Therapeutic Effects of Traditional Chinese Exercises on Musculoskeletal Pain: A Systematic Review and Meta-Analysis

Background. The number of patients with musculoskeletal pain, which seriously affects people’s quality of life, has increased. Traditional Chinese exercises are accepted and practiced to strengthen the body. Objective. This study aims to explore the efficacy of traditional Chinese exercises for the treatment of musculoskeletal pain. Methods. A comprehensive search of randomized controlled trials (RCTs) related to traditional Chinese exercises on patients with musculoskeletal pain was completed using PubMed, SinoMed, CNKI, VIP, and Wanfang Med Online databases. All RCTs published until February 2021 were considered. Two researchers independently screened the literature according to the predesigned inclusion and exclusion criteria, and data was extracted and assessed for their risk of bias via the Cochrane collaboration tool. Meta-analysis was performed using RevMan5.2 and Rx64 4.0.2 software. Results. A total of 45 RCT studies with 3178 patients were included. Traditional Chinese exercises were able to effectively alleviate patients with musculoskeletal pain (MD = −1.54, 95% confidence interval (−1.88, −1.19), P < 0.01). Among them, the Yi Jin Jing exercise was superior to other exercises, while Wu Qin Xi showed no significant effects. Besides, traditional Chinese exercises had significant positive effects on the dysfunction and stiffness of the waist and knee joints. Traditional Chinese exercises could effectively relieve the clinical symptoms of patients with musculoskeletal pain. Particularly, the Yi Jin Jing exercise presented the most significant positive effect on pain reduction.

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Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis

Journal of Clinical Medicine ◽

10.3390/jcm9040941 ◽

2020 ◽

Vol 9 (4) ◽

pp. 941 ◽

Cited By ~ 136

Author(s):

Israel Júnior Borges do Nascimento ◽

Nensi Cacic ◽

Hebatullah Mohamed Abdulazeem ◽

Thilo Caspar von Groote ◽

Umesh Jayarajah ◽

...

Keyword(s):

Scoping Review ◽

Clinical Symptoms ◽

Meta Analysis ◽

Laboratory Data ◽

Gastrointestinal Symptoms ◽

Common Disease ◽

Imaging Data ◽

Laboratory Findings ◽

Number Of Patients ◽

Novel Coronavirus

A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%–99%; n = 4410), cough (61%, 95% CI 39%–81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%–55%; n = 3778), dyspnea (26%, 95% CI 12%–41%; n = 3700), headache in 12% (95% CI 4%–23%, n = 3598 patients), sore throat in 10% (95% CI 5%–17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%–17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83–1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54–45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%–1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.

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Effect of BMI on complications rate, reoperation and functional outcome after Total Knee Arthroplasty, A Systematic Review of Literature

QJM ◽

10.1093/qjmed/hcaa059.015 ◽

2020 ◽

Vol 113 (Supplement_1) ◽

Author(s):

W S Abdelmegied ◽

A M Sallam ◽

M M Ahmed

Keyword(s):

Total Knee Arthroplasty ◽

Knee Arthroplasty ◽

Meta Analysis ◽

Cochrane Collaboration ◽

The Body ◽

Obese Patients ◽

Superficial Infection ◽

Vein Thrombosis ◽

Functional Scores ◽

Total Knee

Abstract Purpose The body mass index (BMI) is widely recognized as a prognostic factor in multiple operations; however, the relationship between the BMI and outcomes following total knee arthroplasty (TKA) is extensively debated. We aimed to evaluate the effect of the BMI at different cutoff values on the outcomes following primary TKA. Methods Electronic databases (PubMed/Medline, Embase and Web of Science) were systematically searched for studies investigating the association between the BMI and outcomes following primary TKA. Two investigators independently reviewed studies for eligibility. A meta-analysis was performed using Review Manager 5.2 software from the Cochrane Collaboration. Results Thirteen articles were identified. The postoperative Knee Society Score appeared to trend lower in obese (BMI ≥ 30 kg/ m2) patients than in non-obese (BMI < 30 kg/m2) patients. The meta-analysis showed that revision with follow-up ≥2 years, any infection, superficial infection and deep vein thrombosis occurred statistically more frequently in obese patients. Conclusion Patients with a BMI ≥ 30 kg/m2 are at a higher risk of lower functional scores and developing complications following primary TKA. It appears reasonable to encourage obese patients to lose weight before selective TKA.

