Indications and Results of Cordectomy for Early Glottic Carcinoma

1993 ◽  
Vol 108 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Kerry D. Olsen ◽  
Jon V. Thomas ◽  
Lawrence W. Desanto ◽  
Vera J. Suman
Keyword(s):  
Survival Curve ◽  
Median Number ◽  
Control Group ◽  
Glottic Carcinoma ◽  
Effective Treatment Option ◽  
Kaplan Meier ◽  
Open Operation ◽  
Product Limit ◽  
Age Range ◽  
Endoscopic Group

Select early glottic carcinomas in patients with normal vocal cord mobility can be successfully treated with cordectomy, performed either endoscopicaliy or by means of an open operation (laryngofissure-cordectomy). From 1976 to 1986, 95 patients underwent cordectomy at our institution. There were 88 men and 7 women, with an age range at the time of surgery of 27 to 84 years. A laryngofissure was used to perform a cordectomy in 61 patients and an endoscopic approach was used in 34. The median number of days in the hospital for the endoscopic group was 2, and for the laryngofissure group it was 6. The Kaplan-Meier product-limit method showed the probability of no recurrence in the first 3 years after an endoscopic cordectomy was 0.9099, and in the laryngofissure-cordectomy group it was 0.9502. To date, there have been four recurrences (11.8%) in the endoscopic group and three (4.9%) in the laryngofissure group. Only one patient with recurrent tumor is known to have died of the cancer. Laryngectomy was necessary for ultimate control in three patients. The Kaplan-Meier survival curve for the 95 patients was the same as that for a sex- and age-matched control group. Cordectomy is an effective treatment option that results in minimal morbidity for select early glottic carcinomas.

scholarly journals Role of nicergoline in corneal wound healing in diabetic rats

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amanda Lemos Barros Martins Portela ◽  
Rafael Neves Moreno ◽  
Maria Helena Madruga Lima Ribeiro ◽  
Fernanda Miguel de Andrade ◽  
Yale Viana Alves ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cox Regression ◽  
Survival Curve ◽  
Diabetic Rats ◽  
Rank Test ◽  
Control Group ◽  
Cox Regression Analysis ◽  
Corneal Epithelial Defect ◽  
Kaplan Meier ◽  
Diabetic Keratopathy

Abstract Background To investigate the effect of nicergoline on the rate of complete corneal ulcer reepithelialization (CCUR) in diabetic rats with diabetic keratopathy. Methods Forty-eight streptozotocin-induced diabetic rats were randomly divided into two groups. The experimental group (n = 24) received nicergoline (10 mg.kg− 1.day− 1), while the control group (n = 24) received a placebo. A corneal epithelial defect was induced using a corneal diamond burr, and defect area was compared at time points of 0, 12, 24, 48 and 72 h after the injury using image analysis software. The probability of CCUR within 72 h was assessed using the Kaplan–Meier survival analysis log-rank test. Results When compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72 h (log-rank = 0.027). Cox regression analysis found no effect of the covariates blood glucose (P = 0.601) or weight (P = 0.322) on the corneal reepithelialization (survival) curve. Conclusions Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.

scholarly journals Asymptotic convergence in distribution of the area bounded by prevalence-weighted Kaplan–Meier curves using empirical process modelling

2018 ◽  
Vol 5 (11) ◽  
pp. 180496
Author(s):  
Aaron Heuser ◽  
Minh Huynh ◽  
Joshua C. Chang
Keyword(s):  
Empirical Process ◽  
Survival Curve ◽  
Population Level ◽  
Weighted Averaging ◽  
Event Analysis ◽  
Social Security Administration ◽  
Survival Curves ◽  
Kaplan Meier ◽  
Population Survival ◽  
Product Limit

The Kaplan–Meier product-limit estimator is a simple and powerful tool in time to event analysis. An extension exists for populations stratified into cohorts where a population survival curve is generated by weighted averaging of cohort-level survival curves. For making population-level comparisons using this statistic, we analyse the statistics of the area between two such weighted survival curves. We derive the large sample behaviour of this statistic based on an empirical process of product-limit estimators. This estimator was used by an interdisciplinary National Institutes of Health–Social Security Administration team in the identification of medical conditions to prioritize for adjudication in disability benefits processing.

scholarly journals Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Xiao-jin Li ◽  
Ru-rong Wang ◽  
Yan Kang ◽  
Jin Liu ◽  
Yun-xia Zuo ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Survival Curve ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Study Group ◽  
Kaplan Meier ◽  
New Strategy ◽  
Lactate Levels ◽  
Sepsis And Septic Shock

