The association between COMT Val158Met polymorphism and migraine risk: A meta-analysis

Cephalalgia ◽  
2016 ◽  
Vol 37 (6) ◽  
pp. 592-598 ◽  
Author(s):  
Yao-Jun Liao ◽  
Jing-Ru Jiang ◽  
San-Qing Jin
Keyword(s):  
Odds Ratio ◽  
Web Of Science ◽  
Meta Analysis ◽  
Additive Model ◽  
Recessive Model ◽  
Multiplicative Model ◽  
Comt Val158met ◽  
Val158met Polymorphism ◽  
Asian Populations ◽  
The Web

Background The COMT Val158Met polymorphism has long been regarded as a risk factor for migraine. The possible association between COMT Val158Met polymorphism and migraine has been evaluated in several studies, but the results are not consistent. Therefore, we conduct this meta-analysis to address these issues. Methods The WEB OF SCIENCE and EMBASE databases were searched for eligible studies. The odds ratio (OR) with the corresponding 95% confidence interval (CI) was calculated to estimate the strength of the association between COMT Val158Met polymorphism and migraine. Results Five studies with 979 cases and 1870 controls were ultimately included in the present meta-analysis. The overall data showed no significant association between COMT Val158Met polymorphism and migraine in the multiplicative model (OR = 0.97, 95% CI: 0.78–1.21, p = 0.805) and dominant model (OR = 1.05, 95% CI: 0.75–1.48, p = 0.773), neither in the additive model (OR = 0.97, 95% CI: 0.77–1.23, p = 0.817) nor in the recessive model (OR = 0.88, 95% CI: 0.71–1.09, p = 0.246). In subgroup analysis, both for Caucasian and Asian populations, no statistically significant associations were observed in any genetic models. Conclusions Our meta-analysis suggested that the COMT Val158Met polymorphism was not associated with migraine risk.

scholarly journals Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and susceptibility to alcohol dependence

2020 ◽  
Author(s):  
Amrita Chaudhary ◽  
Pradeep Kumar ◽  
Vandana Rai
Keyword(s):  
Risk Factor ◽  
Alcohol Dependence ◽  
Keyword Search ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Contrast Model ◽  
Methyl Transferase ◽  
Comt Val158met ◽  
Val158met Polymorphism

Catechol-O-methyl transferase (COMT) enzyme catalyzes the metabolism of dopamine and other catechols in the brain. Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism as risk factor for alcohol dependence (AD) but the results were inconclusive. The aim of present meta-analysis was to evaluate the association of Val158Met (COMT) polymorphism with AD. Authors performed keyword search of the four electronic databases- Pubmed, Google Scholar, Springer Link and Science Direct databases up to December 31,2019 . Total eighteen studies that investigated the association of Val158Met polymorphism with AD were retrieved. The pooled results from the meta-analysis (2,278 AD cases and 3717 healthy controls) did not show association with AD using all five genetic models (allele contrast model: OR = 1.02, 95% CI= 0.90-1.14, p= 0.03; homozygote model: OR = 1.06, 95% CI= 0.81-1.38, p= 0.69; dominant model: OR = 0.99, 95% CI= 0.85-1.14, p= 0.87; co-dominant model: OR = 0.97, 95% CI= 0.86-1.11, p= 0.71; recessive model: OR = 1.05;95% CI= 0.85-1.29, p=0.61). Results of subgroup analysis showed that Val158Met is not risk for AD in Asian and Caucasian population. In conclusion, COMT Val158Met is not a risk factor for alcohol dependence.

scholarly journals PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199295
Author(s):  
Yijuan Xin ◽  
Liu Yang ◽  
Mingquan Su ◽  
Xiaoli Cheng ◽  
Lin Zhu ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Odds Ratio ◽  
Chinese Population ◽  
Meta Analysis ◽  
Asian Population ◽  
Cancer Type ◽  
East Asians ◽  
Asian Populations ◽  
Increased Risk ◽  
Meta Analyses

Objectives To investigate the association between poly(ADP-ribose) polymerase 1 ( PARP1) rs1136410 Val762Ala and cancer risk in Asian populations, as published findings remain controversial. Methods The PubMed and EMBASE databases were searched, and references of identified studies and reviews were screened, to find relevant studies. Meta-analyses were performed to evaluate the association between PARP1 rs1136410 Val762Ala and cancer risk, reported as odds ratio (OR) and 95% confidence interval (CI). Results A total of 24 studies with 8 926 cases and 15 295 controls were included. Overall, a significant association was found between PARP1 rs1136410 Val762Ala and cancer risk in East Asians (homozygous: OR 1.19, 95% CI 1.06, 1.35; heterozygous: OR 1.10, 95% CI 1.04, 1.17; recessive: OR 1.13, 95% CI 1.02, 1.25; dominant: OR 1.13, 95% CI 1.06, 1.19; and allele comparison: OR 1.09, 95% CI 1.03, 1.15). Stratification analyses by race and cancer type revealed similar results for gastric cancer among the Chinese population. Conclusion The findings suggest that PARP1 rs1136410 Val762Ala may be significantly associated with an increased cancer risk in Asians, particularly the Chinese population.

scholarly journals Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hao Chen ◽  
Hiromi Matsumoto ◽  
Nobuyuki Horita ◽  
Yu Hara ◽  
Nobuaki Kobayashi ◽  
...  
Keyword(s):  
Invasive Pneumococcal Disease ◽  
Odds Ratio ◽  
Pneumococcal Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Mortality Rates ◽  
Solid Organ ◽  
Factors Associated ◽  
System Review ◽  
Overall Mortality

AbstractRisk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5–24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95% CI 2.5–3.68), nursing home (OR 1.62, 95% CI 1.13–2.32), nosocomial infection (OR 2.10, 95% CI 1.52–2.89), septic shock (OR 13.35, 95% CI 4.54–39.31), underlying chronic diseases (OR 2.34, 95% CI 1.78–3.09), solid organ tumor (OR 5.34, 95% CI 2.07–13.74), immunosuppressed status (OR 1.67, 95% CI 1.31–2.14), and alcohol abuse (OR 3.14, 95% CI 2.13–4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.

The relationship between methionine synthase rs1805087 polymorphism and hematological cancers risk

2020 ◽  
Vol 16 (28) ◽  
pp. 2219-2233
Author(s):  
Yanliang Bai ◽  
Emmanuel Kwateng Drokow ◽  
Hafiz Abdul Waqas Ahmed ◽  
Juanjuan Song ◽  
Gloria Selorm Akpabla ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Recessive Model ◽  
Methionine Synthase ◽  
Hematological Cancer ◽  
Methionine Synthase Reductase ◽  
Hematological Cancers ◽  
The Relationship ◽  
Allele Model

Background: The relationship between hematological cancer susceptibility and methionine synthase MTR A2756G (rs1805087) polymorphism is inconclusive based on data from past studies. Hence, this updated meta-analysis was conducted to investigate the relationship between methionine synthase reductase (MTR) rs1805087 polymorphism and hematological cancers. Method: We searched EMBASE, Google Scholar, Ovid and PubMed databases for possible relevant articles up to December 31, 2019. Results: The overall pooled outcome of our analysis showed lack of association between the risk of hematological malignancies and MTR A2756G polymorphism under the allele model (G vs A: odds ratio = 1.001, 95% CI: 0.944–1.061; p = 0.983), recessive model (GG vs GA + AA: odds ratio = 1.050, 95% CI: 0.942–1.170; p = 0.382). Conclusion: The findings in this study demonstrate a lack of relationship between hematological cancers and MTR A2756G.

scholarly journals Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis

2019 ◽  
Vol 20 (1) ◽  
pp. 147032031882392 ◽  
Author(s):  
Nina Liu ◽  
Youmin Wang
Keyword(s):  
Diabetic Nephropathy ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Random Effects Model ◽  
Dominant Model ◽  
Study Results ◽  
Subgroup Analyses ◽  
Agt Gene ◽  
T174m Polymorphism

Objective: Although the angiotensinogen ( AGT) gene T174M polymorphism has been implicated in the pathogenesis of diabetic nephropathy (DN), study results have been inconsistent. The present meta-analysis was conducted to determine the correlation of AGT T174M polymorphism with DN. Methods: We retrospectively extracted relevant studies from Embase as well as PubMed databases. Additionally, a fixed- or random-effects model was employed for calculation of pooled odds ratio (OR) along with 95% confidence interval (CI). Results: In total, we identified six studies (1179 cases and 927 controls) regarding the AGT gene T174M polymorphism. The pooled ORs for the association between the AGT T174M polymorphism and DN risk were not statistically significant under all genetic models (M vs T: OR = 1.22, 95% CI = 0.84–1.75; MM vs TT: OR = 1.94, 95% CI = 0.93–4.04; MT vs TT: OR = 1.11, 95% CI = 0.76–1.63; the dominant model: OR =1.19, 95% CI = 0.80–1.77; the recessive model: OR = 1.94, 95% CI = 0.93–4.03). Subgroup analyses based on the type of race showed the M allele of the AGT T174M polymorphism increased DN risk in Asians, but not in Caucasians. Conclusions: Our study indicated that the T174M polymorphism in the AGT gene was associated with DN in Asians.

scholarly journals The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Liyuan Han ◽  
Lina Zhang ◽  
Wenhua Xing ◽  
Renjie Zhuo ◽  
XiaLu Lin ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Recessive Model ◽  
Cochrane Library ◽  
Published Data ◽  
Case Control Studies ◽  
Asian Populations ◽  
Effect Model

Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic.Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947), –1154G/A (rs1570360), –460T/C (rs833061), −634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0.Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, andP(z)=0.01) in Asian and overall populations, while a significant association was also found between –460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, andP(z)=0.02).Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility.

scholarly journals Association of NLRP3 rs35829419 and rs10754558 Polymorphisms With Risks of Autoimmune Diseases: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Zubo Wu ◽  
Suyuan Wu ◽  
Tao Liang
Keyword(s):  
Autoimmune Diseases ◽  
Latin American ◽  
Lupus Erythematosus ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Recessive Model ◽  
Disease Type ◽  
Dominant Model ◽  
Asian Populations

The existing knowledge about the association between NLRP3 rs35829419/rs10754558 polymorphisms and susceptibility to autoimmune diseases (AIDs) remains controversial. Herein, a meta-analysis was performed to evaluate such association. We searched databases for relevant studies published in English up to February 2021. Stata14 was used to assess the odds ratio (OR). As for NLRP3 rs35829419, no significant association to overall AIDs was found in three genetic models [A vs. C: OR (95%CI) = 0.89 (0.69–1.14); AC vs. CC: 1.00 (0.77–1.30); AA/AC vs. CC: 0.93 (0.71–1.20)]. However, subgroup analysis by disease type showed that NLRP3 rs35829419 A allele may have a significant protective effect on rheumatoid arthritis (RA) susceptibility [A vs. C: 0.74 (0.57–0.96)]. NLRP3 rs10754558 polymorphism contributes to significantly reduce the risk of AIDs in the allelic model [G vs. C: 0.78 (0.71–0.87)], homozygote co-dominant model [GG vs. CC: 0.63 (0.51–0.77)], heterozygote co-dominant model [GC vs. CC: 0.78 (0.66–0.91)], dominant model [GG/GC vs. CC: 0.73 (0.63–0.84)], and recessive model [GG vs. GC/CC: 0.73 (0.62–0.88)]. In the subgroup analysis by ethnicity, association was observed between the NLRP3 rs10754558 G allele and AIDs in Latin Americans, but not in European, Arabian, or Asian populations. Stratification by disease type showed a significant association of the NLRP3 rs10754558 G allele with type 1 diabetes (T1D), RA, and systemic lupus erythematosus (SLE), but not with celiac disease (CD), multiple sclerosis (MS), or myasthenia gravis (MG). This meta-analysis suggests that the NLRP3 rs10754558, but not rs35829419, polymorphism is associated with susceptibility to AIDs, especially in Latin American individuals.

scholarly journals Prevalence of Invasive Streptococcus pneumoniae Infections among Iranian Children: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Arshid Yousefi Avarvand ◽  
Mehrdad Halaji ◽  
Donya Zare ◽  
Meysam Hasannejad-Bibalan ◽  
Hadi Sedigh Ebrahim-Saraie
Keyword(s):  
Systematic Review ◽  
Streptococcus Pneumoniae ◽  
Web Of Science ◽  
Data Extraction ◽  
Meta Analysis ◽  
Single Center ◽  
Inclusion Criteria ◽  
Pooled Prevalence ◽  
Iranian Children ◽  
The Web

Background: Streptococcus pneumoniae is an important pathogen of children, mostly in developing countries. We aimed to investigate the prevalence of invasive S. pneumoniae among Iranian children using a systematic review and meta-analysis. Methods: A systematic search was carried out to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, and Google Scholar electronic databases from January of 2010 to December of 2017. Then, seven publications that met our inclusion criteria were selected for data extraction and analysis. Results: Totally, one study was multicenter, and six were single-center based studies. Meanwhile, all of the included studied performed among hospitalized patients. Seven studies reported the prevalence of invasive S. pneumoniae isolated from children, of these the pooled prevalence of S. pneumoniae was 2.5% (95% CI: 0.7%-9.1%). Conclusion: The overall prevalence of invasive S. pneumoniae infections among Iranian children is low (2.5%). However, further clinical studies are required to elucidate the burden of infections among Iranian children, especially in eastern regions.

scholarly journals Association between miR-499 rs3746444 polymorphism and ischemic stroke : A systematic review and meta-analysis

2019 ◽  
Author(s):  
Xiang Hong Liu ◽  
Mei Ling Liu ◽  
Rong Lin ◽  
Yaping Xing ◽  
Tingli Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sensitivity Analysis ◽  
Ischemic Stroke ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Statistical Association ◽  
Large Heterogeneity ◽  
Allelic Model

Abstract Background: To explore the generic association between miR-499 rs3746444 polymorphism and ischemic stroke (IS). Methods: We performed a systematic review and meta-analysis, odds ratio (OR) and 95% confidence intervals (CIs) were used to estimate the association quantitively. Results: A total of 6 studies (involving 2569 IS cases and 2645 controls) were included. miR-499 (rs3746444) polymorphism showed a statistically significant association with IS risk in the allelic model (G allele vs A allele), the dominant model (GG+AG vs AA), the recessive model (GG vs AG+AA) and the homozygote model (GG vs AA). ORs of the above 4 models were 1.20 (95%CI: 1.02, 1.40), 1.21 (95%CI: 1.01, 1.46), 1.40 (95%CI: 1.04, 1.88), 1.48 (95%CI: 1.10, 2.00) respectively. The I square of the allelic model and the dominant model was 58% and 59%, indicating large heterogeneity among included studies. By sensitivity analysis, I square of the two models dropped to 34.5% and 38.4%, the ORs were 1.26 (95%CI: 1.13, 1.42) and 1.28 (95%CI: 1.12, 1.46), there was still a statistical association between miR-499 (rs3746444) polymorphism and IS. The heterozygote model (AG vs AA) was not statistically significant, the OR was 1.18 (95%CI: 0.99, 1.42), the I square was 54%. Notably, by sensitivity analysis, I square of the heterozygote model dropped to 34.6%, the OR was 1.25 (95%CI: 1.08, 1.43), indicating a statistically significant association between miR-499 (rs3746444) polymorphism and IS. There was no publication bias for all the models by Egger's test. Conclusion: miR-499 (rs3746444) polymorphisms is associated with the increase of IS risk.

scholarly journals Association between the polymorphism of MMP-1 gene with knee osteoarthritis risk: a meta-analysis

2019 ◽  
Author(s):  
Feifan Lu ◽  
Pei Liu ◽  
Weiguo Wang ◽  
Qidong Zhang ◽  
Wanshou Guo
Keyword(s):  
Knee Osteoarthritis ◽  
Web Of Science ◽  
Meta Analysis ◽  
Recessive Model ◽  
Cochrane Library ◽  
Knee Oa ◽  
Matrix Metalloproteinase 1 ◽  
Statistical Heterogeneity ◽  
Different Populations ◽  
Allele Model

Abstract Background: The existing studies on the association between polymorphisms of Matrix metalloproteinase-1 (MMP-1) (-1607 1G/2G) (rs1799750) polymorphism and the risk of knee osteoarthritis (OA, a complex multifactorial disease and a major degenerative form of arthritis) in different populations have yielded conflicting findings. Method: Literature search was performed in PubMed, Cochrane Library, Web of science, Google Scholar (From January 1990 to June 2019), and assessing this association by calculating odds ratios with 95% confidence intervals. Subgroup analyses stratified by ethnicity were also conducted. Statistical heterogeneity was quantitatively evaluated by X 2 test with the significance set P<0.10 or I 2 >50%. Result: Five case-control based studies (924 cases and 928 controls) were included. The results suggested that the MMP-1 (-1607 1G/2G) (rs1799750) gene polymorphisms were not associated with knee OA risk in all genetic models (Allele model OR =1.22, 95% CI: 0.72-1.76, p=0.615, Recessive model OR = 1.12, 95% CI: 0.70-2.15, p=0.486, and Dominant model OR = 1.14, 95%CI: 0.64-2.04, p=0.659, Figure 3-5) Conclusions: There is no association between the polymorphism of MMP-1 (-1607 1G/2G) (rs1799750) polymorphism with the risk of knee osteoarthritis, a large number of studies may be necessary to verify this association in different populations and environmental factors.

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