scholarly journals Оцінка ефективності лікування хронічного катарального гінгівіту в працівників птахофабрик за даними клінічних спостережень та параклінічних індексів

2018 ◽  
Author(s):  
T. I. Pupin ◽  
O. I. Kardashevska
Keyword(s):  
Periodontal Diseases ◽  
Main Group ◽  
Factory Workers ◽  
Duration Of Treatment ◽  
Treatment And Prevention ◽  
Clinical Observations ◽  
A Value ◽  
Periodontal Index ◽  
Poultry Farms ◽  
And Control

Summary. The research of periodontal diseases provides the basis for a generalized conclusion that the occurrence of pathological changes in the teeth-containing tissues occurs when the general state of the organism changes, due to the action of a number of endogenous and exogenous factors that determine the approaches to the treatment and prevention of these diseases. Despite the automation and mechanization of poultry farms, an increasing percentage of poultry workers are exposed to adverse productive factors, which lead to occupational diseases, in particular periodontal diseases.The aim of the study – to evaluate the effectiveness of the developed scheme of treatment of chronic catarrhal gingivitis in poultry factory workers according to clinical observations and paraclinical indices.Materials and Methods. To evaluate the effectiveness of the treatment of chronic catarrhal gingivitis (CCG), there were 39 employees of poultry farms, whо were divided into 2 equal groups: the main (20 persons), in which treatment was performed according to the scheme we developed and control (19 people), where patients were treated for according to the “Protocols of the Ministry of Health of Ukraine” the provision of medical care in the specialty “Therapeutic Dentistry”.Results and Discussion. In case of poultry factory workers, patients with CCG, 1 month after treatment, the index of PI in the main group was (0.45±0.03) points, the value of the index of PMA decreased by 2 times: (12.28±2.28) %, the value of the index OHI- S corresponded to satisfactory hygiene: (0.98±0.02) points. Six months after treatment, patients in the main group who tested for stabilization of the periodontal index of PI with a value of (0.45±0.04) points, a decrease in the PMA index to (11.79±2.23) and an OHI-S index of (1.08±0.01) score. In 12–18 months, the value of the index of PI in the main group was (0.63±0.23) points, the index PMA fell to (14.37±2.26) %. The condition of oral hygiene according to the OНI-S index in the main group was assessed as “satisfactory” with a value of (1.28±0.04) points.Conclusions. In the main group, the elimination of the inflammatory process in the gums was clinically observed at all stages, which was confirmed by a decrease in the periodontal indices PMA up to (11.79±2.23) %, PI up to (14.37±2.26) %, a decrease in the index of the hygiene index OHI-S to (1.08±0.01) points. Thus, the proposed therapeutic model allowed to increase the efficiency and reduce the duration of treatment of chronic catarrhal gingivitis in workers of poultry farms.

scholarly journals Improving of treatment of periodontal diseases in workers of the woodworking industry of the Chernivtsi region

2021 ◽  
Vol 106 (2) ◽  
pp. 28-35
Author(s):  
V. Batig ◽  
◽  
O. Tokar ◽  
I. Burdenyuk ◽  
◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Comparison Group ◽  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Treatment And Prevention ◽  
Group A ◽  
Group B ◽  
Periodontal Indices

