Dry needling for scar treatment

2020 ◽  
Vol 38 (6) ◽  
pp. 435-439
Author(s):  
Evgeni Rozenfeld ◽  
Eleanora Sapoznikov Sebakhutu ◽  
Yuval Krieger ◽  
Leonid Kalichman
Keyword(s):  
Wound Healing ◽  
Case Reports ◽  
Healing Process ◽  
Preliminary Evidence ◽  
Mechanisms Of Action ◽  
Wound Healing Process ◽  
Dry Needling ◽  
Physiological Mechanisms ◽  
Positive Effects ◽  
Intervention Protocol

Objective: To review current scientific knowledge as to the efficacy of dry needling of scars on pain and other related symptoms and explore the possible physiological mechanisms of action. Methods: A narrative review of scientific literature published in English. Results: Two randomized controlled trials found that dry needling of scars (using the classic “surrounding the dragon” technique in one study and intradermal needling in a second study) was more effective than sham or control interventions with respect to scar appearance and pain. Two case reports have suggested that scar needling generates a rapid decrease in pain and improvement of mobility in scarred tissues. Another two case reports have reported positive effects of scar needling on the wound healing process. These findings are supported by an animal study examining the effect of needling on the wound healing process and the physiological mechanisms of action underlying the technique. Conclusion: There is preliminary evidence that the “surrounding the dragon” needling technique is a beneficial treatment for patients suffering from scar pain and other scar-related symptoms and can facilitate wound healing and make this process less painful. Further high-quality studies should be conducted to verify/quantify the efficacy of this method, to better understand the underlying mechanisms of action underlying the effects of scar needling and to establish an effective intervention protocol.

Collagen membranes for skin wound repair: A systematic review

2020 ◽  
pp. 088532822098027
Author(s):  
Tiago Akira Tashiro Araujo ◽  
Matheus Cruz Almeida ◽  
Ingrid Avanzi ◽  
Julia Parisi ◽  
Abdias Fernando Simon Sales ◽  
...  
Keyword(s):  
Systematic Review ◽  
Wound Healing ◽  
Healing Process ◽  
Biological Tissues ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Wound Healing ◽  
Efficient Treatment ◽  
Positive Effects ◽  
Collagen Membranes

Membranes or skin dressing are common treatments for skin wound injuries, collagen being one the most effective materials for their manufacturing. Many different sources of collagen with diverse methods of extraction and processing have been used, with evidence of positive effects on the stimulation of skin wound healing. In spite of these factors, there is still limited understanding of the interaction between collagen membranes and biological tissues, especially due to the series of different types of collagen origin. In this context, this study aimed to conduct a systematic review of the available literature examining the effect of various collagen membranes for accelerating skin wound healing in experimental animal models and clinical trials. The present review was performed from March to May of 2020 searching in two databases (PubMed and Scopus). The following Medical Subject Headings (MeSH) descriptors were used: “collagen”, “dressing”, “membranes”, “skin” and “wound”. After the eligibility assessment, 16 studies were included and analyzed. The studies demonstrated that collagen was obtained predominantly from bovine and porcine sources, by acetic acid and/or enzyme dissolution. Additionally, most of the studies demonstrated that the membranes were processed mainly by freeze-drying or lyophilization methods. All the in vivo and clinical trial studies evidenced positive outcomes in the wound healing process, thus confirming that collagen membranes are one of the most efficient treatment for skin wounds, highlighting the enormous potential of this biomaterial to be used for skin tissue engineering purposes.

scholarly journals Topical application of silver-curcumin on wound healing in rabbits

2016 ◽  
Vol 32 (2) ◽  
pp. 55-64
Author(s):  
R Islam ◽  
UK Rima ◽  
MM Haq ◽  
MM Hossain ◽  
MM Rahman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Connective Tissue ◽  
Topical Application ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Wound Management ◽  
Control Group ◽  
Wound Healing Process ◽  
Fibrous Connective Tissue ◽  
Positive Effects

Curcumin, a natural product obtained from the rhizomes of Curcuma longa, is used traditionally in prevention of wound infection. To determine the effects of silver and curcumin combination on surgical wound healing, a study was conducted in rabbits. A total of 32 surgical wounds were created in 16 rabbits in four groups. Information was recorded from Day 0 to Day 42 postoperatively. Swelling area of wound, elevation of suture line from the skin surface, width of sutured area and contraction length were recorded weekly. Treatment with curcumin, 1% silver sulfadiazine (1% SSD) and a mixture of the two resulted in swelling of 11.4 ± 0.1 mm, 11.1 ± 0.4 mm and 11.0 ± 0.1 mm, respectively. Swelling (12.2 ± 0.3mm) and elevation of sutured line was higher (3.4 ± 0.2 mm) in wounds of control group and lower (2.3 ± 0.1 mm) in wounds treated with a mixture of curcumin and 1% SSD. The scores of wound colonization were lowest (0.8) in 1% SSD group followed by mixture of curcumin and 1% SSD (1.0), curcumin (1.3) and tincture of benzoin (1.6) alone. Histopathologically reactive cells decreased markedly in wounds treated with combination of 1% SSD and curcumin at D3 with increased fibrous connective tissue. However, wounds treated with 1% SSD showed fewer reactive cells than curcumin group. Proliferation of fibrous connective tissue was highest in the silver treated wound, which indicates good wound healing process. Overall, wound healing was improved by the topical application of 1% SSD alone. Curcumin had positive effects on wound healing process but less than 1% SSD. These results indicate that 1% silver sulfadiazine is the best topical therapy for wound management in rabbits.Bangl. vet. 2015. Vol. 32, No. 2, 55-64

