N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise

2000 ◽  
Vol 89 (6) ◽  
pp. 2401-2406 ◽  
Author(s):  
Anders Dyhr Toft ◽  
Mette Thorn ◽  
Kenneth Ostrowski ◽  
Sven Asp ◽  
Kirsten Møller ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Strenuous Exercise ◽  
Control Group ◽  
Fish Oil Supplementation ◽  
To Receive

The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation ( n = 10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation ( n = 10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-α, interleukin-6, and transforming growth factor-β1 peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interlukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise.

scholarly journals Modifying the Acute Phase Response of Jersey Calves by Supplementing Milk Replacer with Omega-3 Fatty Acids from Fish Oil

2008 ◽  
Vol 91 (9) ◽  
pp. 3478-3487 ◽  
Author(s):  
M.A. Ballou ◽  
G.D. Cruz ◽  
W. Pittroff ◽  
D.H. Keisler ◽  
E.J. DePeters
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Milk Replacer ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Dietary fish oil prevents reperfusion Ins(1,4,5)P3 release in rat heart: possible antiarrhythmic mechanism

1996 ◽  
Vol 271 (4) ◽  
pp. H1483-H1490 ◽  
Author(s):  
K. E. Anderson ◽  
X. J. Du ◽  
A. J. Sinclair ◽  
E. A. Woodcock ◽  
A. M. Dart
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Saturated Fat ◽  
Inhibitory Effect ◽  
Control Group ◽  
Membrane Phospholipids ◽  
Postischemic Reperfusion ◽  
Dietary Fish ◽  
Fish Oil Supplementation

Dietary enrichment with fish oil-derived n-3 polyunsaturated fatty acids has been shown to suppress the arrhythmias that occur during postischemic reperfusion. We have recently implicated a rapid release of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] during postischemic reperfusion in the generation of these arrhythmias. The effects of dietary supplementation with fish oil on both cardiac Ins(1,4,5)P3 and arrhythmogenic responses to reperfusion were therefore investigated in perfused rat hearts. Comparisons were made with control and n-6 polyunsaturated or saturated fat-supplemented diets. In control hearts, reperfusion increased Ins(1,4,5)P3 levels [from 9 +/- 2 at 20 min ischemia to 26 +/- 3 counts per minute (cpm)/mg protein with 2 min of reperfusion] and produced a high incidence of ventricular tachycardia (92% VT) and ventricular fibrillation (85% VF). Dietary fish oil supplementation, which increased composition of n-3 fatty acids in myocardial membrane phospholipids, prevented the reperfusion-induced rise in Ins(1,4,5)P3 (11 +/- 1 at 20 min ischemia and 12 +/- 2 cpm/mg protein after 2-min reperfusion) and significantly suppressed reperfusion arrhythmias (38% VT, 13% VF; P < 0.01 vs. control group). Thus the inhibition of reperfusion-induced rises in Ins(1,4,5)P3 by n-3 polyunsaturated fatty acids after dietary fish oil supplementation provides a possible mechanism for the inhibitory effect of n-3 fatty acids on reperfusion-induced arrhythmias.

Supplemental fish oil does not alter immune competence or the pathophysiological response to an intramammary infusion of endotoxin in peri-partum multiparous Holstein cows

2009 ◽  
Vol 76 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Michael A Ballou ◽  
Rodrigo C Gomes ◽  
Edward J DePeters
Keyword(s):  
Antimicrobial Activity ◽  
Fish Oil ◽  
Acute Phase ◽  
Whole Blood ◽  
Acute Phase Response ◽  
Post Partum ◽  
Interferon Γ ◽  
Phase Response ◽  
Holstein Cows ◽  
Immune Competence