Objective.To evaluate the clinical effect of safflower yellow on the treatment of severe sepsis and septic shock.Methods.85 patients with severe sepsis and septic shock were randomly selected to receive either therapy according to the international guidelines for management of severe sepsis and septic shock (Surviving Sepsis Campaign 2012) (control group,n= 45) or conventional therapy plus safflower yellow (study group,n= 40). The 28-day mortality and 28-day Kaplan-Meier survival curves were compared as primary outcomes.Results.The 28-day mortality from all causes and in-hospital mortality were significantly lower in the study group (50%, 17.5%) as compared to the control group (78.58%, 54.76%) (P= 0.007, all causes,P< 0.001, in-hospital), and the 28-day Kaplan-Meier survival curve was higher in the study group than in the control group (P= 0.008, all causes,P< 0.001, in-hospital, Log Rank). 72 hours after treatment, secondary outcomes including heart rate, leukocyte counts, lactate levels, and platelet counts of patients in the study group were ameliorated significantly as compared with the control group.Conclusion.This study offers a potential new strategy employing safflower yellow to more effectively treat patients with severe sepsis and septic shock. This trial is registered with identifierChiCTR-TRC-14005196.

scholarly journals Role of Nicergoline in Corneal Wound Healing in Diabetic Rats

2020 ◽  
Author(s):  
Amanda Portela ◽  
Rafael Moreno ◽  
Maria Helena Ribeiro ◽  
Fernanda de Andrade ◽  
Yale Alves ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cox Regression ◽  
Survival Curve ◽  
Diabetic Rats ◽  
Rank Test ◽  
Control Group ◽  
Cox Regression Analysis ◽  
Corneal Epithelial Defect ◽  
Kaplan Meier ◽  
Diabetic Keratopathy

Abstract Background: To investigate the effect of nicergoline on the rate of complete corneal ulcer reepithelialization (CCUR) in diabetic rats with diabetic keratopathy.Methods: Forty-eight streptozotocin-induced diabetic rats were randomly divided into two groups. The experimental group (n=24) received nicergoline (10 mg.kg-1.day-1), while the control group (n=24) received a placebo. A corneal epithelial defect was induced using a corneal diamond burr, and defect area was compared at timepoints of 0, 12, 24, 48 and 72 hours after the injury using image analysis software. The probability of CCUR within 72 hours was assessed using the Kaplan–Meier survival analysis log-rank test. Results: When compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72 hours (log-rank = 0.027). Cox regression analysis found no effect of the covariates blood glucose (P=0.601) or weight (P=0.322) on the corneal reepithelialization (survival) curve. Conclusions: Nicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.

scholarly journals Correlations between ACE single nucleotide polymorphisms and prognosis of patients with septic shock

2017 ◽  
Vol 37 (2) ◽  
Author(s):  
Xin-Man Dou ◽  
Hui-Juan Cheng ◽  
Ling Meng ◽  
Lin-Lin Zhou ◽  
Yi-Hong Ke ◽  
...  
Keyword(s):  
Septic Shock ◽  
Single Nucleotide Polymorphisms ◽  
Survival Curve ◽  
Control Group ◽  
Case Group ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Kaplan Meier ◽  
Genotype Frequencies ◽  
Ace Activity

The aim of the present study is to investigate association between septic shock (SS) and angiotensin I-converting enzyme (ACE) single nucleotide polymorphisms (SNPs). From October 2009 to December 2016, 238 SS patients and 242 healthy individuals were selected for our study. ACE activity was detected, ACE rs4291 and rs4646994 polymorphisms were detected using PCR-restriction fragment length polymorphism (PCR-RFLP). The Kaplan–Meier survival curve was employed to evaluate the association between ACE SNPs and patients’ survival and univariate and multivariate analyses to estimate risk factors for SS. ACE activity in the case group was increased in comparison with the control group. Allele and genotype frequencies of rs4291 and rs4646994 were different between the case and control groups. The TT genotype frequency of the rs4291 polymorphisms and the DD genotype of the rs4646994 polymorphisms of the case group were higher than those in the control group. The AT and TT genotypes indicated a significant elevation of ACE activity than the AA genotype, while a significant decline was found in the DI and II genotypes in comparison with the DI genotype. Patients with TT or DD genotypes had increased fatality rate within 7 and 30 days when compared with those with non-TT or non-DD genotypes. Lower sepsis-related organ failure assessment (SOFA) scores, rs4291, serum ACE and rs4646994 were all considered as risky factors for SS patients. The study demonstrates that TT genotype of rs4291 or DD genotype of rs4646994 may be indicative of a higher risk of SS and a poorer prognosis in SS patients.

