scholarly journals Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Yawen Zeng ◽  
Yuping Li ◽  
Jiazhen Yang ◽  
Xiaoying Pu ◽  
Juan Du ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Heart Diseases ◽  
English Literature ◽  
Scientific Basis ◽  
Organosulfur Compounds ◽  
Immunological Effects ◽  
Functional Components

Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016.Alliumgenus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti-inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results supportAlliumgenus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.

scholarly journals Smoking, drinking, diet and physical activity—modifiable lifestyle risk factors and their associations with age to first chronic disease

2019 ◽  
Vol 49 (1) ◽  
pp. 113-130 ◽  
Author(s):  
Ryan Ng ◽  
Rinku Sutradhar ◽  
Zhan Yao ◽  
Walter P Wodchis ◽  
Laura C Rosella
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Lifestyle Factors ◽  
Competing Risk ◽  
Chronic Obstructive ◽  
Common Disease ◽  
Heavy Smoking ◽  
Lifestyle Risk Factors ◽  
Lifestyle Risk

AbstractBackgroundThis study examined the incidence of a person’s first diagnosis of a selected chronic disease, and the relationships between modifiable lifestyle risk factors and age to first of six chronic diseases.MethodsOntario respondents from 2001 to 2010 of the Canadian Community Health Survey were followed up with administrative data until 2014 for congestive heart failure, chronic obstructive respiratory disease, diabetes, lung cancer, myocardial infarction and stroke. By sex, the cumulative incidence function of age to first chronic disease was calculated for the six chronic diseases individually and compositely. The associations between modifiable lifestyle risk factors (alcohol, body mass index, smoking, diet, physical inactivity) and age to first chronic disease were estimated using cause-specific Cox proportional hazards models and Fine-Gray competing risk models.ResultsDiabetes was the most common disease. By age 70.5 years (2015 world life expectancy), 50.9% of females and 58.1% of males had at least one disease and few had a death free of the selected diseases (3.4% females; 5.4% males). Of the lifestyle factors, heavy smoking had the strongest association with the risk of experiencing at least one chronic disease (cause-specific hazard ratio = 3.86; 95% confidence interval = 3.46, 4.31). The lifestyle factors were modelled for each disease separately, and the associations varied by chronic disease and sex.ConclusionsWe found that most individuals will have at least one of the six chronic diseases before dying. This study provides a novel approach using competing risk methods to examine the incidence of chronic diseases relative to the life course and how their incidences are associated with lifestyle behaviours.

scholarly journals The influence of primary health care organizational models on patients’ experience of care in different chronic disease situations

2011 ◽  
Vol 31 (3) ◽  
pp. 109-120 ◽  
Author(s):  
R Pineault ◽  
S Provost ◽  
M Hamel ◽  
A Couture ◽  
JF Levesque
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Primary Health Care ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Chronic Conditions ◽  
Chronically Ill ◽  
Organizational Models ◽  
Experience Of Care ◽  
Primary Health

Objectives To examine the extent to which experience of care varies across chronic diseases, and to analyze the relationship of primary health care (PHC) organizational models with the experience of care reported by patients in different chronic disease situations. Methods We linked a population survey and a PHC organizational survey conducted in two regions of Quebec. We identified five groups of chronic diseases and contrasted these with a no–chronic-disease group. Results Accessibility of care is low for all chronic conditions and shows little variation across diseases. The contact and the coordination-integrated models are the most accessible, whereas the single-provider model is the least. Process and outcome indices of care experience are much higher than accessibility for all conditions and vary across diseases, with the highest being for cardiovascular-risk-factors and the lowest for respiratory diseases (for people aged 44 and under). However, as we move from risk factors to more severe chronic conditions, the coordination-integrated and community models are more likely to generate better process of care, highlighting the greater potential of these two models to meet the needs of more severely chronically ill individuals within the Canadian health care system.

scholarly journals Effects of supplementation with carnosine and other histidine-containing dipeptides on chronic disease risk factors and outcomes: protocol for a systematic review of randomised controlled trials

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020623 ◽  
Author(s):  
Kirthi Menon ◽  
Aya Mousa ◽  
Barbora de Courten
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Randomised Controlled Trials ◽  
Disease Risk ◽  
Primary Data ◽  
Controlled Trials ◽  
Chronic Disease Risk ◽  
Randomised Controlled

