdale ◽

E. J. Bassey

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Body Mass ◽

Bone Mineral ◽

Dietary Restriction ◽

Calcium Intake ◽

Dietary Assessment ◽

Premenopausal Women ◽

Mineral Density ◽

Total Body

1. Moderately overweight, premenopausal women were assessed for bone mineral density of the total body, lumbar spine and proximal femur before and after 6 months of modest dietary restriction (minimum 4800 kJ/day). The aim was to evaluate the effect of loss of body mass on bone mineral density. 2. Dietary assessment included two analyses of 3 day weighed food intakes, one before and the other after 4 months of dietary restriction. Energy and calcium intakes were significantly reduced by 27% and 5%, respectively. The change in calcium intake was negatively and significantly related to initial levels of calcium intake. 3. A significant mean loss of 3.4 ± 3.1 kg in body mass was achieved mainly in the first 3 months of the study; it was accompanied by significant losses at 6 months in bone mineral density in the total body of 0.7% and in the lumbar spine of 0.5%. There were no changes in the femur. 4. The change in bone mineral density in the total body was significantly related to the reduced absolute calcium intake, initial bone mineral density and loss of body mass. The change in bone mineral density in the spine was significantly related to the change in calcium intake. 5. These modest losses could be a threat in women with lower bone mineral density, and indicate the importance of maintaining a high intake of calcium during dietary restriction.

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Impact of Pain Reported During Isometric Quadriceps Muscle Strength Testing in People With Knee Pain: Data From the Osteoarthritis Initiative

Physical Therapy ◽

10.2522/ptj.20110034 ◽

2011 ◽

Vol 91 (10) ◽

pp. 1478-1489 ◽

Cited By ~ 25

Author(s):

Daniel L. Riddle ◽

Paul W. Stratford

Keyword(s):

Muscle Strength ◽

Muscle Force ◽

Quadriceps Muscle ◽

Quadriceps Strength ◽

Walk Test ◽

Quadriceps Muscle Strength ◽

Strength Tests ◽

Osteoarthritis Initiative ◽

The Relationship ◽

Physical Function Subscale

Background Muscle force testing is one of the more common categories of diagnostic tests used in clinical practice. Clinicians have little evidence to guide interpretations of muscle force tests when pain is elicited during testing. Objective The purpose of this study was to examine the construct validity of isometric quadriceps muscle strength tests by determining whether the relationship between maximal isometric quadriceps muscle strength and functional status was influenced by pain during isometric testing. Design A cross-sectional design was used. Methods Data from the Osteoarthritis Initiative were used to identify 1,344 people with unilateral knee pain and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale scores of 1 or higher on the involved side. Measurements of maximal isometric quadriceps strength and ratings of pain during isometric testing were collected. Outcome variables were WOMAC physical function subscale, 20-m walk test, 400-m walk test, and a repeated chair stand test. Multiple regression models were used to determine whether pain during testing modified or confounded the relationship between strength and functional status. Results Pearson r correlations among the isometric quadriceps strength measures and the 4 outcome measures ranged from −.36 (95% confidence interval=−.41, −.31) for repeated chair stands to .36 (95% confidence interval=.31, .41) for the 20-m walk test. In the final analyses, neither effect modification nor confounding was found for the repeated chair stand test, the 20-m walk test, the 400-m walk test, or the WOMAC physical function subscale. Moderate or severe pain during testing was weakly associated with reduced strength, but mild pain was not. Limitations The disease spectrum was skewed toward mild or moderate symptoms, and the pain measurement scale used during muscle force testing was not ideal. Conclusions Given that the spectrum of the sample was skewed toward mild or moderate symptoms and disease, the data suggest that isometric quadriceps muscle strength tests maintain their relationship with self-report or performance-based disability measures even when pain is elicited during testing.

