scholarly journals Assessment of Serum Zinc Levels of Patients with Thalassemia Compared to Their Siblings

Anemia ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed El Missiry ◽  
Mohamed Hamed Hussein ◽  
Sadaf Khalid ◽  
Naila Yaqub ◽  
Sarah Khan ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Zn Deficiency ◽  
Median Serum ◽  
Significant Difference ◽  
Serum Zn ◽  
Z Scores ◽  
Absolute Lymphocyte Counts ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Height For Age

Zinc (Zn) is essential for appropriate growth and proper immune function, both of which may be impaired in thalassemia children. Factors that can affect serum Zn levels in these patients may be related to their disease or treatment or nutritional causes. We assessed the serum Zn levels of children with thalassemia paired with a sibling. Zn levels were obtained from 30 children in Islamabad, Pakistan. Serum Zn levels and anthropometric data measures were compared among siblings. Thalassemia patients’ median age was 4.5 years (range 1–10.6 years) and siblings was 7.8 years (range 1.1–17 years). The median serum Zn levels for both groups were within normal range: 100 μg/dL (10 μg/dL–297 μg/dL) for patients and 92 μg/dL (13 μg/dL–212 μg/dL) for siblings. There was no significant difference between the two groups. Patients’ serum Zn values correlated positively with their corresponding siblings (r=0.635,P<0.001). There were no correlations between patients’ Zn levels, height for age Z-scores, serum ferritin levels, chelation, or blood counts (including both total leukocyte and absolute lymphocyte counts). Patients’ serum Zn values correlated with their siblings’ values. In this study, patients with thalassemia do not seem to have disease-related Zn deficiency.

scholarly journals A study of serum zinc levels in children with febrile convulsions in comparison with normal and febrile children

2020 ◽  
Vol 7 (3) ◽  
pp. 588
Author(s):  
Madhubalan T. ◽  
Chidambaranathan S. ◽  
Ramamoorthy R.
Keyword(s):  
Statistical Significance ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Normal Children ◽  
Febrile Convulsions ◽  
Significant Difference ◽  
Zinc Levels ◽  
The Brain ◽  
Serum Zinc Levels

Background: A seizure is a paroxysmal time-limited change in motor activity and or behavior that results from abnormal electrical activity in the brain. Seizures are common in the pediatric age group and occur in approximately 10% of children. Most seizures in children are provoked by somatic disorders originating outside the brain such as high fever, infection, syncope, head trauma, hypoxia, or toxins. To determine whether children with febrile convulsion have decreased serum zinc level when compared to normal children and children with fever without convulsions.Methods: The study included children admitted with bronchiolitis in between during the period of September 2018 to January 2019 at Department of Pediatrics, Raja Muthiah Medical College and Hospital. It is a case-control study. A sample size of 50 was selected for each group Totally 3 Groups, 1. Children with febrile convulsions,2. Children with fever without convulsions, 3. Normal Children.Results: The mean serum zinc level in children with febrile convulsions was 42.9 mcg/dl. The serum zinc level in children with fever and normal children was 70 mcg/dl and 71 mcg/dl respectively. On comparing the serum zinc level among the three groups statistical significance was obtained between children with febrile convulsions and the other two groups namely normal children and children with fever alone. Thus, decreased serum zinc level is a significant predisposing factor for febrile convulsions. By using Posthoc Multiple comparisons test we came to know that the Fever convulsion group is significantly different from fever and normal group. There is no significant difference between fever and normal group.Conclusions: This study shows that serum zinc levels are decreased in children with febrile convulsions, thus indicating that zinc deprivation plays a significant role in the pathogenesis of febrile convulsions.

scholarly journals Serum Zinc Status in Post Menopausal Women Attending in a Tertiary Care Hospital of Bangladesh