IntroductionAgeing of populations globally, coupled with the obesity epidemic, has resulted in the rising prevalence of chronic diseases including diabetes, cardiovascular diseases, cancers and neurodegenerative disorders. Prevention of risk factors that contribute to these diseases is key in managing the global burden of chronic diseases. Recent studies suggest that carnosine, a dipeptide with anti-inflammatory, antioxidative and antiglycating properties may have a role in the prevention of chronic diseases; however, no previous reviews have examined the effects of carnosine and other histidine-containing peptides (HCDs) on chronic disease risk factors and outcomes. We aim to conduct a comprehensive systematic review to examine the effects of supplementation with carnosine and other HCDs on chronic disease risk factors and outcomes and to identify relevant knowledge gaps.Methods and analysisElectronic databases including Medline, Cumulative Index of Nursing and Allied Health, Embase and all Evidence-Based Medicine will be systematically searched to identify randomised controlled trials (RCTs) and systematic reviews of RCTs, comparing supplementation with carnosine and/or other HCDs versus placebo, usual care or other pharmacological or non-pharmacological interventions. One reviewer will screen titles and abstracts for eligibility according to prespecified inclusion criteria, after which two independent reviewers will perform data extraction and quality appraisal. Meta-analyses, metaregression and subgroup analyses will be conducted where appropriate.Ethics and disseminationEthics approval is not required as this review does not involve primary data collection. This review will generate level-one evidence regarding the effects of carnosine supplementation on chronic disease risk factors and outcomes and will be disseminated through peer-reviewed publications and at conference meetings to inform future research on the efficacy of carnosine supplementation for the prevention of chronic diseases.PROSPERO registration numberCRD42017075354.

scholarly journals The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men

2008 ◽  
Vol 100 (4) ◽  
pp. 883-889 ◽  
Author(s):  
Wildon R. Farwell ◽  
J. Michael Gaziano ◽  
Edward P. Norkus ◽  
Howard D. Sesso
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Disease Risk ◽  
Alcohol Ingestion ◽  
Health Study ◽  
Parameter Estimates ◽  
Total Plasma ◽  
The Relationship

Individual plasma carotenoids have been associated with various chronic diseases but little is known about the relationship between total plasma carotenoids and risk factors for chronic diseases. In the Physicians' Health Study, we examined 492 men free of CVD and cancer for the relationship between total plasma carotenoids (the sum of α-carotene, β-carotene, lycopene, zeaxanthin, lutein and β-cryptoxanthin) and a wide variety of factors that predict chronic disease. Multivariate linear and logistic regression was performed to calculate parameter estimates (95 % CI) and OR (95 % CI) for total plasma carotenoids. In linear regression models, BMI, hypertension, alcohol intake and plasma levels of each lipid parameter and α-tocopherol significantly predicted levels of total plasma carotenoids. Upon adjustment for multiple chronic disease risk factors, the OR for levels of total plasma carotenoids greater than or equal to the median ( ≥ 1·301 μmol/l) was statistically significant for current smoking (OR 0·21; 95 % CI 0·06, 0·77), weekly alcohol ingestion (OR 2·30; 95 % CI 1·06, 4·99), daily alcohol ingestion (OR 2·46; 95 % CI 1·29, 4·67), each 100 mg/l increase in total cholesterol (OR 0·73; 95 % CI 0·58, 0·91), LDL-cholesterol (OR 1·48; 95 % CI 1·17, 1·89) and HDL-cholesterol (OR 1·58; 95 % CI 1·26, 1·99), each 100 mg/ml increase in intercellular adhesion molecule-1 (OR 0·70; 95 % CI 0·53, 0·93) and each 10 μmol/l increase in α-tocopherol (OR 1·33; 95 % CI 1·12, 1·57), using logistic regression. Few lifestyle and clinical risk factors appear to be related to levels of total plasma carotenoids; however, levels of biomarkers such as plasma lipids and α-tocopherol may be strongly related.

scholarly journals OPENCRONIC Study. Knowledge and Experiences of Spanish Patients and Carers about Chronic Disease

2018 ◽  
Vol 16 (1) ◽  
pp. 39
Author(s):  
Emilio Casariego ◽  
Ana Cebrián-Cuenca ◽  
José Llisterri ◽  
Rafael Micó-Pérez ◽  
Domingo Orozco-Beltran ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Public Opinion ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Online Survey ◽  
Healthcare Systems ◽  
Daily Lives ◽  
And Training

