scholarly journals Hepatitis B, HIV, and Syphilis Seroprevalence in Pregnant Women and Blood Donors in Cameroon

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jodie Dionne-Odom ◽  
Rahel Mbah ◽  
Nicole J. Rembert ◽  
Samuel Tancho ◽  
Gregory E. Halle-Ekane ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Urban Areas ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Cross Sectional ◽  
Effective Prevention ◽  
Seroprevalence Data ◽  
In Pregnancy

Objectives. We estimated seroprevalence and correlates of selected infections in pregnant women and blood donors in a resource-limited setting.Methods. We performed a cross-sectional analysis of laboratory seroprevalence data from pregnant women and voluntary blood donors from facilities in Cameroon in 2014. Rapid tests were performed to detect hepatitis B surface antigen, syphilis treponemal antibodies, and HIV-1/2 antibodies. Blood donations were also tested for hepatitis C and malaria.Results. The seroprevalence rates and ranges among 7069 pregnant women were hepatitis B 4.4% (1.1–9.6%), HIV 6% (3.0–10.2%), and syphilis 1.7% (1.3–3.8%) with significant variability among the sites. Correlates of infection in pregnancy in adjusted regression models included urban residence for hepatitis B (aOR 2.9, CI 1.6–5.4) and HIV (aOR 3.5, CI 1.9–6.7). Blood donor seroprevalence rates and ranges were hepatitis B 6.8% (5.0–8.8%), HIV 2.2% (1.4–2.8%), syphilis 4% (3.3–4.5%), malaria 1.9%, and hepatitis C 1.7% (0.5–2.5%).Conclusions. Hepatitis B, HIV, and syphilis infections are common among pregnant women and blood donors in Cameroon with higher rates in urban areas. Future interventions to reduce vertical transmission should include universal screening for these infections early in pregnancy and provision of effective prevention tools including the birth dose of univalent hepatitis B vaccine.

scholarly journals The Impact of Universal Infant Hepatitis B Immunization on Reducing the Hepatitis B Carrier Rate in Pregnant Women

2018 ◽  
Vol 220 (7) ◽  
pp. 1118-1126 ◽  
Author(s):  
Wei-Ju Su ◽  
Shu-Fong Chen ◽  
Chin-Hui Yang ◽  
Pei-Hung Chuang ◽  
Hsiu-Fang Chang ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Pregnant Women ◽  
Screening Program ◽  
Hepatitis B Surface Antigen ◽  
Carrier Rate ◽  
Cross Sectional ◽  
Hbv Vaccine ◽  
Hbv Vaccination ◽  
The Impact ◽  
Universal Infant

Abstract Background The hepatitis B virus (HBV) status of pregnant women affects HBV vaccine failure in their offspring. This study is aimed to investigate the impact of the universal infant HBV vaccination program on the long-term hepatitis B surface antigen (HBsAg) rate in pregnant women. Methods Using the National Immunization Information System, we examined a 32-year period of cross-sectional data on a maternal HBsAg and hepatitis B e antigen (HBeAg) screening program launched in July 1984. An age-period-cohort model analysis of 940 180 pregnant women screened for July 1996–June 1997 and the years 2001, 2006, 2011, and 2016 was applied. Results The annual HBsAg- and HBeAg-seropositive rates decreased from 13.4% and 6.4%, respectively, for the period 1984–1985 to 5.9% and 1.0% in 2016 (P for both trends < .0001). Pregnant women with birth years after July 1986 (the HBV vaccination cohort) had the lowest relative risk (0.27 [95% confidence interval, .26–.28]) of HBsAg positivity compared with birth years before June 1984. Conclusions The birth cohort effect in relation to the universal infant HBV immunization program has effectively reduced the HBV carrier rate in pregnant women and the burden of perinatal HBV infection on the next generation.

scholarly journals Seroprevalence and Knowledge of Viral Hepatitis and HIV Among People Who Use Drugs Attending Methadone Therapy Clinic in Tanzania: A Cross-sectional Study.

