scholarly journals Letter to Turing

2018 ◽  
Vol 36 (6) ◽  
pp. 73-94 ◽  
Author(s):  
Giuseppe Longo
Keyword(s):  
Scientific Method ◽  
Reaction Diffusion ◽  
Neural Nets ◽  
Scientific Letter ◽  
Alan Turing ◽  
Diffusion Dynamics ◽  
Human Attitude ◽  
Scientific Quest ◽  
The Impact ◽  
Made In

This personal, yet scientific, letter to Alan Turing, reflects on Turing's personality in order to better understand his scientific quest. It then focuses on the impact of his work today. By joining human attitude and particular scientific method, Turing is able to “immerse himself” into the phenomena on which he works. This peculiar blend justifies the epistolary style. Turing makes himself a “human computer”, he lives the dramatic quest for an undetectable imitation of a man, a woman, a machine. He makes us see the continuous deformations of a material action/reaction/diffusion dynamics of hardware with no software. Each of these investigations opens the way to new scientific paths with major consequences for contemporary live and for knowledge. The uses and the effects of these investigations will be discussed: the passage from classical AI to today's neural nets, the relevance of non-linearity in biological dynamics, but also their abuses, such as the myth of a computational world, from a Turing-machine like universe to an encoded homunculus in the DNA. It is shown that these latter ideas, which are sometimes even made in Turing's name, contradict his views.

scholarly journals The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction–diffusion system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Keiichi Kataoka ◽  
Hironori Fujita ◽  
Mutsumi Isa ◽  
Shimpei Gotoh ◽  
Akira Arasaki ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Computational Study ◽  
Reaction Diffusion ◽  
Human Migration ◽  
Reaction Diffusion System ◽  
Diffusion System ◽  
Tooth Root ◽  
Computed Tomography Images ◽  
Diffusion Dynamics ◽  
Root Morphogenesis

AbstractMorphological variations in human teeth have long been recognized and, in particular, the spatial and temporal distribution of two patterns of dental features in Asia, i.e., Sinodonty and Sundadonty, have contributed to our understanding of the human migration history. However, the molecular mechanisms underlying such dental variations have not yet been completely elucidated. Recent studies have clarified that a nonsynonymous variant in the ectodysplasin A receptor gene (EDAR370V/A; rs3827760) contributes to crown traits related to Sinodonty. In this study, we examined the association between theEDARpolymorphism and tooth root traits by using computed tomography images and identified that the effects of theEDARvariant on the number and shape of roots differed depending on the tooth type. In addition, to better understand tooth root morphogenesis, a computational analysis for patterns of tooth roots was performed, assuming a reaction–diffusion system. The computational study suggested that the complicated effects of theEDARpolymorphism could be explained when it is considered that EDAR modifies the syntheses of multiple related molecules working in the reaction–diffusion dynamics. In this study, we shed light on the molecular mechanisms of tooth root morphogenesis, which are less understood in comparison to those of tooth crown morphogenesis.

Handshake antimicrobial stewardship as a model to recognize and prevent diagnostic errors

Diagnosis ◽  
2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Justin B. Searns ◽  
Manon C. Williams ◽  
Christine E. MacBrayne ◽  
Ann L. Wirtz ◽  
Jan E. Leonard ◽  
...  
Keyword(s):  
Antimicrobial Stewardship ◽  
Interrater Reliability ◽  
Diagnostic Errors ◽  
Diagnostic Error ◽  
Primary Treatment ◽  
Treatment Team ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
The Impact ◽  
Made In

AbstractObjectivesFew studies describe the impact of antimicrobial stewardship programs (ASPs) on recognizing and preventing diagnostic errors. Handshake stewardship (HS-ASP) is a novel ASP model that prospectively reviews hospital-wide antimicrobial usage with recommendations made in person to treatment teams. The purpose of this study was to determine if HS-ASP could identify and intervene on potential diagnostic errors for children hospitalized at a quaternary care children’s hospital.MethodsPreviously self-identified “Great Catch” (GC) interventions by the Children’s Hospital Colorado HS-ASP team from 10/2014 through 5/2018 were retrospectively reviewed. Each GC was categorized based on the types of recommendations from HS-ASP, including if any diagnostic recommendations were made to the treatment team. Each GC was independently scored using the “Safer Dx Instrument” to determine presence of diagnostic error based on a previously determined cut-off score of ≤1.50. Interrater reliability for the instrument was measured using a randomized subset of one third of GCs.ResultsDuring the study period, there were 162 GC interventions. Of these, 65 (40%) included diagnostic recommendations by HS-ASP and 19 (12%) had a Safer Dx Score of ≤1.50, (Κ=0.44; moderate agreement). Of those GCs associated with diagnostic errors, the HS-ASP team made a diagnostic recommendation to the primary treatment team 95% of the time.ConclusionsHandshake stewardship has the potential to identify and intervene on diagnostic errors for hospitalized children.