Background: Chronic diseases are currently the main cause of morbidity and mortality and represent a major challenge to healthcare systems. The objective of this study is to know Spanish public opinion about chronic disease and how it affects their daily lives. Methods: Through a telephone or online survey of 24 questions, data was gathered on the characteristics of the respondents and their knowledge and experiences of chronic diseases. Results: Of the 2522 survey respondents, 325 had a chronic disease and were carers, 1088 had a chronic disease and were not carers, 140 did not have a chronic disease but were carers, and 969 did not have chronic disease and were not carers. The degree of knowledge on these diseases was good or very good for 69.4%, 56.0%, 62.2%, and 46.7%, respectively, for each group. All the groups agreed that chronic diseases mainly affect mood, quality of life and having to make sacrifices. Conclusions: Knowledge about chronic diseases is relatively good, although it can be improved among the Spanish population, especially among patients who report having a chronic disease and play the role of carers. However, it is important to continue maintaining the level of information and training concerning these diseases.

scholarly journals Serum Cortisol and BMI in Chronic Diseases and Increased Early Cardiovascular Diseases

2016 ◽  
Vol 13 (2) ◽  
pp. 399-406
Author(s):  
Baghdad Science Journal
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Chronic Diseases ◽  
Cortisol Level ◽  
Serum Cortisol ◽  
Cholesterol Concentration ◽  
Significant Difference ◽  
Gender Groups ◽  
Opposing Effect

The purpose of this study was to examine the role of cortisol, and it is related to BMI in the chronic diseases which may increase early cardiovascular disease (CVD) in old Iraqi. The subjects were 116 adults, aged 51-71 years. Body Mass Index (BMI), Waist Circumferences (WC) and Waist Hip Ratio (WHR) were used as a measure of adiposity. Investigation showed highly significant difference between patients in BMI ranges, most of male were in an obese weight range (48.5%), as well in women. There were no significant correlations between serum cortisol concentration and age both gender groups. While there were highly significant correlations between cortisol level and BMI, waist, and WHR (except in female subjects), also there were highly significant correlations between cortisol level and SBP,DBP (mmHg)only in male. In both groups, total cholesterol concentration, FBS, and A1C were significantly correlated with serum cortisol. Negatively correlated has been observed between serum cortisol and HDL-C in men but not in women. In men, the results of cortisol with CV risk factors (dyslipidemia, D.M, hypertension, at least 2 risk factors and three risk factors) show significant differences (p>0.0). In summary, there is a major association between cortisol levels, obese, and chronic diseases. These conclusions promote the hypothesis that the opposing effect of adiposity on the chronic diseases might be mediated by cortisol. This association could cause early development of cardiovascular diseases even in males.

Prison environment and non-communicable chronic disease modifiable risk factors: length of incarceration trend analysis in Mexico City

2018 ◽  
Vol 72 (4) ◽  
pp. 342-348 ◽  
Author(s):  
Omar Silverman-Retana ◽  
Edson Servan-Mori ◽  
Stefano Michele Bertozzi ◽  
Emanuel Orozco-Nuñez ◽  
Sergio Bautista-Arredondo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Mexico City ◽  
Regression Models ◽  
Computer Assisted ◽  
Modifiable Risk Factors ◽  
Current Smoking ◽  
Cocaine Use ◽  
Prison Environment

BackgroundThere is a lack of evidence regarding chronic disease modifiable risk factors among prisoner populations in Latin America. The purpose of this study was to estimate the prevalence of modifiable risk factors for chronic diseases and to assess their relationship with length of incarceration.MethodsWe analysed data from a cross sectional study in which 4241 prisoners were randomly selected to answer a questionnaire with socio-demographic and health behaviour content using an audio computer-assisted self-interview format. Physical activity (PA), low-quality diet, current smoking and alcohol or cocaine use during the last month in prison were our main outcomes. Quantile regression models and logistic regression models were performed.ResultsOur final analytical sample consisted of 3774 prisoners from four Mexico City prisons. PA was estimated as 579 median metabolic equivalents-min/week, prevalence of alcohol use was 23.4%, cocaine use was 24.2% and current smoking was 53.2%. Our results suggest that, as length of incarceration increased, PA as well as alcohol and cocaine use increased, whereas the quality of diet decreased.ConclusionThis study supports the hypothesis that exposure to prison environment (measured by length of incarceration) fosters modifiable risk factors for chronic diseases, particularly diet quality and cocaine use.

