Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate

1999 ◽  
Vol 277 (3) ◽  
pp. R802-R811 ◽  
Author(s):  
Brenda K. Smith ◽  
David A. York ◽  
George A. Bray
Keyword(s):  
Protein Intake ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Carbohydrate Consumption ◽  
Macronutrient Selection ◽  
Carbohydrate Feeding ◽  
Diet Preference ◽  
Dose Effects ◽  
Series Of Experiments ◽  
Serotonergic Drugs

Systemic treatment with dexfenfluramine (dF), fluoxetine, or serotonin (5-hydroxytryptamine, 5-HT) recently was shown to suppress fat and occasionally protein but not carbohydrate intake in rats when a macronutrient selection paradigm was employed. These reports contrast with the prevailing literature, which for the past decade has described a role for serotonin neurotransmission in the modification of dietary carbohydrate consumption. To test the hypothesis that the suppression of fat selection and/or consumption by systemic serotonin agonists involves stimulation of central 5-HT receptors, a series of experiments was performed in nondeprived rats. In experiment 1, third cerebroventricular (3V) infusion of the nonselective 5-HT antagonist metergoline prevented the reduction in fat but not carbohydrate feeding caused by systemic dF. Furthermore, 3V metergoline alone increased fat intake. In experiments 2 and 3, 3V infusion of 5-HT1B/2C receptor agonistsd-norfenfluramine (dNF) or quipazine inhibited fat intake exclusively. Next, the infusion ofdNF or 5-HT into the region of the paraventricular nucleus (PVN) reduced both fat and protein intake ( experiments 4 and 5). Finally, in experiment 6, when rats were grouped by baseline diet preference, 5-HT infused into the PVN led to a dose-related decrease in fat intake in both carbohydrate- and fat-preferring rats. In contrast, there were no dose effects of 5-HT on carbohydrate or protein intake in either preference group. However, in fat-preferring rats, the highest dose of 5-HT reduced intake of all three macronutrient diets. These results demonstrate a selective effect of exogenous serotonergic drugs in the hypothalamus to reduce fat rather than carbohydrate intake and suggest that higher baseline fat intake enhances responsivity to serotonergic drugs.

scholarly journals Associating Intake Proportion of Carbohydrate, Fat, and Protein with All-Cause Mortality in Korean Adults

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3208
Author(s):  
Yu-Jin Kwon ◽  
Hye Sun Lee ◽  
Ju-Young Park ◽  
Ji-Won Lee
Keyword(s):  
Life Expectancy ◽  
Protein Intake ◽  
Dietary Guidelines ◽  
Carbohydrate Intake ◽  
Minimal Risk ◽  
Fat Intake ◽  
Nutrition Research ◽  
Hazard Ratios ◽  
Prolong Life Expectancy ◽  
All Cause Mortality

Determining the ideal ratio of macronutrients for increasing life expectancy remains a high priority in nutrition research. We aim to investigate the association between carbohydrate, fat, and protein intake and all-cause mortality in Koreans. This cohort study investigated 42,192 participants from the Korea National Health and Nutrition Examination Survey (KNHANES) linked with causes of death data (2007–2015). Hazard ratios (HRs) were calculated using the multivariable Cox proportional regression model after adjusting for confounders. We documented 2110 deaths during the follow-up period. Time to exceed 1% of the all-cause mortality rate was longest in participants with 50–60% carbohydrate, 30–40% fat, and 20–30% protein intake. Adjusted hazard ratio (HR) with 95% confidence intervals (CIs) was 1.313 (1.031–1.672, p = 0.0272) for <50% carbohydrate intake, 1.322 (1.116–1.567, p = 0.0013) for ≥60% carbohydrate intake, 1.439 (1.018–2.035, p = 0.0394) for <30% fat intake, and 3.255 (1.767–5.997, p = 0.0002) for ≥40% fat intake. There was no significant association between protein intake proportion and all-cause mortality. We found a U-shaped association between all-cause mortality and carbohydrate intake as well as fat intake, with minimal risk observed at 50–60% carbohydrate and 30–40% fat intake. Our findings suggest current Korean dietary guidelines should be revised to prolong life expectancy.

scholarly journals What are the major correlates of macronutrient selection in Western populations?

