Impact of statin treatment on patients diagnosed with chronic venous disease. Morphological analysis of the venous wall and clinical implications

Objectives The study evaluates the potential morphological changes that may occur in the venous wall in the case of the patients with chronic venous disease which associates treatment with statins for at least 2 years. Methods Operated patients with chronic venous disease in the CEAP C2-C3 stage were included in the study. 215 venous fragments, collected from 50 patients within the study group and 179 venous fragments collected from 52 patients within the control group were microscopically analysed, evaluating a series of morpho-anatomical parameters. Results In the study group, it was found that, venous reflux predominantly affects small veins, and also, a significant increase in collagen deposits in the adventitia and media tunics, proportional to the thickening of the venous wall. Conclusion Our results indicate possible effects of statins upon the venous morphology. Further studies are needed to determine the impact of these results on daily practice.

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Impact of copper compression stockings on venous insufficiency and lipodermatosclerosis: A randomised controlled trial

Phlebology The Journal of Venous Disease ◽

10.1177/0268355518795329 ◽

2018 ◽

Vol 34 (4) ◽

pp. 224-230 ◽

Cited By ~ 2

Author(s):

Linda P Arendsen ◽

Stella Vig ◽

Ranee Thakar ◽

Abdul H Sultan

Keyword(s):

Surface Area ◽

Controlled Trial ◽

Chronic Venous Disease ◽

Control Group ◽

Venous Disease ◽

Compression Stocking ◽

Compression Stockings ◽

Significant Difference ◽

Randomised Controlled ◽

The Impact

Objective Compression stockings are the primary treatment for lipodermatosclerosis secondary to chronic venous disease, but do not improve the skin condition. The aim of this study was to investigate the impact of copper on lipodermatosclerosis. Methods A double-blind randomised controlled pilot study was performed including patients with bilateral lipodermatosclerosis. One compression stocking of a pair was impregnated with copper. Symptom score and surface area of lipodermatosclerosis were assessed at baseline, after 2, 4 and 8 weeks. Results Sixteen patients were included. There was no significant difference in mean symptom scores; however, there was a significant reduction of the surface area in the study group 42,637 to 35,739 mm2 versus 41,487 to 43,210 mm2 in the control group (p = 0.04). Conclusion This study demonstrates the beneficial effect of copper on lipodermatosclerosis secondary to chronic venous disease with reduction in surface area but no benefit on symptoms. Trials identification number: NCT03283800

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How Did Prenatal Education Impact Women’s Perception of Pregnancy and Postnatal Life in a Romanian Population

Medicina ◽

10.3390/medicina57060581 ◽

2021 ◽

Vol 57 (6) ◽

pp. 581

Author(s):

Anca Maria Balasoiu ◽

Octavian Gabriel Olaru ◽

Romina Marina Sima ◽

Liana Ples

Keyword(s):

Prenatal Care ◽

Newborn Care ◽

Control Group ◽

Postnatal Life ◽

Study Group ◽

Prenatal Education ◽

Questionnaire Online ◽

A Prospective Study ◽

The Impact ◽

Official Information

Background and Objectives: Prenatal education represents an important part of maternal prenatal care in Western countries. In Romania, prenatal education is of recent interest but there is no official information about prenatal courses and their impact on prenatal care and patients in Romania. Material and methods: A prospective study based on the STROBE statement was designed in order to assess the prenatal education delivered in our unit. The study group included women who gave birth at Bucur Maternity, “Saint. John” Hospital, Bucharest, Romania and attended the prenatal courses, compared with a control group (women who gave birth in our unit but did not attend the prenatal lecture). Patients’ perception about the impact of prenatal education was collected by applying a questionnaire. Results: The analysis included 89 women who fulfilled the questionnaire online. In our study, 62 women (69.7%) attended the prenatal education classes and represented the study group while 27 women (30.3%) constituted the control group. Women who attended the prenatal lecture recognized the utility of the topic regarding newborn care (90.3%), while women from the control group did not consider it useful (n = 55.6%), χ2 = 18.412, p < 0.001. Patients from the study group admitted the importance of the topics (93.5%) from the lectures about breast feeding, while the percentage of these women from the control group is significantly lower (55.6%) χ2 = 27.867, p < 0.001. Conclusions: The benefits of prenatal education were recognized by women who attended the prenatal lecture, while women who did not participate underestimated the utility of the topics. Further actions are required to inform mothers about the necessity of antenatal education.

