scholarly journals Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Nirmal Raj Marasine ◽  
Sabina Sankhi ◽  
Rajendra Lamichhane ◽  
Nabin Raj Marasini ◽  
Nim Bahadur Dangi
Keyword(s):  
Medication Adherence ◽  
Side Effects ◽  
Psychiatric Hospital ◽  
Associated Factors ◽  
Antidepressant Drug ◽  
Antidepressant Drugs ◽  
Psychiatric Hospitals ◽  
Bivariate Analysis ◽  
Drug Side Effects ◽  
Cross Sectional

Objective. The present study is aimed at evaluating the side effects of antidepressant drugs, medication adherence (MA), and associated factors among patients diagnosed with depression at a psychiatric hospital in western Nepal. Methods. A prospective cross-sectional study was conducted among 174 patients visiting the outpatient clinic of a psychiatric hospital. The antidepressant side effect checklist (ASEC) was used to classify the reported antidepressant drug side effects into mild, moderate, and severe types. The Naranjo adverse drug reaction (ADR) probability scale was employed to assess the ADRs, and the Morisky Green Levine Adherence (MGLA) score was employed to determine the rate of medication adherence. Descriptive statistics and bivariate analysis were used, and a P value < 0.05 was taken as statistically significant in the multivariate analysis. Results. The patients were mostly female (55.74%), with a median (IQR) age of 32 (20) years. Approximately 74.13% of the patients experienced antidepressant side effects, where insomnia (17.05%) and anxiety (17.05%) were the most common. More than half of the patients (52.29%) had a low level of adherence. Females were 1.01 times more likely to be nonadherent to their antidepressant medications compared to males, adjusted odds ratio (AOR): 1.001 (0.31-1.63). Similarly, illiterate patients tended to be more nonadherent compared to literates, AOR: 1.342 (0. 93-2.82), and unemployed individuals were 1.5 times more likely to be nonadherent to their medications compared to employed individuals, AOR: 1.46 (1.16-4.13). Likewise, patients with severe side effects were more prone to develop nonadherence than those with moderate side effects, AOR: 1.173 (0.42-3.25). A significant association was found between the Naranjo score and medication adherence. Conclusions. This study suggests that antidepressant drug side effects were more prevalent and medication adherence was extremely poor among depressive patients in psychiatric hospitals. Factors such as gender, occupation, education, side effects, and ADRs attributed to poor medication adherence in patients.

scholarly journals Patterns of Prescription of Psychotropic Medications and Their Adherence among Patients with Schizophrenia in Two Psychiatric Hospitals in Accra, Ghana: A Cross-Sectional Survey

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Sharon Ashong ◽  
Irene A. Kretchy ◽  
Barima Afrane ◽  
Ama de-Graft Aikins
Keyword(s):  
Side Effects ◽  
Psychiatric Hospital ◽  
Psychiatric Hospitals ◽  
Psychotropic Medications ◽  
Therapeutic Monitoring ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Adherence To Medication ◽  
Adherence Behaviour

Background. Patients with schizophrenia are managed with antipsychotics and other psychotropic medications. Objectives. This study aimed to assess the commonly prescribed psychotropic medications for patients with schizophrenia, explore the types of therapeutic monitoring that were performed, and find out whether the side effects experienced by the patients played any role in their adherence behaviour. Methods. This hospital-based cross-sectional study enrolled 259 patients with schizophrenia from Accra Psychiatric Hospital and Pantang Psychiatric Hospital. Data were collected on mental status, side effects, types of therapeutic monitoring performed, and adherence behaviour. Results. Olanzapine was the commonly prescribed psychotropic medication. Most of respondents (73.4%) experienced mild levels of side effects. The negative effects were predominantly genitourinary (26%) and gastrointestinal (17.2%). Blood pressure and heart rate measures were the main types of monitoring performed but no measurement of drug levels was reported. About 98.1% of the participants poorly adhered to their medications and the major reasons for poor adherence were economic challenges, forgetfulness, and the feeling of wellness. Conclusion. Adherence to medication is a major health problem among patients with schizophrenia and there is a need to improve adherence and treatment outcomes.

scholarly journals Risk Factors for Undernutrition at Admission Among Adult Hospitalized Patients at a Referral Hospital in Indonesia

