scholarly journals Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

2019 ◽  
Vol 51 (8) ◽  
pp. 390-399 ◽  
Author(s):  
Babiche A. Heil ◽  
Dale L. Paccamonti ◽  
Jenny L. Sones

Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is dependent on body site and several host-related factors. Furthermore, specific phyla have been identified among the different species and within distinct areas of the female reproductive tract, but a “core” microbiome of the female reproductive tract has not been defined in any species. Moreover, the function of the microbiome in the reproductive tract is not yet fully understood. However, it has been suggested that a change in diversity of the microbiome and the presence or absence of specific microbial species might be useful indicators of pregnancy outcomes. Increased comprehensive knowledge of the microbiological communities in the female reproductive tract is needed since adverse outcomes represent a significant problem to many species, including livestock, exotic or endangered species, and humans. To the authors’ knowledge, a review combining current female reproductive tract microbiome data among different mammalian species has not been published yet. Herein is a comprehensive review of what is known in the field of the female reproductive microbiome and how it correlates with reproductive success or failure in mammals. Further studies may lead to optimization of therapies in the treatment of reproductive tract infections and pregnancy failure, and may create opportunities for novel approaches for improving reproductive efficiency in animals and people.

2000 ◽  
Vol 16 (1) ◽  
pp. 249-253 ◽  
Author(s):  
María Y. Makuch ◽  
Neury José Botega ◽  
Luis Bahamondes

The objective of this study was to describe the information that women with tubal infertility recalled having received from physicians when they consulted for a reproductive tract infection (RTI) and the information physicians reported having provided to women consulting for RTIs. Interviews were conducted with 16 women presenting primary tubal infertility selected on the basis of purposeful sampling criteria. Also, 15 physicians working in the public health network in the city of Campinas, Brazil, were selected at random and interviewed. Analysis of the women's statements concerning previous RTI-related medical consultations showed that they did not recall having received any information on either prevention or the impact of RTI on their reproductive future. Analysis of interviews with physicians showed that the information they provided to women consulting for RTIs was incomplete and unclear. The information women recalled having received and that which physicians remembered having provided at the time of treating a patient with RTI was similar. In conclusion, these women lacked adequate or complete information and that it was probably not possible for them to adopt measures to avoid repetition of RTI and minimize risk of tubal infertility.


1986 ◽  
Vol 14 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Paulo Cesar Preza ◽  
Claudia Moura ◽  
Aguinaldo Leite Filho ◽  
Valeria Cavallari ◽  
Franklin Nüdemberg ◽  
...  

A combination of trimethoprim (TMP) 250 mg and sulfametopyrazine (SMP) 200 mg (dose ratio 5:4) in capsules was administered to ten patients undergoing hysterectomy for uterine leiomyoma. Each patient received a total of 3 of these Kelfiprim capsules: 2 capsules in a single administration 36 hours before surgery and 1 capsule 24 hours later. TMP and SMP concentrations were analyzed in plasma and also in the ovary, Fallopian tube and uterus, removed during surgery. The results indicated that in the reproductive organs of the female genital tract TMP reaches the same concentrations as in plasma. In contrast SMP is 3 to 3·5 times less concentrated in these tissues compared with plasma. At the TMP/SMP ratios obtained in these various organs synergism of the two compounds is reported to be particularly prominent for most bacterial strains. These findings indicate that this TMP-SMP combination may be useful in the treatment of female reproductive tract infections.