scholarly journals The influence of density in population dynamics with strong and weak Allee effect

2021 ◽  
Vol 29 (1) ◽  
Author(s):  
Kamrun Nahar Keya ◽  
Md. Kamrujjaman ◽  
Md. Shafiqul Islam
Keyword(s):  
Population Dynamics ◽  
Allee Effect ◽  
Global Bifurcation ◽  
Reaction Diffusion ◽  
Logistic Growth ◽  
Allee Effects ◽  
Reaction Diffusion Model ◽  
Positive Steady States ◽  
The Stability ◽  
The Impact

AbstractIn this paper, we consider a reaction–diffusion model in population dynamics and study the impact of different types of Allee effects with logistic growth in the heterogeneous closed region. For strong Allee effects, usually, species unconditionally die out and an extinction-survival situation occurs when the effect is weak according to the resource and sparse functions. In particular, we study the impact of the multiplicative Allee effect in classical diffusion when the sparsity is either positive or negative. Negative sparsity implies a weak Allee effect, and the population survives in some domain and diverges otherwise. Positive sparsity gives a strong Allee effect, and the population extinct without any condition. The influence of Allee effects on the existence and persistence of positive steady states as well as global bifurcation diagrams is presented. The method of sub-super solutions is used for analyzing equations. The stability conditions and the region of positive solutions (multiple solutions may exist) are presented. When the diffusion is absent, we consider the model with and without harvesting, which are initial value problems (IVPs) and study the local stability analysis and present bifurcation analysis. We present a number of numerical examples to verify analytical results.

scholarly journals Optimal Solutions for the Use of Sewage Sludge on Agricultural Lands

Water ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 585
Author(s):  
Catalina Iticescu ◽  
Puiu-Lucian Georgescu ◽  
Maxim Arseni ◽  
Adrian Rosu ◽  
Mihaela Timofti ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Sewage Sludge ◽  
Agricultural Production ◽  
Agricultural Land ◽  
Chemical Characteristics ◽  
Optimal Solutions ◽  
Physico Chemical ◽  
Agricultural Areas ◽  
The Impact ◽  
Made In

The use of sewage sludge in agriculture decreases the pressure on landfills. In Romania, massive investments have been made in wastewater treatment stations, which have resulted in the accumulation of important quantities of sewage sludge. The presence of these sewage sludges coincides with large areas of degraded agricultural land. The aim of the present article is to identify the best technological combinations meant to solve these problems simultaneously. Adapting the quality and parameters of the sludge to the specificity of the land solves the possible compatibility problems, thus reducing the impact on the environment. The physico-chemical characteristics of the fermented sludge were monitored and optimal solutions for their treatment were suggested so as to allow that the sludge could be used in agriculture according to the characteristics of the soils. The content of heavy metals in the sewage sludge was closely monitored because the use of sewage sludge as a fertilizer does not allow for any increases in the concentrations of these in soils. The article identifies those agricultural areas which are suitable for the use of sludge, as well as ways of correcting some parameters (e.g., pH), which allow the improvement of soil quality and obtained higher agricultural production.

scholarly journals Monitoring the Impact of the Large Building Investments on the Neighborhood

2021 ◽  
Vol 11 (14) ◽  
pp. 6537
Author(s):  
Marian Łupieżowiec
Keyword(s):  
Groundwater Level ◽  
Soil Improvement ◽  
Deep Excavation ◽  
Large Area ◽  
Safety Measures ◽  
High Rise ◽  
The Impact ◽  
Large Building ◽  
Additional Safety ◽  
Made In

The article presents the concept of monitoring buildings and infrastructure elements located near large construction investments (the construction of high-rise buildings of the Oak Terraces housing estate in Katowice and the construction of a tunnel under the roundabout in Katowice along the intercity express road DTŚ). The impacts include deep excavation, lowering of the groundwater level over a large area, and dynamic influences related to the use of impact methods of soil improvement. The presented monitoring includes observation of the groundwater level with the use of piezometers, geodetic measurements of settlement and inclinations, as well as the measurement of vibration amplitudes generated during the works involving shocks and vibrations. It was also important to observe the development of cracks on the basis of a previously made inventory of damage. The results of the monitoring allow corrections to be made in the technology of works (e.g., reduction of vibration amplitudes, application of additional protections at excavations, etc.) or the use additional safety measures. Currently, there are also monitoring systems used during the operation of completed facilities.