SAGE Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 215824402098331
Author(s):  
Nur Chandra Bunawan ◽  
Dwi Suseno ◽  
Drupadi H. S. Dillon ◽  
Ikhwan Rinaldi ◽  
Dyah Purnamasari
Keyword(s):  
Associated Factors ◽  
Multivariate Analyses ◽  
Gastrointestinal Disease ◽  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Initial Hospital ◽  
Comorbidity Index

Patients with undernutrition at admission have higher risks to worsen their nutritional status, which is linked to an increase in morbidity and mortality. This study investigated the prevalence of undernutrition at admission and its associated factors. A cross-sectional study was conducted on patients aged 18 to 59 years old in Internal Medicine ward at Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, between July and September 2019. Factors that might be associated with undernutrition at admission, such as age, sex, marital status, Charlson Comorbidity Index (CCI) and type of comorbidity, depression, and neutrophil–lymphocyte ratio (NLR), were assessed. Bivariate and multivariate analyses were used to determine the associated factors. Sixty hospitalized patients with median age of 42 years and 76.7% with married status joined the study. The most common reason for hospitalization was acute gastrointestinal disease with gallstones as the most common comorbidity. Undernutrition exists in 26.7% of subjects. High CCI score was observed among 11.7% subjects and half of subjects had NLR category ≥5. Bivariate analysis revealed that unmarried status, age ≥40 years, and malignancy were associated with undernutrition at admission. Logistic regression analysis showed malignancy as an independent predictor of undernutrition during the initial hospital admission (odds ratio [OR] = 11.8; 95% confidence interval [CI]: [1.1, 125.7]). The prevalence of undernutrition at admission was 26.7%. Factors associated with an increased prevalence of undernutrition at admission were age <40 years, unmarried status, and malignancy. Malignancy was an independent factor of the prevalence of undernutrition at admission.

scholarly journals Family involvement and patient-experienced improvement and satisfaction with care: a nationwide cross-sectional study in Danish psychiatric hospitals

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Marie Louise Svendsen ◽  
Trine Ellegaard ◽  
Karoline Agerbo Jeppesen ◽  
Erik Riiskjær ◽  
Berit Kjærside Nielsen
Keyword(s):  
Psychiatric Hospital ◽  
Hospital Care ◽  
Psychiatric Hospitals ◽  
Cross Sectional Study ◽  
Satisfaction With Care ◽  
Sectional Study ◽  
Cross Sectional ◽  
Caregiver Relationship ◽  
Patient Reported ◽  
Caregiver Involvement

Abstract Background Randomised controlled trials suggest that family therapy has a positive effect on the course of depression, schizophrenia and anorexia nervosa. However, it is largely unknown whether a positive link also exists between caregiver involvement and patient outcome in everyday psychiatric hospital care, using information reported directly from patients, i.e. patient-reported experience measures (PREM), and their caregivers. The objective of this study is to examine whether caregiver-reported involvement is associated with PREM regarding patient improvement and overall satisfaction with care. Methods Using data from the National Survey of Psychiatric Patient Experiences 2018, we conducted a nationwide cross-sectional study in Danish psychiatric hospitals including patients and their caregivers who had been in contact with the hospital (n = 940 patients, n = 1008 caregivers). A unique patient identifier on the two distinct questionnaires for the patient and their caregiver enabled unambiguous linkage of data. In relation to PREM, five aspects of caregiver involvement were analysed using logistic regression with adjustment for patient age, sex and diagnosis. Results We consistently find that high caregiver-reported involvement is statistically significantly associated with high patient-reported improvement and overall satisfaction with care with odds ratios (OR) ranging from 1.69 (95% confidence interval (CI) 0.95–2.99) to 4.09 (95% CI 2.48–6.76). This applies to the following aspects of caregiver-reported involvement: support for the patient-caregiver relationship, caregiver information, consideration for caregiver experiences and the involvement of caregivers in decision making. No statistically significant association is observed regarding whether caregivers talk to the staff about their expectations for the hospital contact. Conclusion This nationwide study implies that caregiver involvement focusing on the patient-caregiver relationship is positively associated with patient improvement and overall satisfaction with care in everyday psychiatric hospital care.

scholarly journals Efek Samping Terapi Antiretroviral dan Kepatuhan Berobat Penderita HIV/AIDS