Goal. Improving the scheme of treatment and prevention of periodontal diseases in workers of the woodworking industry of Chernivtsi region, who in the process of professional activity have long-term contact with unfavorable factors of the production environment. Materials and methods. 70 workers of the woodworking industry with diagnosed chronic generalized periodontitis of the I degree were treated (35 people – the main group (A); 35 people – comparison group (B)), age – from 25 to 45 years. To compare the results of laboratory studies, an additional survey of 25 healthy individuals of the same age with an intact periodontium were conducted. They formed the control group (C). Clinical examination of patients was performed according to standart methods: subjective (complaints, medical history, life history) and objective (examination, periodontal indices, determination of the level of gingival attachment). Laboratory methods of research included determination of urease and lysozyme activity in saliva, degree of dysbiosis of oral cavity. As maintenance therapy, patients of the main group were prescribed the proposed composition DEPE. Results. After the treatment, a significant improvement in the hygienic status of patients in both groups was observed, but difference between groups A and B in the indicators of oral hygiene after treatment was no statistically significant (pA2–B2 > 0.05). There was a significant improvement in periodontal indices after treatment in patients of both groups (PMA index according to C. Parma, bleeding index according to Muhlemann in Cowell I. modification, Russell periodontal index, PSR-test), but the indicators in patients of the main group were significantly better – pA2–B2 < 0.05. In patients of the main group (A) the level of attachment loss decreased by 1.83 times, comparison group (B) – by 1.71 times. The difference in levels of attachment loss after treatment between groups A and B is statistically significant (pA2–B2 < 0.05). The activity of the enzyme urease in patients of the main group (A) and comparison group (B) after treatment was significantly reduced (pA1–A2 < 0.001, pB1–B2 < 0.001), but only in the main group it reached the level in the control group (C) (pA2–C > 0.05). The level of lysozyme after treatment was significantly increased in patients of both observation groups (pA1–A2 < 0.001, pB1–B2 < 0.001), and reached the level of lysozyme in patients of the control group (C) (pA2–C > 0.05, pB2–C > 0.05). The degree of oral dysbiosis in patients of the main group (A) was significantly reduced by 5.43 times (pA1–A2 < 0.001), and its difference from the degree of dysbiosis in patients of the control group (C) is statistically insignificant (pA2–C > 0.05 ). The degree of oral dysbiosis in patients of the comparison group (B) was significantly reduced by 3.04 times (pB1–B2 < 0.001), but still remained significantly different from oral dysbiosis in patients of the control group (C) (pB2–C < 0.05). Conclusion. The proposed pharmacological composition DEPE is an effective antiseptic solution and can be used in the phase of maintenance therapy to improve the treatment and prevention of periodontal disease in workers of woodworking industry. Key words: decamethoxine, propolis, ethonium, generalized periodontitis, woodworking industry.

scholarly journals EVALUATION OF THE EFFECTIVENESS OF PREVENTION AND TREATMENT OF CHRONIC CATARRHAL GINGIVITIS IN CHILDREN WITH OLIGOPHRENIA

2019 ◽  
Vol 19 (4) ◽  
pp. 49-53
Author(s):  
Н. Dutko
Keyword(s):  
Periodontal Diseases ◽  
Main Group ◽  
Control Group ◽  
Periodontal Tissue ◽  
Effective Measure ◽  
Standard Methods ◽  
Treatment And Prevention ◽  
Prophylactic Measures ◽  
Dental Diseases

