The effect of acute ammonia exposure on selected immunological parameters of Daphnia similoides (Cladocera)

Crustaceana ◽  
2018 ◽  
Vol 91 (4) ◽  
pp. 403-411
Author(s):  
Youhui Huang ◽  
Ye Liang ◽  
Yiming Li ◽  
Mingqi Cai ◽  
Qichen Jiang ◽  
...  
Keyword(s):  
Ammonia Toxicity ◽  
Whole Body ◽  
Natural Environments ◽  
Toxic Substances ◽  
Sod Activity ◽  
Immunological Parameters ◽  
Immune Parameters ◽  
Significant Change ◽  
High Concentrations ◽  
The Impact

Cladocerans have been widely used as bioassay organisms to evaluate the impact of toxic substances. In this study, the activities of selected immunological enzymes and MDA level were investigated to characterize Daphnia similoides’ immune response to ammonia stress. The activity of ACP and CAT showed no significant change during the test. The activity of AKP was significantly increased in the 0.19 and 0.38 mg/l NH3-N exposure groups after 6 h. After 24 h, a significant depression occurred in the high concentrations. After 24 h, significant decreases in SOD activity were observed at the concentrations of 0.38, 0.57 and 0.76 mg/l NH3-N. After 24 h, a significant change in MDA was also observed in 0.57 and 0.76 mg/l. These results suggest that changes in whole-body immune parameters of Daphnia similoides are effective to predict sub-lethal ammonia toxicity and useful as an early warning tool in monitoring studies of natural environments.

scholarly journals Antibiotic Intervention Affects Maternal Immunity During Gestation in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Marilen Benner ◽  
Alejandro Lopez-Rincon ◽  
Suzan Thijssen ◽  
Johan Garssen ◽  
Gerben Ferwerda ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Treated Group ◽  
Mesenteric Lymph Nodes ◽  
Negative Effects ◽  
T Helper 17 ◽  
Immunological Parameters ◽  
Maternal Immunity ◽  
Immune Parameters ◽  
Ensemble Strategy ◽  
The Impact

BackgroundPregnancy is a portentous stage in life, during which countless events are precisely orchestrated to ensure a healthy offspring. Maternal microbial communities are thought to have a profound impact on development. Although antibiotic drugs may interfere in these processes, they constitute the most frequently prescribed medication during pregnancy to prohibit detrimental consequences of infections. Gestational antibiotic intervention is linked to preeclampsia and negative effects on neonatal immunity. Even though perturbations in the immune system of the mother can affect reproductive health, the impact of microbial manipulation on maternal immunity is still unknown.AimTo assess whether antibiotic treatment influences maternal immunity during pregnancy.MethodsPregnant mice were treated with broad-spectrum antibiotics. The maternal gut microbiome was assessed. Numerous immune parameters throughout the maternal body, including placenta and amniotic fluid were investigated and a novel machine-learning ensemble strategy was used to identify immunological parameters that allow distinction between the control and antibiotic-treated group.ResultsAntibiotic treatment reduced diversity of maternal microbiota, but litter sizes remained unaffected. Effects of antibiotic treatment on immunity reached as far as the placenta. Four immunological features were identified by recursive feature selection to contribute to the most robust classification (splenic T helper 17 cells and CD5+ B cells, CD4+ T cells in mesenteric lymph nodes and RORγT mRNA expression in placenta).ConclusionIn the present study, antibiotic treatment was able to affect the carefully coordinated immunity during pregnancy. These findings highlight the importance of inclusion of immunological parameters when studying the effects of medication used during gestation.

Impact of harmful algal blooms (Dinophysis acuminata) on the immune system of oysters and mussels from Santa Catarina, Brazil

2014 ◽  
Vol 95 (4) ◽  
pp. 773-781 ◽  
Author(s):  
Erik Simões ◽  
Renato Campos Vieira ◽  
Mathias Alberto Schramm ◽  
Danielle Ferraz Mello ◽  
Vitor De Almeida Pontinha ◽  
...  
Keyword(s):  
Harmful Algal Blooms ◽  
Algal Blooms ◽  
The Other ◽  
Bivalve Species ◽  
Santa Catarina ◽  
Immunological Parameters ◽  
Immune Parameters ◽  
Dinophysis Acuminata ◽  
Consistent Manner ◽  
The Impact