2021 ◽  
Vol 12 (3) ◽  
pp. 389
Author(s):  
Rico Januar Sitorus ◽  
Novrikasari Novrikasari ◽  
Rizma Adliah Syakurah ◽  
Merry Natalia
Keyword(s):  
Medication Adherence ◽  
Side Effects ◽  
Opportunistic Infection ◽  
Multivariate Regression Analysis ◽  
Adherence Rate ◽  
P Value ◽  
Cross Sectional ◽  
Treatment Side Effects ◽  
The City ◽  
Hiv Aids

<p>Antiretroviral treatment side-effects and patient compliance with medical instructions continue to be a growing challenge for HIV/AIDS patients. Arv therapy has resulted in a substantial intervention that has been successful in preventing transmission and opportunistic infection. The main objective of this study was to analyze the association between side-effects of ARV therapy and medication adherence as well as another potential confounding such as opportunistic infection, family support, stress level, knowledge of ARV, marital status, and occupation. This study is a quantitative approach by using cross-sectional methods. A total of 244 respondents from 1.180 patients with confirmed HIV registered in the Care Support and Treatment (CST) service and Sriwijaya Community in the City of Palembang to respond to the survey. Non-random sampling was used to collect the samples. As the result, the majority of the respondents were male (84,43 %), ≥30 years old (57,4%), and secondary school graduates (52%). After adjusting with stress and opportunistic infection variable, a Multivariate regression analysis revealed a positive relationship between side effects and medication adherence (p-value of 0,041; 0,05), OR Adj 2,131 (1,190-4,988). PLHV who had adverse effects had a 2.131 times worse adherence rate than those who did not. In conclusion, medication adherence must be greatly improved in light of therapeutic side effects, stress levels, and opportunistic infection.</p>

scholarly journals Treatment outcomes and influencing factors on patients with Pulmonary Tuberculosis: a retrospective study

2021 ◽  
Vol 3 (2) ◽  
pp. 105-108
Author(s):  
Jamshid Ayatollahi ◽  
◽  
Abolhasan Halvani ◽  
Mohammadhesam Gharaei Khezri ◽  
Hossein Shahcheraghi ◽  
...  
Keyword(s):  
Side Effects ◽  
Frequency Distribution ◽  
Cross Sectional Study ◽  
The Body ◽  
Sputum Culture ◽  
Response To Treatment ◽  
Sputum Smear ◽  
Drug Side Effects ◽  
Cross Sectional ◽  
Significant Difference

Introduction: Tuberculosis infection caused by Mycobacterium tuberculosis is one of the most common infectious diseases, especially in countries such as Iran. The course of treatment and the number of drugs used vary depending on the severity of the disease and the parts of the body involved. The resistant tuberculosis to treatment has increased in recent years. Thus, this study was conducted to investigate the frequency distribution of response to treatment of patients with tuberculosis in Sirjan, Iran. Methods: This descriptive cross-sectional study investigated all patients with tuberculosis in Sirjan city who had referred to health centers during the years 2011-2019. The data collection tool was a pre-prepared checklist that included information on age, sex, sputum smear results, sputum culture results, diabetes, patients' nationality, drug side effects, and response to treatment. Finally, data was entered into SPSS version 22, and analyzed. Results: In this study, the overall response rate was 83% and the mortality rate was 10%. Between the frequency distribution of response to treatment in terms of gender, age, sputum smear results, sputum culture results, patients' nationality and diabetes was not statistically significant difference. Also, no statistically significant difference was found between the frequency distribution of pulmonary TB treatment response in terms of drug allergy, drug hepatitis and other drug side effects. Conclusion: According to results, can be concluded that none of the variables: age, sex, smear and culture result, and history of diabetes have no an effect on response to treatment and mortality of tuberculosis.

scholarly journals PREVALENCE OF STRESS AND ITS ASSOCIATED FACTORS AMONG MEDICAL STUDENTS IN SABAH, MALAYSIA BORNEO

2019 ◽  
Vol 19 (2) ◽  
pp. 116-125 ◽  
Author(s):  
Aldrin Musiun ◽  
Khamisah Awang Lukman ◽  
Mohammad Saffree Jeffree ◽  
Fredie Robinson ◽  
Mohd Rohaizat Hassan ◽  
...  
Keyword(s):  
Medical Education ◽  
Medical Student ◽  
Medical Students ◽  
Associated Factors ◽  
Health Care Services ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test