Platform Capitalism ‘Made in China’? Intelligent Manufacturing, Taobao Villages and the Restructuring of Work

2019 ◽  
Vol 24 (2) ◽  
pp. 199-217 ◽  
Author(s):  
Boy Lüthje
Keyword(s):  
Intelligent Manufacturing ◽  
Value Chains ◽  
Policy Recommendations ◽  
Employment Policy ◽  
Social Shaping Of Technology ◽  
Social Shaping ◽  
Made In China ◽  
The Impact ◽  
Conditions Of Employment ◽  
Made In

The article examines the development of advanced digital manufacturing (as outlined in the ‘Made-in-China 2025’ government plan) from the perspective of the changing socio-technical paradigms of production. The analysis focuses on the transformations of value chains and work, based on theories of social shaping of technology, regulation theory and regimes of production. Analytically, the author proposes to distinguish between ‘production-driven’ and ‘distribution-driven’ pathways of manufacturing digitalisation. The transformation of semi-rural industrial areas (‘Taobao villages’, named after China’s largest e-commerce platform Taobao) into mass production clusters for e-commerce is depicted as a paradigmatic model of distribution-driven transformation and as a characteristic Chinese strategy in this field. The article examines the impact on industry supply chains and work, leading to ever-more precarious conditions of employment. Policy recommendations focus on local strategies to stabilise supply chain structures and working conditions, as an alternative to the present top-down approaches to manufacturing modernisation in China.

Obstructive nephropathy and renal fibrosis

2002 ◽  
Vol 283 (5) ◽  
pp. F861-F875 ◽  
Author(s):  
Saulo Klahr ◽  
Jeremiah Morrissey
Keyword(s):  
Renal Disease ◽  
Renal Fibrosis ◽  
Interstitial Fibrosis ◽  
Rodent Model ◽  
Renal Diseases ◽  
Obstructive Nephropathy ◽  
Therapeutic Approaches ◽  
Cellular Events ◽  
The Impact ◽  
Made In

Interstitial fibrosis has a major role in the progression of renal diseases. Several animal models are available for the study of renal fibrosis. The models of aminonucleoside-induced nephrotic syndrome, cyclosporin nephrotoxicity, and passive Heyman nephritis are characterized by molecular and cellular events similar to those that occur in obstructive nephropathy. Additionally, inhibition of angiotensin-converting enzyme exerts salutary effects on the progression of renal fibrosis in obstructive nephropathy. Unilateral ureteral obstruction (UUO) has emerged as an important model for the study of the mechanisms of renal fibrosis and also for the evaluation of the impact of potential therapeutic approaches to ameliorate renal disease. Many quantifiable pathophysiological events occur over the span of 1 wk of UUO, making this an attractive model for study. This paper reviews some of the ongoing studies that utilized a rodent model of UUO. Some of the findings of the animal model have been compared with observations made in patients with obstructive nephropathy. Most of the evidence suggests that the rodent model of UUO is reflective of human renal disease processes.

THE IMPACT OF ICT IN MARKETING LIBRARY SERVICES IN ACADEMIC LIBRARY

2021 ◽  
Vol 9 (1) ◽  
pp. 150-156
Author(s):  
Salamatu Baba ◽  
◽  
Dikuma Ibrahim ◽  
Sanda Grema ◽  
◽  
...  
Keyword(s):  
Information And Communication Technology ◽  
Communication Technology ◽  
Academic Library ◽  
Library Services ◽  
Information And Communication ◽  
The Impact ◽  
Role Of Information ◽  
Descriptive Method ◽  
Made In

In order to promote utilizing the available resource made in any library information has to be taken to the door step of a clientele a such information and communication technology will serve as a catalyst in doing that. This paper has explored the role of information and communication technology ICT in academia and as well as the strategies used in propagating the available services in an academic library this is because tailor made information it is highly required so as to avoid wasting the precious time of academicians and this can be only achieving with the help of information and communication technology software, therefore, descriptive method was adopted in the methodology of this study.

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