Positive end-expiratory pressure affects geometry and function of the human diaphragm
2021 ◽
Vol 131
(4)
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pp. 1328-1339
Keyword(s):
We demonstrate that PEEP causes changes in diaphragm geometry, especially muscle shortening, and decreases in vivo diaphragm contractile function. Thus prerequisites for the development of diaphragm longitudinal muscle atrophy are present with the acute application of PEEP. Once confirmed in ventilated critically ill patients, this could provide a new mechanism for ventilator-induced diaphragm dysfunction and ventilator weaning failure in the intensive care unit (ICU).
2011 ◽
Vol 300
(3)
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pp. H943-H950
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Keyword(s):
1993 ◽
Vol 75
(2)
◽
pp. 738-744
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1997 ◽
Vol 272
(6)
◽
pp. H2664-H2670
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2016 ◽
Vol 120
(2)
◽
pp. 188-195
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Keyword(s):
2005 ◽
Vol 83
(2)
◽
pp. 183-190
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