Intestinal Parasites Coinfection Does Not Alter Plasma Cytokines Profile Elicited in Acute Malaria in Subjects from Endemic Area of Brazil

In Brazil, malaria is prevalent in the Amazon region and these regions coincide with high prevalence of intestinal parasites but few studies explore the interaction between malaria and other parasites. Therefore, the present study evaluates changes in cytokine, chemokine, C-reactive protein, and nitric oxide (NO) concentrations in 264 individuals, comparing plasma from infected individuals with concurrent malaria and intestinal parasites to individuals with either malaria infection alone and uninfected. In the studied population 24% of the individuals were infected withPlasmodiumand 18% coinfected with intestinal parasites. Protozoan parasites comprised the bulk of the intestinal parasites infections and subjects infected with intestinal parasites were more likely to have malaria. The use of principal component analysis and cluster analysis associated increased levels of IL-6, TNF-α, IL-10, and CRP and low levels of IL-17A predominantly with individuals with malaria alone and coinfected individuals. In contrast, low levels of almost all inflammatory mediators were associated predominantly with individuals uninfected while increased levels of IL-17A were associated predominantly with individuals with intestinal parasites only. In conclusion, our data suggest that, in our population, the infection with intestinal parasites (mainly protozoan) does not modify the pattern of cytokine production in individuals infected withP. falciparumandP. vivax.

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Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases

Scientific Reports ◽

10.1038/s41598-021-94685-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Laura Tasson ◽

Fabiana Zingone ◽

Brigida Barberio ◽

Romina Valentini ◽

Pamela Ballotta ◽

...

Keyword(s):

Fecal Calprotectin ◽

Healthy Population ◽

C Reactive Protein ◽

Reactive Protein ◽

Severe Fatigue ◽

High Prevalence ◽

Bowel Diseases ◽

Moderate Fatigue ◽

Inflammatory Bowel ◽

Severe Anxiety

AbstractPatients with inflammatory bowel disease (IBD) report fatigue more frequently than healthy population, but the precise mechanisms underlying its presence are unknown. This study aimed to evaluate the prevalence of fatigue in IBD and its relation with potential causative factors. A survey on fatigue, depression, anxiety, sleep disorders, and the presence of sarcopenia and malnutrition, was sent by email to 244 IBD outpatients of the Gastroenterology Unit of Academic Hospital of Padua. Demographics and clinical data, including the levels of fecal calprotectin (FC) and C-reactive protein (CRP), and current pharmacological treatments were obtained from patients’ medical records. Ninety-nine (40.5%) subjects answered the survey. Ninety-two (92.9%) patients reported fatigue, with sixty-six having mild to moderate fatigue and twenty-six severe fatigue. Multivariate analysis showed that abnormal values of CRP (OR 5.1), severe anxiety (OR 3.7) and sarcopenia (OR 4.4) were the factors independently associated with severe fatigue. Fatigue has a high prevalence in subject affected by IBD. Subjects with altered CRP, sarcopenia and severe anxiety appear more at risk of severe fatigue.

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High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation

Human Immunology ◽

10.1016/j.humimm.2012.01.009 ◽

2012 ◽

Vol 73 (4) ◽

pp. 382-388 ◽

Cited By ~ 11

Author(s):

Christopher Sjöwall ◽

Kristina Cardell ◽

Elisabeth A. Boström ◽

Maria I. Bokarewa ◽

Helena Enocsson ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Liver Fibrosis ◽

Chronic Hepatitis C ◽

C Reactive Protein ◽

Hepatitis C Infection ◽

Reactive Protein ◽

High Prevalence

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Body fat distribution and C-reactive protein – a principal component analysis

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2009.10.013 ◽

2011 ◽

Vol 21 (5) ◽

pp. 347-354 ◽

Cited By ~ 5

Author(s):

A. Oliveira ◽

C. Lopes ◽

M. Severo ◽

F. Rodríguez-Artalejo ◽

H. Barros

Keyword(s):

Principal Component Analysis ◽

Body Fat ◽

Protein A ◽

Principal Component ◽

Fat Distribution ◽

Component Analysis ◽

Body Fat Distribution ◽

C Reactive Protein ◽

Reactive Protein

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Pattern recognition of enrichment levels of SELEX-based candidate aptamers for human C-reactive protein