2020 ◽  
Author(s):  
Semvua Kilonzo ◽  
Daniel W. Gunda ◽  
David C. Majinge ◽  
Hyasinta Jaka ◽  
Paulina M. Manyiri ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Hepatitis B Surface Antigen ◽  
People Who Use Drugs ◽  
Infection Rates ◽  
Cross Sectional ◽  
B Virus

Abstract Background: Methadone therapy clinics have been recently introduced in Tanzania, aiming at reducing risk behaviors and infection rates of viral hepatitis and HIV among people who use drugs. The objective of this study was to estimate the prevalence, associated factors and knowledge level of these conditions among people who use drugs attending a methadone clinic in Tanzania.Methods: We enrolled 253 People who using drugs receiving Methadone therapy. Clinical data was retrospectively collected from the medical records and face-to face interviews were conducted to determine the behavioral risk factors and respondents’ knowledge on viral hepatitis and HIV.Results: An overall seroprevalence of viral hepatitis (either hepatitis B surface antigen or anti-hepatitis C virus) was 6.3%, while that of hepatitis B virus mono infection was 3.5% and anti-hepatitis C virus mono infection was 3.5%. Seroprevalence of HIV was 12.6%. Viral hepatitis was strongly predicted by advanced age (>35 years) (p=0.02) and staying at Kirumba area (p=0.004), and HIV infection was predicted by increased age (>37 years) (p=0.04) and female sex (p<0.001). Regarding the knowledge of viral hepatitis, majority of the respondents were unaware of the transmission methods and availability of hepatitis B virus vaccines and only 17% were classified as well informed (provided ≥ 4 correct answers out of 7 questions). Good knowledge was highly predicted by higher education level of the individual (p=0.001).Conclusions: Despite the efforts to curb viral hepatitis and HIV infections through Methadone clinics, infection rates among people who use drugs are still high and the general knowledge on preventive measures is inadequate.

Effects of Novel Coronavirus 2019 Infection on Antenatal Hematological Parameters in Pregnant Women

2021 ◽  
Vol 15 (11) ◽  
pp. 3279-3284
Author(s):  
Monika . ◽  
Israt Saba Mari ◽  
Monika Maheshwari ◽  
Shahida Shaikh ◽  
Qararo Shah Syed ◽  
...  
Keyword(s):  
Antenatal Care ◽  
Pregnant Women ◽  
Urban Areas ◽  
Research Evaluation ◽  
Hematological Parameters ◽  
Haematological Parameters ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Group I ◽  
In Pregnancy

Background: Disturbance of haematological parameters is prevalent in pregnancy globally leading to a range of feto-maternal complications. Covid-19 infection has potential to enhance the severity of and complications impending due to anaemia in pregnancy. Objective: To determine the effects of Covid-19 infection on haematological parameters during antenatal care among pregnant women in rural Sindh. Study Design: Cross sectional study. Setting: Shaikh Zaid Institute, Chandka Medical College, Larkana. Duration: From March 1, 2021, and May 31, 2021. Materials and Method: A sample of 110 pregnant women, of 18-50 years of age, presenting in first through third trimester with single alive pregnancy, were included in the study after taking a valid written consent. The Research Evaluation Committee of SMBBMU- Larkana granted approval. Women having any haemoglobinopathy were excluded. Covid-19 test conducted through rt-PCR method. A standard questionnaire was used to collect data of two groups. Analysis was performed through SPSS Version-23. Descriptive and inferential statistics were calculated. Results: Mean ± SD age was 30.3 ± 6.99 (Range: 19 to 45) years. Both groups were identical in age. Mean ± SD gestational age was 28.12 ± 4.66 weeks (Range: 20-38). Covid-19 positive women had lower mean Hb (9.7 ± 2.11) than the covid-19 negative (10.54 ± 2.51; P = 0.158). Other haematological parameters like MCV, serum ferritin, TIBC, TLC & platelets were statistically different between groups. Women of eldest group i-e; in 41-50 years, from urban areas, second trimester (gest. age 13-24 weeks), and nulliparous had been affected more from covid-19 (P = 0.271, 0.748, 0.290 & 0.053). Frequency and severity of anaemia was more among Covid-19 positive women. Conclusion: Covid‐19 demands maternal healthcare to be extra vigilant to the haematological parameters of pregnant women during antenatal care till delivery. Keywords: Antenatal care, pregnancy, anaemia, haemoglobin, Covid‐19.