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First two years of reimbursed enzyme replacement therapy in the treatment of Fabry disease in Poland

F1000Research ◽

10.12688/f1000research.55313.1 ◽

2021 ◽

Vol 10 ◽

pp. 841

Author(s):

Michał Nowicki ◽

Monika Komar ◽

Mariusz Kusztal ◽

Katarzyna Mizia-Stec ◽

Tomasz Liberek ◽

...

Keyword(s):

Enzyme Replacement Therapy ◽

Fabry Disease ◽

Replacement Therapy ◽

Clinical Symptoms ◽

Final Diagnosis ◽

The Body ◽

Lysosomal Storage ◽

Enzyme Replacement ◽

Number Of Patients ◽

Mean Time

Fabry disease (FD) is an ultra-rare genetic lysosomal storage disease caused by pathologic gene variants resulting in insufficient expression of α-galactosidase A. This enzyme deficiency leads to accumulation of globotriaosylceramide and globotriaosylsphingosine in plasma and in different cells throughout the body, causing major cardiovascular, renal, and nervous system complications. Until 2018, reimbursed enzyme replacement therapy (ERT) for FD was available in all European Union countries except Poland. We present the preliminary results of the first two years of reimbursed ERT in Poland. We obtained data from the seven largest academic centers in Katowice, Kraków, Wrocław, Poznań, Gdańsk, Warszawa, and Łódź. The questionnaire included the following data: number of patients treated, number of patients qualified for ERT, and patient characteristics. All centers returned completed questionnaires that included data for a total of 71 patients (28 men and 43 women) as of June 2021. Thirty-five patients with the diagnosis of FD confirmed by genetic testing (22 men and 13 women) had already qualified for reimbursed ERT. Mean (SD) age at the commencement of the ERT program was 39.6 (15.5) years (range 18-79 years). Mean time from the first clinical symptoms reported by the patients to the FD diagnosis was 21.1 (8.9) years, and the mean time from the final diagnosis of FD to the beginning of ERT was 4.7 (4.6) years. FD is still underdiagnosed in Poland. To identify undiagnosed FD patients and to ensure that patients in Poland benefit fully from ERT, implementation of an effective nationwide screening strategy and close cooperation with a network of rare disease centers is advised.

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The Effect of Trimetazidine Added to Pharmacological Treatment on All-Cause Mortality in Patients with Systolic Heart Failure

Cardiology ◽

10.1159/000375288 ◽

2015 ◽

Vol 131 (1) ◽

pp. 22-29 ◽

Cited By ~ 9

Author(s):

Stefan Grajek ◽

Michał Michalak

Keyword(s):

Heart Failure ◽

Pharmacological Treatment ◽

Controlled Trial ◽

Meta Analysis ◽

Antioxidant Properties ◽

Systolic Heart Failure ◽

Cochrane Collaboration ◽

Positive Effects ◽

Prospective Randomized Controlled Trial ◽

All Cause Mortality

The anti-ischemic agent trimetazidine (TMZ) added to pharmacological treatment appears to have positive effects on cardiac parameters of patients with heart failure (HF) as a result of specific antioxidant properties. Objectives: We aimed to verify whether the marked improvement provided by TMZ in echocardiographic and clinical parameters was likely to translate into reduced all-cause mortality in systolic HF patients. Methods: Meta-analysis of available published prospective randomized controlled trial (RCT) data (1967-2014) retrieved from PubMed, Web of Science and Cochrane Collaboration. Results: A total of 326 patients from 3 RCTs were analyzed: 164 who received TMZ on top of pharmacological HF therapy and 162 controls. Study durations ranged from 12 to 48 months. The analysis had no publication bias and the studies were homogeneous (p = 0.442, I2 = 0). The results show a significant effect of TMZ on the reduction of all-cause mortality (RR = 0.283, p < 0.0001). The rate of events attributable to the drug was lower with TMZ than it was among control patients. Conclusion: This meta-analysis suggests that in patients with HF, TMZ given as an add-on therapy is likely to provide a protective effect, reduce all-cause mortality and increase event-free survival, and could be an effective and useful adjunct to our armamentarium for the treatment of HF patients.