1999 ◽  
Vol 58 (4) ◽  
pp. 755-763 ◽  
Author(s):  
John M. de Castro
Keyword(s):  
Negative Feedback ◽  
Protein Intake ◽  
Negative Impact ◽  
Eating Behaviour ◽  
Stomach Contents ◽  
Time Of Day ◽  
Carbohydrate Intake ◽  
Lunar Phase ◽  
Macronutrient Intake ◽  
Fat Intake

In order to better understand the factors that may influence and regulate the intake of the macronutrients carbohydrate, fat and protein a 7 d diet diary technique was employed to study eating behaviour in the natural environment of free-living human subjects. In general, factors that promote energy intake tend to promote fat and protein intake to a greater extent than carbohydrate intake. This increased intake occurs as the result of: environmental factors such as social facilitation and the time of day, week or lunar phase; subjective factors such as hunger and elation; individual difference factors such as obesity, restraint and ageing. There are indications that the intake of macronutrients is regulated by negative feedback systems. In the short term, the amount of protein remaining in the stomach at the onset of a meal appears to have a restraining effect on intake, especially protein intake. Over several days, macronutrient intake appears to be affected by a nutrient-specific delayed negative feedback. Protein intake during 1 d is negatively associated with protein intake 2 and 3 d later, while carbohydrate intake is negatively related to later carbohydrate intake, and fat intake to later fat intake; both peaking after a 2 d delay. Studies of the intakes of twins suggested that many aspects of the control of macronutrient intake are influenced by inheritance; these factors include the overall amounts ingested, the before-meal stomach contents and the responsiveness of the subject to the negative impact of the stomach contents. The results indicate that macronutrient intakes are regulated by multiple persistent processes that are to a large extent inherited.

scholarly journals Overview of Macro Nutrient Intake and Nutritional Status of Students at the Putri Hidayatullah Islamic Boarding School, Ternate City

2021 ◽  
Vol 9 (12) ◽  
pp. 13-21
Author(s):  
Hisdawati Abubakar ◽  
Yohannes Willi Helm ◽  
Nofiandri ◽  
Fadila
Keyword(s):  
Nutritional Status ◽  
Protein Intake ◽  
Nutrient Intake ◽  
Sampling Technique ◽  
Boarding School ◽  
Carbohydrate Intake ◽  
Physical Growth ◽  
Vulnerable Groups ◽  
Second Phase ◽  
Fat Intake

Adolescents are one of the nutritionally vulnerable groups. At this time, adolescents enter the second phase of rapid growth and then physical growth declines as young adults enter. Problems that arise in adolescents are undernutrition and overnutrition. One that is related to nutritional status is nutrient intake which is very influential on a person's nutritional status. Nutrient intake is influenced by eating habits and eating patterns of adolescents themselves. The purpose of this study was to determine the description of macronutrient intake and nutritional status at the Putri Hidayatullah Islamic Boarding School, Ternate City. The type of research used is descriptive research. The sampling technique used total sampling with a total sample of 29 people. The tools used were Microtoise, Bathroom Scale and form food recall 24. The results showed that the intake of macronutrients, as many as 28 people (96.6%) with less energy intake, 29 people (100.0%) with less protein intake, 16 people (55.2%) with more fat intake and 26 people (89.7%) with less carbohydrate intake. There were 25 people (86.2%) with normal nutritional status. It was concluded that from the results of the respondents had less protein intake and most had less energy and carbohydrate intake. On the other hand, most of these teenagers have good fat intake with normal nutritional status.

A Comparison of the Nutrient Intakes of Macronutrient-Based Dieting and Strict Dieting Bodybuilders

2018 ◽  
Vol 28 (5) ◽  
pp. 502-508 ◽  
Author(s):  
Ahmed Ismaeel ◽  
Suzy Weems ◽  
Darryn S. Willoughby
Keyword(s):  
Vitamin E ◽  
Vitamin C ◽  
Protein Intake ◽  
Saturated Fat ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Nutrient Intakes ◽  
Food Frequency ◽  
Added Sugars ◽  
Descriptive Assessment