Seroprevalence of Blood Borne Pathogens among Health Care Workers and Their Hepatitis B Vaccination Status in Tertiary Care Hospitals in India

2016 ◽  
Vol 9 (1) ◽  
pp. 280 ◽  
Author(s):  
Maryam Dafei ◽  
Shiv K. Sarin ◽  
Anjur T. Kannan ◽  
Kamal Agrawal ◽  
Suneela Garg ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Simple Random Sampling ◽  
Hepatitis B Vaccination ◽  
Cross Sectional ◽  
Tertiary Care Hospitals ◽  
Anti Hiv

<p><strong>BACKGROUND &amp; AIM: </strong>Occupational exposure to blood-borne pathogens, mainly human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C (HCV), poses a serious risk to healthcare workers (HCWs), especially in developing countries, due to the high prevalence of these pathogens and fewer safety precautions. The aim of this study was to investigate the seroprevalence of HBV, HCV, and HIV infections and to measure the vaccination practices in HCWs at three tertiary care hospitals in Delhi, India.</p><p><strong>METHOD:</strong> In a descriptive (cross-sectional) study, the HCWs of three tertiary hospitals were selected by simple random sampling and divided into four different groups (nurses, laboratory and operational theater technicians, doctors and housekeeping workers). The participants were screened for the presence of hepatitis B surface antigen (HBs Ag), antibody to hepatitis B surface antigen (anti HBs), antibody to hepatitis C (anti HCV), and antibody to HIV (anti HIV). From June 2010 to April 2012, a structured questionnaire was administered to 850 HCWs after obtaining consent.</p><p><strong>RESULTS: </strong>Among 850 HCWs, 51.8% were nurses and 50.6% were female with a mean (SD) age of 34(8.7) years.  The overall seroprevalence of HBsAg, anti-HCV, and anti-HIV was 1.1%, 0.3%, and 0.1%, respectively. There was a high proportion of HBsAg positivity among housekeeping workers (4.9%) followed by nurses (3.3%). Out of 9 positive cases of HBsAg, 66% (6) were never vaccinated and out of a total of 11 positive subjects, 72 % (8) had previous exposure in the workplace. Complete HBV vaccination was done in 78.2% (605) of the HCWs and 11.3% (75) were partially vaccinated. Only 20.1% had checked their anti-HBs. Protective (&gt;10 IU/mL) anti-HBs was seen in 70.6% (600) of the participants, indicating that nearly one third of HCWs were not protected against HBV infection. The majority of the study subjects (63.6%) believed that they were immunized against hepatitis B and did not need to check the immunity titer.</p><p><strong>CONCLUSION: </strong>Not all HCWs were vaccinated and the majority of vaccinated subjects did not know their immunity level. Housekeeping workers had a high seropositivity rate of infections and a low rate of vaccination against HBV. Institutional policy and training were found to be of paramount importance to improve the quality of health in HCWs.</p>

scholarly journals Frequency of Hepatitis B Virus carrier by Detecting AntiHBc Antibody among HBsAg Negative Blood Donors

2016 ◽  
Vol 15 (1) ◽  
pp. 66-69
Author(s):  
Kashfia Islam ◽  
Mazharul Hoque ◽  
Samsun Nahar ◽  
Syed Dawood Md. Taimur ◽  
Zeenat Farzana Rahman ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Blood Donors ◽  
Blood Donation ◽  
Hepatitis B Surface Antigen ◽  
Medical Science ◽  
Chromatography Method ◽  
Cross Sectional ◽  
B Virus ◽  
History Of

Background & Objective: Transfusion associated hepatitis B virus (TAHBV) infection continues to be a major problem despite mandatory screening for hepatitis B surface antigen (HBsAg). This is because HBsAg is not detected during the window period of the infection. This study was designed to assess the frequency of anti HBc antibody among HBsAg negative donor and also to determine the demographic profile of healthy blood donors.Material & Method: This cross sectional observational study was carried out in the Department of Transfusion Medicine, BSMMU, Dhaka during the period of May 2014 to April 2015. A total number of 100 consecutive healthy blood donors who were clinically and physically healthy and serologically found to be free from HBsAg, HCV and HIV by rapid chromographic test were included in this study.Results: Within the 100 patients among them history of jaundice was found in 17(17.0%). There all (100.0%) subjects had negative HBsAg and 14(14.0%) subjects had positive anti HBc-Ab. Anti HBc-Ab was statistically significant (p<0.001) in Z-test.Conclusion: This study was undertaken to assess the prevalence of anti HBc antibody among healthy blood donors with HBsAg negative in rapid chromatography method. The prevalence of anti HBc antibody was about 14 (14.0%) among 100 HBsAg negative blood donors. History of blood donation was found in almost two third 65 (65.0%). So, anti HBc antibody screening is an useful tool for estimating the risk of transfusion transmitted HBV infection.Bangladesh Journal of Medical Science Vol.15(1) 2016 p.66-69

scholarly journals PREVALENCE OF HBV, HCV AND HIV IN BLOOD DONORS AT LIAQUETPUR

2006 ◽  
Vol 13 (01) ◽  
pp. 23-26
Author(s):  
MUHAMMAD AYUB KHAN ◽  
Muhammad Ashraf ◽  
ABDUL REHMAN ◽  
Azam Ali ◽  
MUHAMMAD ASHRAF ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Cross Sectional Study ◽  
Age Group ◽  
Total Blood ◽  
Cross Sectional ◽  
Transfusion Center ◽  
Blood Transfusion Center ◽  
Study Setting

