Palisading granulomatous dermatitis and panniculitis (palisading granuloma) of dogs

2021 ◽  
pp. 030098582110305
Author(s):  
Michael Lund ◽  
Elizabeth A. Mauldin ◽  
Enrico Radaelli ◽  
Charles W. Bradley
Keyword(s):  
Clinical Features ◽  
Medical Records ◽  
Inclusion Criteria ◽  
Cellular Infiltrate ◽  
Inflammatory Lesions ◽  
Favorable Prognosis ◽  
Dermal Collagen ◽  
Granulomatous Dermatitis ◽  
Multiple Nodules ◽  
E Cadherin

Palisading granulomatous dermatitis and panniculitis is recognized in various cutaneous inflammatory lesions secondary to presumed collagen damage. Cutaneous nodules with a palisading arrangement of histiocytes surrounding foci of collagen degeneration have been clinically termed palisading granuloma in dogs. Study aims were to characterize the cellular infiltrate of canine palisading granuloma and document salient clinical features. Inclusion criteria were met for 36 dogs and encompassed nodular dermal and subcutaneous histiocyte-predominant cellular infiltrates targeting and enveloping collagen fibers/necrotic foci with palisading configurations. Infectious causes were ruled out via standard histochemical stains and/or clinical data. Medical records were reviewed for signalment, clinical features, treatment, outcome, and comorbidities. Immunohistochemistry (IBA1, CD204, E-cadherin) and Masson’s trichrome stain were used to assess histiocytic populations and dermal collagen, respectively. The histiocytes had moderate or strong immunolabeling for IBA1 and CD204 in 36/36 dogs (100%) and mild positive immunolabeling for E-cadherin in 3/36 dogs (8%). Alteration of collagen was graded as moderate or strong in 32/36 dogs (89%) and mild in 3/36 dogs (8%). Large breeds predominated with 30/36 dogs (83%) being ≥23 kg. Focal nodules were identified in 31/36 dogs (86%). The head/face were involved in 19/36 dogs (53%) and the extremities in 18/36 dogs (50%). Lesions from the 5/36 dogs (14%) with multiple nodules contained prominent eosinophilic infiltrates. Following excision, there was no evidence of recurrence. In conclusion, palisading granulomas are a distinct, non-neoplastic, histiocyte-predominant inflammatory condition in dogs associated with altered dermal collagen and favorable prognosis.

scholarly journals Clinical Features and Disease Course of Cancer Patients Infected with SARS-CoV-2 During Anticancer Treatments

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aleksandra Babić ◽  
Jelena Milin-Lazović ◽  
Sanja Milenković ◽  
Jelena Dobrić ◽  
Zlata Hufnagel ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Clinical Features ◽  
Medical Records ◽  
Cancer Stage ◽  
Disease Course ◽  
Clearance Time ◽  
Favorable Prognosis ◽  
Anticancer Treatment ◽  
Ecog Ps ◽  
Radio Chemotherapy

Abstract Background: Cancer patients infected with SARS-CoV-2 during their active anticancer treatment represent a highly vulnerable population. We aimed this investigation to show clinical features and outcomes of the patients who had mild to moderate COVID-19 symptoms or were asymptomatic at the admission to the COVID Center. Patients and methods: The retrospective study included 25 cancer patients confirmed with SARS-CoV-2 within seven days of their last anticancer treatment. Clinical data were collected from medical records and processed by methods of descriptive and inferential statistics. Results: Patients’ mean age was 68.1±10.4 years. More than 2/3 of the patients were with ECOG PS 0 and 1, and about 4/5 of patients were in III or IV cancer stage. The most frequently applied types of therapy were radiotherapy and combined radio/chemotherapy. Eleven (44.0%) patients had bilateral while 4 (16%) had unilateral pneumonia. The most frequent symptoms were fever (72%), fatigue (72%), dyspnea (32%), and cough (32%). 1/5 of the patients needed oxygen support. Mean neutrophil (2.6±1.2), lymphocyte (0.9±0.6) and platelets (200.1±88.1) number significantly increased from admission to discharge (p=0.004, p=0.005, p<0.001). Median CRP significantly decreased from 40.4 (6.2-96.2) at admission to 11.35 (3.75-27.65) at discharge (p=0.008). Twenty-four patients were cured, and one patient died. Naso-pharyngeal SARS-CoV-2 clearance time was 19.4±6.9 days; the minimum was seven, and the maximum was 39 days. Conclusion: Cancer patients infected with SARS-CoV-2 during active anticancer treatment can successfully overcome COVID-19 without developing further respiratory or other complications during hospitalization. An increase in lymphocyte and neutrophil counts, with a decrease in CRP, may be markers of a favorable prognosis.