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Twin Pregnancies Complicated by a Single Malformed Fetus: Chorionicity, Outcome and Management

Twin Research and Human Genetics ◽

10.1375/twin.13.5.501 ◽

2010 ◽

Vol 13 (5) ◽

pp. 501-507 ◽

Cited By ~ 8

Author(s):

Ali Gedikbasi ◽

Alpaslan Akyol ◽

Gokhan Yildirim ◽

Ali Ekiz ◽

Ahmet Gul ◽

...

Keyword(s):

Gestational Age ◽

Statistical Significance ◽

Expectant Management ◽

Control Group ◽

Study Group ◽

Preliminary Evaluation ◽

Gestational Age At Birth ◽

The Impact ◽

Twin Pregnancies ◽

Age At Birth

The objective of this study was to evaluate the impact of one abnormal fetus in a twin pregnancy, to compare impact of chorionicity and clinical outcome of intervention and expectant management. Thirty-seven dichorionic (DC) twins and 18 monochorionic (MC) twins complicated with one malformed fetus were evaluated for gestational age, birthweight and perinatal outcome. Six hundred and forty-two twin pregnancies were evaluated in the database. The control groups consisted of 429 DC and 86 MC twins without anomalous fetus. Mean birthweight and gestational age at birth for DC control group were (n= 429; 2137g and 34.71 weeks), DC study group,n= 37; 2117g (p= .338) and 33.97 weeks (p= .311), and DC study group with major malformations,n= 30; 2019g (p= .289) and 33.3 weeks (p= .01), and showed only significance for gestational age. There was no statistical significance between MC control group,n= 86; 2097g and 34.93 weeks, and MC study group,n= 18; 2237g (p= .338), and 34.42 weeks (p= .502). Because of limited data, the preliminary evaluation for expectant management and intervention, and survival of at least one normal fetus showed no impact. We conclude that, although, all DC twin pregnancies have a risk for preterm delivery, DC twins complicated with major malformation of one twin, have a lower mean gestational age at birth. Preliminary results for intervention does not improve fetal outcome for DC and MC twins and needs further evaluation with greater studies of impact or review.

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Analysis of the Impact of Personalized Nursing Service and Hospice Care on the Quality of Life of Elderly Cancer Patients

Tobacco Regulatory Science ◽

10.18001/trs.7.4.24 ◽

2021 ◽

Vol 7 (4) ◽

pp. 469-473

Author(s):

Ting Fang ◽

Nian Wang ◽

Meng Chen ◽

Hongmei Ma

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Advanced Cancer ◽

Hospice Care ◽

Pain Treatment ◽

Control Group ◽

Study Group ◽

The Difference ◽

The Impact

Objective Explore the impact of personalized nursing services and hospice care on the quality of life of elderly patients with advanced cancer. Method We selected 80 elderly cancer patients admitted to our hospital from September 2020 to May 2021, and divided these patients into a study group and a control group using a random number table method. The patients in the control group used conventional nursing methods to treat and care for the patients, and the patients in the study group used hospice care measures and combined personalized nursing measures. The quality of life and pain treatment effects of the two groups of patients before and after treatment were compared. Result Before treatment, the quality-of-life scores of the two groups of patients were low, and there was no statistical difference (P>0.05); After treatment, the quality of life of the two groups of patients improved, but compared with the control group, the improvement was more obvious in the study group, and the difference was statistically significant (P<0.05). In terms of pain treatment effect, the total effective rate of pain treatment in the study group was 87.5%, which was significantly better than the 62.5% in the control group. The difference was statistically significant (P<0.05). Conclusion Personalized nursing services and hospice care are conducive to improving the survival and treatment of elderly patients with advanced cancer, and can be used as a clinical application program for the care of advanced cancer patients.