The purpose of this study was to provide a descriptive assessment of the nutritional habits of competitive bodybuilders and compare the nutrient intakes of macronutrient-based dieting and strict dieting individuals. Data from 41 subjects (30 males and 11 females) were used in analyses. Participants completed a comprehensive food frequency questionnaire, and diets were analyzed using a computer system. Males consumed an average of 2,577.2 kcal (SD = 955.1), with an average fat intake of 83.6 g (SD = 41.3), an average carbohydrate intake of 323.3 g (SD = 105.2), and an average protein intake of 163.4 g (SD = 70.4). There were no significant differences between male macronutrient-based dieting and strict dieting bodybuilders when mean intakes were compared for all nutrients, including the macronutrients, selected vitamins and minerals, dietary fiber, added sugars, and saturated fat. Females in this study consumed an average of 1,794 kcal (SD = 453.1), with an average fat intake of 58.3 g (SD = 23.1), a mean carbohydrate intake of 217.8 g (SD = 85.9), and an average protein intake of 103.8 g (SD = 35.7). For females, macronutrient-based dieters consumed significantly greater amounts of several nutrients, including protein, vitamin E, vitamin K, and vitamin C. Over half of individuals from all groups consumed less than the recommended amounts of several of the micronutrients. Based on this information, it is recommended that competitive bodybuilders should be advised to take their micronutrition into greater consideration.

scholarly journals When, how much and what foods are eaten are related to total daily food intake

2009 ◽  
Vol 102 (8) ◽  
pp. 1228-1237 ◽  
Author(s):  
John M. de Castro
Keyword(s):  
Protein Intake ◽  
Daily Intake ◽  
Overweight And Obesity ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Dietary Interventions ◽  
Breakfast Cereal ◽  
Total Intake ◽  
Different Types ◽  
Daily Intakes

Intake in the morning is associated with a reduction in the total intake for the day, while intake at night is associated with greater overall daily intake. These associations are macronutrient specific, with morning carbohydrate intake associated with reduced daily carbohydrate intake, morning fat intake associated with reduced daily fat intake and morning protein intake associated with reduced daily protein intake. Since different types of foods contain differing proportions of macronutrients, the present study investigated the associations of different types of foods ingested at various times of day with total daily and macronutrient intakes. The intakes of 388 male and 621 female free-living individuals reported in 7 d diet diaries were reanalysed. The intakes of twenty-four different types of foods and seven different drinks occurring during the morning (04.00–10.29 hours), afternoon (10.30–16.59 hours) and evening (17.00–02.00 hours) were identified and related to overall daily intakes. Dairy foods, ice cream, beef, other meats, potatoes, pastry, nuts, chips and snacks, condiments, alcohol and soda were significantly associated with higher total intake over the day, while fruit, soup, breakfast cereal, pasta, pizza, water, coffee/tea and diet soda were either not associated or were associated with lower overall intake. Dietary energy density appeared to mediate the associations between particular foods and beverages and overall energy intake. This suggests that eating low-density foods in the morning and avoiding high-density foods at night might aid in reducing overall intake and may be useful in dietary interventions for overweight and obesity.

scholarly journals Dietary intake of protein and fat of 12- to 36-month-old children in a Dutch Total Diet Study

2021 ◽  
Author(s):  
Annemieke Maria Pustjens ◽  
Jacqueline Jozefine Maria Castenmiller ◽  
Jan Dirk te Biesebeek ◽  
Polly Ester Boon
Keyword(s):  
The Netherlands ◽  
Protein Intake ◽  
Age Groups ◽  
Fat Intake ◽  
Total Diet Study ◽  
Consumption Data ◽  
Group 12 ◽  
Food Consumption Survey ◽  
Total Diet ◽  
Diet Study

Abstract Purpose This study attempted gaining insight into the intake of protein and fat of 12- to 36-month-old children in the Netherlands. Methods In 2017, a Total Diet Study (TDS) was carried out in the Netherlands including following three age groups: 12–17-, 18–23- and 24- to 36-month-old children. Protein and fat concentrations of 164 composite samples were analysed and combined with the consumption data from the Dutch National Food Consumption Survey 2012–2016 (DNFCS). Results Median protein intake of the 12- to 35-month-old Dutch children based on the TDS was 35 g/day with main contributions from the food subgroups “milk and milk-based beverages”, “beef” and “yoghurts and desserts”. Median fat intake was 34 g/day with main contributions from the food subgroups “margarines”, “cheeses” and “milk and milk-based beverages”. For the youngest age group (12- to 18-month-old children), (ready to drink) follow-on formula was one of the main contributors to the fat intake. Conclusion Compared to the EFSA reference values, protein intake of the Dutch 12- to 36-month-old children is high, whereas fat intake follows the reference intake. A TDS is a suitable instrument to estimate macronutrient intakes.

