Abstract 3584: The Prevalence and Factors Associated With 1-Year Angina among Post-MI Patients

Background: A primary goal of in-hospital treatment and outpatient care following myocardial infarction (MI) is the eradication of angina. However, the prevalence of angina and the factors associated with angina in the year after MI are unknown. Methods: The primary outcome of the PREMIER multi-center prospective study was presence of angina, as measured by the Seattle Angina Questionnaire (SAQ), 1 year after MI hospitalization. Multivariable regression modeling identified the socio-demographic factors, clinical history, MI presentation, inpatient therapies and complications, and outpatient treatment characteristics associated with 1-year angina, adjusted for site. . Results: Of 1957 patients in the cohort, 83 patients (4.2%) reported daily or weekly angina, and 306 patients (15.6%) reported less than weekly angina 1 year after their index MI. After multivariable analysis (figure ), angina 1 year after an index MI was associated with younger age, non-white race, baseline angina, history of CABG surgery, no inpatient revascularization, recurrent rest angina during MI hospitalization, persistent smoking after MI hospitalization, outpatient revascularization after MI hospitalization, and depressive symptoms (either as an inpatient or during the year after MI hospitalization). Conclusions: Angina 1 year after MI hospitalization is associated with several modifiable factors, including persistent smoking and depressive symptoms in the year after MI discharge. Recognition of these relationships will be important in monitoring and treating at-risk patients for post-MI angina.

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Abstract 13030: Causes of Cardiovascular and Non-cardiovascular Mortality in the Ischemia Trial

Circulation ◽

10.1161/circ.142.suppl_3.13030 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Mandeep S Sidhu ◽

Karen P Alexander ◽

Zhen Huang ◽

Sean M O’Brien ◽

Bernard R Chaitman ◽

...

Keyword(s):

Management Strategies ◽

Multivariable Analysis ◽

International Study ◽

Factors Associated ◽

Clinical Events ◽

All Cause Mortality ◽

History Of ◽

Multivariable Analyses ◽

Clinical Events Committee

Background: In the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial, all-cause mortality was similar in patients with stable ischemic heart disease (SIHD) randomized to invasive (INV) and conservative (CON) management strategies. This analysis details specific causes of cardiovascular (CV) and non-CV mortality by treatment group. Methods: In ISCHEMIA, 289 deaths occurred after a median follow-up of 3.2 years; 145 (5.6%) in INV and 144 (5.6%) in CON (HR 1.05, CI 0.83-1.32). Deaths were adjudicated by an independent Clinical Events Committee as CV, non-CV with or without a CV contributor or undetermined. The protocol defined CV death as deaths from CV causes, non-CV causes with CV contributor, and cause undetermined; non-CV death was defined as death from non-CV causes without a CV contributor. Multivariable analyses were used to identify factors associated with cause-specific death. Results: CV death was similar between groups [INV 92 (3.6%), CON 111 (4.3%); HR 0.87 (CI 0.66, 1.15)], but INV had more non-CV death [INV 53 (2.0%), CON 33 (1.3%); HR 1.63 (CI 1.06, 2.52)]; fewer undetermined deaths [INV 12 (0.5%) and CON 26 (1.0%); HR 0.48 (0.24, 0.95)] and more malignancy deaths [INV 41 (1.6%), CON 20 (0.8%); HR 2.11 (1.24, 3.61)]. In multivariable analysis, risk factors associated with CV death were age [HR 1.42 (CI 1.19-1.70) per 10-year increase], diabetes [HR 1.39 (CI 1.03-1.87)], history of heart failure [HR 1.96 (CI 1.33-2.91)], and eGFR [HR 1.18 (CI 1.11-1.26) per 5-ml/min decrease below 80ml/min]. Factors associated with non-CV death were age [HR 2.31 (CI 1.75-3.03) per 10-year increase] and randomization to INV [HR 1.76 (CI 1.13-2.75)]. Conclusions: In ISCHEMIA, all-cause mortality was similar for the INV and CON strategies. Excess non-CV deaths in INV with a higher number of deaths from malignancy but a higher number of undetermined deaths in CON requires further evaluation.