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Cytokines Produced by Lymphocytes in the Incompetent Great Saphenous Vein

Mediators of Inflammation ◽

10.1155/2018/7161346 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Ewa Grudzińska ◽

Andrzej Lekstan ◽

Ewelina Szliszka ◽

Zenon P. Czuba

Keyword(s):

Saphenous Vein ◽

Oscillatory Flow ◽

Great Saphenous Vein ◽

Interleukin 1 ◽

Lymphocyte Culture ◽

Chronic Venous Disease ◽

Control Group ◽

Venous Disease ◽

Culture Supernatants ◽

Necrosis Factor

The pathogenesis of chronic venous disease (CVD) remains unclear, but lately inflammation is suggested to have an important role in its development. This study is aimed at assessing cytokines released by lymphocytes in patients with great saphenous vein (GSV) incompetence. In 34 patients exhibiting oscillatory flow (reflux) in GSV, blood was derived from the cubital vein and from the incompetent sapheno-femoral junction. In 12 healthy controls, blood was derived from the cubital vein. Lymphocyte culture with and without stimulation by phytohemagglutinin (PHA) was performed. Interleukins (IL) 1β, 2, 4, 10, 12 (p70), and 17A; interleukin 1 receptor α (IL-1ra); tumor necrosis factor-α (TNF-α); interferon-gamma (IFN-γ); and RANTES were assessed in culture supernatants by the Bio-Plex assay. In both stimulated and unstimulated samples, in the examined group, IL-1β and IFN-γ had higher concentrations and RANTES had lower concentrations when compared to those in the control group. In the examined group, IL-4 and IL-17A had higher concentrations without stimulation and TNF-α had higher concentrations with stimulation. The GSV samples had higher IL-2, IL-4, IL-12 (p70), and IFN-γ concentrations without stimulation and lower IL-2 and TNF-α concentrations with stimulation when compared to those of the upper limb in the examined group. These observations indicate that the oscillatory flow present in incompetent veins causes changes in the cytokine production by lymphocytes, promoting a proinflammatory profile. However, the relations between immunological cells, cytokines, and the endothelium require more insight.

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Hemostasis in Infertile Patients Participating in Assisted Reproduction Programmes

Doctor Ru ◽

10.31550/1727-2378-2021-20-6-6-11 ◽

2021 ◽

Vol 20 (6) ◽

pp. 6-11

Author(s):

A.O. Godzoeva ◽

◽

I.E. Zazerskaya ◽

V.S. Vlasov ◽

T.V. Vavilova ◽

...

Keyword(s):

Reproductive Technologies ◽

Control Group ◽

Study Group ◽

Study Objective ◽

Hemostasis System ◽

Fibrin Monomer ◽

Study Results ◽

Venous Thromboembolic Events ◽

The Impact ◽

Infertile Patients

Study Objective: To evaluate the impact of multifollicular ovarian stimulation in in vitro fertilisation (IVF) programmes on hemostasis. Study Design: perspective comparative study. Materials and Methods. The study included 68 patients divided into two groups: study group (n = 36) — infertile patients; control group (n = 32) — healthy non-pregnant women of reproductive age. The protocol with gonadotrophin releasing hormone antagonists was used for ovulation stimulation. Hemostasis system in study patients was evaluated in 2 weeks after embryos were transferred to uterus; in control group — on day 20–22 of menstrual period. For the study group, we evaluated clotting test parameters of hemostasis system, D-dimers (D-d) and fibrin monomer (FM). Study Results. We have not found statistically significant differences between hemostasis screening results of study groups. We have identified increase in pro-coagulatory properties of blood in the study group patients: increase in FM and D-d (р < 0.0001 in both cases). There is an association between study parameters and pregnancy (p < 0.001) and no association with obesity, age and infertility. Conclusion. In IVF programme, FM and D-d levels rise, evidencing hypercoagulation development. An increase in FM levels was even more significant and can be used as an early and specific fibrogenesis marker. Keywords: assisted reproductive technologies, fibrin monomer, D-dimer, hypercoagulation, venous thromboembolic events.