Abstract 6087: Fragmented QRS Complex on 12-lead ECG Developed During the First 48 Hours after Acute Myocardial Infarction Predicts Mortality

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Mithilesh K Das ◽  
Mark A Michael ◽  
Hussam Suradi
Keyword(s):  
Myocardial Infarction ◽  
Survival Curve ◽  
Control Group ◽  
Qrs Complex ◽  
S Wave ◽  
Coronary Syndrome ◽  
Fragmented Qrs ◽  
Kaplan Meier ◽  
Number Of Patients

Fragmented QRS complex (fQRS) signifies myocardial infarction (MI) scar. Myocardial scar acts as a substrate for ventricular arrhythmias and a risk for death. We postulated that the development of new fQRS during the first 48 hours after an acute MI signifies mortality. Serial ECGs of 896 pts with acute coronary syndrome (ACS) and their mortality during follow-up were studied. MI was diagnosed by history, ECG and elevated cardiac enzymes. Serial ECGs were recorded at presentation, 8 hours, 16 hours and 24 – 48 hours. The fQRS on 12-lead ECG was defined by the presence of fragmented QRS, notched R or S wave, or RSR′ pattern without any bundle branch block, in at least 2 contiguous leads in one of the coronary artery territories (LAD: lead V1 to V6, LCx: lead I, aVL and V6, and RCA: lead II, III and aVF). The MI group (n =441, 98.4% males, age 63±11 yrs) and the control (unstable angina) group (n=455, 97.1% males, age 61±11 yrs, P=NS). 104 (24%) patients had STMI and 337 (76%) patients had NSTMI. fQRS developed in a significantly higher number of patients in the MI group as compared to the control group (224 [50.8%] vs. 17 [3.7%], p<0.001), respectively. New Q-waves developed in 122 (27.7%) and 2 (0.4%) patients in MI group and control group, respectively. fQRS was a multivariate predictor of mortality in ACS group as well as in the MI group, whereas Q wave did not predict mortality during a 23+/−17 months of follow-up. Kaplan-Meier survival curve revealed a significantly higher mortality in fQRS vs. non-fQRS group (p=0.001),. The development of fQRS within the first 48 hours of ACS patients predicts mortality during follow-up in patients with MI.

Heparin Bonded Hemodialysis e-PTFE Grafts Result in 20% Clot Free Survival Benefit

2009 ◽  
Vol 10 (3) ◽  
pp. 153-156 ◽  
Author(s):  
Ingemar Davidson ◽  
Clayton Hackerman ◽  
Aschmeeta Kapadia ◽  
Abu Minhajuddin
Keyword(s):  
Survival Curve ◽  
Graft Patency ◽  
Control Group ◽  
Heparin Binding ◽  
Rank Tests ◽  
Upper Arm ◽  
Free Survival ◽  
Kaplan Meier ◽  
One Year ◽  
Meier Survival Curve

Luminal surface heparin bonded hemodialysis e-PTFE grafts (N=83) with prolonged bioactivity retention (CBAS® technology) were compared to 67 control e-PTFE grafts using Kaplan-Meier survival curve estimates. Log-rank tests were used for statistical comparisons between groups. Heparin bonded graft recipients were on average 3.5 years older (NS), and had upper arm grafts in 66% vs. 43% (p=0.003) compared to controls. There was no clot-free survival (CFS) difference between groups for upper arm vs. forearm placed grafts (p=0.792). Patient mortality at one year was 15%, with no group difference. The overall combined clot-free survival for all 150 e-PTFE grafts was 69% at 12 months. At 6 and 12 months, CFS for the heparin bonded graft group was 88% and 78%, which is significantly higher than that of 69% and 58% for the control group, respectively, (p=0.007). It is concluded that heparin binding technology to artificial surfaces has evolved to a clinically powerful technique for the hemodialysis patient resulting in a 20% improved primary graft patency of about 80% at one year.

scholarly journals Therapeutic effect of teriparatide combined with lowfrequency pulsed electromagnetic field on hip fracture

2020 ◽  
Vol 19 (10) ◽  
pp. 2227-2233
Author(s):  
Xiang Sun ◽  
Xuefeng Guo ◽  
Wen Cao ◽  
Qiang Dong
Keyword(s):  
Electromagnetic Field ◽  
Hip Fracture ◽  
Survival Curve ◽  
Low Frequency ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Kaplan Meier ◽  
Harris Score ◽  
Pulsed Electromagnetic ◽  
Experimental Group

