scholarly journals Preparative Purification of Recombinant Proteins: Current Status and Future Trends

2013 ◽  
Vol 2013 ◽  
pp. 1-18 ◽  
Author(s):  
Mayank Saraswat ◽  
Luca Musante ◽  
Alessandra Ravidá ◽  
Brian Shortt ◽  
Barry Byrne ◽  
...  
Keyword(s):  
High Performance ◽  
Cost Effective ◽  
Downstream Processing ◽  
Current Status ◽  
Comprehensive Overview ◽  
Two Phase ◽  
Phase Partitioning ◽  
Absolute Requirement ◽  
Flow Filtration ◽  
Selection Of

Advances in fermentation technologies have resulted in the production of increased yields of proteins of economic, biopharmaceutical, and medicinal importance. Consequently, there is an absolute requirement for the development of rapid, cost-effective methodologies which facilitate the purification of such products in the absence of contaminants, such as superfluous proteins and endotoxins. Here, we provide a comprehensive overview of a selection of key purification methodologies currently being applied in both academic and industrial settings and discuss how innovative and effective protocols such as aqueous two-phase partitioning, membrane chromatography, and high-performance tangential flow filtration may be applied independently of or in conjunction with more traditional protocols for downstream processing applications.

scholarly journals III–V Nanowires: Synthesis, Property Manipulations, and Device Applications

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Ming Fang ◽  
Ning Han ◽  
Fengyun Wang ◽  
Zai-xing Yang ◽  
SenPo Yip ◽  
...  
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Volume Ratio ◽  
Chemical Vapor ◽  
Cost Effective ◽  
Research Field ◽  
Synthesis Methods ◽  
Comprehensive Overview ◽  
Device Applications ◽  
Property Control

III–V semiconductor nanowire (NW) materials possess a combination of fascinating properties, including their tunable direct bandgap, high carrier mobility, excellent mechanical flexibility, and extraordinarily large surface-to-volume ratio, making them superior candidates for next generation electronics, photonics, and sensors, even possibly on flexible substrates. Understanding the synthesis, property manipulation, and device integration of these III–V NW materials is therefore crucial for their practical implementations. In this review, we present a comprehensive overview of the recent development in III–V NWs with the focus on their cost-effective synthesis, corresponding property control, and the relevant low-operating-power device applications. We will first introduce the synthesis methods and growth mechanisms of III–V NWs, emphasizing the low-cost solid-source chemical vapor deposition (SSCVD) technique, and then discuss the physical properties of III–V NWs with special attention on their dependences on several typical factors including the choice of catalysts, NW diameters, surface roughness, and surface decorations. After that, we present several different examples in the area of high-performance photovoltaics and low-power electronic circuit prototypes to further demonstrate the potential applications of these NW materials. Towards the end, we also make some remarks on the progress made and challenges remaining in the III–V NW research field.

Design and Analysis of Rotary Positive Displacement Mechanism for Oil-Less Compression

2010 ◽  
Author(s):  
Holger Roser
Keyword(s):  
High Speed ◽  
High Performance ◽  
Effective Means ◽  
Cost Effective ◽  
Industrial Applications ◽  
Two Phase ◽  
Major Drawback ◽  
Displacement Mechanism ◽  
Flow Losses ◽  
Positive Displacement

In this paper, a simple positive displacement mechanism is investigated, which comprises two counter-rotating meshing rotors within a casing. Although considered for various applications more than a century ago, the basic geometry of this mechanism has not been further explored or adapted to modern gas compressor technology. As a fully balanced rotational mechanism operating at uniform angular velocity, potential applications range from pumps to expanders, from slow large displacement to high-speed devices; nonetheless, this research focuses on high-performance oil-less gas compressors as an ideal application. During one complete cycle, the main rotor compresses and discharges the fluid, whilst the secondary rotor seals the compression chamber. Important features of this mechanism are the circular profiles of the rotors, the potential to accommodate large ports for reduced flow losses, and ease of cooling. The simple geometry facilitates a cost-effective means of achieving tight operating clearances between rotors and casing for enhanced sealing without the need for liquid lubricants such as oil. This study and preliminary tests indicate that pressure ratios suitable for standard industrial applications can be obtained over a broad speed range, whilst minimizing friction and flow losses, a major drawback of current technologies. Moreover, two-phase compression and injection of liquids prior to compression have been studied and identified as a means to further improve efficiency and cooling.

