scholarly journals Ectropion and Conjunctival Mass in a Patient with Primary Bilateral Conjunctival Amyloidosis

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Alessandro Meduri ◽  
Miguel Rechichi ◽  
Cosimo Mazzotta ◽  
Sergio Zaccharia Scalinci ◽  
Mahmoud O. Jaroudi
Keyword(s):  
Systemic Disease ◽  
Lower Eyelid ◽  
The Body ◽  
Clinical Presentations ◽  
Histopathologic Evaluation ◽  
Clinical Consequences ◽  
Systemic Disorder ◽  
Uncommon Condition ◽  
Work Up ◽  
Conjunctival Lesion

Background. Amyloidosis is a group of disorders characterized by deposition of an extracellular protein, known as amyloid, in an abnormal fibrillar form with highly characteristic histopathologic staining properties. The clinical presentation can vary from a focal, localized lesion where amyloidosis has minor clinical consequences to extensive systemic disease that can involve any organ system of the body. Ocular amyloidosis can occur as a localized lesion or as a part of a systemic disorder. Conjunctival amyloidosis is an uncommon condition that is rarely associated with systemic disease. It may be a manifestation of an immunologic disorder. Case Report. We report the case of a patient with bilateral conjunctival amyloidosis who was referred to us with the suspicion of a malignant conjunctival lesion. Examination of both eyes showed a yellow-pink mass with prominent intrinsic vessels, subconjunctival hemorrhage, and ectropion of the left lower eyelid. Diagnosis of primary localized conjunctival amyloidosis was made based on histopathologic evaluation of incisional biopsy and negative systemic work-up. Conclusion. Ocular amyloidosis is a rare disease that is slowly progressive and has a wide variety of clinical presentations. Consequently, the clinical diagnosis is often overlooked or delayed. Definitive diagnosis is achieved through histopathologic evaluation of biopsy specimen.

scholarly journals Systemic association of uveitis in Nepalese population

2017 ◽  
Vol 7 (1) ◽  
pp. 35-40
Author(s):  
Jyoti Baba Shrestha ◽  
Dev Narayan Shah
Keyword(s):  
Viral Infections ◽  
Systemic Disease ◽  
Diagnostic Protocol ◽  
Immunological Disorder ◽  
Systemic Disorder ◽  
Laboratory Investigations ◽  
Set Up ◽  
Almost All ◽  
A Prospective Study ◽  
Work Up

Background: Infectious diseases are very common in Nepal and almost all infections are capable of causing uveitis. Parasitic infestations affect large number of Nepalese population and any parasitic infestation can potentially lead to development of uveitis. Local and systemic viral infections, immunological disorder like autoimmune diseases and malignancies can lead  to uveitis. All these emphasize the necessity of proper systemic evaluation and investigation to identify the underlying systemic illness causing uveitis in order to see the pattern of systemic illness and determine the commonest associated systemic disease with uveitis.Methods: A prospective study was conducted at BP Koirala Lions Centre for Ophthalmic Studies from November 2008 to April 2010. All the patients underwent a standard diagnostic protocol when indicated by special tests and procedures performed in order of likelihood.Results: A total of 308 patients with uveitis was seen during the study period. For 146 (47.4%) patients, a specific diagnosis was established based on history, ocular examination and laboratory investigations. A definite association with systemic disease was determined for 82 (26.6%) patients. A well established clinical uveitis entity without a recognizable systemic disorder was present in 64 (20.8%) cases. A diagnosis could not be established in 162 (52.6%) cases. Toxoplasmosis was found to be most frequently associated with uveitis accounting for 5.8 % of the total cases followed by tuberculosis (3.6%), herpes infections (3%), ankylosing spondylitis (2.9%), leprosy (2.3%), sarcoidosis (1.6%) and parasitic infestations (1.3%).Conclusion: The importance of relevant systemic work up in uveitis cases in our set up has been reemphasized by the present study.

Fournier’s gangrene due to Salmonella Typhimurium in a healthy male: a rare aberrant infection

2020 ◽  
Vol 20 ◽  
Author(s):  
Varsha Gupta ◽  
Lipika Singhal ◽  
Kritika Pal ◽  
Mani Bhushan ◽  
Rajeev Sharma ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Systemic Disease ◽  
External Genitalia ◽  
Fournier’S Gangrene ◽  
The Body ◽  
Healthy Male ◽  
Fournier's Gangrene ◽  
Salmonella Infections ◽  
Chief Complaints ◽  
Human Infections