Purpose: To evaluate the therapeutic effect of teriparatide in combination with low-frequency pulsed electromagnetic field in the management of hip fracture.Methods: Patients with hip fracture internal fixation and under conventional postoperative basic adjuvant therapy were compared with those patients who received teriparatide combined with low frequency pulsed electromagnetic field after operation. The content of Bone-Specific AlkalinePhosphatase (BALP), type I Procollagen Carboxy Terminal Propeptide (PICP), serum bone glaprotein (BGP), Ca2+, hip function and degree of bone scab formation were evaluated using Harris score and Fernadez-esteve scoring system. Kaplan-Meier survival curve was plotted to analyze differences in short-term prognosis of different postoperative adjuvant treatment measures.Results: Harris score of the hip joint and the effect of bone formation in the experimental group were higher than that of the control group. The blood levels of BGP, BALP, PICP and serum Ca2+ in the experimental group were higher than that of the control group (p < 0.05). The plotted Kaplan-Meier survival curve indicates that the prognosis of the experimental group was better than that of control group (p < 0.05).Conclusion: The adjuvant therapy of teriparatide combined with low-frequency pulsed electromagnetic field can improve the recovery function and enhance the prognosis of patients who underwent hip fracture surgery. Keywords: Teriparatide; Low frequency pulsed electromagnetic field, hip fracture

POSSIBILITY TO REDUCE THROMBOCYTOPENIA AFTER CHEMORADIOTHERAPY IN ONCOLOGICAL PATIENTS

2017 ◽  
Vol 63 (3) ◽  
pp. 466-469
Author(s):  
Luiza Korytova ◽  
Aleksey Meshechkin ◽  
Oleg Korytov ◽  
V. Krasnikova
Keyword(s):  
Combined Treatment ◽  
Treated Group ◽  
Median Number ◽  
Blood Analysis ◽  
Control Group ◽  
Level Control ◽  
Normal Range ◽  
Oncological Patients ◽  
Level Increase ◽  
And Control

Objective was to establish efficiency of sodium nucleospermat in correcting thrombocytopenia after chemoradiotherapy in oncological patients. Methods and materials. The study included data on 32 patients that had undergone combined treatment from January till May 2016. After detecting thrombocytopenia patients were randomized into two groups (16 patients in each): treated group, where patients received sodium nucleospermat, and control group, where sodium nucleospermat was not used. Thrombocyte level control was done on 5th, 10th and 15th day after treatment was over. Results and discussion. All 16 patients showed positive dynamics in increasing thrombocyte level after Sodium nucleospermat injection course was finished. This was proven by first (5th day) blood analysis. On average thrombocyte level after sodium nucleospermat treatment has risen to normal, at 161х109/1. Only 3 patients from this group had to pause radiotherapy for 5 days. Control group patients, which did not receive sodium nucleospermat, showed evidence of thrombocyte level recovery by 10th day only. On average thrombocyte level increase was insignificant, and median number was 111*109/l. Low thrombocyte level was main reason to pause radiotherapy for 11 (69%) patients in control group. Conclusion. Sodium nucleospermat allowed raising thrombocyte level to the lower normal range, which surpassed by 40%-50% in control group patients. Use of sodium nucleospermat did not show any cases of allergic reactions, toxicity or complications in oncological patients.

scholarly journals Expression and clinical significance of miR-3615 in hepatocellular carcinoma

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098154
Author(s):  
Xin Yuan ◽  
Yize Zhang ◽  
Zujiang Yu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Survival Curve ◽  
Clinicopathological Characteristics ◽  
The Cancer Genome Atlas ◽  
Prognostic Information ◽  
Ki 67 ◽  
Tissue Samples ◽  
Expression Levels ◽  
Kaplan Meier ◽  
Serum Alpha Fetoprotein

Objective To investigate the association between microRNA-3615 (miR-3615) expression and the prognosis and clinicopathological features in patients with hepatocellular carcinoma (HCC). Methods We obtained clinicopathological and genomic data and prognostic information on HCC patients from The Cancer Genome Atlas (TCGA) database. We then analyzed differences in miR-3615 expression levels between HCC and adjacent tissues using SPSS software, and examined the relationships between miR-3615 expression levels and clinicopathological characteristics. We also explored the influence of miR-3615 expression levels on the prognosis of HCC patients using Kaplan–Meier survival curve analysis. Results Based on data for 345 HCC and 50 adjacent normal tissue samples, expression levels of miR-3615 were significantly higher in HCC tissues compared with adjacent tissues. MiR-3615 expression levels in HCC patients were negatively correlated with overall survival time and positively correlated with high TNM stage, serum Ki-67 expression level, and serum alpha-fetoprotein level. There were no significant correlations between miR-3615 expression and age, sex, and pathological grade. Conclusion MiR-3615 may be a promising new biomarker and prognostic factor for HCC.

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