The objective was to determine the effects of supplementing the diet with fish oil during the peri-partum period on the immune competence and the pathophysiological response to a lipopolysaccharide-induced mastitis challenge. Multiparous Holstein cows (n=30) were completely randomized to one of two treatments at 3 weeks pre-partum. Treatments differed only in the source of supplemental lipid and included either Energy Booster® or fish oil. Treatment diets were fed from −21 d relative to expected date of parturition until 10 d post partum. Treatments were fed as a bolus prior to the a.m. feeding. The dose of lipid during the pre-partum period was 250 g/d, whereas the amount of lipid supplemented post partum was adjusted to the level of intake, approximately 0·92% of the previous day's dry matter intake. Ex-vivo analyses of immune competence were measured including the antimicrobial activity of whole blood against Escherichia coli, Salmonella typhimurium and Candida albicans as well as the production of interferon-γ by peripheral blood mononuclear cultures. At 7 days in milk cows were infused with 100 μg of Esch. coli lipopolysaccharide into one rear quarter. Supplementing fish oil increased plasma concentrations of eicosapentaenoic and docosahexaenoic acids, but had no affect on the proportions of arachidonic acid at calving. Fish oil did not influence the production of interferon-γ or the antimicrobial activity of whole blood against any of the microorganisms. Furthermore, fish oil had no ameliorative effect on either the local or the systemic acute phase response following an intramammary lipopolysaccharide challenge in early lactating Holstein cows. Supplementing fish oil in the diet of peri-partum cows will not protect them from deleterious effects of an excessive acute phase response.

scholarly journals PSX-6 Effect of dietary microalgae and fish oil on the nursery pig acute-phase response.

2018 ◽  
Vol 96 (suppl_3) ◽  
pp. 491-492
Author(s):  
A Lee ◽  
L You ◽  
Z Li ◽  
S Oh ◽  
M Alcorn ◽  
...  
Keyword(s):  
Fish Oil ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Nursery Pig

Strenuous exercise: analogous to the acute-phase response?

1991 ◽  
Vol 81 (5) ◽  
pp. 677-683 ◽  
Author(s):  
Lindsay M. Weight ◽  
Donald Alexander ◽  
Peter Jacobs
Keyword(s):  
Acute Phase ◽  
Total Protein ◽  
Protein Level ◽  
Acute Phase Response ◽  
Interleukin 1 ◽  
Phase Response ◽  
Strenuous Exercise ◽  
Iron Level ◽  
C Reactive Protein ◽  
Reactive Protein

1. It has been suggested that the physiological consequences of strenuous exercise are analogous to those of the acute-phase response. 2. In 70 male and 20 female competitive distance runners, a marked, but transient, neutrophil leucocytosis occurred immediately after these athletes completed a standard (42 km) marathon race. Concomitant significant increases were noted in the plasma cortisol levels, creatine kinase activity, C-reactive protein level, total protein level and albumin level (P <0.01). 3. The plasma fibrinogen, C-reactive protein and total protein concentrations were markedly increased both 24 h and 48 h after exercise (P <0.01). The serum haptoglobin level was significantly decreased after exercise (P <0.01), and increased 48 h later (P <0.05). There was no change in the serum iron level, total iron-binding capacity, per cent saturation of transferrin and serum ferritin level. 4. A significant increase in interleukin-1-type activity was demonstrated immediately and 24 h after exercise (P <0.01). 5. It is concluded that the metabolic sequelae of sustained exercise are similar, but not analogous, to the acute-phase response, and interleukin-1 probably plays a significant role in linking the haematological and immunological changes observed after sustained strenuous exercise.

scholarly journals Supplementation With Omega 3 in a Diet With Omega 9 Fatty Acids. Study on Serum, Thymus and Brain of Growing Rat

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 589-589
Author(s):  
Anabel Impa Condori ◽  
María Godoy ◽  
Inés Fernandez ◽  
Nora Slobodianik ◽  
María Feliu
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Olive Oil ◽  
Essential Fatty Acids ◽  
Control Group ◽  
Omega 3 ◽  
Funding Sources ◽  
Growing Rat ◽  
Group Control Group ◽  
Fish Oil Supplementation