Introduction: Human Salmonella infections have been classically distinguised into diseases caused by typhoidal and non-typhoidal salmonella (NTS). Typhiodal salmonella includes S. enterica serovars Typhi and Paratyphi that cause the systemic disease but are restricted to human infections, while NTS consists mainly of other serovars that predominantly cause self-limiting gastroenteritis in humans. Localisation of foci with persisting infection occurs due to dissemination of the bacteria throughout the body and can cause a variety of rare clinical syndromes at aberrant sites. Fournier’s gangrene, a rapidly progressive, often fatal, necrotizing fasciitis of the external genitalia and perineum due to Salmonella Typhimurium, is a rare manifestation and has never been reported. Case: A 22-year-old male, apparently healthy patient with no relevant past medical history presented to surgical emergency with chief complaints of swelling of bilateral scrotal area. Infective etiology was considered and a diagnosis of fournier’s gangrene was made. Pure growth of Salmonella Typhimurium was obtained after repeated subculture and was identified biochemically and on serotyping, as Salmonella enterica serotype Typhimurium using specific antisera. Conclusion: In our case report, we describe a case of fournier’s gangrene due to Salmonella Typhimurium in an otherwise healthy male to highlight the unusual presentation of Non typhoidal salmonellae at an aberrant site. We also emphasize the importance of using selective media like Selenite F broth for isolation of Salmonella Typhimurium from a pus sample.

Rebalance the oral microbiota as efficacy tool in endocrine, metabolic, and immune disorders

2020 ◽  
Vol 20 ◽  
Author(s):  
Ciro Gargiulo Isacco ◽  
Andrea Ballini ◽  
Danila De Vito ◽  
Kieu Cao Diem Nguyen ◽  
Stefania Cantore ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Current Treatment ◽  
Oral Bacteria ◽  
The Body ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Philosophical Approach ◽  
Treatment And Prevention ◽  
Cardio Vascular Disease ◽  
Cardio Vascular

: The current treatment and prevention of oral disorders follow a very sectoral control and procedures considering mouth and its structures as system completely independent from the rest of the body. The main therapeutic approach is carried out on just to keep the levels of oral bacteria and hygiene in an acceptable range compatible with one-way vision of oral-mouth health completely separated from a systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact on the diagnosis of more complex systemic disease and its progression. Dysbiosis is consequence of oral and gut microbiota unbalance with consequences, as reported in current literature, in cardio vascular disease, diabetes mellitus, rheumatoid arthritis, and Alzheimer’s disease. Likewise, there is the need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve non-conventional approaches.

Wegener’s granulomatosis: diagnostic dilemma

2001 ◽  
Vol 115 (1) ◽  
pp. 46-47 ◽  
Author(s):  
A. Banerjee ◽  
J. M. Armas ◽  
J. H. Dempster
Keyword(s):  
Early Diagnosis ◽  
Wegener’S Granulomatosis ◽  
Systemic Disease ◽  
Wegener's Granulomatosis ◽  
The Body ◽  
Facial Nerve Paralysis ◽  
Diagnostic Dilemma ◽  
Nerve Paralysis ◽  
Atypical Presentations ◽  
High Index Of Suspicion

Wegener’s granulomatosis is a systemic disease characterized by a granulomatous lesion that can affect any organ throughout the body.This case-report illustrates the problem posed by a patient presenting with bilateral serous otitis media with marked sensorineural hearing loss, facial nerve paralysis and an atypical serological picture. The importance of early diagnosis and the protocol for the management of a patient with an uncertain diagnosis is discussed. Due to atypical presentations, only a high index of suspicion will ensure an early diagnosis.

scholarly journals Cervical intradural extramedullay vascular schwannoma in a thirty eight year old male

2019 ◽  
Vol 6 (7) ◽  
pp. 2634
Author(s):  
Shipra Singhal ◽  
Sufian Zaheer ◽  
Rashmi Arora
Keyword(s):  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Neck Region ◽  
The Body ◽  
Vascular Changes ◽  
Vascular Tissues ◽  
Clinical Presentations ◽  
Cervical Swelling ◽  
Head Neck

Schwannomas are benign peripheral nerve sheet tumours that may arise almost anywhere in the body but are commonly seen in the head, neck region and in the extremities. They may be associated with variable clinical presentations depending on their location. The peripheral nerves are closely related to vascular tissues morphologically and physiologically and therefore schwannomas may be associated with vascular changes like vascular hyperplasia and vascular dilation. Here authors represent one such case where a 38-year-old patient presented with a cervical swelling which on histopathology was diagnosed as vascular schwannoma.

scholarly journals CUTANEOUS METASTASES UNVEILING BREST CANCER – THERAPEUTIC AND DIAGNOSTIC CONSIDERATIONS

2020 ◽  
Vol 7 (1) ◽  
pp. 164-168
Author(s):  
Florica Sandru ◽  
Mihai Cristian Dumitrascu ◽  
Aida Petca ◽  
Raluca Gabriela Miulescu ◽  
Tiberiu Tebeica ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Systemic Disease ◽  
Lymph Node Biopsy ◽  
The Body ◽  
Cervical Region ◽  
Cutaneous Lesions ◽  
Dermatology Department ◽  
Efficient Treatment ◽  
Surgery Department