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THERAPEUTIC EFFECTS OF ANCIENT INDIAN CLASSICAL MUSIC

10.36106/ijar/1811810 ◽

2020 ◽

pp. 1-3

Author(s):

Vikas Gandhe ◽

Manasi Tare

Keyword(s):

Music Therapy ◽

Classical Music ◽

Positive Impact ◽

Vital Role ◽

The Body ◽

Therapeutic Effects ◽

Positive Effects ◽

Different Types ◽

Mind And Body ◽

Indian Classical Music

Music plays a vital role in each and every human being’s life. It’s undeniable that music affects human emotions whether it's sadness, happiness, anger, stress, or depression. Ancient Indian classical music originated 2000 years ago. It’s based on seven basic notes that were derived from sounds of birds and animals. The permutations and combinations of these notes create melodious structures with musical motifs called “Raga”. These Ragas create different types of emotions in mind that in turn make positive effects on the body. Different Ragas are sung (vocally) or played (instrumentally) in particular time of the day during the entire 24 hours for its immense positive impact on mind and body. Hence it is used in a form of therapy known as “Music therapy” to be used therapeutically to treat multiple diseases. The types of Ragas, time of different Raga and its effects on the human body therapeutically is shown in tabular form in this paper.

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Diabetes, Age, and Duration of Supplementation Subgroup Analysis for the Effect of Coenzyme Q10 on Oxidative Stress: A Systematic Review and Meta-Analysis

Complementary Medicine Research ◽

10.1159/000515249 ◽

2021 ◽

pp. 1-14

Author(s):

Ghazaleh Hajiluian ◽

Javad Heshmati ◽

Sahar Jafari Karegar ◽

Mahdi Sepidarkish ◽

Ali Shokri ◽

...

Keyword(s):

Oxidative Stress ◽

Systematic Review ◽

Coenzyme Q10 ◽

Antioxidant Defense ◽

Randomized Clinical Trials ◽

Assessment Tool ◽

Meta Analysis ◽

The Body ◽

Cochrane Library ◽

Positive Effects

Background: Coenzyme Q10 (CoQ10) has been known as ubiquinone or ubidecarenone, which is a kind of lipid-soluble and vitamin-like antioxidant. It has a potent antioxidant effect against oxidation status via various mechanisms, including its ability to regenerate other antioxidants, such as vitamin E and vitamin C, and to increase antioxidant enzymes. Moreover, CoQ10 can quench free radicals and prevent lipid peroxidation. The aim of this systematic review and meta-analysis was to evaluate the effect of CoQ10 on oxidative stress variables. Methods: A comprehensive electronic database search in Scopus, Web of Science, Embase, Cochrane Library, and Medline was performed to identify eligible randomized clinical trials. A meta-analysis of included studies was performed on selected variables using a random-effects model. Quality assessment was conducted by means of the Cochrane risk of bias assessment tool. Results: To evaluate the effect of CoQ10 supplementation, 17 trials and 972 participants were included for the meta-analysis. The pooled analysis of primary studies showed that CoQ10 increased serum total antioxidant capacity (standardized mean difference [SMD] 0.62 mmol/L, 95% CI 0.18–1.05, I2 = 76.1%, p ˂ 0.001) and superoxide dismutase (SMD 0.40 U/mg, 95% CI 0.12–0.67, I2 = 9.6%, p ˂ 0.345) levels and decreased malondialdehyde (SMD –1.02 mmol/L, 95% CI –1.60 to –0.44, I2 = 88.2%, p ˂ 0.001) level significantly compared to the placebo group. Although the effect of CoQ10 on nitric oxide (SMD 1.01 µmol/L, 95% CI –1.53 to 3.54, p ˂ 0.001, I2 = 97.8%) and glutathione peroxidase (SMD –0.01 mmol/L, 95% CI –0.86 to 0.84, p ˂ 0.001, I2 = 88.6%) was not significant, CoQ10 can be mentioned as an improvement in antioxidant defense status against reactive oxygen species. Conclusion: These supplements have positive effects on antioxidant defense against oxidizing agents and elevate antioxidant enzyme levels in the body. However, due to limited research the results should be taken with caution.