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Parental risk factors associated with congenital heart disease in a Thai population: multivariable analysis

Asian Biomedicine ◽

10.2478/abm-2021-0033 ◽

2021 ◽

Vol 15 (6) ◽

pp. 267-276 ◽

Cited By ~ 1

Author(s):

Chayamon Suwansumrit ◽

Worawan Jittham

Keyword(s):

Risk Factors ◽

Family History ◽

Cigarette Smoke ◽

Congenital Heart ◽

Heart Diseases ◽

Multivariable Analysis ◽

Significant Risk ◽

Maternal Exposure ◽

Factors Associated ◽

History Of

Abstract Background Congenital heart diseases (CHDs) are the most common types of birth defects and contribute to a large proportion of infant morbidities and mortalities worldwide. These defects may require multiple surgical interventions impacting the infant's quality of life. Objectives To identify risk factors associated with CHD in a population of Thai children. Methods We conducted a case–control study of patients attending the Pediatric Clinic, Naresuan University Hospital, Thailand. We included data from pediatric patients diagnosed with CHDs as cases, and patients without cardiovascular abnormalities as controls. Risk data were collected from July 2019 to April 2020 using face-to-face interviews. Multiple logistic regression was used to analyze parental factors associated with CHDs. Results We included 249 cases classified into 2 groups according to severity and 304 patients as controls. For those less-severely affected (155 patients, 62.2%), ventricular septal defect (27.7%) was the most prevalent, whereas for those with severe CHDs, tetralogy of Fallot was the most prevalent (14.0%). There was no difference in sex distribution or maternal obstetric history between the groups. In multivariable analysis, a family history of CHDs (adjusted odds ratio [AOR] 4.67, 95% confidence interval (CI) 1.61–13.57, P = 0.005) and maternal exposure to second-hand cigarette smoke (AOR 1.58, 95% CI 1.03–2.42, P = 0.002) were identified as significant risk factors for CHDs. Conclusion A family history of CHDs and maternal exposure to second-hand cigarette smoke are associated with having offspring with CHDs in the population studied. These findings help us to encourage affected parents to obtain a fetal echocardiogram.

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Nephrolithiasis in gout: prevalence and characteristics of Brazilian patients

Advances in Rheumatology ◽

10.1186/s42358-019-0106-4 ◽

2019 ◽

Vol 60 (1) ◽

Cited By ~ 1

Author(s):

Leonardo Santos Hoff ◽

Claudia Goldenstein-Schainberg ◽

Ricardo Fuller

Keyword(s):

Uric Acid ◽

Clinical History ◽

Potassium Citrate ◽

Male Gender ◽

Inverse Association ◽

Tertiary Referral Hospital ◽

Urine Ph ◽

Factors Associated ◽

Primary Gout ◽

History Of

Abstract Background The aims of this article were to assess the prevalence of nephrolithiasis and the factors associated with nephrolithiasis in Brazilian patients with primary gout. Methods One hundred twenty-three patients with primary gout were recruited from a tertiary referral hospital in São Paulo, Brazil. All patients underwent ultrasonography and had their clinical and laboratory characteristics assessed. Results One hundred fifteen (93.5%) patients were male, with a mean age of 62.9 ± 9.4 years. Twenty-three (18.7%) patients had asymptomatic nephrolithiasis (detected only by ultrasonography), 7 (6.0%) had symptomatic nephrolithiasis (detected by ultrasonography and a positive clinical history), and 13 (10.0%) had a history of kidney stones, but ultrasonography at evaluation did not show nephrolithiasis. Therefore, 35.0% of the patients had nephrolithiasis (detected either by ultrasonography and/or a positive clinical history). Nephrolithiasis was associated with male gender (43 [100%] vs 72 [90%], p = 0.049), the use of potassium citrate (13 [30.2%] vs 0, p < 0.001) and the use of medications for diabetes (10 [23.3%] vs 8 [10%], p = 0.047) and dyslipidemia (15 [34.9%] vs 10 [12.5%], p = 0.003); benzbromarone had an inverse association with nephrolithiasis (21 [48.8%] vs 55 [68.8%], p = 0.030). In patients with and without nephrolithiasis, no differences were found in the laboratory and ultrasonography characteristics, including serum uric acid levels, urinary uric acid excretion and urine pH. Conclusions The prevalence of nephrolithiasis in primary gout was 35.0%, and 18.7% of the patients were asymptomatic. Nephrolithiasis was associated with male gender, diabetes and dyslipidemia. A positive history of nephrolithiasis probably biased the prescription of potassium citrate and benzbromarone.