scholarly journals The association of triglyceride levels with the incidence of initial and recurrent acute pancreatitis

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Robert J. Sanchez ◽  
Wenzhen Ge ◽  
Wenhui Wei ◽  
Manish P. Ponda ◽  
Robert S. Rosenson
Keyword(s):  
Acute Pancreatitis ◽  
Medical Records ◽  
Adult Population ◽  
Baseline Period ◽  
Prior History ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Recurrent Acute Pancreatitis ◽  
History Of ◽  
Nationally Representative

Abstract Background This retrospective cohort study assessed the annualized incidence rate (IR) of acute pancreatitis (AP) in a nationally representative US adult population, as well as the variation in the risk of AP events across strata of triglyceride (TG) levels. Methods Data were obtained from IQVIA’s US Ambulatory Electronic Medical Records (EMR) database linked with its LRxDx Open Claims database. Inclusion criteria included ≥1 serum TG value during the overlapping study period of the EMR and claims databases, ≥1 claim in the 12-month baseline period, and ≥ 1 claim in the 12 months post index. All TG measurements were assigned to the highest category reached: < 2.26, ≥2.26 to ≤5.65, > 5.65 to ≤9.94, > 9.94, and > 11.29 mmol/L (< 200, ≥200 to ≤500, > 500 to ≤880, > 880, and > 1000 mg/dL, respectively). The outcome of interest was AP, defined as a hospitalization event with AP as the principal diagnosis. Results In total, 7,119,195 patients met the inclusion/exclusion criteria, of whom 4158 (0.058%) had ≥1 AP events in the prior 12 months. Most patients (83%) had TGs < 2.26 mmol/L (< 200 mg/dL), while < 1% had TGs > 9.94 mmol/L (> 880 mg/dL). Overall, the IR of AP was low (0.08%; 95% confidence internal [CI], 0.08–0.08%), but increased with increasing TGs (0.08% in TGs < 2.26 mmol/L [< 200 mg/dL] to 1.21% in TGs > 11.29 mmol/L [> 1000 mg/dL]). In patients with a prior history of AP, the IR of AP increased dramatically; patients with ≥2 AP events at baseline had an IR of 29.98% (95% CI, 25.1–34.9%). Conclusion The risk of AP increases with increasing TG strata; however, the risk increases dramatically among patients with a recent history of AP.

scholarly journals Clinical characteristics of inpatients with coronavirus disease 2019 (COVID-19) in Sichuan province

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen Wang ◽  
Lei Chen ◽  
Qiao He ◽  
Mingqi Wang ◽  
Mei Liu ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Clinical Features ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Sichuan Province ◽  
Chest Ct ◽  
Shortness Of Breath ◽  
Course Of Disease ◽  
West China ◽  
Radiologic Abnormality

Abstract Background The outbreak of COVID-19 has resulted in serious concerns in China and abroad. To investigate clinical features of confirmed and suspected patients with COVID-19 in west China, and to examine differences between severe versus non-severe patients. Methods Patients admitted for COVID-19 between January 21 and February 11 from fifteen hospitals in Sichuan Province, China were included. Experienced clinicians trained with methods abstracted data from medical records using pre-defined, pilot-tested forms. Clinical characteristics between severe and non-severe patients were compared. Results Of the 169 patients included, 147 were laboratory-confirmed, 22 were suspected. For confirmed cases, the most common symptoms from onset to admission were cough (70·7%), fever (70·5%) and sputum (33·3%), and the most common chest CT patterns were patchy or stripes shadowing (78·0%); throughout the course of disease, 19·0% had no fever, and 12·4% had no radiologic abnormality; twelve (8·2%) received mechanical ventilation, four (2·7%) were transferred to ICU, and no death occurred. Compared to non-severe cases, severe ones were more likely to have underlying comorbidities (62·5% vs 26·2%, P = 0·001), to present with cough (92·0% vs 66·4%, P = 0·02), sputum (60·0% vs 27·9%, P = 0·004) and shortness of breath (40·0% vs 8·2%, P <  0·0001), and to have more frequent lymphopenia (79·2% vs 43·7%, P = 0·003) and eosinopenia (84·2% vs 57·0%, P = 0·046). Conclusions The symptoms of patients in west China were relatively mild, and an appreciable proportion of infected cases had no fever, warranting special attention.

