scholarly journals Ulcerative Necrobiosis Lipoidica: Is There a Place for Anti-TNFα Treatment?

2012 ◽  
Vol 2012 ◽  
pp. 1-2 ◽  
Author(s):  
Rita Guedes ◽  
Inês Leite ◽  
Armando Baptista ◽  
Natividade Rocha
Keyword(s):  
Adverse Events ◽  
Female Patient ◽  
Inflammatory Disease ◽  
Alternative Treatment ◽  
Clinical Case ◽  
Necrobiosis Lipoidica ◽  
The Past ◽  
Systemic Treatments ◽  
Efficient Alternative

Necrobiosis lipoidica is a rare granulomatous and inflammatory disease. Its management is particularly difficult when ulceration is present. The authors describe the clinical case of a 65-year-old female patient with necrobiosis lipoidica, who had been submitted in the past to several topical and systemic treatments with little or no improvement. She started treatment with subcutaneous etanercept and showed significant improvement without adverse events until today. The aim of this article is to report a valid and efficient alternative treatment to recalcitrant cases.

scholarly journals MANAGEMENT OF PREGNANCY, DELIVERY AND POST-NATAL PERIOD IN THE PATIENT WITH DRUG RESISTANT DESTRUCTIVE PULMONARY TUBERCULOSIS AFTER SEVERAL SURGERIES

2018 ◽  
Vol 96 (6) ◽  
pp. 58-63
Author(s):  
S. I. Kayukova ◽  
O. G. Komissarova ◽  
N. L. Karpina ◽  
V. V. Romanov ◽  
E. V. Uvarova ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Female Patient ◽  
Clinical Case ◽  
Drug Resistant ◽  
Successful Management ◽  
The Past ◽  
Advanced Form ◽  
Extensive Drug Resistance

The article describes a clinical case of the successful management of pregnancy, delivery and post-natal period in the female patient with fibrous cavernous tuberculosis with extensive drug resistance and multiple thoracic surgeries in the past. This clinical case demonstrates that it is possible for a mother with the advanced form of tuberculosis to give birth to a healthy mature newborn.

scholarly journals Biological drugs in the therapy of atopic dermatitis and bronchial asthma: focus on dupilumab

2021 ◽  
pp. 129-137
Author(s):  
Vera A. Reviakina ◽  
Natalia A. Geppe ◽  
Aleksandr B. Malakhov ◽  
Oleg V. Kaliuzhin ◽  
Natalia G. Astaf'eva ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Clinical Case ◽  
Allergic Diseases ◽  
Significant Progress ◽  
Biological Drugs ◽  
The Past

Significant progress has been made over the past decade in the treatment of allergic diseases such as atopic dermatitis and bronchial asthma. Dupilumab, which targets interleukin IL-4 and IL-13, has become an innovative targeted therapy. Immunobiologic therapy with the interleukin inhibitor is indicated for patients with moderate to severe uncontrolled atopic dermatitis, moderate to severe eosinophilic phenotype of uncontrolled Bronchial asthma and patients with poorly controlled severe chronic polyposis rhinosinusitis. A clinical case and recent data on the use of dupilumab for the treatment of type 2 inflammatory disease and prospects for its use are discussed.

The Importance of Abutment Teeth Preparation Guide for Telescopic Double Crown Restorations with Friction Element

DENTA ◽  
2017 ◽  
Vol 11 (1) ◽  
pp. 69
Author(s):  
Anindita Apsari ◽  
Chaterina Dyah Nanik K
Keyword(s):  
Case Management ◽  
Female Patient ◽  
Alternative Treatment ◽  
Speech Disorders ◽  
Friction Element ◽  
The Third ◽  
Double Crown ◽  
Abutment Teeth ◽  
Tooth Preparation ◽  
Crown Preparation