Blooms of the harmful alga Dinophysis acuminata, which produces okadaic acid (OA), are becoming recurrent in Santa Catarina coast, where most of the shellfish marine farms in Brazil are located. We evaluated the impact of D. acuminata blooms on various haemato-immunological parameters and on tissue integrity of cultivated oysters (Crassostrea gigas) and mussels (Perna perna). Animals were sampled during two natural algal blooms, one at Praia Alegre (PA: 2950 cells l−1) and the other at Praia de Zimbros (PZ: 4150 cells l−1). Control animals were sampled at the same sites, 30 days after the end of the bloom. The assayed parameters were: total (THC) and differential (DHC) haemocyte counts, percentage of apoptotic haemocytes (AH), phenoloxidase activity (PO), agglutinating titre (AT) and total protein concentration in haemolymph (PC). Histological analyses were carried out in oysters from PZ. The results showed that some immune parameters were modulated during the toxic blooms, but not in a consistent manner, especially in mussels that accumulated more OA (10×) than oysters. For example, mussel THC decreased significantly (54%) during the bloom at PA, whereas it augmented markedly (64%) at PZ. PO activity was significantly altered by the algal blooms in both bivalve species, while PC increased significantly (66%) only in mussels from PZ bloom. The other parameters (DHC, AH and AT) did not vary in both bivalve species. Histological analyses showed an intense haemocytic infiltration throughout the oyster digestive epithelium, particularly into the stomach lumen during the algal bloom.

scholarly journals Single Whole-Body Cryostimulation Procedure versus Single Dry Sauna Bath: Comparison of Oxidative Impact on Healthy Male Volunteers

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Paweł Sutkowy ◽  
Alina Woźniak ◽  
Paweł Rajewski
Keyword(s):  
Thiobarbituric Acid ◽  
Whole Body ◽  
Human Organism ◽  
Healthy Male ◽  
Thiobarbituric Acid Reactive Substances ◽  
Sod Activity ◽  
High And Low Temperatures ◽  
The Impact ◽  
Environmental Temperatures ◽  
Male Subjects

Exposure to extreme heat and cold is one of the environmental factors whose action is precisely based on the mechanisms involving free radicals. Fluctuations in ambient temperature are among the agents that toughen the human organism. The goal of the study was to evaluate the impact of extremely high (dry sauna, DS) and low (whole-body cryostimulation, WBC) environmental temperatures on the oxidant-antioxidant equilibrium in the blood of healthy male subjects. The subjects performed a single DS bath (n=10; 26.2 ± 4.6 years) and a single WBC procedure (n=15; 27.5 ± 3.1 years). In the subjects’ blood taken immediately before and 20 min after the interventions, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and the concentration of thiobarbituric acid reactive substances in erythrocytes (TBARSer) and blood plasma (TBARSpl) were determined. Single WBC and DS procedures induced an increase in the activity of SOD and GPx, as well as SOD and CAT, respectively. The SOD activity was higher after WBC than after DS. Extremely high and low temperatures probably induce the formation of reactive oxygen species in the organisms of healthy men and, therefore, disturb the oxidant-antioxidant balance.

ANALISIS RASIO UNTUK MENGUKUR KINERJA KEUANGAN PERUSAHAAN (STUDI KASUS PADA PT MEKAR KARYA PRATAMA)

2019 ◽  
Vol 9 (1B) ◽  
pp. 15
Author(s):  
Rizki Ahmad Fauzi
Keyword(s):  
Financial Performance ◽  
Financial Statements ◽  
Corporate Activity ◽  
Significant Change ◽  
Overall Ratio ◽  
The Impact ◽  
Solvency Ratio

Based on the results of the analysis of the ratio of the financial statements can be seen from liquidity ratio in 2010 can already be said to be liquid and in 2011 occurred very significant increase in this ratio that makes the company's liquidity to be too high. Judging from the solvency ratio, in 2010 the company could not be said solvable because the value of this ratio is still quite high. However, in 2011 this ratio decreased significantly which shows that the company can already be said to be solvable. From the ratio of the activity, in 2010 and 2011 the ratio of corporate activity can already be said to be good. Despite the decrease from 2010 to 2011 on some of these ratios, but the overall ratio of activity of the company is good enough. Judging from the ratio of profitability, in 2010 and 2011 the profitability of the company can not be said to be good because it is still very low and no significant change from the year 2010 to the year 2011 for this ratio.The overall financial performance of PT Mekar Karya Pratama from year 2010 to year 2011 can be said to be good, although there are some things that must be considered and they should be repaired as liquidity is too high which causes the idle funds and the impact on the profitability is low. Keyword:Rasio Analysis

Effects of Quarantine Due to the COVID-19 on Sleep Duration and Quality in Algerians

2020 ◽  
Vol 60 (2) ◽  
pp. 182-193
Author(s):  
Kacem Abdelhadi ◽  
Houar Abdelatif ◽  
Zerf Mohamed ◽  
Bengoua Ali
Keyword(s):  
Statistical Analysis ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Online Survey ◽  
Public Awareness ◽  
Italian Version ◽  
Sleep Timing ◽  
Algerian Population ◽  
Significant Change ◽  
The Impact

SummaryThis study tests the impact of COVID-19 on sleep of Algerian population before and during the COVID-19 quarantine by an estimated online survey, adapted from the PSQI Italian version. Including 1210 participants (age between 18-60 years old). The statistical analysis was carried out using SPSS version 22.0 software. Our results showed a significant change in sleeping quality during quarantine, the sleep timing markedly changed, we also noticed additional use of sleeping medications. Algerian scientists recommend to build public awareness and to provide necessary information regarding Algerian sleep quality, especially for Algerian adults.