2020 ◽  
Vol 1 (1) ◽  
pp. 8-12
Author(s):  
Risnawati Ramli

Reproductive Tract Infections (ISR) occur because of the process of entering and breeding the germs that cause infections into the female reproductive tract. Caring for sexual organs is often not done as often as caring for other organs. Though sexual organs need extra attention. In these sexual organs, the resulting sweat is quite excessive. So that the sexual organs become moist. prevention that can be done to prevent the occurrence of sexually transmitted diseases that is with care and maintain the cleanliness of the reproductive organs. Treatments that can be done are consuming healthy and nutritious eating, avoid using tight pants, check with your doctor if you experience vaginal discharge for a very long time, make it a habit to cleanse the genitals after sexual intercourse, do not use pantyliner, avoid having sexual intercourse with multiple partners. Washing the genitals every day, changing clothes frequently, at least twice a day in the bath, during menstruation, use soft pads, always wash hands before touching the genitals, avoid using other people's towels or washcloths and shave a portion of pubic hair to prevent bacterial growth


2001 ◽  
Vol 9 (4) ◽  
pp. 203-207 ◽  
Author(s):  
Susan W. Cook ◽  
Hunter A. Hammill ◽  
Richard A. Hull

Objective:The presence of enterobacteria such asEscherichia coliin the vagina of normal women is not synonymous with infection. However, vaginalE. colimay also cause symptomatic infections. We examined bacterial virulenceproperties that may promote symptomatic female reproductive tract infections (RTI) and neonatal sepsis.Methods:E. coliisolated as the causative agent from cases of vaginitis (n = 50), tubo-ovarian abscess (n = 45) and neonatal sepsis (n = 45) was examined for selected phenotypic and genetic virulence properties. Results were compared with the frequency of the same properties among fecalE. colinot associated with disease.Results:A significantly greater proportion of infectionE. coliexhibited D-mannose resistant hemagglutination compared with fecalE. coli(p< 0.01). This adherence phenotype was associated with the presence of P fimbriae (pap) genes which were also significantly more prevalent among isolates from all three infection sites (p< 0.01). The majority ofpap+isolates contained thepapG3allele (Class II) regardless of infection type. Increased frequency of Type 1C genes among vaginitis and abscess isolates was also noted. No significant differences in frequency of other bacterial adherence genes, fim, sfa, uca (gaf) or dra were observed. E. coli associated with vaginitis was significantly more likely to be hemolytic ( HIY+) than were fecal isolates (p< 0.05). The HIY+phenotype was also more prevalent among tubo-ovarian abscess and neonatal sepsis isolates (p< 0.08).Conclusions:E. coliisolated from female RTI and neonatal sepses possess unique properties that may enhance their virulence. These properties are similar to those associated with otherE. coliextra-intestinal infections, indicating that strategies such as vaccination or bacterial interference that may be developed against urinary tract infections (UTI) and otherE. coliextra-intestinal infections may also prevent selected female RTI.


2021 ◽  
Vol 7 (2) ◽  
Author(s):  
Gnatoulma Katawa ◽  
Christèle Nguepou Tchopba ◽  
Manuel Ritter ◽  
Malik da Silva ◽  
Adjoa H Ameyapoh ◽  
...  

2011 ◽  
pp. 45-52
Author(s):  
Van Thang Vo ◽  
Quang Minh Nguyen

Objectives: This study defines the prevalence and factors relating to lower reproductive tract infections of female workers of Ba Ria Rubber Company. Subjects and Methods: Using the design of cross-sectional study from June 2009 to May 2010, a total number of 506 female workers of Ba Ria Rubber Company had been chosen to be interviewed, examined and tested for diagnosing of lower reproductive tract infections and related factors. Results and Discussion: It showed that the prevalence of lower reproductive tract infections (RTIs) was 43.1% in which 25.23% of Candida albicans, 1.83% of Trichomonas, 15.14% of Gardneralla and 57.80% of bacteria. Conclusion: Some related factors were work place, characteristics of job, economic conditions, the quality of water supply, female workers’ history of abortion, contraceptive methods, bathroom and environmental conditions at work place. Key words: Reproductive tract infections (RTIs), working environmental conditions.


2011 ◽  
Vol 3 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Christopher Aye Egbe ◽  
Uchenna Chukwunweike Onwufor ◽  
Richard Omoregie ◽  
Onaiwu Idahosa Enabulele

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