Biomedical Engineering / Biomedizinische Technik ◽

10.1515/bmt-2015-0230 ◽

2017 ◽

Vol 62 (3) ◽

Author(s):

Xinliang Yu ◽

Ruqin Yu ◽

Xiaohai Yang

Keyword(s):

Pattern Recognition ◽

Latent Variables ◽

Molecular Descriptors ◽

Principal Component ◽

Support Vector ◽

C Reactive Protein ◽

Reactive Protein ◽

Systematic Evolution ◽

Model C ◽

Exponential Enrichment

AbstractSelecting aptamers for human C-reactive protein (CRP) would be of critical importance in predicting the risk for cardiovascular disease. The enrichment level of DNA aptamers is an important parameter for selecting candidate aptamers for further affinity and specificity determination. This paper is the first report on pattern recognition used for CRP aptamer enrichment levels in the systematic evolution of ligands by exponential enrichment (SELEX) process, by applying structure-activity relationship models. After generating 10 rounds of graphene oxide (GO)-SELEX and 1670 molecular descriptors, eight molecular descriptors were selected and five latent variables were then obtained with principal component analysis (PCA), to develop a support vector classification (SVC) model. The SVC model (C=8.1728 and

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Antibodies against Malondialdehyde in Haemodialysis Patients and Its Association with Clinical Outcomes: Differences between Subclasses and Isotypes

Journal of Clinical Medicine ◽

10.3390/jcm9030753 ◽

2020 ◽

Vol 9 (3) ◽

pp. 753

Author(s):

Shailesh Kumar Samal ◽

Abdul Rashid Qureshi ◽

Mizanur Rahman ◽

Peter Stenvinkel ◽

Johan Frostegård

Keyword(s):

Significant Risk ◽

Premature Death ◽

C Reactive Protein ◽

Reactive Protein ◽

Multivariate Risk ◽

Increased Risk ◽

All Cause Mortality ◽

Low Levels ◽

Antibody Levels

Patients on haemodialysis (HD-patients) have an increased risk of premature death. Low levels of IgM antibodies against malondialdehyde (anti-MDA) are associated with increased risk of cardiovascular disease (CVD) with underlying potential mechanisms described. Here, we studied subclasses and isotypes of anti-MDA in 210 HD-patients with mortality as outcome (56% men, median age 66, Interquartile range (IQR) 51–74 years, vintage time 29 (15–58) months, mean follow up period of 41 (20–60)months). Patients were also divided into inflamed c-reactive protein (CRP >5.6 mg/mL) and non-inflamed. Antibody levels were measured by ELISA. In multivariate risk analysis, patients in low tertile of IgM anti-MDA sub-distribution hazard ratio (sHR 0.54); 95% confidence interval (CI: 0.34–0.89) inversely and significantly associated with all-cause mortality after five years, after adjusting for confounders. Low tertile of IgG (sHR 0.48, 95%CI: 0.25–0.90, p = 0.02) and IgG1 (sHR 0.50, CI: 0.24–1.04, p = 0.06) was associated low mortality among non-inflamed patients. In contrast, anti-MDA IgG2 among inflamed patients was significantly associated with increased mortality, IgG2(sHR 2.33, CI: 1.16–4.68, p = 0.01). IgM anti-MDA was a novel biomarker among HD-patients with low levels being associated with mortality, while low levels of IgG and IgG1 but not IgA anti-MDA were associated with mortality only among non-inflamed patients. IgG2 anti-MDA was a significant risk marker among inflamed patients, which could be related to infection.