<p><strong><em>Background: </em></strong><em>Telescopic double crown restoration can be used as an alternative treatment if the patient wants the tooth to be maintained as long as the supporting tooth has a healthy periodontal. In dental preparation telescopic double crown support requires a preparation guide so that the preparation can be acurate. Minimal preparation can cause the results of the telescopic double crown restoration to be overcontoured, so that the patient may occur uncomfortable, speech disorders and esthetic is not good. <strong>Objective:</strong> to provide information about the importance teeth preparation guidelines for prosthodontic treatment with telescopic double crown restorations. <strong>Case: </strong>A 72-year-old female patient, coming to the dentist wants to make dentures so that she can chew food well and improve her appearance. The remaining teeth are only 13 and 23. In making the denture, the patient wants the teeth to be retained (not removed) and the denture is aesthetically good. <strong>Case Management: </strong>Make a diagnostic wax-up on a semiadjustable articulator to estimate the results of restoration, </em><em>mould</em><em> </em><em>the patient's teeth before starting the preparation with three times putty for the preparation guide and making a temporary crown. the first putty mold is cut mesial-distal right in the middle of the incical teeth, the second putty mould is cut in the labial-palatal direction right in the middle of the tooth mould, the third putty mould is fixed on the stock tray to make the temporary crown. Preparation of teeth 13 and 23 with regard to the putty cut preparation guide, then moulding the maxilla and mandibula with double impressions using an individual tray, after that make the temporary crown directly with the third putty mould. <strong>Conclusion: </strong>The preparation guide of teeth is very necessary so that the making of telescopic double crown restorations is not overcontoured, so that esthetic and retention can be achieved which are good and do not cause speech disorders.</em></p><p><strong><em>Keywords:</em></strong><em> Telescopic double crown, tooth preparation guide, esthetic</em></p><p><strong><em>Correspondence:</em></strong><em> Anindita Apsari. Prostodonsia, Fakultas Kedokteran Gigi, Universitas Hang Tuah, Arief Rahman Hakim 150, Surabaya, Telepon 031-</em><em>5945864, </em><em>5912191, </em><em>E</em><em>mail: <span style="text-decoration: underline;">[email protected]</span></em></p>

scholarly journals Challenges and Novel Opportunities of Radiation Therapy for Brain Metastases in Non-Small Cell Lung Cancer

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2141
Author(s):  
Paola Anna Jablonska ◽  
Joaquim Bosch-Barrera ◽  
Diego Serrano ◽  
Manuel Valiente ◽  
Alfonso Calvo ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Brain Metastases ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
The Past ◽  
Systemic Treatments ◽  
Systemic Therapies

Approximately 20% patients with non-small cell lung cancer (NSCLC) present with CNS spread at the time of diagnosis and 25–50% are found to have brain metastases (BMs) during the course of the disease. The improvement in the diagnostic tools and screening, as well as the use of new systemic therapies have contributed to a more precise diagnosis and prolonged survival of lung cancer patients with more time for BMs development. In the past, most of the systemic therapies failed intracranially because of the inability to effectively cross the blood brain barrier. Some of the new targeted therapies, especially the group of tyrosine kinase inhibitors (TKIs) have shown durable CNS response. However, the use of ionizing radiation remains vital in the management of metastatic brain disease. Although a decrease in CNS-related deaths has been achieved over the past decade, many challenges arise from the need of multiple and repeated brain radiation treatments, which carry along not insignificant risks and toxicity. The combination of stereotactic radiotherapy and systemic treatments in terms of effectiveness and adverse effects, such as radionecrosis, remains a subject of ongoing investigation. This review discusses the challenges of the use of radiation therapy in NSCLC BMs in view of different systemic treatments such as chemotherapy, TKIs and immunotherapy. It also outlines the future perspectives and strategies for personalized BMs management.

scholarly journals Clinical Characterisation and Management of the Main Treatment-Induced Toxicities in Patients with Hepatocellular Carcinoma and Cirrhosis

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 584
Author(s):  
Fausto Meriggi ◽  
Massimo Graffeo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Impairment ◽  
Hepatic Cirrhosis ◽  
Disease Stage ◽  
The Past ◽  
Systemic Treatments ◽  
Key Points ◽  
Locoregional Therapies ◽  
Almost All ◽  
Selection Of

The incidence of hepatocellular carcinoma (HCC) continues to increase worldwide, particularly in Western countries. In almost all cases, HCC develops in subjects with hepatic cirrhosis, often as the result of hepatitis B or C virus infection, alcohol abuse or metabolic forms secondary to non-alcoholic steatohepatitis. Patients with HCC and hepatic symptoms can therefore present symptoms that are attributable to both conditions. These patients require multidisciplinary management, calling for close interaction between the hepatologist and the oncologist. Indeed, the treatment of HCC requires, depending on the disease stage and the degree of hepatic impairment, locoregional therapies that can in turn be broken down into surgical and nonsurgical treatments and systemic treatments used in the event of progression after the administration of locoregional treatments. The past decade has seen the publication of countless papers of great interest that have radically changed the scenario of treatment for HCC. Novel therapies with biological agents and immunotherapy have come to be standard options in the approach to treatment of this cancer, obtaining very promising results where in the past chemotherapy was almost never able to have an impact on the course of the disease. However, in addition to being costly, these drugs are not devoid of adverse effects and their management cannot forgo the consideration of the underlying hepatic impairment. Patients with HCC and cirrhosis therefore require special attention, starting from the initial characterisation needed for an appropriate selection of those to be referred for treatment, as these patients are almost never fit. In this chapter, we will attempt to investigate and clarify the key points of the management of the main toxicities induced by locoregional and systemic treatments for HCC secondary to cirrhosis.