Objective: To know the prevalence of hepatitis B, hepatitis C and HIV.Design: Observational cross sectional study. Setting: Blood Transfusion Center Tehsil Headquarter HospitalLiaquetpur. Subjects and Methods: The data of blood donors from 2001 to 2003. Results: Total blood donors studiedwere 1426. The prevalence for hepatitis B was 5.96% (CL 4.84%-7.32%) It was 0.07% (CL <0.01% - 0.44%) for HCVand zero for HIV. The prevalence of HBV in males was 6.03% (CL 4.87%-7.45%) while 5.05% (CL 1.91%-11.63%) infemales (p=0. 6917). The prevalence in 17-20 years age group was 6.4% (CL 3.92%-10.23%), 5.81% (CL 4.6%-7.33%)in 21-40 years age group and in 41-60 years age group it was 4.35% (CL 1.33%-28.19%) [p=0.9029]. Conclusion:Hepatitis B is common, hepatitis C is an uncommon health problem while HIV is not present in this area.

scholarly journals Seroprevalence of Hepatitis B and Hepatitis C among Blood Donors at Dharan, Sunsari, Nepal

2016 ◽  
Vol 2 (1) ◽  
pp. 13-16
Author(s):  
Sabina Rai ◽  
Pranita Dongol ◽  
Hemanta Khanal
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Technical College ◽  
Blood Donors ◽  
Cross Sectional Study ◽  
P Value ◽  
Age Group ◽  
Cross Sectional ◽  
Blood Samples ◽  
Donated Blood

Hepatitis B and Hepatitis C are the chronic viral infection that might be transmitted by blood transfusion. Nepal is known to have lowest seroprevalence in Asia. The main objective of the present study is to find out the prevalence of hepatitis B and Hepatitis C and their co-infection among blood donors during study period from March to August 2014. This was a cross sectional study among volunteer blood donors in Dharan who had donated the Blood. A total of 4930 donated blood samples were collected and screened for hepatitis B and hepatitis C by using a rapid enzyme immunoassay (EIA) technique. Among 4930 blood samples under study, the overall seroprevalence of hepatitis B were 0.22% (11 out of 4930) and hepatitis C were 0.39% (19 out of 4930) (P value = 0.01) and the prevalence being lower in females than males for both cases. Hepatitis B were more in age group of 21 -30 (0.4%) but hepatitis C in age group of 31-40 (0.5%). Hepatitis B and C are potential threats to be transmitted from unscreened blood.Sunsari Technical College Journal 2015, 2(1):13-16

scholarly journals Trends in Prevalence of Hepatitis B (HBV) and Hepatitis C (HCV) virus infection among blood donors in Apollo Hospital, Dhaka, Bangladesh, 2007-2011

Pulse ◽  
2014 ◽  
Vol 6 (1-2) ◽  
pp. 27-32 ◽  
Author(s):  
KM Huda ◽  
TA Nasir
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Public Health Problem ◽  
Hcv Infection ◽  
Infection Prevalence ◽  
Major Public Health Problem ◽  
Transmitted Infection ◽  
Recruitment And Selection

Transfusion transmitted infection (TTIs) is still a concern associated with blood transfusion as hepatitis B and hepatitis C remains a major public health problem in a country like Bangladesh. The trends of the prevalence of HBsAg and HCV infection among the healthy blood donors even in a tertiary level hospital could be a guide for planning and implementing programs for preventive measures. All samples of a total 18,381 unit of blood were screened for hepatitis B surface antigen and anti-hepatitis C virus antibodies at Apollo Hospitals Dhaka over a period of 5 years (2007-2011). The prevalence of HBV and HCV infection was calculated by year to demonstrate the trends. The overall sero prevalence rate of HBV and HCV among all blood donors at Apollo Hospitals, Dhaka during 2007 to 2011 was 1.42% and 0.10% respectively. There was decreasing trend observed in sero prevalence of HBV (1.77% vs 1.64%) and HCV (0.13% vs 0.02%) over five years of time, although this change was not statistically significant (p=0.16 for HBV and p=0.20 for HCV). However, a significant decreasing trend was observed in the sero prevalence of HBV among blood donors aged 30 years and above, which was 1.04% in 2011 against 1.73% in 2007 (p=0.04). The decreasing trend in the prevalence of HBV and HCV infection might be the result of improvement in donor recruitment and selection, replacement donation exclusion in transfusion services, and possibly decreasing HBV infection prevalence in general population. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20330 Pulse Vol.6 January-December 2013 p.27-32