2019 ◽  
Vol 9 (2) ◽  
pp. 147-150
Author(s):  
Nadia Ferdous ◽  
Farzana Akonjee Mishu ◽  
Shamsunnahar ◽  
Fahmida Islam ◽  
Shabnam Sarwar Sejooti
Keyword(s):  
Clinical Symptoms ◽  
Tertiary Care ◽  
Serum Zinc ◽  
Premenopausal Women ◽  
Care Hospital ◽  
College Hospital ◽  
Medical College ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross-sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology , Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal womenaged between 45-70 years were considered as case and another 50 regular menstruating premenopausal women aged between 30-40 years were selected as control. Results: The mean age of case and control groups was 50.5± 2.3 years and 36.5± 4.4 years respectively. In this study serum zinc levels in cases and controls were 71.54 ± 5.69 ìg /dl and 74.68 ± 5.453 ìg/dl respectively, and there was significant difference(p<0.01). Conclusion: Serum zinc level was significantly decreased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum zinc levels might be incorporated in every postmenopausal for possible prevention of complications. Birdem Med J 2019; 9(2): 147-150

scholarly journals Pengaruh suplementasi zink terhadap parameter hematologi atlet sepatu roda setelah latihan endurance

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Mirza Hapsari Sakti Titis Penggalih ◽  
Mustika Cahya Nirmala Dewinta ◽  
Choiri Khumaidah Fikriyah ◽  
Noni Kustia ◽  
Assyifatu Rahmah Zada ◽  
...  
Keyword(s):  
Endurance Training ◽  
Endurance Exercise ◽  
Zinc Supplementation ◽  
Cell Damage ◽  
Serum Zinc ◽  
Hemoglobin Concentration ◽  
Significant Difference ◽  
Leukocyte Counts ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: In sports such as roller skates, endurance can lead to increased inflammation and muscle cell damage, free radical formation, and zinc excretion from sweat and urine that affect the increased redistribution of zinc from blood to tissue. This mechanism causes a decrease in blood zinc levels, erythrocyte numbers and hemoglobin concentrations, increased leukocyte counts and the body’s oxidative stress parameters that have an impact on the athlete’s performance decline. Zinc supplementation may be given to maintain the athlete’s hematologic parameters during endurance exercise.Objectives: To examine the effect of zinc supplementation on serum zinc level, hemoglobin concentration, erythrocyte and leukocyte counts, and blood MDA level of skate athletes after endurance exercise.Method: This study was an experimental clinical trial using pre and post-test designs on 8 athletes incorporated in the Pre-PON DIY Wheels Team. The study was conducted in two periods, one week of endurance exercise without zinc supplementation and one week of endurance exercise with 30 mg/d of zinc supplementation. Blood sampling was performed on the seventh day of each period, before and after endurance training.Results: There was a decrease in erythrocytes and hemoglobin concentration, and a significant increase in leukocyte count after endurance training in both periods (p<0.05), but no significant difference in serum zinc levels and MDA levels after endurance training in both periods (p>0.05). Although there were no significant differences in all athlete hematologic parameters between two treatments (p>0.05), there was an improvement in serum zinc levels, hemoglobin concentrations, erythrocyte, and leukocyte counts.Conclusion: Zinc supplementation 30 mg/day for one week did not have a significant effect on the athlete’s hematology parameters after endurance exercise.

scholarly journals Zinc Intake, Zinc Serum Levels, and Intelligence in School Children in Rural Areas

2021 ◽  
Vol 9 (E) ◽  
pp. 394-397
Author(s):  
Rostika Flora ◽  
Nur Alam Fajar ◽  
Fatmalina Febri ◽  
Indah Yuliana ◽  
Yuliarti Yuliarti ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
School Children ◽  
Significant Relationship ◽  
Rural Areas ◽  
Serum Zinc ◽  
Zinc Intake ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

BACKGROUND: Children in rural areas are susceptible to zinc deficiency. Zinc deficiency in children can affect cognitive function in children. Zinc plays a role in cellular function and critical brain growth processes, including cell replication, DNA and RNA synthesis, and the release of neurotransmitters. AIM: This study aimed to analyze the condition of zinc deficiency and its relationship with the level of intelligence in children in rural areas. METHODS: The study design was cross-sectional, with a sample of 44 elementary school children aged 9–12 years taken randomly. Blood was drawn to measure serum Zn-levels, and serum Zn-levels were measured using Colorimetric Assay Kit (E-BC-K137). Zinc intake data were obtained from the food recall form, which was carried out 3 × 24 h. The level of intelligence is measured by the Culture Fair Intelligence Test method. The sample characteristics data obtained through a questionnaire. Furthermore, the data were analyzed using the Chi-square test. RESULTS: About 84.2% of children with insufficient zinc intake had low serum Zn-levels. There was a significant relationship between zinc intake and serum zinc levels (p = 0.026; PR = 4.293). Children with low serum zinc levels of 96.5% have intelligence levels below average. There was a significant relationship between serum zinc levels and intelligence level as well (p = 0.001; PR = 24,500). CONCLUSION: Zinc deficiency in children is characterized by low serum Zn-levels. Low serum Zn-level is caused by low zinc intake, thus children with low serum Zn-levels are at risk of having intelligence level below average. Therefore, health education about the importance of zinc intake in children should be given to parents, so that the incidence of zinc deficiency in children can be reduced.

