Protective Effects of Peroxisome Proliferator-Activated Receptor-αAgonist, Wy14643, on Hypoxia/Reoxygenation Injury in Primary Rat Hepatocytes
Keyword(s):
Group A
◽
This study investigates the effects and possible mechanism of an agonist of PPARα, Wy14643, on primary hepatocytes subjected to H/R injury in rats. H/R induced a significant increase ALT, AST, MDA in the culture medium and ROS in the hepatocytes. These effects were reversed by pretreatment with Wy14643 in the dose-dependent manner. The activity of SOD and the level of GSH in the hepatocytes were decreased after H/R, which were increased by Wy14643 pretreatment. Moreover, the mRNA expressions of PPARαsignificantly increased in H/R+Wy14643 groups when compared with that in H/R group. A PPARαagonist, Wy14643, exerts significant protective effect against H/R injury in primary hepatocytes via PPARαactivation and attenuating oxidative stress.
2014 ◽
Vol 92
(9)
◽
pp. 717-724
◽
2001 ◽
Vol 280
(4)
◽
pp. C807-C813
◽
2008 ◽
Vol 18
(2)
◽
pp. 329-338
◽
2016 ◽
Vol 2016
◽
pp. 1-11
◽
2009 ◽
Vol 28
(2)
◽
pp. 123-131
◽