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Investigation of the Relationship Between Quadriceps Angle and Quadriceps Muscle Strength in Male Athletes

Turkiye Klinikleri Journal of Sports Sciences ◽

10.5336/sportsci.2019-71553 ◽

2020 ◽

Vol 12 (2) ◽

pp. 129-136

Author(s):

Bihter AKINOĞLU ◽

Tuğba KOCAHAN ◽

Banu KABAK ◽

Ezgi ÜNÜVAR ◽

Adnan HASANOĞLU

Keyword(s):

Muscle Strength ◽

Quadriceps Muscle ◽

Male Athletes ◽

Quadriceps Muscle Strength ◽

The Relationship

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Membrane estrogen receptor α is essential for estrogen signaling in the male skeleton

Journal of Endocrinology ◽

10.1530/joe-18-0406 ◽

2018 ◽

Vol 239 (3) ◽

pp. 303-312 ◽

Cited By ~ 2

Author(s):

H H Farman ◽

K L Gustafsson ◽

P Henning ◽

L Grahnemo ◽

V Lionikaite ◽

...

Keyword(s):

Estrogen Receptor ◽

Estrogen Receptor Α ◽

Estrogen Signaling ◽

Areal Bone Mineral Density ◽

Male Mice ◽

Mineral Density ◽

Intact Male ◽

Trabecular Thickness ◽

Total Body

The importance of estrogen receptor α (ERα) for the regulation of bone mass in males is well established. ERα mediates estrogenic effects both via nuclear and membrane-initiated ERα (mERα) signaling. The role of mERα signaling for the effects of estrogen on bone in male mice is unknown. To investigate the role of mERα signaling, we have used mice (Nuclear-Only-ER; NOER) with a point mutation (C451A), which results in inhibited trafficking of ERα to the plasma membrane. Gonadal-intact male NOER mice had a significantly decreased total body areal bone mineral density (aBMD) compared to WT littermates at 3, 6 and 9 months of age as measured by dual-energy X-ray absorptiometry (DEXA). High-resolution microcomputed tomography (µCT) analysis of tibia in 3-month-old males demonstrated a decrease in cortical and trabecular thickness in NOER mice compared to WT littermates. As expected, estradiol (E2) treatment of orchidectomized (ORX) WT mice increased total body aBMD, trabecular BV/TV and cortical thickness in tibia compared to placebo treatment. E2 treatment increased these skeletal parameters also in ORX NOER mice. However, the estrogenic responses were significantly decreased in ORX NOER mice compared with ORX WT mice. In conclusion, mERα is essential for normal estrogen signaling in both trabecular and cortical bone in male mice. Increased knowledge of estrogen signaling mechanisms in the regulation of the male skeleton may aid in the development of new treatment options for male osteoporosis.

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AB0915 BONE MINERAL DENSITY AND FRACTURE FREQUENCY IN PREMENOPAUSAL WOMEN WITH RHEUMATIC DISEASES

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-eular.2740 ◽

2020 ◽

Vol 79 (Suppl 1) ◽

pp. 1759.2-1759

Author(s):