Prevention of hard dental tissue diseases and periodontal diseases in children is one of the urgent issues of pediatric dentistry. This is especially true for the category of children with psychoneurological pathology. Due to the high prevalence of dental diseases, decreased immunity, and sometimes difficult assess to dental care for children with mental retardation, dental disease prevention is the most effective measure to maintain the normal functioning of the dentofacial apparatus. The results obtained by examining the children with oligophrenia allowed us to work up an algorithm for therapeutic and preventive measures aimed at preventing the development of oral tissue diseases in these children. The algorithm included measures for primary and secondary prevention of periodontal diseases. To assess the efficacy of the algorithm, the study involved a group of 55 mentally impaired children. The control group consisted of 50 children with oligophrenia, who were treated by traditional methods. Taking into account the burdened mental status of the children when developing the individual hygiene regimens, a motivational approach was worked out in co-operation with a psychiatrist and a paediatrician. Evaluation of treatment outcomes in the groups was performed in 1 month after the completion of the full course of treatment and prevention and in long-term intervals, in 6 and 12 months. Clinical evaluation of treatment efficacy was performed according to the following criteria: "normalization", "improvement", "progression". In one month following the regimen proposed, the "normalization" of the affected tissues was diagnosed in 40 children of the main group (72,73 ± 6,06%), p <0,01. The "improvement" of periodontal tissue condition was observed in 10 children (18.18 ± 5.25%), p <0.05. Only 5 children in the main group (9.09 ± 3.91%) failed to demonstrate any positive changes. In 6 months following the application of the treatment and prevention algorithm, the children of the main group demonstrate the "normalization" of periodontal tissue in 65,45 ± 6,47% of cases, while in the children of the control group this indicator was twice lower, 32,00 ± 6.66%, p <0.01. The "improvements" were found in 21.82 ± 5.62% of the children in the main group and in 14.00 ± 4.96% of the children in the control group, p <0.05. No effect of treatment and progression of inflammatory process were observed in 7 children of the main group that was in 4.2 times less than in children of the control group. In long-term follow-up, in 1 year, 61.82 ± 6.61% of children with oligophrenia, who received the treatment and prophylactic measures proposed demonstrated the "normalization" of the periodontal tissue health. In the children treated with standard methods, this indicator was 2.2 times lower (28.00 ± 6.41%), p <0.01. The "improvement" of periodontal condition was recorded in 27.27 ± 6.06% of children in the main group versus 10.00 ± 4.28% of the children in the control group, p <0.01. Treatment for 10.91 ± 4.24% of the children of the main group failed to be effective, but for the children of the control group this indicator was in 5.7 times higher during the long-term observation. The data obtained indicate the lack of effectiveness of standard methods of treatment for chronic catarrhal gingivitis and confirm the high efficiency of the developed algorithm for treatment and prevention of dental diseases in children with oligophrenia. The authors of this article confirm that the research and publication of the results were not associated with any conflicts regarding commercial or financial relations, relations with organizations and/or individuals who may have been related to the study, and interrelations of co-authors of the article.

TO STUDY THE CPITN INDEX IN THE TREATMENT OF CHRONIC CATARRHAL GINGIVITIS AND CHRONIC GENERALIZED PERIODONTITIS OF MILD SEVERITY USING AN ADAPTOGEN-MODIFIED GEL

2021 ◽  
pp. 25-28
Author(s):  
Алик Эдикович Петросян ◽  
Наталия Владимировна Чиркова ◽  
Арпине Бронислави Антонян ◽  
Артем Игоревич Архипов
Keyword(s):  
Periodontal Diseases ◽  
Age Groups ◽  
Integrated Approach ◽  
Periodontal Tissues ◽  
Mild Degree ◽  
Treatment And Prevention ◽  
Comparative Aspect ◽  
Periodontal Index ◽  
Frequent Relapses ◽  
Anti Inflammatory