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Abstract P641: Risk and Predictors of New Cancer Diagnoses After Acute Ischemic Stroke

Stroke ◽

10.1161/str.52.suppl_1.p641 ◽

2021 ◽

Vol 52 (Suppl_1) ◽

Author(s):

Stephanie Buchman Rutrick ◽

Meenakshi Bassi ◽

Yahya B Atalay ◽

Marialaura Simonetto ◽

Bhavan Shah ◽

...

Keyword(s):

Weight Loss ◽

Ischemic Stroke ◽

Multivariable Analysis ◽

Clinical Factors ◽

Factors Associated ◽

Unexplained Weight Loss ◽

C Statistic ◽

Incident Cancer ◽

History Of ◽

History Of Cancer

Introduction: Acute ischemic stroke (AIS) may be the first sign of occult cancer. We aimed to better define the incidence of cancer in the year after AIS and to identify clinical factors associated with new cancer diagnoses. Methods: This was a retrospective cohort study using data from the Cornell Acute Stroke Academic Registry (CAESAR) on patients hospitalized at our center with AIS from 2011-2015. Patients with history of cancer were excluded. Through automated electronic data capture and manual abstraction of inpatient and outpatient medical records, we collected data on patients’ demographics, comorbidities, presentation, radiographic characteristics, stroke subtype, and clinical outcomes. Patients were followed for 1 year after the index AIS for a new diagnosis of pathologically-confirmed cancer. Cox hazards regression adjusting for the competing risk of death was used to evaluate associations between clinical factors and incident cancer. Factors significantly associated in multivariable analysis were entered into a risk stratification score, and this score’s discriminatory ability was evaluated by Harrell’s C-statistic. Results: After excluding 253 patients with history of cancer, this analysis included 963 patients with AIS. During a mean follow-up of 222 days, 16 patients (1.7%; 95% CI, 1.0-2.7%) were diagnosed with cancer. The most common cancers were lung (n=7) and leukemia (n=4) and the median time to cancer diagnosis was 13 days (IQR, 7-194 days). Among patients with cryptogenic stroke, the 1-year cancer incidence rate was 1.7% (95% CI, 0.6-3.7%). Clinical factors associated with incident cancer in multivariable analysis were venous thromboembolism during the AIS hospitalization (HR, 12.5; 95% CI, 3.3-47.0), unexplained weight loss within 6 months (HR 11.7; 95% CI, 3.3-42.0), and three-territory acute infarcts (HR, 4.1, 95% CI, 1.3-13.4). These factors were used to create a clinical score that had a C-statistic of 0.7 (95% CI, 0.5-0.8). Conclusions: In a large urban cohort of AIS, the estimated 1-year incidence of first-ever cancer was 1.7%. Unexplained weight loss, concomitant venous thromboembolism, and three-territory acute infarction pattern may serve as clues to occult cancer with AIS.

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Bilateral Solar Retinopathy After Gazing at the Great American Eclipse

Journal of VitreoRetinal Diseases ◽

10.1177/2474126418788495 ◽

2018 ◽

Vol 2 (5) ◽

pp. 316-320

Author(s):

Himanshu K. Banda ◽

Sabin Dang ◽

Anjali G. Shah ◽

Gaurav K. Shah

Keyword(s):