Animal hair as a rare cause of pilonidal sinus – a case report

Nowa Medycyna ◽  
2018 ◽  
Vol 25 (4) ◽  
Author(s):  
Paweł Dutkiewicz ◽  
Przemysław Ciesielski
Keyword(s):  
Case Report ◽  
Inflammatory Disease ◽  
Pilonidal Sinus ◽  
Human Hair ◽  
Clinical Case ◽  
Chronic Inflammatory Disease ◽  
Animal Origin ◽  
Safe Procedure ◽  
The World ◽  
Animal Hair

Pilonidal sinus is a chronic inflammatory disease caused by the penetration of hair into the skin. Most often, it is located in the intergluteal area, but it may also develop at a different location. It is usually caused by the penetration of human hair, but animal hair can alaso cause it in rare cases. In the world publications, there are reports of the disease in other, often distant locations, e.g. the suprapubic area, armpit, foot, penis, umbilicus, eyelid, clitoris, intermammary cleft, nose, or scar after removing a Tenckhoff catheter. Usually, it is human hair that causes the formation of pilonidal sinus, but the literature also reports cases caused by animal hair in people who shear sheep. There is no other Polish publication describing pilonidal sinus of animal origin. The article presents a case of atypical pilonidal sinus caused by animal hair, located between the fingers of the patient who is professionally involved in shearing dogs. In the presented clinical case, treatment involved staged fistulotomy with the use of surgical thread. The patient was cured and full function of the hand was preserved. Staged fistulotomy is a safe procedure and can be used to treat pilonidal sinus of the hand.

Improved quality of reporting safety data of medication in paediatric randomised controlled trials

2021 ◽  
pp. archdischild-2020-321197
Author(s):  
Taco Jan Prins ◽  
Corine Rollema ◽  
Eric van Roon ◽  
Tjalling de Vries
Keyword(s):  
Adverse Events ◽  
Randomised Controlled Trials ◽  
Safety Data ◽  
Drug Event ◽  
Controlled Trials ◽  
Quality Of Reporting ◽  
Event Reporting ◽  
The Past ◽  
Randomised Controlled

ObjectiveEvaluating the reporting of safety data of medication in paediatric randomised controlled trials (RCTs) in 2017–2018 compared with our earlier study.DesignLiterature search with a systemic appraisal of adverse drug event reporting.Main outcome measuresQuality of reporting of safety data using Consolidated Standards of Reporting Trials (CONSORT) and Ioannidis scores in paediatric drug RCTs. The CONSORT score consists of nine recommendations of the CONSORT Group issued to improve the quality of reporting adverse events. The Ioannidis score is based on these advices. We considered a CONSORT score of at least 6 and an Ioannidis score of at least 3 as sufficient.ResultsWe reviewed 100 RCTs published in 2017 and 2018. Ninety-four (94%) articles mentioned adverse events compared with 78% in the earlier study. Fifty-seven per cent used a standardised method for reporting adverse events compared with 34% in our earlier study. In 26 of the articles, the expected adverse events were defined, and 27 articles had a preset standardised scale for adverse events. Of these, 62 articles (62%) had a CONSORT score of 6 or higher compared with 18% in 2010. In the present study, 67% had an Ioannidis score of 3 or higher, whereas in the earlier study this was 29%. Both differences are statistically significant (p<0.05).ConclusionsReporting safety data in paediatric RCTs has improved over the past 10 years. However, there is still room for improvement and for further improvement. Authors and editors should give more attention to methods for collecting, reporting and presenting safety data of RCTs in studies and manuscripts.

scholarly journals Urban Risks and Resilience

2021 ◽  
pp. 197-211
Author(s):  
Susan L. Cutter
Keyword(s):  
Adverse Events ◽  
Case Studies ◽  
Mitigation Strategies ◽  
Urban Resilience ◽  
Building Capacity ◽  
Urban Informatics ◽  
The Past ◽  
End Point ◽  
Point Versus

AbstractThe resilience concept has become more significant in the past decade as a means for understanding how cities prepare and plan for, absorb, recover from, and more successfully adapt to adverse events. Definitional differences—resilience as an outcome or end-point versus resilience as a process of building capacity—dominate the literature. Lagging behind are efforts to systematically measure resilience to produce a baseline and subsequent monitoring, in order to gauge what, where, and how intervention or mitigation strategies would strengthen or weaken urban resilience. The chapter reviews research and practitioner attempts to develop urban informatics for resilience and provides selected case studies of cities as exemplars.

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