Stress is accepted as the accumulation of unpleasant state of physical, mental and emotion on a person. Medical education has been known as one of the most stressful academic curriculum.  Hence, medical students may subjected to multiple psychological changes and challenges throughout the years of medical education.  The aim of this study was to determine the prevalence of stress and its associated factors among medical students. This cross sectional study was conducted from April to May 2018 in medical school in Sabah. It involved 396 medical students through universal sampling.  Self-administered questionnaires were used as an instrument for data collection. The questionnaires included were Sociodemographic Questionnaire, Depression, Anxiety and Stress Scales 21 (DASS-21) and Medical Student Stressors Questionnaire (MSSQ). Bivariate analysis (Chi Square test, Fisher’s Exact Test, Independent T test and Man-Whitney U test) were used to analyse the association. The response rate was 90.2%. The prevalence of stress among medical students were 33.3%.  Significant associated factors include financial support inadequacy (p=0.010) and all categories of medical student stressors. The mean score of the academic related stressors was found to be at 2.117 (±0.758) which was the highest mean score among medical student stressors assessed by MSSQ. The result of this study can be used as a basis for implementation of preventive measures such as provision of comprehensive, integrated and responsive mental health care services in university-based settings.

Adverse Drug Reaction Monitoring of Antidepressant Drugs in a Mental Health Institute in Odisha

2021 ◽  
pp. 6479-6483
Author(s):  
Priti Das ◽  
Jyotiranjan Nayak ◽  
Sarada Prasanna Swain
Keyword(s):  
Mental Health ◽  
Causality Assessment ◽  
Antidepressant Drug ◽  
Antidepressant Drugs ◽  
Cross Sectional ◽  
Adverse Drug Reaction Monitoring ◽  
Health Institute ◽  
Medical College ◽  
Centre Of Excellence ◽  
Mental Health Institute

Introduction: Antidepressants are used primarily in the management of depressive and anxiety disorders. The occurrence of adverse drug reactions (ADRs) to antidepressants is a major challenge as it influences patient compliance. Aim: The aim of this study was to find out the ADR profile of antidepressant drugs in a mental health institute in Odisha. Materials and Methods: This is a cross sectional observational study conducted in Department of Pharmacology in collaboration with Mental Health Institute (Centre of Excellence) S.C.B Medical College and Hospital, Cuttack from September 2017 to September 2019. Patients who received at least one antidepressant drug were included in the study irrespective of age and sex. Data were collected by interviewing the patients or attendants and on detection of ADR, it was recorded on suspected ADR reporting form designed by PvPI. Causality, severity and preventability of ADRs were assessed by, WHO-UMC causality assessment, modified Hartwig-Siegel Scale and modified Schumock-Thornton criteria respectively. Results: Out of 180 patients taking antidepressants, ADRs were reported in 24% of patients, with either possible or probable causality. None were labelled as certain. ADRs were observed in 50% of patients who received TCAs and among 34.5% who received polytherapy. Insomnia (27%), fatigue (17%) and agitation (13%) were most common ADRs. Most of the ADRs were of mild severity (91%) and not preventable (84%). Conclusion: Insomnia, fatigue and agitation were among most common ADRs. There was increased chance of ADRs with polytherapy and use of TCAs. Most ADRs were mild and not preventable.

scholarly journals Inhaler Technique and Adherence to Inhaled Medications among Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Vietnam

