Cell Resistance and in Antimicrobial Resistance with Waning Vaccination

2021 ◽  
pp. 1-14
Author(s):  
E. Ahmed ◽  
M. A. Sohaly
Keyword(s):  
Antimicrobial Resistance ◽  
Virus Replication ◽  
Genetic Material ◽  
Random Variable ◽  
Two Dimensions ◽  
Host Cells ◽  
Geometric Problem ◽  
One Dimensional ◽  
A Cell ◽  
Anti Fungal

Viruses are obligatory minute intra-cellular infectious agents with very simple composition. They are nonliving macro molecules outside the host cell while turned into living active organisms inside host cells. The genetic material (DNA or RNA) carrying the information crucial for virus replication and enforces the cell to approve virus replication. Consequently, it is cellular resistance against the virus that determines whether a cell at any site is infected or not. In this study, we interest in the resistance of cell which may be infected by some disturbance such as a function of [Formula: see text] or as a random variable. Antimicrobial resistance (AMR) is the wider word for resistance in various kinds of microorganisms and includes resistance to antibacterial, antiviral, anti-parasitic, and anti-fungal medicines. Here we study the AMR problem and also, the waning vaccination in the Percolation area. Percolation is a purely geometric problem in which clusters of connected sites or bonds are clearly defined static objects. We are studying cellular automata from Domany–Kinzel on the population of AMRs as on the spreading network. Each connection is rewired on a one-dimensional chain and combined with any probability p node. Additionally, the Domany–Kinzel model will be applied for AMR and waning vaccination in two dimensions.

A CELL-CENTERED LAGRANGIAN SCHEME FOR COMPRESSIBLE MULTI-MEDIUM FLOW

2010 ◽  
Vol 24 (13) ◽  
pp. 1283-1286
Author(s):  
DONGHONG WANG ◽  
NING ZHAO ◽  
YONGJIAN WANG
Keyword(s):  
Space Dimension ◽  
Two Dimensions ◽  
Test Cases ◽  
One Dimensional ◽  
Minimal Error ◽  
Medium Flow ◽  
A Cell ◽  
The One ◽  
Parameter Values ◽  
Lagrangian Scheme

In this paper, a kind of Godunov-type Lagrangian scheme is developed in the one space dimension. The Riemann problems are constructed at the interface and the velocity and pressure are evaluated using an implicit characteristic method. Two different methods are used to solve for the equation of energy conservation. Four one-dimensional numerical examples are first presented to obtain the parameter through comparison of the L1 errors with the changing parameter values. The method having the minimal error is then extended to two dimensions and a cell-centered conservative Lagrangian scheme is proposed for the compressible multi-medium flow. The numerical results for some classical two dimensional hydrodynamic test cases show that the proposed numerical methods are effective and feasible.

The Biology of Viruses

2019 ◽  
Author(s):  
Anna Jeffery-Smith ◽  
C. Y. William Tong
Keyword(s):  
Nucleic Acid ◽  
Host Cell ◽  
Genetic Material ◽  
Cell Types ◽  
Host Cells ◽  
Host Cell Membrane ◽  
Cell Receptors ◽  
A Cell ◽  
Independent Synthesis ◽  
Different Cell Types