Актуальность постоянных научных исследований в области пародонтологии обусловлена большой частотой воспалительно-деструктивных заболеваний пародонта среди всех возрастных групп населения во всем мире. Лечение и профилактика данной патологии является одной из наиболее сложных и трудоемких в терапевтической стоматологии. На сегодняшний день существует множество лекарственных препаратов отечественного и зарубежного производства, предназначенных для лечения воспалительных заболеваний пародонта. Чаще всего в их состав входят антисептики, противовоспалительные компоненты, ферментные и витаминные препараты. Нехватка в составе данных лекарственных средств иммунокорригирующих препаратов и адаптогенов, в дальнейшем приводят к развитию частых рецидивов. Отсутствие комплексного подхода к лечению данных заболеваний не только приводит к длительному его течению, но и не редко приводит к хронизации процесса, что явилось предпосылкой для исследования влияния стоматологического геля, модифицированного адаптогеном на ткани пародонта при лечении хронического катарального гингивита и хронического генерализованного пародонтита легкой степени. Изучение научной литературы подтверждает, что применение в медицине адаптогенов, при лечении различных заболеваний, оказывает выраженное противовоспалительное, иммуномодулирующее, вяжущее и седативное действие. Данная статья предусматривает изучение комплексного пародонтального индекса у пациентов при лечении хронического катарального гингивита и хронического генерализованного пародонтита легкой степени тяжести в сравнительном аспекте The relevance of ongoing scientific research in the field of periodontology is due to the high frequency of inflammatory and destructive periodontal diseases among all age groups of the population around the world. Treatment and prevention of this pathology is one of the most difficult and time-consuming in therapeutic dentistry. To date, there are many medicines of domestic and foreign production intended for the treatment of inflammatory periodontal diseases. Most often, they include antiseptics, anti-inflammatory components, enzyme and vitamin preparations. The lack of immunocorrecting drugs and adaptogens in the composition of these drugs, further lead to the development of frequent relapses. The lack of an integrated approach to the treatment of these diseases not only leads to its prolonged course, but also not infrequently leads to the chronization of the process, which was a prerequisite for studying the effect of a dental gel modified with an adaptogen on periodontal tissues in the treatment of chronic catarrhal gingivitis and chronic generalized periodontitis of mild degree. The study of scientific literature confirms that the use of adaptogens in medicine, in the treatment of various diseases, has a pronounced anti-inflammatory, immunomodulatory, astringent and sedative effect. This article provides for the study of the complex periodontal index in patients in the treatment of chronic catarrhal gingivitis and chronic generalized periodontitis of mild severity in a comparative aspect

scholarly journals OPTIMIZATION OF METHODS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY PERIODONTAL DISEASES

2019 ◽  
Vol 15 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Ризван Мамедов ◽  
Rizvan Mamedov ◽  
Нигяр Садыгова ◽  
Nigar Sadigova ◽  
Лала Ибрагимова ◽  
...  
Keyword(s):  
Comparison Group ◽  
Periodontal Diseases ◽  
Main Group ◽  
Laboratory Evaluation ◽  
Control Group ◽  
Standard Regimen ◽  
Clinical Observations ◽  
Normal Microflora ◽  
Microbial Associations ◽  
Treatment Research

Relevance. Medicines, taking into account the role of various microbial associations in the development of severe generalized forms of gingivitis and periodontitis, should have high antimicrobial activity, but their use can also cause growth inhibition and representatives of normal microflora. The purpose ― to evaluate the effectiveness of complex treatment of inflammatory periodontal diseases using new prophylactic agents. Material and research methods. For a comparative clinical and laboratory evaluation of the effectiveness of the therapeutic and prophylactic agents used, the patients were divided into 3 groups. With HGPLS - the control group - 18, in which treatment was limited only to hygienic education and the conduct of professional hygiene. The comparison group (20 people with CHPH) received treatment according to the generally accepted standard regimen and prescribed Curasept ADS 712 gel toothpaste. The main group (20 people with CHPH) received the standard therapy with Curaprox Enzycal toothpaste 1450ppm. Microbiological studies of a mixed oral fluid and clinical indices were performed in the work — the SBI bleeding index of the gingival sulcus (Muhlemann, 1971), Silness-Loe hygienic index (S-L, 1964). Evaluation of the cleansing, anti-inflammatory and hemostatic effects of the proposed medications was carried out before treatment and 1,3.6 months after treatment. Research results. The control group, the frequency of occurrence of A.actinomycetemcimitans and P.intermedia three months after the completion of treatment and preventive measures was 5.6 ± 5.4 and 11.1 ± 7.4 %, in the comparison group, where Curasept ADS toothpaste was administered 712, the indicators for the above bacteria dropped to zero. The detected values of the hygienic index three months after treatment in the main, control groups and in the comparison group, respectively, amounted to 1.12 ± 0.038; 1.30 ± 0.028 and 1.13 ± 0.041. In the long-term clinical observations in the main group, the values of the Conclusion. According to the data obtained, the use of Curaprox Enzycal paste with 3 enzymes and sodium fluoride in the minimum amount for use revealed its high prophylactic efficacy.

scholarly journals Improvement of the scheme of treatment of periodontal tissue diseases in patients with urinary system pathology