2019 ◽  
Vol 16 (2) ◽  
pp. 185 ◽  
Author(s):  
Chau Ngo ◽  
Dung Phan ◽  
Giap Vu ◽  
Phu Dao ◽  
Phuong Phan ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Medication Adherence ◽  
Pulmonary Disease ◽  
Associated Factors ◽  
Chronic Obstructive ◽  
Inhaler Technique ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Sub-optimal chronic obstructive pulmonary disease (COPD) management has been found largely due to patients’ medication non-adherence and incorrect inhaler technique. This study aimed to examine inhaler use technique and medication adherence among Vietnamese COPD patients as well as potential associated factors. A cross-sectional study involving 70 COPD exacerbators was conducted. Inhaler technique and adherence were evaluated by the 10-item and 12-item Test of Adherence to Inhaler (TAI). Data on the history of COPD, home prescription of inhalers and duration of hospitalization were also collected. Generalized linear regression models were used to determine the associated factors with inhaler use and medication adherence. The results showed that the proportion of patients with good inhaler technique was 22.7% for metered-dose inhalers (MDI), 30.4% for dry powder inhalers (DPI) and 31.8% for soft-mist inhalers (SMI). Full exhalation was the most common mistake. The rates of non-compliance patterns were: “ignorant” (77.1%), “sporadic” (58.6%), and “deliberate” (55.7%). Worse dyspnea, greater health condition impairment, and an increased frequency of exacerbations and hospitalizations were found to be associated negatively with correct inhaler use and treatment adherence. Instructions to COPD patients about using inhalers should focus on correct inhaler technique and adherence even when feeling healthy.

scholarly journals Prevalence and Associated Factors of Regular Nonsteroidal Anti-inflammatory Drugs used in a Rural Community, Thailand

2017 ◽  
Vol 9 (9) ◽  
pp. 58 ◽  
Author(s):  
Pongsom Luanghirun ◽  
Patid Tanaboriboon ◽  
Pawaris Mahissarakul ◽  
Chanikarn Tongruang ◽  
Chanita Chaichirawiwat ◽  
...  
Keyword(s):  
Side Effects ◽  
Qualitative Study ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Attitudes And Practices ◽  
Pain Medications ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

BACKGROUND: In Thailand, 67.2% of the population widely uses analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), which may lead to serious side effects. However, the information of regular NSAIDs used in Thailand is still limited.METHODS: A mixed method cross-sectional study was conducted. Quantitative data were collected using questionnaires to determine the prevalence and factors associated with regular NSAID use. The qualitative study was conducted using group and in-depth interviews to determine the knowledge, attitudes and practices of NSAID users.RESULTS: Of 771 participants, the prevalence of NSAID use was 31.1 and regular NSAID use was 7.4. Age, pain at the hips or thighs and pain score were independent factors associated with regular NSAID use. The qualitative study indicated that the use of NSAIDs was influenced by drug effectiveness, sources of NSAIDs and consideration of benefits and risks of the drugs.CONCLUSION: This was the first report on the prevalence and associated factors of regular NSAID use in Thailand. In this community, nonprescribed NSAIDs might cause some serious side effects and undesirable drug interaction. Information on side effects of pain medications should be disseminated to the public including guidelines on how to use pain medications.

scholarly journals Adherence to drug treatment among schizophrenic patients in Jigawa State, Nigeria

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Ado Shehu ◽  
Saleh Ngaski Garba ◽  
Emmanuel Ejembi Anyebe ◽  
Mb Tukur ◽  
Hayat Gomma
Keyword(s):  
Side Effects ◽  
Drug Treatment ◽  
Behavioural Change ◽  
Health Care Financing ◽  
Sampling Technique ◽  
Community Treatment ◽  
Bivariate Analysis ◽  
Cost Of Treatment ◽  
Cross Sectional ◽  
Schizophrenic Patients

Schizophrenia is among the most common psychiatric disorders, affecting approximately 1% of the world’s population and is among the leading cause of disability. Adherence to drug therapy is associated with favourable clinical outcomes and good quality of life among schizophrenic patients undergoing treatment. This study assessed the prevalence and factors responsible for adherence/ non-adherence to drug treatment among schizophrenic patients in Jigawa State. We used a descriptive hospital-based cross-sectional study design and recruited three hundred and ninety- nine patients using multi-stage sampling technique. The mean and standard deviation of age of the respondents was 42.3±11.2. The level of drug adherence was 47.1%. On bivariate analysis, cost of treatment, types of treatment, side effects, and effects of treatment on the performance were found to be associated with low adherence of drugs treatment (P<0.05). On adjusting for confounding effect using logistic regression analysis, the cost of treatment of more than one thousand naira per day (AOR=3.00, 95%CI=2.75-8.83) and presence of side effects (AOR=4.01, 95%CI=1.45-16.09) were found to be predictors of non-adherence to drug treatments. Supervised community treatment, behavioural change communications along with community mental health care financing were recommended in order to increase access and decrease non-adherence to drugs.

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