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Effectiveness of Hydrocolloid Dressings for Treating Pressure Ulcers in Adult Patients: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17217881 ◽

2020 ◽

Vol 17 (21) ◽

pp. 7881

Author(s):

Magdalena Sylwia Kamińska ◽

Anna Maria Cybulska ◽

Karolina Skonieczna-Żydecka ◽

Katarzyna Augustyniuk ◽

Elżbieta Grochans ◽

...

Keyword(s):

Systematic Review ◽

Pressure Ulcers ◽

Meta Analysis ◽

Random Effect ◽

Cochrane Collaboration ◽

Adult Patients ◽

Therapeutic Effects ◽

Study Selection ◽

Meta Analyses ◽

The Cochrane Collaboration

The aim of this study was to assess the effectiveness of hydrocolloid dressings in the treatment of grade I, II, III, and IV pressure ulcers in adult patients. We compared the therapeutic effects of hydrocolloids and alternative dressings in pressure ulcer treatment. We conducted a systematic review, using a literature search only in English, from database inception until 20 April 2020, to identify randomized trials comparing various types of dressings applied in the healing of pressure ulcers. The databases were PubMed, Embase, and Cumulative Index to Nursing and Allied Health Literature (CINAHL). The study selection was performed independently by two reviewers. Data were extracted based on the guidelines included in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The risk of bias in the included studies was assessed using a standardized critical appraisal instrument developed by the Cochrane Collaboration. Random-effect meta-analysis of data from three or more studies was performed using meta-analysis software (Comprehensive Meta-Analysis V3, Biostat, New Jersey, USA). A total of 1145 records were identified, of which 223 were qualified after further verification, of which eight were finally included in further analysis. Hydrocolloid dressings were not superior to control therapeutics (p = 0.839; Z = 0.203; CI 95%: 0.791–1.334). They were not associated with higher healing rates (p = 0.718; Z = 0.361; OR: 0.067; CI 95%: 0.297–0.431), nor did they decrease the incidence of adverse events compared with control therapeutics (p = 0.300; Z = −1.036; OR: 0.067; CI 95%: 0.394–1.333). In the above cases, Egger’s test also did not indicate publication bias (t value = 0.779, p = 0.465; t value = 1.198, p = 0.442; t value = 0.834, p = 0.465, respectively). The present meta-analysis shows that hydrocolloid dressings are not significantly better than alternative ones in the healing of pressure ulcers in adult patients.

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Molecular and biological functions of gingerol as a natural effective therapeutic drug for cervical cancer

Journal of Ovarian Research ◽

10.1186/s13048-021-00789-x ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Parinaz Zivarpour ◽

Elhameh Nikkhah ◽

Parisa Maleki Dana ◽

Zatollah Asemi ◽

Jamal Hallajzadeh

Keyword(s):

Cervical Cancer ◽

Herbal Medicines ◽

Zingiber Officinale ◽

The Body ◽

Therapeutic Drug ◽

Therapeutic Effects ◽

Immune System Dysfunction ◽

Number Of Patients ◽

Advanced Stages ◽

Valuable Compounds

AbstractCervical cancer is one of the most common and important gynecological cancers, which has a global concern with an increasing number of patients and mortality rates. Today, most women in the world who suffer from cervical cancer are developing advanced stages of the disease. Smoking and even exposure to secondhand smoke, infections caused by the human papillomavirus, immune system dysfunction and high-risk individual-social behaviors are among the most important predisposing factors for this type of cancer. In addition, papilloma virus infection plays a more prominent role in cervical cancer. Surgery, chemotherapy or radical hysterectomy, and radiotherapy are effective treatments for this condition, the side effects of these methods endanger a person’s quality of life and cause other problems in other parts of the body. Studies show that herbal medicines, including taxol, camptothecin and combretastatins, have been shown to be effective in treating cervical cancer. Ginger (Zingiber officinale, Zingiberaceae) is one of the plants with valuable compounds such as gingerols, paradols and shogoals, which is a rich source of antioxidants, anti-cancer and anti-inflammatory agents. Numerous studies have reported the therapeutic effects of this plant through various pathways in cervical cancer. In this article, we look at the signaling mechanisms and pathways in which ginger is used to treat cervical cancer.

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e-Health Interventions for Healthy Aging: A Systematic Review

10.21203/rs.2.22247/v2 ◽

2020 ◽

Author(s):

Ronald Buyl ◽

Idrissa Beogo ◽

Maaike Fobelets ◽

Carole Deletroz ◽

Philip Van Landuyt ◽

...