2021 ◽  
Vol 108 (4) ◽  
pp. 16-19
Author(s):  
Yu. Kilmukhametova ◽  
◽  
V. Batig ◽  
O. Soltis ◽  
M. Ostafiychuk ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Periodontal Diseases ◽  
Periodontal Tissue ◽  
Urinary System ◽  
Traditional Treatment ◽  
Treatment Regimens ◽  
Periodontal Tissues ◽  
Treatment And Prevention ◽  
Periodontal Index ◽  
Before And After

The aim of the study. Study of the effectiveness of our proposed scheme of treatment of periodontal tissues in patients with pathology of the urinary system comparing to a traditional scheme. Research methods. The study involved 72 patients with pathologies of the urinary system: glomerulonephritis, pyelonephritis and urolithiasis. They were divided into 2 groups: basic and comparison. The first group received our treatment, which consisted of professional hygiene and subsequent application of a combination of ointments of Thiotriazoline and Zinc Oxide, and rinsing with 0.05% solution of Chlorhexidine bigluconate for 5 days. The traditional treatment consisted of professional oral hygiene and rinsing with 0.05 % chlorhexidine bigluconate solution twice a day for 5 days. Patients before and after treatment were examined and indexed. In patients with a complex of antioxidant drugs, the results were better than in patients who underwent traditional treatment of periodontal tissues. Scientific novelty. Periodontal tissue pathology is one of the predominant groups of diseases of the oral cavity, so the problem of their treatment or prevention is quite relevant. Periodontal diseases in patients with pathology of the urinary system to date are studied insufficiently. There are not enough studies about the causes, features of the course, treatment and prevention of periodontal pathologies in this group of patients. Therefore, the development of new or improvement of existing treatment regimens in patients with diseases of the urinary system is of considerable interest to both scientists and practitioners. Conclusions. Our results showed that our proposed scheme of treatment of periodontal tissues in patients with pathologies of the urinary system is more effective than traditional treatment. Key words: periodontal tissue disease, pathology of the urinary system, Thiotriazoline, Zinc Oxide, Chlorhexidine bigluconate, PMA, Russell periodontal index, CPITN.

Thromboembolic complications prevention in the obstetric practice

2017 ◽  
pp. 19-24
Author(s):  
O.V. Grishchenko ◽  
◽  
V.V. Bobrytska ◽  
Keyword(s):  
Pulmonary Embolism ◽  
Comparison Group ◽  
Main Group ◽  
Control Group ◽  
Efficacy And Safety ◽  
Thromboembolic Complications ◽  
Moderate Risk ◽  
Obstetric Practice ◽  
Thrombotic Complications ◽  
And Control

The objective: To evaluate the clinical efficacy and safety of Enoxaparin-Pharmex for the prevention of thrombotic complications (pulmonary embolism) in the postoperative period in patients with moderate risk of these complications. Patients and methods. The study included 50 women after a caesarean section had an average degree of risk of pulmonary embolism. Patients were divided into the main group (n=25) and control group (n=25) in accordance with the treatment: patients of the main group received postoperative Еnoxaparin- Pharmex, group comparisons enoxaparin sodium (brand foreign manufacturer’s). Patients in both groups received the drug at a dose of 20 mg for 5 days, 1 time per day subcutaneously. Results. The research data analysis showed identity results of hemostasiogram of patients in the main group and the comparison group, no side effects after treatment in both groups. Conclusion. The clinical studies suggest the drug Enoxaparin-Pharmex is effective, safe LMWH, which can be used to prevent troboembolic complications, including post-operative treatment in obstetric practice. Spectrum of Enoxaparin-Pharmex can be extended to the prevention and treatment of thromboembolic conditions of varying severity with appropriate doses of the drug. Key words: Enoxaparin-Pharmex, prevention of pulmonary embolism.

scholarly journals A Novel Approach for Tuning the Physicochemical, Textural, and Sensory Characteristics of Plant-Based Meat Analogs with Different Levels of Methylcellulose Concentration