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The Impact of Pre-emptive Large Dose of Methylprednisolone Combined With Gabapentin on Pain Treatment and Convalescence After Total Knee Arthroplasty in Elderly. A Randomized Control Study

10.21203/rs.3.rs-149103/v1 ◽

2021 ◽

Author(s):

Henryk Liszka ◽

Małgorzata Zając ◽

Artur Gądek

Keyword(s):

Total Knee Arthroplasty ◽

Single Dose ◽

Knee Arthroplasty ◽

Opioid Analgesic ◽

Control Group ◽

Study Group ◽

Intensity Level ◽

Old Patients ◽

Total Knee ◽

The Impact

Abstract Background The aim of the study was to assess whether administration of gabapentin and methylprednisolone as “pre-emptive analgesia” in a group of patients above 65 years of age would be effective in complex pain management therapy following total knee arthroplasty (TKA). Material and Methods One hundred seventy, above 65 years old patients were qualified for the study, and 10 patients were excluded due to clinical situation. One hundred sixty patients were double-blind randomized into two groups: the study (eighty patients) and controls (eighty patients). The study group received as “pre-emptive” analgesia a single dose of 300 mg oral gabapentin and 125 mg intravenous methylprednisolone, while the others placebo. Perioperatively, all the patients received opioid and nonopioid analgesic agents calculated for 1 kg of body weight. We measured the levels of inflammatory markers (leukocytosis, C-reactive protein - CRP), pain intensity level at rest (numerical rating scale - NRS), the life parameters and all complications. Results Following administration of gabapentin and methylprednisolone as “pre-emptive” analgesia CRP values being lower on all postoperative days ( 1, 2 days - p<0,00001, 3 day – p=000538), leukocytosis on day 2 (p<0,0086) and 3 (p<0,00042), the NRS score at rest 6, 12 (p<0,000001), 18 (p<0,00004) and 24 (p=0,005569) hours postoperatively . Methylprednisolone with gabapentin significantly decreased the dose of parenteral opioid preparations (p=0,000006). The duration time of analgesia was significantly longer in study group (p<0,000001). No infectious complications were observed; in the control group, one patient manifested transient ischaemic attack (TIA). Conclusion The use of gabapentin and methylprednisolone at a single dose decreases the level of postoperative pain on the day of surgery, the dose of opioid analgesic preparations, the level of inflammatory parameters without infectious processes.

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The impact of compression garments on the quality of life in patients with chronic venous disease

Physiotherapy ◽

10.1515/physio-2016-0011 ◽

2017 ◽

Vol 24 (2) ◽

Author(s):

Iwona Demczyszak ◽

Edyta Sutkowska ◽

Magdalena Jasiak ◽

Małgorzata Fortuna ◽

Justyna Mazurek

Keyword(s):

Quality Of Life ◽

Lower Extremity ◽

Compression Therapy ◽

Chronic Venous Disease ◽

Venous Disease ◽

Compression Garments ◽

Before And After ◽

The Impact ◽

Career Status

AbstractIntroduction. Assessment of quality of life in patients suffering from chronic venous disease of the lower extremity who were treated with compression garments. Methods. Patients of both sexes aged 30-75 years with chronic venous disease and at least varices, but without active ulceration, were qualified for the study. To assess the quality of life, the CIVIQ-20 questionnaire was used before and after 4 weeks of compression therapy with second class compression. Results. The combined results of the CIVIQ scale rose from 61.49% before compression to 75.17% after 4 weeks of compression therapy (p 0.01). No correlation was found between sex, age, career status or type of work and the averaged CIVIQ score. Conclusions. Compression therapy with special garments significantly improves the quality of life in patients with chronic venous disease. Larger studies are still needed in this field.