In order to be classified as a virus, certain criteria have to be fulfilled. Viruses must ● Be only capable of growth and multiplication within living cells, i.e. obligate intracellular parasite. Host cells could include humans, animals, insects, plants, protozoa, or even bacteria. ● Have a nucleic acid genome (either RNA or DNA, but not both) surrounded by a protein coat (capsid). ● Have no semipermeable membrane, though some have an envelope formed of phospholipids and proteins. ● Be inert outside of the host cell. Enveloped viruses are susceptible to inactivation by organic solvents such as alcohol. ● Perform replication by independent synthesis of components followed by assembly (c.f. binary fission in bacteria). Viruses are considered as a bundle of genetic programmes encoded in nucleic acids and packaged with a capsid +/ - envelope protein, which can be activated on entry into a host cell (compare this with computer viruses packaged in an enticing way in order to infect and take over control of your PC). Although they share some similarities in their properties, mycoplasma and chlamydia are true bacteria. The virion (assembled infectious particle) consists of viral nucleic acid and capsid. The nucleic acid of a virus can either be ribonucleic acid (RNA) or deoxyribonucleic acid (DNA), and the amount of genetic material varies widely, with some viruses able to encode a few proteins and others having genetic material that encodes hundreds of proteins. In association with the nucleic acid there may be non- structural viral proteins, such as a viral polymerase. The nucleic acid and non- structural proteins are protected by a surrounding layer of capsid proteins. The capsid includes proteins which can attach to host cell receptors. The proteins and the cell receptors to which they bind determine a virus’ tropism, i.e., the ability to bind to and enter different cell types. The term nucleocapsid refers to the nucleic acid core surrounded by capsid protein. Some viruses also have an envelope made up of phospholipids and proteins surrounding the nucleocapsid. This envelope can be formed by the host cell membrane during the process of a virus budding from a cell during replication.

scholarly journals Assessing a Linear Nanosystem's Limiting Reliability from its Components

2008 ◽  
Vol 45 (03) ◽  
pp. 879-887 ◽  
Author(s):  
Nader Ebrahimi
Keyword(s):  
Present State ◽  
Size Range ◽  
Two Dimensions ◽  
The Other ◽  
One Dimension ◽  
Present Moment ◽  
One Dimensional ◽  
The One ◽  
Fixed Moment ◽  
Nanosized Systems

Nanosystems are devices that are in the size range of a billionth of a meter (1 x 10-9) and therefore are built necessarily from individual atoms. The one-dimensional nanosystems or linear nanosystems cover all the nanosized systems which possess one dimension that exceeds the other two dimensions, i.e. extension over one dimension is predominant over the other two dimensions. Here only two of the dimensions have to be on the nanoscale (less than 100 nanometers). In this paper we consider the structural relationship between a linear nanosystem and its atoms acting as components of the nanosystem. Using such information, we then assess the nanosystem's limiting reliability which is, of course, probabilistic in nature. We consider the linear nanosystem at a fixed moment of time, say the present moment, and we assume that the present state of the linear nanosystem depends only on the present states of its atoms.

Microglia extracellular vesicles: focus on molecular composition and biological function

2021 ◽  
Vol 49 (4) ◽  
pp. 1779-1790 ◽  
Author(s):  
Lorenzo Ceccarelli ◽  
Chiara Giacomelli ◽  
Laura Marchetti ◽  
Claudia Martini
Keyword(s):  
Extracellular Vesicles ◽  
Molecular Mechanisms ◽  
Biological Function ◽  
Biological Effects ◽  
Genetic Material ◽  
Cell Communication ◽  
Molecular Composition ◽  
Cargo Proteins ◽  
A Cell ◽  
The Central Nervous System

Extracellular vesicles (EVs) are a heterogeneous family of cell-derived lipid bounded vesicles comprising exosomes and microvesicles. They are potentially produced by all types of cells and are used as a cell-to-cell communication method that allows protein, lipid, and genetic material exchange. Microglia cells produce a large number of EVs both in resting and activated conditions, in the latter case changing their production and related biological effects. Several actions of microglia in the central nervous system are ascribed to EVs, but the molecular mechanisms by which each effect occurs are still largely unknown. Conflicting functions have been ascribed to microglia-derived EVs starting from the neuronal support and ending with the propagation of inflammation and neurodegeneration, confirming the crucial role of these organelles in tuning brain homeostasis. Despite the increasing number of studies reported on microglia-EVs, there is also a lot of fragmentation in the knowledge on the mechanism at the basis of their production and modification of their cargo. In this review, a collection of literature data about the surface and cargo proteins and lipids as well as the miRNA content of EVs produced by microglial cells has been reported. A special highlight was given to the works in which the EV molecular composition is linked to a precise biological function.