scholarly journals Changes in blood lipid concentrations associated with changes in intake of dietary saturated fat in the context of a healthy low-carbohydrate weight-loss diet: a secondary analysis of the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) trial

2019 ◽  
Vol 109 (2) ◽  
pp. 433-441 ◽  
Author(s):  
Cynthia W Shih ◽  
Michelle E Hauser ◽  
Lucia Aronica ◽  
Joseph Rigdon ◽  
Christopher D Gardner
Keyword(s):  
Weight Loss ◽  
Lipid Profile ◽  
Secondary Analysis ◽  
Saturated Fat ◽  
Blood Lipid ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
Weight Loss Diet ◽  
Low Carbohydrate ◽  
Saturated Fat Intake

ABSTRACTBackgroundFor low-carbohydrate diets, a public health approach has focused on the replacement of carbohydrates with unsaturated fats. However, little research exists on the impacts of saturated fat intake on the lipid profile in the context of whole-food-based low-carbohydrate weight-loss diets.ObjectivesThe primary aim of this secondary analysis of the DIETFITS weight loss trial was to evaluate the associations between changes in percentage of dietary saturated fatty acid intake (%SFA) and changes in low-density lipoproteins, high-density lipoproteins, and triglyceride concentrations for those following a healthy low-carbohydrate (HLC) diet. The secondary aim was to examine these associations specifically for HLC dieters who had the highest 12-month increases in %SFA.MethodsIn the DIETFITS trial, 609 generally healthy adults, aged 18–50 years, with body mass indices of 28–40 kg/m2 were randomly assigned to a healthy low-fat (HLF) or HLC diet for 12 months. In this analysis, linear regression, both without and with adjustment for potential confounders, was used to measure the association between 12-month change in %SFA and blood lipids in 208 HLC participants with complete diet and blood lipid data.ResultsParticipants consumed an average of 12–18% of calories from SFA. An increase of %SFA, without significant changes in absolute saturated fat intake, over 12 months was associated with a statistically significant decrease in triglycerides in the context of a weight-loss study in which participants simultaneously decreased carbohydrate intake. The association between increase in %SFA and decrease in triglycerides was no longer significant when adjusting for 12-month change in carbohydrate intake, suggesting carbohydrate intake may be a mediator of this relationship.ConclusionsThose on a low-carbohydrate weight-loss diet who increase their percentage intake of dietary saturated fat may improve their overall lipid profile provided they focus on a high-quality diet and lower their intakes of both calories and refined carbohydrates. This trial was registered at clinicaltrials.gov as NCT01826591.

scholarly journals Habitual diet in four populations of African origin: a descriptive paper on nutrient intakes in rural and urban Cameroon, Jamaica and Caribbean migrants in Britain

2001 ◽  
Vol 4 (3) ◽  
pp. 765-772 ◽  
Author(s):  
Louise I Mennen ◽  
Maria Jackson ◽  
Sangita Sharma ◽  
Jean-Claude N Mbanya ◽  
Janet Cade ◽  
...  
Keyword(s):  
Saturated Fat ◽  
Carbohydrate Intake ◽  
Fat Intake ◽  
African Origin ◽  
Rural And Urban ◽  
Habitual Diet ◽  
Rural Cameroon ◽  
Similar Genetic Background ◽  
Total Fat ◽  
The Uk