SERO PREVALENCE OF TRANSFUSION TRANSMITTED INFECTIONS (TTI) IN VOLUNTARY BLOOD DONORS IN A TERTIARY CARE HOSPITAL AT SRINAGAR

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Nadia Shafi Chickan ◽  
Altaf Hussain Mir ◽  
Masaratt-ul Gani ◽  
Shazia Handoo ◽  
Farooq Ahmad Ganie
Keyword(s):  
Health Care ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Blood Donors ◽  
Hepatitis B Surface Antigen ◽  
Tertiary Care ◽  
Care Facility ◽  
Health Care Facility ◽  
Care Hospital ◽  
Serum Samples

Introduction: Blood transfusion plays an vital role in patients management and is live saving in my instances. it plays a pivotal role as a specialized modality of treatment and saves millions of lives worldwide each year and reduces morbidity. Stringent screening of blood not only ensure safe supply of blood and blood products, but also gives us idea about prevalence of ttis among general population Objective: to determine the serroperavalance of tti among blood donors in lalded hospital Materials and methods: A retrospective study was carried out over a period of 3 years from January 2017 to December 2019.serum samples were screened for hepatitis B surface antigen ,antibodies to human immunodeficiency virus Type 1 and 2 ,hepatitis c virus and syphilis in department of transfusion medicine was carried out Result: The result shows that 55 (3.72%) of the blood donors had TTIs. The prevalence of Hepatitis B, Hepatitis C, Malaria, Syphilis and Human immunodeficiency viruses (HIV), was found to be 31(0.21%), 23 (0.15%), 01 (0.0.006%), 01 (0.006%) and 02 (0.0.23%) respectively. None were positive for malaria. Conclusion: Transfusion Transmittable Infections pose a threat to patients admitted in any health care facility and if not carefully screened for will cause significant morbidity. Careful screening of all donor blood units in the blood bank of a hospital is absolutely necessary to prevent any untoward incidence of TTI in patients admitted to a health care facility Keywords: Transfusion, Sero-Prevalence, Donors, Transfusion Transmissible Infections.

scholarly journals A prospective study of demographic profile, risk factors and pregnancy outcome in Hepatitis B and Hepatitis C virus positive pregnant women in a tertiary care centre

2020 ◽  
Vol 9 (6) ◽  
pp. 2393
Author(s):  
Arti Sharma ◽  
Shubhra Agarwal ◽  
Garima Bajpai ◽  
Anupriya Singh ◽  
Nikita Agarwal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Abuse ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Intravenous Drug ◽  
Intravenous Drug Abuse ◽  
In Pregnancy

Background: Viral hepatitis is the most common liver disease in pregnancy and is also the most common cause of jaundice in pregnancy in tropical countries. Risk factors for transmission are intravenous drug abuse, surgical and dental procedures done without adequate sterilization of instruments, sexual route etc. Early diagnosis and management can prevent maternal and fetal complications. This study was done to evaluate the frequency, risk factors and pregnancy outcome in hepatitis B virus (HBV) and hepatitis C virus (HCV) positive antenatal women.Methods: This case control study was conducted in Teerthankar Mahaveer Medical College and Research Centre, Moradabad, Uttar Pradesh, India from January 2017 to June 2018 on total 2511 pregnant women. The serum samples were checked for presence of hepatitis B surface antigen (HBsAg) and presence of IgG antibodies to HCV. Analysis of sociodemographic profile, risk factors and pregnancy outcome were done in all HBV and HCV positive women.Results: Out of 2511 pregnant women, 292 were tested positive for hepatitis. Maximum number of women were in the age group of 21-30 years. Most of the seropositive women were multipara. Frequency of positivity was maximum for HCV (67.1%). The risk factors for transmission in study population were intravenous drug abuse, blood transfusion, history of surgery and tattooing.Conclusions: Hepatitis infection rate is increasing. Universal screening for HBV and HCV can be recommended in pregnant women in developing countries. Education and awareness of public and health care workers can reduce the risk of transmission. 

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