ASSESSMENT OF ECONOMIC EFFICIENCY AT THE DESIGN STAGES OF FLEXIBLE MANUFACTURE SYSTEMS

2021 ◽  
pp. 26-32
Author(s):  
J. F. Mammadov ◽  
G. S. Abdullayev ◽  
I. L. Korshunov ◽  
I. R. Aliyev
Keyword(s):  
Economic Efficiency ◽  
Hydraulic System ◽  
High Performance ◽  
Cost Effective ◽  
Correct Choice ◽  
Point Of View ◽  
Active Elements ◽  
Economic Justification ◽  
Flexible Manufacture ◽  
Selection Of

Based on the analysis of economic and technical indicators of the efficiency of the flexible manufacture system (FMS), the criteria for choosing a cost-effective project of the hydraulic system were determined, taking into account the minimization of automated technical systems, technological equipment and increasing the productivity of the designed enterprise. The ranking method is used to decide the correct choice of the most effective FMS project. An algorithm is proposed to substantiate economic efficiency by minimizing the costs of the selected active elements and increasing the productivity of the investigated production. On the basis of a sequential, parallel and parallel-circular layout diagram of the production modules of the FMS, a study is carried out on their choice and economic justification. To determine specific comparative economic indicators from the point of view of minimizing the number of active elements and their temporal indicators of technological operations, an algorithm for choosing a layout diagram of a FMS production module is proposed. The developed algorithm makes it possible to evaluate the economic efficiency taking into account the number of active elements, their types and types of technological operations. The process of selection of the parallel-circular layout scheme of FMS depending on the number of finished products has been substantiated which ensures high performance of the parallel-circular layout scheme of FMS.

Assessment of Silicon—On—Insulator Technologies for Vlsi

1985 ◽  
Vol 53 ◽  
Author(s):  
B-Y. Tsaur
Keyword(s):  
High Performance ◽  
Cost Effective ◽  
Silicon On Insulator ◽  
Current Status ◽  
High Dose ◽  
Future Prospects ◽  
Device Structures ◽  
Radiation Hardened ◽  
Near Term ◽  
Soi Technology

ABSTRACTA high—performance, cost—effective silicon—on—insulator (SOI) technology would have important near—term applications in radiation—hardened electronics and longer term applications in submicrometer VLSI. The advantages of SOI over bulk Si technology for these applications will be outlined, and CMOS, CJFET, andbipolar device structures being developed for SOI will be discussed. The current status and future prospects of the two most promising SOI technologies —— beam recrystallization and high—dose oxygen implantation —— will be reviewed, with emphasis on such issues critical to commercialization as material quality and manufacturing feasibility.

Decision Support Tools for Selection of External Protective Coating for Pipelines

2017 ◽  
Author(s):  
S. Yasseri ◽  
H. Bahai ◽  
M. T. Rahmati
Keyword(s):  
Decision Support ◽  
High Performance ◽  
Selection Process ◽  
Decision Support Tool ◽  
Cost Effective ◽  
Single Type ◽  
Support Tool ◽  
Support Tools ◽  
Good Coating ◽  
Selection Of

A good coating is one with high performance and durability; has a low surveillance and maintenance requirement; is easily applied with no health risks and finally is cost effective. It is unlikely that a single type of coating would be able to satisfy all these needs. Thus, a decision support tool is needed to help identify the most appropriate choice. This paper presents three simple methods for this selection process, and allows the judgment of more than one expert to be aggregated in order to reach a consensus. An example is presented which demonstrates the application of these methods, by providing the decision-maker the ability to weigh options and set priorities in deciding on the best compromise solution for a corrosion coating material.

scholarly journals Latest Advances in Protein-Recovery Technologies from Agricultural Waste

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2748
Author(s):  
Farhana Iylia Fatinee Mohd Yusree ◽  
Angela Paul Peter ◽  
Mohd Zuhair Mohd Nor ◽  
Pau Loke Show ◽  
Mohd Noriznan Mokhtar
Keyword(s):  
High Efficiency ◽  
Agricultural Waste ◽  
Cost Effective ◽  
Extraction Methods ◽  
Water Soluble ◽  
Membrane Extraction ◽  
Protein Recovery ◽  
Two Phase ◽  
Phase Partitioning ◽  
Extraction And Purification

In recent years, downstream bioprocessing industries are venturing into less tedious, simple, and high-efficiency separation by implementing advanced purification and extraction methods. This review discusses the separation of proteins, with the main focus on amylase as an enzyme from agricultural waste using conventional and advanced techniques of extraction and purification via a liquid biphasic system (LBS). In comparison to other methods, such as membrane extraction, precipitation, ultrasonication, and chromatography, the LBS stands out as an efficient, cost-effective, and adaptable developing method for protein recovery. The two-phase separation method can be water-soluble polymers, or polymer and salt, or alcohol and salt, which is a simpler and lower-cost method that can be used at a larger purification scale. The comparison of different approaches in LBS for amylase purification from agricultural waste is also included. Current technology has evolved from a simple LBS into microwave-assisted LBS, liquid biphasic flotation (LBF), thermoseparation (TMP), three-phase partitioning (TPP), ultrasound-assisted LBS, and electrically assisted LBS. pH, time, temperature, and concentration are some of the significant research parameters considered in the review of advanced techniques.

Electron-deficient boron-based catalysts for C–H bond functionalisation

2021 ◽  
Author(s):  
Yuanhong Ma ◽  
Shao-Jie Lou ◽  
Zhaomin Hou
Keyword(s):  
Review Article ◽  
Current Status ◽  
Comprehensive Overview

This review article provides a comprehensive overview to recognise the current status of electron-deficient boron-based catalysis in C–H functionalisations.

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