Diffusion-Limited Cell Dehydration: Analytical and Numerical Solutions for a Planar Model

1999 ◽  
Author(s):  
Alexander V. Kasharin ◽  
Jens O. M. Karlsson
Keyword(s):  
Analytical Solution ◽  
Numerical Solutions ◽  
Planar System ◽  
One Dimensional ◽  
Diffusion Limited ◽  
Dimensional Diffusion ◽  
Constant Diffusivity ◽  
A Cell ◽  
Cell Dehydration ◽  
The One

Abstract The process of diffusion-limited cell dehydration is modeled for a planar system by writing the one-dimensional diffusion-equation for a cell with moving, semipermeable boundaries. For the simplifying case of isothermal dehydration with constant diffusivity, an approximate analytical solution is obtained by linearizing the governing partial differential equations. The general problem must be solved numerically. The Forward Time Center Space (FTCS) and Crank-Nicholson differencing schemes are implemented, and evaluated by comparison with the analytical solution. Putative stability criteria for the two algorithms are proposed based on numerical experiments, and the Crank-Nicholson method is shown to be accurate for a mesh with as few as six nodes.

Analysis for the Effect of Inverter Ripple Current on Fuel Cell Operating Condition

2001 ◽  
Author(s):  
Randall S. Gemmen
Keyword(s):  
Boundary Condition ◽  
Fuel Cell ◽  
Mass Transport ◽  
Transient Behavior ◽  
Mechanical State ◽  
Dimensional Model ◽  
One Dimensional ◽  
Fuel Cell Stack ◽  
A Cell ◽  
The Impact

Abstract The effect of inverter ripple current on fuel cell stack performance and stack lifetime remains uncertain. This paper provides a first attempt to examine the impact of inverter load dynamics on the fuel cell. Since reactant utilization is known to impact the mechanical state of a fuel cell, it is suggested that the varying reactant conditions surrounding the cell govern, at least in part, the lifetime of the cells. This paper investigates these conditions through the use of a dynamic model for the bulk conditions within the stack, as well as a one-dimensional model for the detailed mass transport occurring within the electrode of a cell. These two independent modeling approaches help to verify their respective numerical procedures. In this work, the inverter load is imposed as a boundary condition to the models. Results show the transient behavior of the reactant concentrations within the stack, and of the mass diffusion within the electrode under inverter loads with frequencies between 30 Hz and 1250 Hz.

The Structure of Emotional Response: 1984 Presidential Candidates

1988 ◽  
Vol 82 (3) ◽  
pp. 737-761 ◽  
Author(s):  
George E. Marcus
Keyword(s):  
Emotional Response ◽  
Two Dimensions ◽  
Negative Emotionality ◽  
One Dimensional ◽  
Presidential Candidates ◽  
The Past ◽  
Emotional Appraisal ◽  
Psychological Models ◽  
Dimensional Models ◽  
Feeling Thermometer

Over the past two decades psychological models of affect have changed from valence (one-dimensional) models to multiple-dimensional models. The most recent models, circumplex models, are two-dimensional. Feeling thermometer measures, which derive their theoretical logic from earlier (valence) models of emotional appraisal, are shown to be confounded. Underlying the variation obtained using feeling thermometer measures are two dimensions of emotional response, mastery (positive emotionality) and threat (negative emotionality). Analysis of the 1984 NES survey suggests that positive emotional response is twice as influential as negative emotional response in predicting presidential candidate vote disposition to the presidential candidates. Reliance on emotional response is shown to be uniformly influential across various strata of the electorate.Policy considerations have little direct influence on vote disposition, though policy considerations are indirectly related to vote disposition through the influence of issues on the degree of feelings of threat evoked by the candidates.

scholarly journals THE EFFECT OF THE THIRD DIMENSION ON ROUGH SURFACES FORMED BY SEDIMENTING PARTICLES IN QUASI-TWO-DIMENSIONS

2002 ◽  
Vol 16 (08) ◽  
pp. 1217-1223 ◽  
Author(s):  
K. V. MCCLOUD ◽  
M. L. KURNAZ
Keyword(s):  
Two Dimensions ◽  
Scaling Analysis ◽  
Silica Spheres ◽  
Two Dimensional ◽  
One Dimensional ◽  
The Third ◽  
Roughness Exponent ◽  
Third Dimension ◽  
Dimensional Cell ◽  
Roughness Exponents