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals Changes in Serum Zinc Levels in Relation to Blood Pressure During Anaesthesia

2003 ◽  
Vol 40 (138) ◽  
pp. 67-71
Author(s):  
H K Garg ◽  
P Agrawal ◽  
S Haleem
Keyword(s):  
Venous Blood ◽  
Serum Zinc ◽  
Study Groups ◽  
Surgical Operation ◽  
Defence Mechanisms ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Age And Sex ◽  
Maximum Rise

Fifty age and sex matched patients admitted for surgical operation, were divided intonormotensive (control) and hypertensive (study) groups. Systolic and diastolic bloodpressures were recorded preoperatively, 10 min after intubation, at max-increase ofBP and 24 hours postoperatively. 5 ml. venous blood samples were drawn at thesetime periods, and serum zinc was also estimated. Control Gp (normotensive) subjectrecorded fall (p < 0.001) in serum Zn 10 min after intubation (n = 18) and max. Riseof BP (n = 7), Twelve subjects in study Gp recorded a rise in serum Zn at max. Increaseof BP (p < 0.01). The pattern in normotensives points towards mobilization of zinc,while in hypertensives, homeostatic, defence mechanisms appear to resist mobilizationof serum Zn till maximum rise in BP occurs, indicating hormonal and other influenceson serum Zn levels during anaesthesia.Key Words: Serum Zinc, Systolic BP, Diastolic BP, Anaesthesia

scholarly journals Association between Serum Zinc and hs-CRP Concentrations in Different Metabolic Syndrome Phenotypes

2021 ◽  
Author(s):  
Susan Darroudi ◽  
Batool Tayefi ◽  
Habibollah Esmaily ◽  
Fatemeh Sadabadi ◽  
Hamideh Moalemzadeh Haghighi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Zinc ◽  
Heart Association ◽  
Flame Atomic Absorption ◽  
Increased Risk ◽  
Serum Zn ◽  
Hs Crp ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Abstract Background: Metabolic syndrome (MetS) is associated with an increased risk of cardiovascular disease and all-cause mortality. Zinc (Zn) is an essential trace element for the synthesis, storage, and release of insulin. The relationship between serum Zn and MetS is controversial. In this study we have evaluated whether serum Zn levels are associated with hsCRP level according to MetS phenotypes. Method: A total of 9493 individuals (3768 men and 5635 women) were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. We measured the concentration of serum Zn by flame atomic absorption (Varian AA240FS) and we divided the subjects into quartile of serum Zn. We used SPSS version 18 statistical analyses for all. GraphPad Prism 6 for figures was used.Results: In this study there were significant differences between quartiles of Zn according to sex. The results showed that the level of serum hs-CRP were higher in subjects with metabolic syndrome who also had a serum Zn >95 µg/dl. In subjects with serum Zn <70 µg/dl, an increase in serum hs-CRP was associated with an increased risk of MetS by 2.2%, 1.022(CI: 1.01-1.034). Moreover, among subjects in the first, second and third quartiles of serum Zn, some phenotypes of metabolic syndrome (WHB, WHT, WTG, WTB, WHBG, WHTG, and WTBG) were associated with a risk of increasing hs-CRP level (p< 0.05). Conclusion: Serum hs-CRP concentrations were related to MetS phenotypes. This relationship was modified by serum Zn level. According to the number of MetS components serum Zn levels decreased as the number of MetS component increased, and low serum zinc levels (Q1) showed an overall greater prevalence of MetS.