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 560
Author(s):  
Allah Bakhsh ◽  
Se-Jin Lee ◽  
Eun-Yeong Lee ◽  
Nahar Sabikun ◽  
Young-Hwa Hwang ◽  
...  
Keyword(s):  
Profile Analysis ◽  
Control Sample ◽  
Texture Profile ◽  
Crude Fiber Content ◽  
A Value ◽  
Novel Approach ◽  
Meat Analog ◽  
And Control ◽  
Water Holding ◽  
Different Levels

This study assessed the effects of Methylcellulose (MC) at different concentrations on plant-based meat analog (PBMA) patties, comprised of commercial texture vegetable protein (C-TVP) and textured isolate soy protein (T-ISP) as key ingredients, and compared to beef patty control. A significantly higher difference was observed in moisture content in control with increasing MC concentration than the C-TVP and T-ISP patties. However, protein varied significantly among three different protein sources, with control had higher protein content than PBMA patties. Crude fiber content recorded higher values in C-TVP as compared to control. Significantly lower pH values were recorded in control than C-TVP and T-ISP respectively. Regardless, with the addition of MC or ingredient PBMA and control patties tend to reduce lightness (L*) and redness (a*) value after cooking. Although control sample before cooking exhibits lighter and redder than PBMA patties (C-TVP and T-ISP). Likewise, water holding capacity (WHC) decreases as the concentration of MC increases (1.5–4%) in control and PBMA patties. Warner-Bratzler shear force (WBSF) and texture profile analysis (TPA), including hardness, chewiness, and gumminess of control, were significantly higher than C-TVP and T-ISP. Consequently, panelists’ in the sensory analysis presented that C-TVP patties containing 3% of MC had better sensory properties than T-ISP. Hence, PBMA patties with C-TVP and incorporation of 3% MC are considered ideal for manufacturing of meat analog as related to control (beef).

scholarly journals Effects of Camu-Camu (Myrciaria dubia) Powder on the Physicochemical and Kinetic Parameters of Deteriorating Microorganisms and Salmonella enterica Subsp. enterica Serovar Typhimurium in Refrigerated Vacuum-Packed Ground Beef

Agriculture ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 252
Author(s):  
Jorge Luiz da Silva ◽  
Vasco Cadavez ◽  
José M. Lorenzo ◽  
Eduardo Eustáquio de Souza Figueiredo ◽  
Ursula Gonzales-Barron
Keyword(s):  
Ground Beef ◽  
Treated Group ◽  
B Value ◽  
Kinetics Parameters ◽  
Psychrotrophic Bacteria ◽  
Color Changes ◽  
A Value ◽  
Spoilage Bacteria ◽  
Serovar Typhimurium ◽  
And Control

This study aims to evaluate the effects of camu-camu powder (CCP), Amazonian berry fruit with documented bioactive properties, physicochemical meat parameters, and the growth kinetics parameters of S. enterica ser. Typhimurium, psychrotrophic bacteria (PSY), and lactic acid bacteria (LAB) in vacuum-packed ground beef. Batches of ground beef were mixed with 0.0%, 2.0%, 3.5%, and 5.0% CCP (w/w), vacuum-packed as 10 g portions, and stored at 5 °C for 16 days. Centesimal composition analyses (only on the initial day), pH, TBARS, and color were quantified on storage days 1, 7, and 15, while PSY and LAB were counted on days 0, 3, 6, 9, 13, and 16. Another experiment was conducted with the same camu-camu doses by inoculating S. enterica ser. Typhimurium microbial kinetic curves were modeled by the Huang growth and Weibull decay models. CCP decreased TBARS in beef from 0.477 to 0.189 mg MDA·kg−1. No significant differences in meat pH between treated and control samples were observed on day 15. CCP addition caused color changes, with color a* value decreases (from 14.45 to 13.44) and color b* value increases (from 17.41 to 21.25), while color L* was not affected. Higher CCP doses caused progressive LAB growth inhibition from 0.596 to 0.349 log CFU·day−1 at 2.0% and 5.0% CCP, respectively. Similarly, PSY growth rates in the treated group were lower (0.79–0.91 log CFU·day−1) compared to the control (1.21 log CFU·day−1). CCP addition at any of the investigated doses produced a steeper S. enterica ser. Typhimurium inactivation during the first cold storage day, represented by Weibull’s concavity α shape parameter, ranged from 0.37 to 0.51, in contrast to 1.24 for the control. At the end of the experiment, however, S. enterica ser. Typhimurium counts in beef containing CCP were not significantly different (p < 0.05) from the control. Although CCP affects bacterial kinetics, it does not protect ground beef against spoilage bacteria and Salmonella to the same degree it does against lipid peroxidation.