Multimodal Imaging ◽

Vision Loss ◽

Clinical History ◽

Total Solar Eclipse ◽

Visual Recovery ◽

Protective Measures ◽

Factors Associated ◽

History Of ◽

Funduscopic Examination ◽

Over Time

Purpose: We report a case of bilateral solar retinopathy following the Great American Eclipse on August 21, 2017. We summarize findings on multimodal imaging and risk factors associated with solar retinopathy. Methods: A teenage boy presented with painless vision loss 4 days following viewing a total solar eclipse. Funduscopic examination, optical coherence tomography, and fluorescein angiography revealed findings characteristic of solar retinopathy. Multifocal electroretinography was also performed. We add to the literature the first reported case of solar retinopathy following the Great American Eclipse. Results: The patient was observed with serial examinations over several weeks. Gradual trend toward visual recovery was noted on imaging. Conclusions: In combination with clinical history of sungazing and funduscopic examination, distinct findings on imaging help secure a diagnosis of solar retinopathy. Visual symptoms in solar retinopathy generally improve over time. Appropriate protective measures with counseling and filtered eyewear are recommended for eclipse viewers.

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Modifiable Factors Associated with Cognitive Impairment in 1,143 Japanese Outpatients: The Project in Sado for Total Health (PROST)

Dementia and Geriatric Cognitive Disorders Extra ◽

10.1159/000447963 ◽

2016 ◽

Vol 6 (2) ◽

pp. 341-349 ◽

Cited By ~ 14

Author(s):

Kaori Kitamura ◽

Yumi Watanabe ◽

Kazutoshi Nakamura ◽

Kazuhiro Sanpei ◽

Minako Wakasugi ◽

...

Keyword(s):

Cognitive Impairment ◽

Green Tea ◽

Leisure Time Physical Activity ◽

Multiple Logistic Regression Analysis ◽

Tea Consumption ◽

Fruit Consumption ◽

Factors Associated ◽

Modifiable Factors ◽

History Of ◽

Low Bmi

Background/Aims: Evidence on modifiable factors associated with cognitive impairment in Japanese patients is scarce. This study aimed to determine modifiable factors for cognitive impairment in a Japanese hospital-based population. Methods: Subjects of this cross-sectional study were 1,143 patients of Sado General Hospital (Niigata, Japan) registered in the Project in Sado for Total Health (PROST) between June 2008 and September 2014. We assessed disease history, body mass index (BMI), leisure time physical activity, walking time, smoking and drinking habits, and consumption of vegetables, fruits, and green tea as predictors, with cognitive impairment defined by the Mini-Mental State Examination (score <24) as an outcome. Multiple logistic regression analysis was performed to calculate odds ratios (ORs) for cognitive impairment. Results: The mean subject age was 68.9 years, and the prevalence of cognitive impairment was 21.5%. Multivariate analysis revealed that age (p < 0.001), low BMI (<21.1; OR 1.39, 95% CI 1.12-1.72), a history of stroke (p = 0.003), a history of myocardial infarction (p = 0.038), low fruit consumption (p for trend = 0.012), and low green tea consumption (p for trend = 0.032) were independently associated with a higher prevalence of cognitive impairment. Conclusions: Modifiable factors, such as low BMI, low fruit consumption, and low green tea consumption, are associated with cognitive impairment. Longitudinal studies will be needed to confirm these findings.

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Prevalence and Factors Associated With Fecal Shedding of Giardia spp. in Domestic Cats

Journal of the American Animal Hospital Association ◽

10.5326/0420424 ◽

2006 ◽

Vol 42 (6) ◽

pp. 424-429 ◽

Cited By ~ 19

Author(s):

Robert J. Vasilopulos ◽

Andrew J. Mackin ◽

Lora G. Rickard ◽

G. Todd Pharr ◽

Carla L. Huston

Keyword(s):

Diagnostic Test ◽

Clinical History ◽

Gastrointestinal Parasites ◽

Domestic Cats ◽

Fecal Shedding ◽

Factors Associated ◽

Cryptosporidium Spp ◽

History Of ◽

Private Breeder ◽

Higher Sensitivity

The prevalence of cats shedding Giardia cysts (13.6%) in the present study was found to be higher than previously reported (1% to 11%) and may reflect a higher sensitivity for the diagnostic test used. The presence of Cryptosporidium spp. oocysts, coccidial oocysts, and a clinical history of chronic (>2 weeks) gastrointestinal signs were significantly associated with the presence of Giardia spp. cysts in the feces. There were no associations between the presence of Giardia spp. cysts and type of housing, acute gastrointestinal signs, vomiting, gender, source of cat (i.e., animal shelter versus private breeder), or gastrointestinal parasites other than Cryptosporidium spp. and intestinal coccidial agents.