Levels of Serum Zinc and Manganese among Post-Menopausal Patients with Thyroid Dysfunction

2016 ◽  
Vol 5 (02) ◽  
pp. 4821
Author(s):  
Sharique Ahmad* ◽  
Saeeda Wasim
Keyword(s):  
Thyroid Dysfunction ◽  
Serum Zinc ◽  
Flame Atomic Absorption ◽  
Flame Atomic Absorption Spectrophotometer ◽  
Serum Zn ◽  
Zinc Levels ◽  
Post Menopausal ◽  
Manganese Level ◽  
Serum Zinc Levels

The objective of this study is to shed more light on the role of trace metals and their mode of action in hyperthyroidism and hypothyroidism in Post-Menopausal Patients. The content of the trace elements Zinc and Manganese (Zn, and Mn) in the serum of patients was determined. Forty patients with hyperthyroidism and hypothyroidism were participated in this study. Serum zinc and manganese were determined using flame atomic absorption spectrophotometer technique. The study showed that serum zinc and manganese levels of hyperthyroidism patients were significantly lower (p<0.05). While a significant increase in serum manganese level with decrease serum zinc levels in patients with hypothyroidism (p<0.05).  The present study confirmed a significant change in the levels of serum Zn, Mn in hyperthyroidism and hypothyroidism among Post-Menopausal patients and these changes may be related to pathophysiology of thyroid disease.

scholarly journals Investigation of Serum Zinc Level in Patients with Hearing Loss and its Association with Tinnitus

2020 ◽  
Author(s):  
V Zand ◽  
P Hosseinpoor ◽  
MH Baradaranfar ◽  
M Meybodian ◽  
M Mandegari ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Correlation Coefficient ◽  
Serum Zinc ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Study Results ◽  
Significant Difference ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Introduction: This study aims to determine the serum zinc level in patients with hearing loss and its relation with tinnitus.  Materials & Methods: In this Cross-Sectional study, 110 patients older than 20 years old with Complaining of hearing loss and tinnitus were involved. Participating patients were first visited by an ear, nose, and throat specialist with a history and physical examination, and were assessed for standard hearing loss as well as the intensity and frequency of tinnitus by standard audiometric tests. Then, fasting blood samples were taken to check serum zinc levels. Results:The mean serum level was 85.32 ± 27 27.62, and the mean frequency of tinnitus was 4.94 ± 2.76, both of which had significant differences between different groups (P = 0.001). The mean intensity of tinnitus was 7.77 ± 4.56, and there was no significant difference between different groups (P = 0.677). Serum zinc level and tinnitus frequency were associated with a correlation coefficient of 0.205 (P = 0.032), and serum zinc level and tinnitus severity were associated with a correlation coefficient of 0.249 (P = 0.009). Conclusion: According to the present study results, the positive effect of serum zinc levels on the severity and frequency of tinnitus has been determined so that with decreasing serum zinc levels, tinnitus occurs at lower frequencies.

scholarly journals Serum zinc levels in children with upper respiratory tract infection in the age 2-12years in Pakistan.

2020 ◽  
Vol 27 (09) ◽  
pp. 1927-1930
Author(s):  
Firdos Jabeen ◽  
Muhammad Fayaz Khan Burki ◽  
Muhammad Naeem Burki ◽  
Nawab Zada Khan ◽  
Abdus Salam ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Serum Zinc ◽  
Zinc Level ◽  
Upper Respiratory Tract ◽  
Serum Zinc Level ◽  
Serum Zn ◽  
Upper Respiratory ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objectives: The persuasive evidence shows that proper Zinc (Zn) nutrition is important for human health. Hence an attempt was made to evaluate the serum Zn levels in children suffering from high respiratory infection in children aged 2-12years in Pakistan. Study Design: Case-control study. Setting: Jinnah Medical Teaching Hospital Peshawar with the collaboration of National Physical Standard Laboratory PCSIR Islamabad. Period: March 2017 to March 2019. Material & Methods: 60 children who were suffering from upper respiratory tract infection and were admitted in the Paediatric ward of Jinnah medical teaching hospital Peshawar. 60 normal controls of the same genders with an age range 2-12 years were selected for this study. Serum zinc levels were measured with atomic absorption spectrophotometer (AAS). Results: The serum zinc level was found to be low in 80% patients. Mean ±SD of serum zinc were 58.9 ±2.70µg/dl in diseased group and 100 ±2.22µg/dl in controls respectively. In patients serum zinc level was significantly lower than that of healthy controls (P<0.001). Conclusion: We may conclude that Zinc deficiency may play a role in the pathogenesis of upper tract respiratory infection since most diseased children have low serum Zn level.

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