Abstract Objectives Fatty acids have an important role in nutrition. The objective was to analyze the effect of diet containing olive oil, with and without the supplementation with omega 3, on serum, thymus and brain's fatty acid profiles of growing rats. Methods Weanling Wistar rats fed during 10 days a diet containing olive oil as fat (O group). Other group received the same diet supplemented with 24mg/day of fish oil (OS group). Control group(C) received diet according AIN´93. Serum, thymus and brain's fatty acids profiles were determined by gas chromatography. Statistical analysis used ANOVA. Results Results (%Area) were expressed as the Mean ± SD: SERUM: OLEIC O:23.44 ± 3.68a;  OS:18.31 ± 2.22a;  C:10.60 ± 2.01b;  LINOLEIC(LA) O:12.44 ± 1.65b;  OS:12.98 ± 4.31b;  C:18.27 ± 2.81a;  LINOLENIC(ALA) O:0.30 ± 0.09b;  OS:0.32 ± 0.08b;  C:0.92 ± 0.34a;  EPA O:0.65 ± 0.17b;  OS:1.63 ± 0.49a;  C:0.80 ± 0.23b;  DHA: O:1.57 ± 0.58b;  OS:4.00 ± 1.70a;  C:1.33 ± 0.19b. THYMUS: OLEIC O:21.54 ± 5.92;  OS:24.40 ± 5.04;  C:18.22 ± 3.23;  LINOLEIC O:5.90 ± 0.56b;  OS:6.50 ± 0.61b;  C:10.89 ± 2.18a;  ALA O:0.27 ± 0.02b;  OS:0.30 ± 0.07b;  C:0.49 ± 0.19a;  EPA O:0.49 ± 0.28;  OS:0.50 ± 0.13;  C:0.50 ± 0.12;  DHA O:0.47 ± 0.10b;  OS:0.70 ± 0.12a;  C:0.52 ± 0.16b. BRAIN: OLEIC O:13.11 ± 2.64;  OS:12.94 ± 1.07;  C:13.14 ± 1.56;  LA O:1.17 ± 0.46;  OS:1.05 ± 0.33;  C:1.26 ± 0.19;  ALA O:0.15 ± 0.03;  OS:0.12 ± 0.04;  C:0.16 ± 0.06;  EPA O:0.46 ± 0.18;  OS:0.38 ± 0.09;  C:0.33 ± 0.07;  DHA: O:11.39 ± 2.04;  OS:11.32 ± 1.69;  C:11.66 ± 1.63. Means with one letter (a, b) in common, were not significantly different (p &gt; 0.05). In sera, O and OS showed lower ALA and LA and higher oleic levels, compared to C. OS presented high levels of EPA and DHA. In thymus, O and OS groups showed lower levels of ALA and LA than C. DHA only increased in the OS group. No changes were presented in the brain. Conclusions The results suggest that olive oil exacerbated omega-9 family with diminution of essential fatty acids while organism tries to sustain brain essential fatty acids. Fish oil supplementation increased serum and thymus DHA levels, not modifying low levels of other essential fatty acids. Another source of supplementation may be convenient to analyze. Funding Sources Supported by University of Buenos Aires, Argentina.

Cytokine immunoreactivity in plasma does not change after moderate endurance exercise

1992 ◽  
Vol 73 (4) ◽  
pp. 1396-1401 ◽  
Author(s):  
J. A. Smith ◽  
R. D. Telford ◽  
M. S. Baker ◽  
A. J. Hapel ◽  
M. J. Weidemann
Keyword(s):  
Acute Phase ◽  
Endurance Exercise ◽  
Acute Phase Response ◽  
Human Subjects ◽  
Plasma Concentrations ◽  
Phase Response ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Blood Neutrophils ◽  
Circulating Cytokines

We investigated whether increased concentrations of circulating cytokines may be responsible for exercise-induced priming of blood neutrophils (J. A. Smith et al. Int. J. Sports Med. 11: 179–187, 1990). The plasma concentrations of tumor necrosis factor-alpha, interleukin- (IL) 1 beta, IL-6, granulocyte-macrophage colony-stimulating factor, and neopterin in trained and untrained human subjects were measured by immunoassay before and after 1 h of cycling at 60% of maximal oxygen uptake. C-reactive protein and creatine kinase (CK) were also measured before and 24 h after exercise as markers of the “acute-phase response” and muscle damage (C. Taylor et al. J. Appl. Physiol. 62: 464–469, 1987), respectively. The small changes in the plasma concentrations of cytokines or neopterin observed after exercise in both trained and untrained subjects were not significantly different to those found in a control group of nonexercised subjects. However, untrained subjects did exhibit an acute-phase response (P = 0.04) 24 h after exercise without additional release of CK into plasma. Baseline training differences were confined to a twofold elevation in CK activity (P = 0.04). The results show that circulating cytokines are unlikely to be responsible for the priming of neutrophil microbicidal activity observed after moderate endurance exercise (J. A. Smith et al. Int. J. Sports Med. 11: 179–187, 1990).