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Healthy Aging ◽

Meta Analysis ◽

Cochrane Collaboration ◽

Target Population ◽

Health Interventions ◽

Healthy Behaviors ◽

Positive Effects ◽

Population Type

Abstract Background: Healthy aging (HA) is a contemporary challenge for population health worldwide. Electronic health (e-Health) interventions have the potential to support empowerment and education of adults aged 50 and over. Objectives: To summarize evidence on the effectiveness of e-Health interventions on HA and explore how specific e-Health interventions and their characteristics effectively impact HA.Methods: A systematic review was conducted based on the Cochrane Collaboration methods including any experimental study design published in French, Dutch, Spanish and English from 2000 to 2018. Results: Fourteen studies comparing various e-Health interventions to multiple components controls were included. The target population, type of interventions and outcomes measured were very heterogeneous across studies, thus a meta-analysis was not possible. However, effect estimates indicate that e-Health interventions could improve physical activity. Positive effects were also found for other healthy behaviors (e.g. healthy eating), psychological outcomes (e.g. memory) and clinical parameters (e.g. blood pressure). Given the low certainty of the evidence related to most outcomes, these results should be interpreted cautiously.Conclusions: This systematic review found limited evidence supporting the effectiveness of e-Health interventions, although the majority of studies show positive effects of these interventions for improving physical activity in older adults. Thus, better quality evidence is needed regarding the effects of eHealth on the physiological, psychological and social dimensions of HA.Systematic review registration: The review protocol was registered in PROSPERO (registration number: CRD42016033163).

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The Effect of Artemisinin-Based Drugs vs Non-artemisinin-based Drugs on Gametophyte Carrying in the Body After the Treatment of Uncomplicated Falciparum Malaria: A Systematic Review and Meta-analysis

Frontiers in Pharmacology ◽

10.3389/fphar.2021.707498 ◽

2022 ◽

Vol 12 ◽

Author(s):

Yuanyuan Zou ◽

Nadia Julie ◽

Shiyuan Guo ◽

Yexiao Tang ◽

Hongying Zhang ◽

...

Keyword(s):

Falciparum Malaria ◽

Meta Analysis ◽

Clinical Malaria ◽

The Body ◽

Control Group ◽

Therapeutic Effects ◽

Serious Adverse Events ◽

Intervention Measures ◽

Significant Difference ◽

The Difference

The WHO recommends Artemisinin-based combination therapy (ACTs) as the first-line treatment for malaria. This meta-analysis aims to analyze the effects of artemisinin and its derivatives as well as non-artemisinin drugs on the gametophytes in the host during the treatment of falciparum malaria. Fourteen studies were included in this analysis, and the artemisinin combination drugs involved were: artemether-lumefantrine (AL), artemisinin (AST), artemether-benflumetol (AB), dihydroartemisinin-piperaquine + trimethoprim + primaquine (CV8), amodiaquine + sulfadoxine-pyrimethamine (ASP), pyronaridine-phosphate + dihydroartemisinin (PP-DHA), dihydroartemisinin (DHA), and mefloquine + artesunate (MA), with 1702 patients. The control intervention measures involved the following: sulfadoxine-pyrimethamine (SP), mefloquine (MQ), atovaquone-proguanil (AT-PG), chloroquine + sulfadoxine-pyrimethamine (C-SP), quinine (Q), pyronaridine-phosphate (PP), pyronaridine (PN), and mefloquine + primaquine (MP), with 833 patients. The effect of ACTs was more obvious (OR = 0.37, 95%CI: 0.22–0.62, p < 0.05). In the control group of second malaria attacks, the difference between the two groups was not statistically significant (RD = 1.16, 95%CI: 0.81–1.66, p < 0.05); there was no significant difference in treatment failure during follow-up (RD = -0.01, 95%CI: 0.04–0.03, p < 0.05). There were also very few serious adverse events in both groups. ACTs showed good therapeutic effects in preventing gametocythemia but did not control the recrudescence rate and overall cure, which indicated the effectiveness of the combination of antimalarial drugs. Further research is required to explore which compatibility method is most conducive to the development of clinical malaria control.

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