The roughness exponent of surfaces obtained by dispersing silica spheres into a quasi-two-dimensional cell is examined. The cell consists of two glass plates separated by a gap, which is comparable in size to the diameter of the beads. Previous work has shown that the quasi-one-dimensional surfaces formed have two roughness exponents in two length scales, which have a crossover length about 1 cm. We have studied the effect of changing the gap between the plates to a limit of about twice the diameter of the beads. If the conventional scaling analysis is performed, the roughness exponent is found to be robust against changes in the gap between the plates; however, the possibility that scaling does not hold should be taken seriously.

scholarly journals Reovirus core proteins λ1 and σ2 promote stability of disassembly intermediates and influence early replication events

2020 ◽  
Author(s):  
Stephanie Gummersheimer ◽  
Pranav Danthi
Keyword(s):  
Conformational Changes ◽  
Genetic Material ◽  
Point Mutations ◽  
Host Cells ◽  
Capsid Proteins ◽  
Endosomal Membrane ◽  
The Core ◽  
Core Proteins ◽  
Early Replication ◽  
Outer Capsid

ABSTRACTThe capsids of mammalian reovirus contain two concentric protein shells, the core and the outer capsid. The outer capsid is comprised of µ1-σ3 heterohexamers which surround the core. The core is comprised of λ1 decamers held in place by σ2. After entry into the endosome, σ3 is proteolytically degraded and µ1 is cleaved and exposed to form ISVPs. ISVPs undergo further conformational changes to form ISVP*s, resulting in the release of µ1 peptides which facilitate the penetration of the endosomal membrane to release transcriptionally active core particles into the cytoplasm. Previous work has identified regions or specific residues within reovirus outer capsid that impact the efficiency of cell entry. We examined the functions of the core proteins λ1 and σ2. We generated a reovirus T3D reassortant that carries strain T1L derived σ2 and λ1 proteins (T3D/T1L L3S2). This virus displays a lower ISVP stability and therefore converts to ISVP*s more readily. To identify the basis for lability of T3D/T1L L3S2, we screened for hyper-stable mutants of T3D/T1L L3S2 and identified three point mutations in µ1 that stabilize ISVPs. Two of these mutations are located in the C-terminal ϕ region of µ1, which has not previously been implicated in controlling ISVP stability. Independent from compromised ISVP stability, we also found that T3D/T1L L3S2 launches replication more efficiently and produces higher yields in infected cells. In addition to identifying a new role for the core proteins in disassembly events, these data highlight that core proteins may influence multiple stages of infection.IMPORTANCEProtein shells of viruses (capsids) have evolved to undergo specific changes to ensure the timely delivery of genetic material to host cells. The 2-layer capsid of reovirus provides a model system to study the interactions between capsid proteins and the changes they undergo during entry. We tested a virus in which the core proteins were derived from a different strain than the outer capsid. We found that this mismatched virus was less stable and completed conformational changes required for entry prematurely. Capsid stability was restored by introduction of specific changes to the outer capsid, indicating that an optimal fit between inner and outer shells maintains capsid function. Separate from this property, mismatch between these protein layers also impacted the capacity of virus to initiate infection and produce progeny. This study reveals new insights into the roles of capsid proteins and their multiple functions during viral replication.

scholarly journals On the use of a cell-centered finite-volume scheme on prismatic meshes in boundary layers

2021 ◽  
pp. 1-44
Author(s):  
Pavel Alexeevisch Bakhvalov
Keyword(s):  
Reynolds Number ◽  
Finite Volume ◽  
High Reynolds Number ◽  
Finite Volume Scheme ◽  
Wall Surface ◽  
One Dimensional ◽  
Volume Scheme ◽  
Dimensional Reconstruction ◽  
A Cell ◽  
High Reynolds

We consider the cell-centered finite-volume scheme with the quasi-one-dimensional reconstruction and generalize it to anisotropic prismatic meshes suitable for high-Reynolds-number problems. We offer a new algorithm of flux computation based on the reconstruction along the wall surface, whereas in the original schemes it was along the tangent to the wall surface. We also study how does the curvature of mesh elements influence the accuracy if taken into account.

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