Clinical features of pharyngeal cancer: a retrospective study of 258 consecutive patients

2001 ◽  
Vol 115 (2) ◽  
pp. 112-118 ◽  
Author(s):  
A. Escribano Uzcudun ◽  
P. Bravo Fernández ◽  
J. J. Sánchez ◽  
A. García Grande ◽  
I. Rabanal Retolaza ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Head And Neck ◽  
Clinical Features ◽  
Medical Records ◽  
Performance Status ◽  
Nasopharyngeal Cancer ◽  
University Hospital ◽  
Premalignant Lesions ◽  
Pharyngeal Cancer ◽  
Presenting Symptoms

Pharyngeal cancer still presents an unsatisfactory mortality (30-40 per cent in most series, with a slightly better prognosis for nasopharyngeal cancer relative to both oropharyngeal and hypophyarngeal cancers) despite advances in treatment. Therefore, it is critical to know the clinical features of pharyngeal cancer. The purpose of this study was to investigate the most relevant clinical features of pharyngeal cancer (oropharyngeal, hypopharyngeal, and nasopharyngeal) in order to improve knowledge of this malignancy with the aim of ameliorating diagnosis and treatment.The retrospective study was based on a review of medical records from 258 consecutive patients with pharyngeal cancer (oropharyngeal, hypopharyngeal and nasopharyngeal) diagnosed at La Paz University Hospital, Madrid, Spain, between January 1 1991 and and December 31 1995. Medical records were provided by the Departments of Otorhinolaryngology, Head and Neck Surgery, Radiation Oncology, and Medical Oncology.All medical records were analysed for the following clinical variables: 1) incidence, 2) sociodemographics, 3) sites (oropharynx, hypopharynx, nasopharynx) and subsites, 4) clinical and histological staging, 5) pathlogy, 6) presenting symptoms, 7) time to diagnosis, 8) patients’ general performance status at diagnosis, 9) personal cancer history and synchronous head and neck tumours, 10) premalignant lesions, and 11) paediatric cases.Our most outstanding finding was the excessively long time that elapsed between first clinical manifestation appearance and conclusive diagnosis of pharyngeal cancer (4.7 months for pharynx, 4.5 for oropharynx, 4.4 for hypopharynx and 6.5 for nasopharynx cancers). It was found that nasopharyngeal cancer was quite different from both oropharyngeal and hypopharyngeal cancers with respect to its potential aetiology, risk factors and clinical presentation. In addition it has a better prognosis.

scholarly journals Profil pasien preeklamsia berat dan eklamsia di ICU dan HCU RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Vania Nita Patty ◽  
Diana Ch. Lalenoh ◽  
Debby D. Wuisan
Keyword(s):  
Medical Records ◽  
Hellp Syndrome ◽  
Seizure Activity ◽  
Study Data ◽  
Severe Preeclampsia ◽  
Inclusion Criteria ◽  
Median Length ◽  
Hypertension In Pregnancy ◽  
Grand Mal ◽  
New Onset