Elucidating The Genetic Factors Contributing Towards Susceptibility And Severity Of Covid 19

2021 ◽  
Vol 01 ◽  
Author(s):  
Syeda Marriam Bakhtiar ◽  
Syeda Eeman Zahra Bokhari ◽  
Iqra Riasat ◽  
Erum Dilshad
Keyword(s):  
Risk Factors ◽  
Chronic Disease ◽  
Genetic Factors ◽  
Potential Role ◽  
Viral Transmission ◽  
Modifiable Risk Factors ◽  
Animal Host ◽  
Factors Associated ◽  
Human Source

: COVID-19 or SARS-CoV-2 or 2019-nCov is a pandemic disease that occurred in December 2019 from Wuhan, Hubei Province of China. It was first transmitted from the animal host to a human source, after which it followed human-human transmission and spread exponentially worldwide. Various countries have fallen prey to this virus, but there are certain countries or populations, which have been more affected by this than others. Moreover, the demographics of transmission and affected individuals are also variable from country-country. The purpose of this article is to highlight the non-modifiable risk factors for COVID-19 and their analysis in various populations affecting their susceptibility. Besides age, gender, and blood group, two major genetic factors associated with this disease are discussed here including the potential of IL-6, in causing chronic disease conditions and the rs1800795 G/C-174 IL-6 polymorphism in the IL-6 gene and with the potential role of ACE-2 receptor in viral transmission and pathogenicity with its protective and disease-causing variants.

Risk Factors of COVID-19 Critical Outcomes in the Eastern Mediterranean Region: A Multicountry Retrospective Study (Preprint)

2021 ◽  
Author(s):  
Faris Lami ◽  
Maisa Elfadul ◽  
Hiba Abdulrahman Rashak ◽  
Mohannad Al Nsour ◽  
Hashaam Akhtar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mediterranean Region ◽  
Eastern Mediterranean ◽  
Heart Diseases ◽  
Eastern Mediterranean Region ◽  
Renal Diseases ◽  
Contributing Factors ◽  
Country Study ◽  
Wide Scale

BACKGROUND The establishment of empirical evidence in the Eastern Mediterranean Region (EMR) necessitates the implementation of wide-scale studies to describe the demographic, clinical features, and severity profile ofCOVID-19 patients. OBJECTIVE Hence, this study aimed to to assess the patterns of COVID-19 severity and mortality in seven countries and to determine the risk factors of COVID-19 severity and mortality. METHODS This multi-country study was based on a retrospective review of medical records of hospitalized patients confirmed to have COVID-19. This study included data from Iraq, Pakistan, Sudan, Somalia, Morocco, Egypt, and Yemen. All demographic and clinical data were extracted from hospital records (paper files) by trained data collectors. RESULTS A total of 4141 patients were included in this study from seven countries. Comorbidities were reported by nearly half of the patients, with hypertension (HT)(24.7%)and diabetes (22.7%) being the most common. Older age, diabetes mellitus, hypertension, and heart diseases were significantly associated with COVID-19 severity and mortality. Ever smoking and renal diseases were significantly associated with severity but not mortality, while male gender, respiratory diseases, and malignancy were significantly associated with mortality but not severity. CONCLUSIONS The study confirmed the role of comorbidities and demographic features on the severity and mortality of COVID-19. Understanding the contributing factors ensures attentive care and informs clinical management of patients with poorer prognosis in early stages of

An intersectoral network for chronic disease prevention: the case of the Alberta Healthy Living Network

2009 ◽  
Vol 29 (4) ◽  
pp. 153-161
Author(s):  
R Geneau ◽  
B Legowski ◽  
S Stachenko
Keyword(s):  
Chronic Disease ◽  
Disease Prevention ◽  
Chronic Diseases ◽  
Causes Of Death ◽  
Qualitative Case Study ◽  
Chronic Disease Prevention ◽  
Policy Advocacy ◽  
Healthy Living

Chronic Diseases (CDs) are the leading causes of death and disability worldwide. CD experts have long promoted the use of integrated and intersectoral approaches to strengthen CD prevention efforts. This qualitative case study examined the perceived benefits and challenges associated with implementing an intersectoral network dedicated to CD prevention. Through interviewing key members of the Alberta Healthy Living Network (AHLN, or the Network), two overarching themes emerged from the data. The first relates to contrasting views on the role of the AHLN in relation to its actions and outcomes, especially concerning policy advocacy. The second focuses on the benefits and contributions of the AHLN and the challenge of demonstrating non-quantifiable outcomes. While the respondents agreed that the AHLN has contributed to intersectoral work in CD prevention in Alberta and to collaboration among Network members, several did not view this achievement as an end in itself and appealed to the Network to engage more in change-oriented activities. Managing contrasting expectations has had a significant impact on the functioning of the Network.

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