Effect of fish-oil supplementation on levels of (n-3) poly-unsaturated fatty acids in the lipoprotein fractions of bovine plasma

2001 ◽  
Vol 73 (3) ◽  
pp. 523-531 ◽  
Author(s):  
N.W. Offer ◽  
B.K. Speake ◽  
J. Dixon ◽  
M. Marsden
Keyword(s):  
Fatty Acids ◽  
Sugar Beet ◽  
Fish Oil ◽  
Milk Fat ◽  
Unsaturated Fatty Acids ◽  
Density Lipoprotein ◽  
Control Group ◽  
Triglyceride Fraction ◽  
Fish Oil Supplementation ◽  
Long Chain

AbstractEight mid-lactation Holstein-Friesian dairy cows were used in an experiment to investigate whether poor transfer to milk of (n-3) long chain (≥C20) poly-unsaturated fatty acids (n-3 LCPUFA), from diets containing fish oil, is related to their mode of transport in plasma lipoproteins. The cows were split into two groups of four, each of which was housed with 24 other cows which did not provide blood data in this experiment. All cows received a basal diet ad libitum consisting of (kg/t dry matter) silage (539), grain distillers’ grains (148), rolled barley (248) and soya (65). All cows also received a mid-day meal of 2·76 kg per cow per day of molassed sugar-beet shreds. The control group (C) received no oil supplement but those in the treatment group (F) received 300 g per cow per day of fish oil absorbed onto the sugar-beet shreds. Fish oil inclusion progressively depressed milk fat concentration of the four cows from each group over the 3 weeks of the experiment so that levels were approximately 20 g/kg lower for cows in treatment F than for those in C (P < 0·05). Mean concentrations over all cows of the long-chain (≥C20, n-3) poly-unsaturated fatty acids in milk fat (g/100 g) were 0·12 and 0·54 for treatments C and F respectively, whilst corresponding output in milk (g/day) increased from 116 to 3·91, an average efficiency of transfer of 4·6%. The fatty acid compositions of the lipoproteins were measured in plasma samples from the four cows from each group after 3 weeks on the experimental diets The proportions (g/100 g fatty acids) of C20: 5 (n-3) in cholesteryl (CE) and phospholipid (PL) of high-density lipoprotein (HDL) in the plasma were respectively increased from 0·97 to 4·39 (P < 0·05) and from 1·15 to 4·74 (P < 0·01) by the fish-oil supplementation. For C22: 6 (n-3), the proportions in CE and PL of HDL respectively increased (P < 0·001) from 0·02 to 0·23 and from 0·16 to 2·18 as a result of the supplementation. The mean proportions (g/100 g fatty acids) of C20: 5 (n-3) and C22: 6 (n-3) in the triglyceride fraction of very low-density lipoprotein were 1·05 and 2·3 respectively and were not significantly altered by fish-oil supplementation (P > 0·05). It is suggested that the low transfer efficiency of (n-3) LCPUFA to the milk is partly due to their transport in the plasma largely as components of HDL lipids which are unavailable to the mammary gland.

scholarly journals Pengaruh pemberian minyak ikan terhadap konsentrasi asam lemak dan gejala klinis malaria

2019 ◽  
Vol 15 (1) ◽  
Author(s):  
Haerani Rasyid ◽  
Danny Suwandi
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Control Group ◽  
Double Blind ◽  
Epa And Dha ◽  
Post Test ◽  
Fever Attacks ◽  
And Control ◽  
Fish Oil Supplementation ◽  
Fever Attack

The aim of the study is to find out the effects of fish oil supplementation on fatty acids concentration (Eicosapentanoat Acid and Docosahexaenoat Acid), fever attacks and Dikke Drupple (DDR) interpretation of samples. This study was designed as “A Randomized Double Blind Pretest and Post-test Controled Group“. Samples were divided into two groups, experiment group with fish oil suplementation (8% EPA, 35 DHA) and control group (placebo) for 8 weeks. This study was conducted in a malaria endemic, Kadaila village, subdistrict of Karossa, District of Mamuju in 2003. The result of the study showed significant increased concentration of EPA and DHA of the experiment group than the control group (p 0,05). The fever attack was significantly decreased (p 0,05) in experiment group than the control group, while DDR was not significantly different (p 0,05) between two groups.

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