Abstract: Preeclampsia was defined as hypertension in pregnancy that occurs after 20th weeks of pregnancy meanwhile eclampsia is the new onset of a grand mal seizure activity and is one of the complications of preeclampsia. Preeclampsia and eclampsia are still the major causes of high maternal and infant mortality in Indonesia (1.5% -25%). Severe preeclampsia becomes an indication of obstetric patients to be admitted to ICU. This study was aimed to obtain the profile of patients with severe preeclampsia and eclampsia admitted to the ICU and HCU Prof. Dr. R.D. Kandou Hospital. This was a descriptive retrospective study. Data were obtained from the medical records of patients admitted to the ICU and HCU from September 2014 to August 2016. There were 33 patients that met the inclusion criteria consisted of 11 patients (33%) with severe preeclampsia and 22 patients (67%) with eclampsia. Most patients were aged ≤ 25 years and the median length of stay in this study was 2 days. HELLP syndrome was found in 9 patients (27.3%) and DIC in 1 (3%) patient. There were five patients with ventilator and three patients died due to eclampsia. Conclusion: Most patients in this study were patients with eclampsia and the mortality rate was 9.1%.Keywords: severe preeclampsia, eclampsia, ICU, HCU Abstrak: Preeklamsia didefinisikan sebagai hipertensi dalam kehamilan yang terjadi setelah minggu ke- 20 kehamilan, sedangkan eklamsia adalah onset baru aktifitas kejang grand mal dan merupakan salah satu komplikasi dari preeklamsia. Preeklamsia dan eklamsia masih menjadi penyebab utama tingginya angka kematian ibu dan bayi di Indonesia (1,5%-25%). Preeklamsia berat menjadi indikasi pasien obstetri masuk ke ICU. Penelitian ini bertujuan untuk mengetahui gambaran pasien preeklamsia berat dan eklamsia yang dirawat di ICU dan HCU RSUP Prof. Dr. R.D. Kandou. Jenis penelitian ialah deskriptif retrospektif. Data diperoleh melalui data rekam medik pasien yang dirawat di ICU dan HCU periode September 2014 - Agustus 2016 dan didapatkan sebanyak 33 pasien yang memenuhi kriteria inklusi. Total pasien preeklamsia berat ialah 11 orang (33%) dan eklamsia sebanyak 22 orang (67%). Usia ≤25 tahun ialah usia terbanyak dan median lama rawat dalam penelitian ini ialah 2 hari. Kejadian HELLP syndrome pada kasus ini sebanyak 9 orang (27,3%) dan DIC sebanyak 1 orang (3%). Pasien dengan ventilator sebanyak 5 orang dan pasien yang meninggal akibat eklamsia sebanyak 3 orang. Simpulan: Dalam penelitian ini pasien terbanyak ialah pasien eklamsia dengan angka kematian 9,1%. Kata kunci: preeklamsia berat, eklamsia, ICU, HCU

scholarly journals Potential Incompatibility Problem of Intravenous Drugs’ Administration among Intensive Care Unit (ICU) Patients at PKU Muhammadiyah Yogyakarta Hospital

2019 ◽  
Vol 9 (4) ◽  
pp. 238
Author(s):  
Ardhanarishwari Umi Salamah ◽  
Fita Rahmawati ◽  
Fivy Kurniawati
Keyword(s):  
Medical Records ◽  
Dosage Form ◽  
Electrolyte Solutions ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Icu Patients ◽  
Injectable Drugs ◽  
Intravenous Drugs

Drugs’ administration among hospitalized patients in ICU commonly is given intravenously. Mixing the intravenous drugs may result in incompatibility problem that might affect the drugs’ stability and bioavailability. The aim of the study was to investigate the potential incompatibility problem of  intravenous mixing drugs’ administration among ICU patients at PKU Muhammadiyah Yogyakarta Hospital. This study was a cross-sectional study in which design and data was obtained from ICU patients’ medical record retrospectively with purposive sampling in order to observe the pattern of intravenous drug’s combination. The potential incompatibility problem was analyzed using Handbook on Injectable Drugs. There were 79 out of 119 medical records which fulfilled sample inclusion criteria taken in this study. Parenteral dosage form was commonly used rather than non parenteral (62.06%) among ICUs’ patients. The potential incompatibility pattern consisted of incompatibility of intravenous drugs, electrolyte solutions/parenteral nutritions in mixture form, and the electrolyte solutions/parenteral nutritions, which are administrated simultaneously. Potential incompatibility of intravenous dosage was found in 50 events out of 79 patients (0.63 events per patients), which consisted of 8 events (8.51%) in using of drugs administrated simultaneously, 10 events (19.23%) in using of electrolyte solutions/parenteral nutritions in mixture form, and 32 events (11.72%) in using of electrolyte solutions/parenteral nutritions administrated simultaneously. Common potential incompatibilities types were precipitation of drugs and drug’s adsorption to packaging materials.

scholarly journals GAMBARAN PENGGUNAAN TERAPI GEA (GASTROENTERITIS ) PADA PASIEN ANAK DI RSUD BATARA SIANG PANGKEP SULSEL

2021 ◽  
Vol 3 (3) ◽  
pp. 189-198
Author(s):  
Dwi Fitrah Wahyuni ◽  
Riska Riska
Keyword(s):  
Experimental Study ◽  
Medical Records ◽  
Pediatric Patients ◽  
Diarrheal Disease ◽  
Evaluation Study ◽  
Initial Therapy ◽  
Regional Hospital ◽  
Inclusion Criteria ◽  
South Sulawesi ◽  
Appropriate Therapy