Der energieflexible und effiziente Energiewertstrom/The efficient and flexible energy value stream

2015 ◽  
Vol 105 (05) ◽  
pp. 313-318
Author(s):  
F. Feder ◽  
K. Erlach ◽  
F. Hosak ◽  
H. Lepple
Keyword(s):  
Energy Consumption ◽  
Low Energy ◽  
Energy Usage ◽  
Energy Value ◽  
Value Stream ◽  
Building Technology ◽  
A Value ◽  
Energy Flows ◽  
Low Energy Consumption ◽  
And Control

Die wachsende Volatilität im deutschen Energiesektor bietet jenen Unternehmen zukünftig einen Wettbewerbsvorteil, die ihren Energieverbrauch kontinuierlich senken und flexibel anpassen können. Als Werkzeug dafür wurde die Energiewertstrom-Methode um weitere Energieflüsse aus der Gebäude- und Versorgungstechnik sowie um Aspekte der Energieflexibilität erweitert. Dies erlaubt die Gestaltung eines energiekostenoptimalen Wertstroms. &nbsp; In the light of the increasing volatility in the German energy sector, companies that are able to constantly reduce and control their energy consumption will gain a competitive advantage. Therefore, the Energy Value Stream Method has been extended by adding further energy flows in building technology as well as aspects of flexible energy usage. This enables the design of a value stream that results in low energy consumption and costs.

Results of complex treatment of patients with operable pancreatic head cancer using preoperative intra-arterial chemotherapy in combination with radiation therapy in multifractionation mode

2022 ◽  
pp. 32-36
Author(s):  
D. A. Sklyar ◽  
A. V. Pavlovsky ◽  
A. A. Polikarpov ◽  
S. A. Popov ◽  
V. E. Moiseenko ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Pancreatic Head ◽  
Main Group ◽  
Arterial Infusion ◽  
Conformal Radiation Therapy ◽  
Head Cancer ◽  
Pancreatic Head Cancer ◽  
Postoperative Pancreatitis ◽  
Pancreatic Fistulas ◽  
And Control

The aim of this study was to assess the safety and efficacy of treating patients with operable pancreatic cancer after preoperative intra-arterial infusion of chemotherapy combined with conformal radiation therapy in a multi-fractionation mode. Patients (n = 40) were randomized into two groups: the main one – intra-arterial infusion of chemotherapy + radiation therapy + surgery (n = 20), and control – intra-arterial infusion of chemotherapy + surgery (n = 20). Neoadjuvant therapy consisted of intra-arterial infusion of chemotherapy (chemoembolization of a pancreatic head tumor with oxaliplatin 85 mg/m2) followed by intra-arterial chemo infusion with gemcitabine 1000 mg/m2. In the main group, radiation therapy was also carried out in two fractions per day, 2 Gy with an interval of 4–6 hours, 5 days a week, up to a total dose of 50 Gy. In the main group, the lower incidence of postoperative pancreatitis and the pancreatic fistulas were statistically confirmed, the incidence of grade 2 therapeutic pathomorphisis increased, as well as the median life expectancy.

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