AbstractBackground:The prevalence of chronic diseases is increasing in West Africa, the Caribbean and its migrants to Britain. This trend may be due to the transition in the habitual diet, with increasing (saturated) fat and decreasing fruit and vegetable intakes, both within and between countries.Objective:We have tested this hypothesis by comparing habitual diet in four African-origin populations with a similar genetic background at different stages in this transition.Design:The study populations included subjects from rural Cameroon (n=743), urban Cameroon (n=1042), Jamaica (n=857) and African–Caribbeans in Manchester, UK (n=243), all aged 25–74 years. Habitual diet was assessed by a food-frequency questionnaire, specifically developed for each country separately.Results:Total energy intake was greatest in rural Cameroon and lowest in Manchester for all age/sex groups. A tendency towards the same pattern was seen for carbohydrates, protein and total fat intake. Saturated and polyunsaturated fat intake and alcohol intake were highest in rural Cameroon, and lowest in Jamaica, with the intakes in the UK lower than those in urban Cameroon. The percentage of energy from total fat was higher in rural and urban Cameroon than in Jamaica and the UK for all age/sex groups. The opposite was seen for percentage of energy from carbohydrate intake, the intake being highest in Jamaica and lowest in rural Cameroon. The percentage of energy from protein increased gradually from rural Cameroon to the UK.Conclusions:These results do not support our hypothesis that carbohydrate intake increased, while (saturated) fat intake decreased, from rural Cameroon to the UK.

scholarly journals Perbedaan Keragaman Pangan, Pola Asuh Makan, dan Asupan Zat Gizi Makro pada Balita dari Ibu Bekerja dan Ibu Tidak Bekerja

2021 ◽  
Vol 5 (3) ◽  
pp. 276
Author(s):  
Hesti Permata Sari ◽  
Lilis Permatasari ◽  
Widya Ayu Kurnia Putri
Keyword(s):  
Protein Intake ◽  
Nutrient Intake ◽  
Sampling Techniques ◽  
Fat Intake ◽  
Feeding Patterns ◽  
Child Feeding ◽  
Cross Sectional ◽  
Food Diversity ◽  
Business Women

Background: Toddlers are a group that is vulnerable to experiencing nutritional problems. The nutritional status of toddlers is very dependent on the role of caregivers, especially mothers. Business women have less time together with toddlers so that it will have an impact on mothers' attention to the growth and development of toddlers, child feeding patterns, food diversity, and macro-nutrient intake of toddlers. Research in Padang states that business women have a 1,3 times risk of experiencing malnutrition in children. Purpose: Know the differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife. Method: The design of this study was an observational analytic with cross sectional approach. The research was conducted on medium socioeconomic housing in Banyumas Regency. The sample are toddlers aged 12-59 months as many as 78 toddlers, taken using total sampling techniques. Data were statistically tested using independent T tests. Results: The results of study showed no differences in child feeding patterns (p = 0.605), food diversity (p = 0.767), energy intake (p = 0.483), protein intake (p = 0.806), fat intake (p = 0.787) and carbohydrate intake (p = 0.337) in toddlers from business women and housewife. Conclusions: There were no differences in child feeding patterns, food diversity, and macro nutrient intake in toddlers from business women and housewife.

scholarly journals Efecto del consumo de hidratos de carbono en los deportes de resistencia

2019 ◽  
pp. 1-7
Author(s):  
Ricardo LÓPEZ-SOLÍS ◽  
Brenda Hildeliza CAMACHO-DÍAZ ◽  
Roberto CAMPOS-MENDIOLA ◽  
María Araceli ORTÍZ-RODRÍGUEZ
Keyword(s):  
Blood Glucose ◽  
Endurance Sports ◽  
Carbohydrate Consumption ◽  
Glucose Levels ◽  
Oxidation Rates ◽  
Health Authorities ◽  
Carbohydrate Feeding ◽  
Promotion Of Physical Activity ◽  
And Performance ◽  
Blood Glucose Concentrations

The aim of this review is to summarize the effects of carbohydrate consumption on endurance sports. Due to the promotion of physical activity by health authorities, participation in endurance sports is increasing. Regardless of the level, athletes look for ways to optimize their performance through training and nutrition. In consequence, research in the field of sports nutrition has focused on those strategies that can improve performance. Fatigue during prolonged exercise is associated with depletion of muscle glycogen and reduced blood glucose concentrations. Therefore, carbohydrate feeding during exercise has shown that it can improve capacity and performance, because it helps maintain blood glucose levels, as well as, increase carbohydrate oxidation rates and preserve glycogen, finding better results when are consumed multiple-tranportable carbohydrates for absortion (e.g., fructose and glucose), since in this way is possible to increase absorption rates, gastric emptying and fluid absorption, in addition to decrease gastrointestinal distress.

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