GEA (Gastroenteritis) or diarrhea is a disease caused by digestive tract disorders that are infected by bacteria. Treatment of early diarrhea, especially the choice of initial therapy, greatly affects the success of providing appropriate and appropriate therapy. This study aims to determine the rationality of therapy in pediatric patients at Batara Siang Pangkep Regional Hospital, South Sulawesi City. This study is a non-experimental study with a retrospective descriptive evaluation study using patient medical records. The samples that met the inclusion criteria were 65 patients. Acute diarrhea was mostly found in men as many as 38 patients (58%) while for women as many as 27 patients (42%). Characteristics of age 1-3 years (82%). The result showed that there are 3 therapeutic regimen in pediatric patient namely cotrimoxazole,electrolit, and zinc. So from these data meet the standards of management of diarrheal disease in children.

scholarly journals Acne:Clinico-Epidemiological Study In DermatologyVenereology Outpatient Clinic Of Dr. M. Djamil Hospital Padang During January 2016 – December 2018

2020 ◽  
Vol 13 (4) ◽  
pp. 325-328
Author(s):  
Satya Wydya Yenny
Keyword(s):  
Retrospective Study ◽  
Family History ◽  
Epidemiological Study ◽  
Clinical Features ◽  
Outpatient Clinic ◽  
Medical Records ◽  
Skin Disorder ◽  
Epidemiological Data ◽  
Common Type ◽  
History Of

Although acne is usually recognized as an adolescent skin disorder, the prevalence of adults with acne is increasing. The clinical and epidemiological data of acne were evaluated with a view to establishing possible contributing etiological factors and observing whether clinical features differ from adolescent acne. Division of Dermatology and Venereology Outpatient Clinic Dr. M. Djamil hospital padang during January 2016 until December 2018.Retrospective study performed in Medical Cosmetic Division of Dermatology and Venereology Outpatient Clinic Dr. M. Djamil hospital padang during January 2016 until December 2018. Data was taken from medical records. Out of 224 patients included in the study 54.01% were women and 45.98 % were men. Majority of the patients had comedonal acne (45.53 %), whereas nodulocystic was the least common (13.39%). Most common predominant site of involvement was cheek (44.20 %), followed by chin (25.45 %), and mandibular area (14.58 %). Family history of acne was present in 57.70 %. Scarring was observed in a 39.2 %. Acne is predominant in women, with the most commonly involved of the cheeks, with the most common type was comedones type.

The Rationality of Using Diclofenac in Outpatient Cases of Osteoarthritis of RSUP MH Palembang Period January-March 2018

2021 ◽  
Vol 2 (1) ◽  
pp. 43-50
Author(s):  
Dara Prameswari ◽  
Nita Parisa ◽  
Muhammad Totong Kamaluddin
Keyword(s):  
Side Effects ◽  
Medical Records ◽  
Daily Activity ◽  
Sampling Technique ◽  
Synergistic Interaction ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Correct Dose ◽  
History Of ◽  
Lowback Pain

Rationality of Diclofenac Use in Osteoarthritis Outpatient Case at RSUP MHPalembang in January-March 2018. Osteoarthritis (OA) is the most common diseasein joints that affects people in their middle until late years. In Indonesia the prevalenceof OA is relatively high and disturbs their daily activity. Diclofenac is one of the drug ofchoice in treating OA. To avoid multiple side effects from Diclofenac use, the usagemust be in accordance to rationality indicators which are correct dose, correctfrequency, and correct length of use. This study is aimed to know the rationality ofDiclofenac use in Osteoarthritis outpatient cases at RSUP Mohammad HoesinPalembang. This study is a descriptive observational with a cross-sectional approachto know the rationality of Diclofenac use in outpatient cases of osteoarthritis at RSUPMohammad Hoesin Palembang. Samples were medical records of OA patients inoutpatient setting from January to March 2018 which fulfilled the inclusion andexclusion criteria. Sampling technique used was total sampling. The amount ofsamples fulfilling the inclusion criteria were 201 patients, with the most were aged 46-65 years (60.2%), female (55.7%), and has a history of comorbidity which includes lowback pain (22.8%). The result of this study shows pattern of Diclofenac use with dosageof 2 x 25mg (73.6%), length of use about <7 days (57.2%). In combination with otherdrugs there were no interaction to be found (84.4%), or synergistic interaction (8.5%)and antagonistic interaction (7.1%). The use of diclofenac in osteoarthritis cases atoutpatient setting in RSUP Dr Mohammad Hoesin Palembang is rational and needs tobe maintained.

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