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Impact of the Clinical Pharmacist on Readmission in Patients with Acute Coronary Syndrome

Annals of Pharmacotherapy ◽

10.1345/aph.1e640 ◽

2005 ◽

Vol 39 (9) ◽

pp. 1423-1427 ◽

Cited By ~ 32

Author(s):

Kate M O'Del ◽

Suzan N Kucukarslan

Keyword(s):

Unstable Angina ◽

Clinical Pharmacist ◽

Positive Impact ◽

Patient Care Team ◽

Direct Patient Care ◽

Control Group ◽

Study Group ◽

Coronary Syndrome ◽

Coronary Syndromes ◽

The Impact

BACKGROUND: Previous studies have reported a positive impact of pharmacists on care of patients with chronic illnesses. The impact of the clinical pharmacist on hospital readmission in patients with acute coronary syndromes (ACS) has yet to be evaluated, as of this writing. OBJECTIVE: To evaluate the impact of the clinical pharmacist as a direct patient-care team member on cardiac-related readmission in patients admitted to the general cardiology unit with ACS. METHODS: A prospective, nonrandomized observational study compared patients who received standard practice care with patients admitted to a service with a clinical pharmacist to provide care at the bedside. Patients admitted to and discharged from the general cardiology unit for ACS were included. The primary endpoint of the study was cardiac-related readmission at 30 days following hospital discharge. Secondary endpoints included length of stay and medication utilization. Interventions provided by the clinical pharmacist in the study group were documented. RESULTS: Cardiac readmission at 30 days was similar between the groups (p = 0.59%). In the subset of patients with unstable angina, readmission in the study group was significantly lower than in the control group (1.3% vs 9.1%; p = 0.04%). Patients in both groups were similarly managed using drug therapy and invasive coronary interventions. The medical staff's rate of acceptance of recommendations provided by the pharmacist was 94.4%. The most common interventions were medication education and identification of indicated therapy. CONCLUSIONS: The addition of pharmacists did not decrease readmission in patients with ACS. The finding of significant reduction in readmission in the subset of patients with unstable angina should be considered “hypothesis generating” for future randomized studies to confirm the results.

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Static foot disorders: a major risk factor for chronic venous disease?

Phlebology The Journal of Venous Disease ◽

10.1258/phleb.2011.010060 ◽

2011 ◽

Vol 27 (1) ◽

pp. 13-18 ◽

Cited By ~ 13

Author(s):

J-F Uhl ◽

M Chahim ◽

F-A Allaert

Keyword(s):

Risk Factor ◽

Daily Practice ◽

Chronic Venous Disease ◽

Venous Stasis ◽

Venous Disease ◽

Prolonged Standing ◽

Flat Feet ◽

Study Population ◽

Ceap Classification ◽

Standardized Measurement

Objective To study the relationship between the static foot disorders (SFDs) and chronic venous disease (CVD). Material and methods A retrospective study of 824 feet in unselected 412 patients seen by one phlebologist using a standardized record form. A complete clinical, aetiological, anatomical and pathological elements (CEAP) classification was determined. Alleged venous symptoms were recorded using a 10-point visual analogue scale and scored using a customized questionnaire. A standardized measurement of the Djian-Annonier angle was used to quantify and identify the presence of any static disorder of the foot. Results There were 156 men (37.8%) and 256 women (62.2%) who were included in this study. A majority of patients (59.3%) had a CEAP classification of C3 or greater. Static disorders of the feet were found to be very common in the study population: 137 feet were hollow feet (16.6%) and 120 flat feet (14.5%). Thus, 31% of all of the feet had some form of SFD. A significant correlation was found between the incidence of SFD and body mass index ( P < 0.01), the presence of symptoms ( P<0.001) and prolonged standing during the day (>5 hours, P < 0.05). The severity of the CVD, represented by the CEAP clinical classes, was also found to be very significantly related to the SFD ( P < 0.001). This correlation was found to be independent of age. Conclusion Static disorders of the foot can be considered as an important risk factor that negatively affects CVD. In daily practice, it is often underestimated. This emphasizes the crucial importance of the detection of SFD during the clinical exam of all CVD patients. Correction of static disorders of the feet will improve symptoms due to the SFD, as well as those related to venous stasis. These results can easily be explained by improvement of foot pump efficacy during walking.

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