B-cell and T-cell values in peripheral blood in Polish mixed-breed rabbits with addition of blood of meet breeds

2014 ◽  
Vol 17 (3) ◽  
pp. 421-426 ◽  
Author(s):  
B. Tokarz-Deptuła ◽  
P. Niedźwiedzka-Rystwej ◽  
B. Hukowska-Szematowicz ◽  
M. Adamiak ◽  
A. Trzeciak-Ryczek ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
B Cell ◽  
Cd8 T Cells ◽  
Peripheral Blood ◽  
Laboratory Animals ◽  
Immunological Parameters ◽  
Four Seasons ◽  
Mixed Breed ◽  
The Impact

Abstract In Poland, rabbit is a highly valued animal, due to dietetic and flavour values of its meat, but above all, rabbits tend to be commonly used laboratory animals. The aim of the study was developing standards for counts of B-cells with CD19+ receptor, T-cells with CD5+ receptor, and their subpopulations, namely T-cells with CD4+, CD8+ and CD25+ receptor in the peripheral blood of mixed-breed Polish rabbits with addition of blood of meet breeds, including the assessment of the impact of four seasons of the year and animal sex on the values of the immunological parameters determined. The results showed that the counts of B- and T-cells and their subpopulations in peripheral blood remain within the following ranges: for CD19+ B-cells: 1.05 - 3.05%, for CD5+ T-cells: 34.00 - 43.07%, CD4+ T-cells: 23.52 - 33.23%, CD8+ T-cells: 12.55 - 17.30%, whereas for CD25+ T-cells: 0.72 - 2.81%. As it comes to the season of the year, it was observed that it principally affects the values of CD25+ T-cells, while in the case of rabbit sex, more changes were found in females.

U.S. Regulatory Approaches: A Critical Appraisal

1992 ◽  
Vol 25 (3) ◽  
pp. 13-21
Author(s):  
R. L. Williamson
Keyword(s):  
Decision Making ◽  
Command And Control ◽  
Regulatory System ◽  
Federal Agencies ◽  
Toxic Substances ◽  
Use Of Technology ◽  
Treatment Technologies ◽  
New Treatment ◽  
And Control ◽  
The Impact

The American approach to environmental regulation is characterized by fragmentation of responsibilities, primary reliance on command and control regulations, extraordinary complexity, a preference for identifiable standards, and heavy resort to litigation. This system has provided important benefits, including significant reduction of environmental contamination, substantial use of science in decision-making, broad participatory rights, and the stimulation of new treatment technologies. However, these gains have been achieved at excessive cost. Too much reliance is placed on command and control methods and especially on technology-based standards. There is too much resort to litigation, and inadequate input from science. Participatory rights are being undermined, and there is a poor allocation of decision-making among the federal agencies and the states. Over-regulation sometimes leads to under-regulation, and insufficient attention is given to the impact on small entities. The responsibility for these difficulties rests with everyone, including the federal agencies, the Congress, the general public and the courts. Changes in the regulatory system are needed. We should abandon the use of technology-based standards to control toxic substances under the Clean Water Act in favor of strong health- and environmentally based standards, coupled with taxes on toxic substances in wastewater.

Evaluation of Toxicity in Receiving Streams

1992 ◽  
Vol 26 (9-11) ◽  
pp. 2357-2360
Author(s):  
J. Zagorc-Koncan ◽  
M. Dular
Keyword(s):  
Dissolved Oxygen ◽  
Toxic Substances ◽  
Toxicity Evaluation ◽  
Copper Cyanide ◽  
Polluted River ◽  
Design Information ◽  
Point Of Entry ◽  
Receiving Stream ◽  
The Impact

A laboratory river model for the study of self-purification inhibition in a stream containing toxic substances is presented. It enables an engineering - technological prediction of the impact of toxic substances or wastewaters on dissolved oxygen (DO) profile in an organically polluted river downstream from the point of entry of toxic effluent thus providing rapidly and inexpensively significant design information to an environmental scientist or engineer. The method was applied to the toxicity evaluation of wastewaters from electroplating industry. The effects of copper, cyanide (representing two significant constituents of this type of wastewaters) and wastewater from electroplating industry on the biodegradation of organic municipal pollution in receiving stream were evaluated experimentally.

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