Metastatic cutaneous lesions are seen more commonly in breast cancer than in any other malignancy in women. Secondary breast cancer happens when cancer cells spread from the breast to other parts of the body. Sometimes breast cancer cells can spread to the skin. This can happen through the blood or lymphatic system. The presence of skin metastases signifies widespread systemic disease and a poor prognosis. The chest wall, the abdomen, the back, and the upper extremities are common sites.We present the case of a 69-year-old woman presented to our Surgery Department in June 2019, after appearing in the Dermatology Department a week ago, for the appearance of multiple subcutaneous painless, hardened, skin-colored nodules spread to the cervical region, anterior chest walls and upper limbs. Anatomopathological examination of the skin biopsy, performed on the anterior face of the left arm, showed dermal fragment with neoplastic, suggestive for lobular breast carcinoma (stage IV). The patient was referred to the oncological surgery department where our patient underwent a left total mastectomy and sentinel lymph node biopsy. The technique of mastectomy was the Madden technique. The surgery has no healing character, being more a necessity intervention that seeks to avoid the complications of the local evolution of the disease, such as ulceration, hemorrhage or suppuration, the possibility of applying the other forms of treatment (radiotherapy and / or polychemotherapy), elimination of a source of permanent metastatic sowing thus leading to more efficient treatment.

Substernal goitre presenting with upper and lower extremity oedema

2021 ◽  
Vol 14 (11) ◽  
pp. e245036
Author(s):  
Rebekah LeAnn Bennett Daggett ◽  
Daniel Farishta ◽  
Hugo Cuellar ◽  
Cherie-Ann O Nathan
Keyword(s):  
Lower Extremity ◽  
Initial Assessment ◽  
Uneventful Recovery ◽  
Surgical Removal ◽  
Extensive Literature ◽  
Rare Presentation ◽  
Clinical Presentations ◽  
Left Innominate Vein ◽  
Home Placement ◽  
Work Up

Substernal goitre is characterised by compressive symptoms of the airway and oesophagus. Chronic, progressive symptoms usually result in surgical removal. We report a rare presentation of substernal goitre in a male in his early 70s who suffered from severe bilateral lower extremity (LE) lymphoedema, resulting in immobility and nursing home placement, and left upper extremity lymphoedema. Our initial assessment led to a filariasis work-up, which was negative, due to the patient’s prior 2-year residence in India and service overseas. Chest CT scan revealed an incidental substernal goitre extending posterior to the left innominate vein and aortic arch to the level of the left mainstem bronchus. The patient underwent a left hemithyroidectomy via cervical excision and sternotomy and had an uneventful recovery with resolution of lymphoedema and mobility. Despite extensive literature regarding clinical presentations of substernal goitre, severe lymphoedema of the LE is not a well-established association.

Pustular rashes

2020 ◽  
pp. 291-300
Keyword(s):  
Skin Disease ◽  
Systemic Disease ◽  
The Body ◽  
Pustular Psoriasis ◽  
Dermatophytic Fungi ◽  
The Common

This chapter describes the common pustular rashes that occur in children. This includes infective causes due to bacteria such as staphylococcus, streptococcus, and pseudomonas, dermatophytic fungi, viruses, parasites, and yeasts. Non-infective causes include primary skin disease such as acne, pustular psoriasis, and neonatal pustular conditions as well as systemic disease and drugs. The chapter lists all the diseases then discusses them according to the body sites that are most commonly affected. A brief clinical summary of each condition is then provided with cross references to other relevant sections of the book.

Uveitis

2018 ◽  
pp. 443-520 ◽  
Keyword(s):  
Clinical Features ◽  
Systemic Disease ◽  
Practical Approach ◽  
Anatomy And Physiology ◽  
Uveal Tract ◽  
Inflammatory Conditions ◽  
Clinical Presentations

‘Uveitis’ provides the reader with a practical approach to the assessment and management of this group of intraocular inflammatory conditions. After outlining the relevant anatomy and physiology of the uveal tract, the chapter addresses the key clinical presentations of uveitic diseases before discussing each syndrome in more detail. Using a patient-centred approach the key clinical features, investigations and treatment (medical and surgical) are described for each condition. Emphasis is given to the association of some forms of uveitis with systemic disease, and the need for appropriate investigation.

Sclera

2018 ◽  
pp. 319-333
Keyword(s):  
Clinical Features ◽  
Systemic Disease ◽  
Practical Approach ◽  
Posterior Scleritis ◽  
Anatomy And Physiology ◽  
Clinical Presentations ◽  
Anterior Scleritis

‘Sclera’ provides the reader with a practical approach to the assessment and management of scleral disease. After outlining the relevant anatomy and physiology of this structure, the chapter addresses the key clinical presentations arising from scleral disease, notably episcleritis, anterior scleritis and posterior scleritis. Using a patient-centred approach the key clinical features, investigations and treatment (medical and surgical) are described for each condition. Emphasis is given to the possible association with systemic disease, and the need for appropriate investigation.

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