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Risk factors related to seropositivity for Leptospira spp. in horses in the Serra Catarinense region

Ciência Rural ◽

10.1590/0103-8478cr20190483 ◽

2020 ◽

Vol 50 (7) ◽

Cited By ~ 1

Author(s):

Deise Keli Farias ◽

Gabriela Dick ◽

Silvério Bunn ◽

André Thaler Neto ◽

Carolina Rech ◽

...

Keyword(s):

Infectious Disease ◽

Risk Factors ◽

Animal Species ◽

Clinical History ◽

Control Measures ◽

Serum Samples ◽

Factors Associated ◽

Leptospira Spp ◽

History Of ◽

And Control

ABSTRACT: Leptospirosis is a zoonotic infectious disease caused by the bacterium Leptospira spp. The consequences of infection in horses are unclear, and the serogroups involved vary depending on the region. This study aimed to evaluate the seropositivity of unvaccinated horses in the Serra Catarinense region and the possible risk factors associated with the infection. We used 207 horses from 26 properties, with no clinical history of infection and unvaccinated for leptospirosis. We submitted serum samples to the microscopic agglutination serum (SAM) to obtain the main reference serogroups. We considered animals with titre ≥100 as infected. The results of the serology revealed seropositivity in 45.4% (94/207) of the animals studied. The most frequent antibodies reportedwere those against the serogroups Australis 16.9% (35/207), Ichterhaemorrhagiae 14.4% (30/207), and Grippotyphosa 5.31% (11/207). Among the primary risk factors associated with the infection we reported extensive rearing system (OR = 1.27; P<0.05) and the presence of other animal species such as cattle (OR = 3.85; P<0.01) and capybaras (OR = 2.07; P=0.06). The findings presented in this study showed that leptospirosis is endemic in horses in the Serra Catarinense region, and revealed the need for emergency surveillance and control measures specific to this important zoonosis.

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Factors that Predict Smoking Cessation among Older Koreans: Based on the Korea National Health and Nutrition Examination Survey 2016–2018

Korean Journal of Family Medicine ◽

10.4082/kjfm.20.0203 ◽

2021 ◽

Vol 42 (5) ◽

pp. 363-368

Author(s):

Han Kyul Lim ◽

Yong Soon Park ◽

Jeong Hyeon Kim ◽

Jeong Hyun Kim

Keyword(s):

Smoking Cessation ◽

National Health ◽

Multivariable Analysis ◽

Age Group ◽

Nutrition Examination Survey ◽

Factors Associated ◽

Logistic Analysis ◽

Health And Nutrition ◽

Quit Smoking ◽

History Of

Background: Tobacco smoking is associated with several diseases and deaths in older Koreans. This study aimed to evaluate the factors associated with smoking cessation in older Koreans. Methods: We selected 579 subjects who started smoking before the age of 65 years from the Korea National Health and Nutrition Examination Survey 2016–2018. We excluded the subjects who quit smoking before the age of 65 years, and then categorized the rest of subjects into those who stopped smoking after the age of 65 years and those who are constant smokers. Multivariable logistic analysis was performed to evaluate the factors related to smoking cessation among older Koreans. Results: Among the participants, 66.1% were persistent smokers. After multivariable analysis, the factors significantly associated with smoking cessation were as follows: being in the age group of 75–79 years (adjusted odds ratio [aOR], 4.07; 95% confidence interval [CI], 2.12–7.83), being in the age group of 70–74 years (aOR, 3.10; 95% CI, 1.72–5.61), a family history of ischemic heart disease (aOR, 3.36; 95% CI, 1.09–10.35), and having had no cancer screening (aOR, 0.36; 95% CI, 0.18–0.70). Conclusion: Further efforts to identify the factors related to smoking cessation will help formulate a smoking cessation policy.

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