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Regression Correction Equation to Adjust Serum Iron and Ferritin Concentrations Based on C-Reactive Protein and Albumin in Patients Receiving Primary and Secondary Care

Journal of Nutrition ◽

10.1093/jn/nxz008 ◽

2019 ◽

Vol 149 (5) ◽

pp. 877-883 ◽

Cited By ~ 3

Author(s):

Stephen T McSorley ◽

Alexander Tham ◽

Iain Jones ◽

Dinesh Talwar ◽

Donald C McMillan

Keyword(s):

Iron Deficiency ◽

Linear Regression ◽

Serum Ferritin ◽

Secondary Care ◽

Serum Iron ◽

C Reactive Protein ◽

Reactive Protein ◽

Iron Deficient ◽

Significant Difference ◽

Low Levels

ABSTRACT Background Systemic inflammation, even at low levels, can greatly interfere with measures of iron status, making diagnosis of iron deficiency difficult. The objective of the present study was to create linear regression correction equations to adjust serum ferritin and iron concentrations based on measurements of the acute-phase proteins C-reactive protein (CRP) and albumin. Methods Data from a cohort (1) of patients (n = 7226) in primary and secondary care who had serum ferritin, iron, CRP, and albumin measured at the same time point were examined. Linear regression coefficients were calculated for CRP and albumin with serum iron and ferritin as the outcome variables. Patients with ferritin <15 µg/L or serum iron <10 µmol/L were categorized as iron deficient. The equation was then applied to a cohort (2) of patients with colorectal cancer who had ferritin and iron measured preoperatively ( n = 356). Results In cohort 1 there was a significant difference in the proportions of patients with serum ferritin <15 µg/L and serum iron <10 µmol/L, respectively, when the unadjusted (7% and 55%), adjusted based on CRP alone (13% and 26%), adjusted based on albumin alone (11% and 37%), and adjusted based on both CRP and albumin (24% and 15%) values were compared (both P < 0.001). In cohort 2 there was a significant difference in the proportions of patients with serum ferritin <15 µg/L and serum iron <10 µmol/L, respectively, when the unadjusted (28% and 66%), adjusted based on CRP alone (39% and 57%), adjusted based on albumin alone (39% and 59%), and adjusted based on both CRP and albumin (46% and 44%) values were compared (P < 0.001 and P < 0.004). Conclusions In both cohorts the greatest increase in the proportion of patients meeting definitions of iron deficiency was found when adjustment was made for both CRP and albumin together. Even low levels of inflammation had a significant effect on serum iron and ferritin values.

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Low Levels of Procalcitonin or Presepsin Combined with Significantly Elevated C-reactive Protein May Suggest an Invasive Fungal Infection in Hematological Patients With Febrile Neutropenia

HemaSphere ◽

10.1097/hs9.0000000000000170 ◽

2019 ◽

Vol 3 (1) ◽

pp. e170

Author(s):

Igor Stoma ◽

Igor Karpov ◽

Anatoly Uss ◽

Svetlana Krivenko ◽

Igor Iskrov ◽

...

Keyword(s):

Febrile Neutropenia ◽

Fungal Infection ◽

Invasive Fungal Infection ◽

C Reactive Protein ◽

Reactive Protein ◽

Hematological Patients ◽

Low Levels

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Metabolic and Functional Profile of Premenopausal Women With Metabolic Syndrome After Training With Elastics as Compared to Free Weights

Biological Research For Nursing ◽

10.1177/1099800416674307 ◽

2016 ◽

Vol 19 (2) ◽

pp. 190-197 ◽

Cited By ~ 5

Author(s):

Jorge Flandez ◽

Noelia Belando ◽

Pedro Gargallo ◽

Julio Fernández-Garrido ◽

Ronald A. Vargas-Foitzick ◽

...

Keyword(s):

Metabolic Syndrome ◽

Premenopausal Women ◽

Control Group ◽

Positive Trend ◽

C Reactive Protein ◽

Functional Profile ◽

Reactive Protein ◽

Almost All ◽

Sedentary Women ◽

Experimental Group

The aim of this study was to compare the effects of a strength training program (STP) using free weights (FW) versus elastic tubing (ET) in 62 premenopausal, sedentary women diagnosed with metabolic syndrome (MS). Participants were randomly assigned to the FW or ET experimental group (EG) or a control group whose members remained sedentary. Members of each EG followed their assigned STP for 12 weeks, and biomarkers (BMs) related to MS and motor function (MF) parameters were evaluated. Both EGs showed a significant reduction in C-reactive protein level and a positive trend in the other BMs. Almost all MF parameters increased significantly in both EGs. No positive changes were found in the CG. These results indicate that the implementation of an STP, with either FW or ET, improves both metabolic health and MF and should be considered part of the basic approach to health care in women.

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