N. Toroptsova ◽

O. Dobrovolskaya ◽

O. Nikitinskaya ◽

N. Demin ◽

A. Smirnov ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Lumbar Spine ◽

Serum Vitamin ◽

Premenopausal Women ◽

Healthy Controls ◽

C Reactive Protein ◽

Mineral Density ◽

Serum Vitamin D ◽

Reactive Protein

Background:The onset of the disease in young and middle age is typical for rheumatic diseases (RDS), but most studies on osteoporosis were conducted in patients (pts) older than 50 years, which included postmenopausal women.Objectives:To assess bone mineral density (BMD), fracture frequency and the factors associated with low BMD in premenopausal women with RDs.Methods:160 women (median age, 36 [29; 43] years): 120 pts with RDs (43 rheumatoid arthritis (RA), 53 systemic sclerosis (SSc) and 24 psoriatic arthritis (PsA)) and 40 age-matched healthy controls were enrolled in the study. We performed a dual-energy X-ray absorptiometry (DXA, Hologic Discovery A, USA) to measure BMD in lumbar spine, femoral neck and total hip. BMD decreasing grade was evaluated by the Z-score <-2SD. All pts were interviewed using a unified questionnaire including assessment of daily dietary calcium intake. Serum vitamin D, C-reactive protein and erythrocyte sedimentation rate (ESR) measurements were done.Results:25% pts with RDs and only 8% healthy controls have low BMD (p=0.02). RA, SSc and PsA pts had low BMD in 37%, 21% and 13%, respectively, that was more often than in healthy women (p=0.004, p=0.046 and p= 0.081, respectively). 9,3% RA pts and 7,5% SSc pts had low energy fractures. BMD of RDs pts in all areas of measurement demonstrated a direct correlation with height, weight, body mass index, and serum vitamin D concentration and an inverse correlation with the cumulative dose of glucocorticoids. Also, proximal femur BMD inversely correlated with RDs duration. BMD of femoral neck and total hip inversely correlated with C-reactive protein level in SSc pts. In RA women we found a direct correlation between lumbar spine and femur neck BMD and ESR.Conclusion:25% of premenopausal women with RDs had reduced BMD and needed monitoring and osteoporosis prevention, while 9.3% pts with RA and 7.5% women with SSc needed anti-osteoporotic treatment.Disclosure of Interests:None declared

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Comparison of Y-Balance Test Performance by maturation status in youth distance runners

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967121s00084 ◽

2021 ◽

Vol 9 (7_suppl3) ◽

pp. 2325967121S0008

Author(s):

Mitchell J. Rauh ◽

Micah C. Garcia ◽

David M. Bazett-Jones ◽

Jason T. Long ◽

Kevin R. Ford ◽

...

Keyword(s):

Muscle Strength ◽

Quadriceps Muscle ◽

Limb Length ◽

Distance Running ◽

Distance Runners ◽

Long Distance ◽

Balance Test ◽

Convenience Sample ◽

Quadriceps Muscle Strength ◽

Increased Risk

Background: Distance running is a popular interscholastic sport, but also has an associated high risk of running-related injuries. Recent literature suggests that functional tests may help to identify athletes at increased risk of injury. The Y-Balance Test (YBT) is an objective measure used to assess functional muscle strength and balance and to expose asymmetries between tested limbs. Purpose: To determine if YBT performance was associated with maturation status in healthy, youth distance runners. We hypothesized that mid-pubertal (MP) runners would demonstrate less functional reach distance than pre-pubertal (PrP) or post-pubertal (PoP) runners. Methods: A convenience sample of 142 (Females: n=79, Males: n=63) uninjured youth runners (ages 13.5±2.7 years; weekly running distance: 18.2±20.4 km) were recruited from the local community. All runners met inclusion criteria, indicating that they were between 9 and 19 years old and participated in long-distance running activities such as school/club track and field, cross country, road races, trail running, and/or soccer. The runners completed a modified Pubertal Maturational Observation Scale (PMOS), then were screened for right (R) and left (L) anterior (ANT), posteromedial (PM) and posterolateral (PL) reach distances (cm) normalized by lower limb length (cm). Composite reach distance was calculated by the sum of the three reach distances divided by three times the limb length multiplied by 100 for R and L limbs. ANOVA with Bonferroni post hoc tests were used to compare maximum normalized reach distances for the three directions and composite reach distance by maturation status and sex. Results: Overall, 31.7% were classified as PrP status, 26.1% as MP, and 42.3% as PoP, with similar percentages by sex ( p=0.84). The only significant mean difference was found for R ANT maximum normalized reach distance between PrP and PoP ( p=0.02), indicating a greater normalized reach in PrP athletes. No significant mean differences were found for R or L PM and PL maximum normalized reach distances, or for R or L composite reach distances, by maturation status or when stratified by maturation and sex ( p>0.05). Conclusions: In this sample of youth runners, the YBT was only a discriminator of anterior reach distance between pre-pubertal and post-pubertal runners. As decreased anterior reach is associated with reduced quadriceps muscle strength and anterior knee pain, reduced anterior reach in post-pubertal runners may potentially signify an increased risk of sustaining a running-related injury. Thus, preventive efforts to ensure good functional quadriceps muscle strength may be merited.

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