scholarly journals CHROMOLAENA ODORATA: AS NATURE’S WOUND HEALER

2019 ◽  
pp. 63-65
Author(s):  
MONMOYURI BHUYAN ◽  
PULAK DEB ◽  
DEBAPROTIM DASGUPTA
Keyword(s):  
Wound Healing ◽  
Traditional Medicine ◽  
Soft Tissues ◽  
Healing Process ◽  
The Body ◽  
World Health ◽  
Wound Healing Process ◽  
Chromolaena Odorata ◽  
Positive Effects ◽  
The World

According to the world health organization, more than 80% of the world’s population relies on traditional medicine for their primary health needs. The use of herbal medicines represents a long history of human interactions with the environment. The study of wound-healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemical are involved in the healing process of the body, including antioxidants and cytokines. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via the various mechanism. Injury to the soft tissues is followed by wound healing, which consists of four stages: hemostasis, inflammation, proliferation and remodeling. Chromolaena odorata is a weed that is traditionally used for the treatment of various ailments in humans and animals. However, it exhibits anti-inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable health care, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future use for the treatment of wounds.

Accelerated wound healing process in rat by probiotic Lactobacillus reuteri derived ointment

2019 ◽  
Vol 30 (3) ◽  
Author(s):  
Zohreh Khodaii ◽  
Saman Afrasiabi ◽  
Seied Ali Hashemi ◽  
Abdolreza Ardeshirylajimi ◽  
Mahboobeh Mehrabani Natanzi
Keyword(s):  
Wound Healing ◽  
Lactobacillus Reuteri ◽  
Histopathological Examination ◽  
Healing Process ◽  
Treated Group ◽  
Probiotic Bacterium ◽  
Control Group ◽  
Wound Healing Process ◽  
Positive Effects ◽  
Antioxidant Agents

Abstract Background Antioxidant agents have positive effects on wound healing process and on the other hand probiotics also have great antioxidation or oxidation-resistance properties. Methods In this study, we investigated the effects of Lactobacillus reuteri derived ointment as a probiotic bacterium on the wound healing process using a full-thickness rat skin model. The wound diameter and contraction percent measurement, histopathological examination, and myeloperoxidase (MPO) enzyme activity evaluation were carried out during the period of study. Results Amount of deposit collagen was significantly increased; epithelization speed and epidermis production were also observed in the ointment-treated group, while the inflammation rate was also significantly lower than the control group. In addition, a significant reduction in the activity of enzyme MPO was also detected in the ointment-treated group. Conclusions According to the results, probiotic ointment effectively accelerates the wound healing process and it can be used as a promising drug for wound dressing application.

Ozonated Oils and Cutaneous Wound Healing

2019 ◽  
Vol 25 (20) ◽  
pp. 2264-2278 ◽  
Author(s):  
Yunsook Lim ◽  
Heaji Lee ◽  
Brittany Woodby ◽  
Giuseppe Valacchi
Keyword(s):  
Wound Healing ◽  
Tissue Repair ◽  
Wound Closure ◽  
State Of The Art ◽  
Healing Process ◽  
Actual State ◽  
Wound Healing Process ◽  
Cutaneous Wounds ◽  
Positive Effects ◽  
Wound Tissue

Wound tissue repair is a complex and dynamic process of restoring cellular structures and tissue layers. Improvement in this process is necessary to effectively treat several pathologies characterized by a chronic delayed wound closure, such as in diabetes, and the investigation of new approaches aimed to ameliorate the wound healing process is under continuous evolution. Recently, the usage of vegetable matrices in the form of ozonated oils has been proposed, and several researchers have shown positive effects on wound healing, due to the bactericidal, antiviral, and antifungal properties of these ozonated oils. <p></p> In the present review, we intend to summarize the actual state of the art of the topical usage of ozonated oil in cutaneous wounds with special emphasis to the importance of the ozonated degree of the oil.

scholarly journals Effects of Biphalin on Corneal Epithelial Wound Healing

Proceedings ◽  
2018 ◽  
Vol 2 (25) ◽  
pp. 1552 ◽  
Author(s):  
Erdost Yıldız ