The effect of strontium-loaded rough titanium surface on early osseointegration

2017 ◽  
Vol 32 (5) ◽  
pp. 561-569 ◽  
Author(s):  
Jiang Huanhuan ◽  
Hao Pengjie ◽  
Xu Sheng ◽  
Wang Binchen ◽  
Shu Li
Keyword(s):  
Magnetron Sputtering ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Atomic Ratio ◽  
Area Ratio ◽  
Titanium Implants ◽  
Bone Area ◽  
Bone Apposition ◽  
Removal Torque ◽  
Torque Values

It is not clear whether surface bioactive chemistry plays an important role in the early osseointegration of micro-structured titanium implants that have the same surface topography at the micrometer and submicrometer scales. In this study, magnetron sputtering methodology was employed for the preparation of Sr coating on sandblasted and acid-etched (SLA) titanium implant without changing the surface characteristics. The study of the surface morphology of the coating was carried out with the use of scanning electron microscopy, and the chemical composition of the surface was examined by X-ray energy-dispersive spectrometry. Twenty SLA implants together with 20 Sr-SLA implants were randomly inserted into the proximal tibia of 20 rats. The early osseointegration of the Sr-SLA implant was compared with SLA implant by removal torque test and histological analysis following two and eight weeks of implantation, correspondingly. As revealed by the surface characteristics, both Sr-SLA and SLA surfaces exhibited similar typical isotropic irregular indentations. The strontium ions were effectively incorporated into the SLA surface (the atomic ratio is 2%). Following two and eight weeks of healing, significant increases in removal torque values ( p < 0.05) were taken into observation in respect of Sr-SLA implant. Histologically, the Sr-SLA implants displayed significantly higher bone-to-implant contact percentages and bone area ratio in comparison with the SLA implant at eight weeks ( p < 0.05). At two weeks, the bone-implant contact percentages, together with bone area ratio of Sr-SLA surface appeared to be a little bit slightly greater than that of SLA surface. But the statistical difference was not significant. These results indicated that the chemical modification with Sr incorporated by magnetron sputtering treatment in moderately rough surfaced implants remarkably increases early bone apposition.

scholarly journals Effect of Cyclic Precalcification of Nanotubular TiO2Layer on the Bioactivity of Titanium Implant

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Il Song Park ◽  
Eun Jin Yang ◽  
Tae Sung Bae
Keyword(s):  
Titanium Implant ◽  
Treatment Method ◽  
Titanium Implants ◽  
Effective Surface ◽  
Removal Torque ◽  
Self Organized ◽  
Bioactive Properties ◽  
Activation Level ◽  
Anodized Titanium ◽  
Torque Values

The objective of this study is to investigate the effect of cyclic precalcification treatment to impart bioactive properties for titanium implants. Before precalcification, the titanium implants were subjected to blasting using hydroxyapatite (HAp), a resorbable blasting medium (RBM treated), and anodized using an electrolyte containing glycerol, H2O, and NH4F. Precalcification treatment was performed by two different methods, namely, continuous immersion treatment (CIT) and alternate immersion treatment (AIT). In CIT, the RBM treated and anodized titanium implants were immersed in 0.05 M NaH2PO4solution at 80°C and saturated Ca(OH)2solution at 100°C for 20 min, whereas during AIT, they were immersed alternatively in both solutions for 1 min for 20 cycles. Anodizing of the titanium implants enables the formation of self-organized TiO2nanotubes. Cyclic precalcification treatment imparts a better bioactive property and enables an increase in activation level of the titanium implants. The removal torque values of the RBM treated, CIT treated, and AIT treated titanium implants are10.8±3.7 Ncm,17.5±3.5 Ncm, and28.1±2.4 Ncm, respectively. The findings of the study indicate the cyclic precalcification in an effective surface treatment method that would help accelerate osseointegration and impart bioactive property of titanium implants.

scholarly journals Torque Analysis of a Triple Acid-Etched Titanium Implant Surface

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Ana Emília Farias Pontes ◽  
Cássio Torres de Toledo ◽  
Valdir Gouveia Garcia ◽  
Fernando Salimon Ribeiro ◽  
Celso Eduardo Sakakura
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Acid Etching ◽  
Subtraction Method ◽  
Implant Surface ◽  
Removal Torque ◽  
Torque Analysis ◽  
Preliminary Study ◽  
Torque Values ◽  
Titanium Implant Surface

The present study aimed to evaluate the removal torque of titanium implants treated with triple acid etching. Twenty-one rats were used in this study. For all animals, the tibia was prepared with a 2 mm drill, and a titanium implant (2 × 4 mm) was inserted after treatment using the subtraction method of triple acid etching. The flaps were sutured. Seven animals were killed 14, 28, and 63 days after implant installation, and the load necessary for removing the implant from the bone was evaluated by using a torque meter. The torque values were as follows: 3.3 ± 1.7 Ncm (14 days), 2.2 ± 1.3 Ncm (28 days), and 6.7 ± 1.4 Ncm (63 days). The torque value at the final healing period (63 days) was statistically significantly different from that at other time points tested (ANOVA,p=0.0002). This preliminary study revealed that treatment with triple acid etching can create a promising and efficient surface for the process of osseointegration.

scholarly journals Ultraviolet A and Ultraviolet C Light-Induced Reduction of Surface Hydrocarbons on Titanium Implants

2019 ◽  
Vol 13 (01) ◽  
pp. 114-118 ◽  
Author(s):  
Zaheer Naauman ◽  
Zainul Ahmad Bin Rajion ◽  
Shahbaz Maliha ◽  
Pauzi Hariy ◽  
Q. Saeed Muhammad ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Titanium Implant ◽  
Treated Group ◽  
Atomic Ratio ◽  
Titanium Implants ◽  
Control Group ◽  
Uva Irradiation ◽  
Peak Intensity ◽  
Ultraviolet C ◽  
Group A

Abstract Objective The carbon, titanium, and oxygen levels on titanium implant surfaces with or without ultraviolet (UV) pretreatment were evaluated at different wavelengths through X-ray photoelectron spectroscopy (XPS). Materials and Methods This interventional experimental study was conducted on nine Dio UFII implants with hybrid sandblasted and acid-etched (SLA) surface treatments, divided equally into three groups. Control group A samples were not given UV irradiation, while groups B and C samples were given UVA (382 nm, 25 mWcm2) and UVC (260 nm, 15 mWcm2) irradiation, respectively. The atomic ratio of carbon, titanium, and oxygen was compared through XPS. Results Mean carbon-to-titanium ratio and C1 peaks considerably increased in Group A compared to those in experimental Groups B and C. The intensity of Ti2p and O1s peaks was more pronounced for group C compared to that for groups A and B. Conclusions Although the decrease in surface hydrocarbons was the same in both UV-treated groups, the peak intensity of oxygen increased in the UVC-treated group. Thus, it can be concluded that compared with UVA irradiation, UVC irradiation has the potential to induce more hydrophilicity on SLA-coated implants.

Removal Torque Analysis of Implants in Rabbit Tibia After Topical Application of Simvastatin Gel

2014 ◽  
Vol 40 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Fatima Neves Faraco-Schwed ◽  
Luiz Macedo Mangueira ◽  
Joao Vitor Albuquerque Ribeiro ◽  
Alexsandro Da Silva Antao ◽  
Jamil Awad Shibli
Keyword(s):  
Topical Application ◽  
Topical Administration ◽  
Titanium Implants ◽  
Removal Torque ◽  
Implant Placement ◽  
Group I ◽  
Torque Wrench ◽  
Rabbit Tibia ◽  
Torque Analysis ◽  
Torque Values

The aim of this study was to evaluate the effects of topical application of simvastatin gel (7.5 mg) on the removal torque of titanium implants in the rabbit tibia. A total of 32 surgeries were performed on 16 New Zealand rabbits for the placement of 2 implants in 1 tibia of each rabbit. Only 1 of the surgical defects was injected with 30 mg/mL of simvastatin gel before implant placement. The initial torque was set at 20 N.cm, and removal torque testing was performed 28 and 56 days postoperatively with a Tonishi torque wrench. Surgical defects were divided into 4 groups: group IG-28 (test, 28 days), group IG-56 (test, 56 days), group I-28 (control, 28 days), and group I-56 (control, 56 days). Removal torque values were higher in group IG-56 than in groups IG-28, I-28, and I-56 (P &lt; .05). Groups IG-28, I-28, and I-56 showed similar values (P &gt; .05). Removal torque force increased under the influence of simvastatin, indicating that topical administration of a 7.5-mg dose of simvastatin gel is effective in improving the torque force required to remove implants inserted in the rabbit tibia.

scholarly journals Cellular Responses Evoked by Different Surface Characteristics of Intraosseous Titanium Implants

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Liviu Feller ◽  
Yusuf Jadwat ◽  
Razia A. G. Khammissa ◽  
Robin Meyerov ◽  
Israel Schechter ◽  
...  
Keyword(s):  
Surface Energy ◽  
Surface Chemistry ◽  
High Surface ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Cellular Responses ◽  
Titanium Implants ◽  
Implant Surface ◽  
Bone To Implant Contact ◽  
And Migration

The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.

scholarly journals The Affinity of Human Fetal Osteoblast to Laser-Modified Titanium Implant Fixtures

2020 ◽  
Vol 14 (1) ◽  
pp. 52-58 ◽  
Author(s):  
Lee Kian Khoo ◽  
Sirichai Kiattavorncharoen ◽  
Verasak Pairuchvej ◽  
Nisanat Lakkhanachatpan ◽  
Natthamet Wongsirichat ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Adhesion ◽  
Surface Chemistry ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Titanium Implants ◽  
Cell Maturation ◽  
Implant Surface ◽  
Pure Grade

Introduction: Implant surface modification methods have recently involved laser treatment to achieve the desired implant surface characteristics. Meanwhile, surface modification could potentially introduce foreign elements to the implant surface during the manufacturing process. Objectives: The study aimed to investigate the surface chemistry and topography of commercially available laser-modified titanium implants, together with evaluating the cell morphology and cell adhesion of human fetal osteoblast (hFOB) seeded onto the same implants. Method: Six (6) samples of commercially available laser-modified titanium implants were investigated. These implants were manufactured by two different companies. Three (3) implants were made from commercially pure grade 4 Titanium (Brand X); and three were made from grade 5 Ti6Al4V (Brand Y). The surface topography of these implants was analyzed by scanning electron microscope (SEM) and the surface chemistry was evaluated with electron dispersive x-ray spectroscopy(EDS). Human fetal osteoblasts were seeded onto the implant fixtures to investigate the biocompatibility and adhesion. Results & Discussion: Brand X displayed dark areas under SEM while it was rarely found on brand Y. These dark areas were consistent with their organic matter. The hFOB cell experiments revealed cell adhesion with filopodia on Brand X samples which is consistent with cell maturation. The cells on Brand Y were morphologically round and lacked projections, one sample was devoid of any noticeable cells under SEM. Cell adhesion was observed early at 48 hrs in laser-irradiated titanium fixtures from both the brands. Conclusion: The presence of organic impurities in Brand X should not be overlooked because disruption of the osseointegration process may occur due to the rejection of the biomaterial in an in-vivo model. Nevertheless, there was insufficient evidence to link implant failure directly with carbon contaminated implant surfaces. Further studies to determine the toxicity of Vanadium from Ti6Al4V in an in-vivo environment should indicate the reason for different cell maturation.

The Influence of Low-Level Laser on Osseointegration Around Machined and Sandblasted Acid-Etched Implants: A Removal Torque and Histomorphometric Analyses

2015 ◽  
Vol 41 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Eduardo Rolim Teixeira ◽  
Marco Antônio Rambo Osório Torres ◽  
Kleber Ricardo Monteiro Meyer ◽  
Sabrina Rebollo Zani ◽  
Rosemary Sadami Arai Shinkai ◽  
...  
Keyword(s):  
Surface Characteristics ◽  
Control Group ◽  
Implant Surface ◽  
Removal Torque ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser ◽  
Bone To Implant Contact ◽  
Torque Values ◽  
And Control

Evaluation of the influence of laser application on osseointegration around implants with different surface characteristics is limited. This study aims to evaluate the influence of low-level lasers on the early stages of osseointegration. Ninety-six external hex implants (3.75 mm × 5.0 mm) were placed in 24 rabbits—one machined and one sandblasted acid-etched per tibia. The rabbits were later divided into the laser group, which received a total dose of 24 J/cm2 of gallium-aluminum-arsenide laser over 15 days, and a control group. At 16 and 30 days after surgery, removal torque and histomorphometric analyses were performed. No statistical differences in removal torque or histomorphometric analyses were verified between laser and control groups regardless of implant surface (P &gt; .05). Time was the only variable presenting significant differences between measurements (P &lt; .05). Low-level laser had no significant short-term effect on bone-to-implant contact and removal torque values regardless of implant surface characteristics.

Effect of Surface Nanotopography on Bone Response to Titanium Implant

2016 ◽  
Vol 42 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Gileade P. Freitas ◽  
Helena B. Lopes ◽  
Evandro C. Martins-Neto ◽  
Paulo T. de Oliveira ◽  
Marcio M. Beloti ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Close Contact ◽  
Clinical Success ◽  
Low Cost ◽  
Titanium Implant ◽  
Bone Surface ◽  
Bone Area ◽  
Trabecular Thickness ◽  
Removal Torque ◽  
Bone Response

Clinical success of implant therapy is directly related to titanium (Ti) surface properties and the quality of bone tissue. The treatment of Ti implants with H2SO4/H2O2 is a feasible, reproducible, and low-cost technique to create surface nanotopography (Ti-Nano). As this nanotopography induces osteoblast differentiation, we hypothesized that it may affect bone response to Ti. Thus, this study was designed to evaluate the bone response to a machined Ti implant treated with H2SO4/H2O2 to generate Ti-Nano and to compare it with a commercially available microtopographic Ti implant (Ti-Porous). Implants were placed in rabbit tibias and evaluated after 2 and 6 weeks, and the bone tissue formed around them was assessed by microtomography to record bone volume, bone surface, specific bone surface, trabecular number, trabecular thickness, and trabecular separation. Undecalcified histological sections were used to determine the percentages of bone-to-implant contact, bone area formed between threads, and bone area formed in the mirror area. At the end of 6 weeks, the removal torque was evaluated using a digital torque gauge. The results showed bone formation in close contact with both Ti-Nano and Ti-Porous implants without relevant morphological and morphometric differences, in addition to a similar removal torque irrespective of surface topography. In conclusion, our results have shown that a simple and low-cost method using H2SO4/H2O2 is highly efficient for creating nanotopography on Ti surfaces, which elicits a similar bone response compared with microtopography presented in a commercially available Ti implant.

scholarly journals Evaluation of Bone Healing on Sandblasted and Acid Etched Implants Coated with Nanocrystalline Hydroxyapatite: AnIn VivoStudy in Rabbit Femur

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lory Melin Svanborg ◽  
Luiz Meirelles ◽  
Victoria Franke Stenport ◽  
Per Kjellin ◽  
Fredrik Currie ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Bone Healing ◽  
Healing Time ◽  
Titanium Implants ◽  
Bone Area ◽  
Removal Torque ◽  
Nanocrystalline Hydroxyapatite ◽  
Torque Analysis ◽  
Hydroxyapatite Nanocrystals ◽  
Rabbit Femur

This study aimed at investigating if a coating of hydroxyapatite nanocrystals would enhance bone healing over time in trabecular bone. Sandblasted and acid etched titanium implants with and without a submicron thick coat of hydroxyapatite nanocrystals (nano-HA) were implanted in rabbit femur with healing times of 2, 4, and 9 weeks. Removal torque analyses and histological evaluations were performed. The torque analysis did not show any significant differences between the implants at any healing time. The control implant showed a tendency of more newly formed bone after 4 weeks of healing and significantly higher bone area values after 9 weeks of healing. According to the results from this present study, both control and nano-HA surfaces were biocompatible and osteoconductive. A submicron thick coating of hydroxyapatite nanocrystals deposited onto blasted and acid etched screw shaped titanium implants did not enhance bone healing, as compared to blasted and etched control implants when placed in trabecular bone.

Sign in / Sign up

Export Citation Format

Share Document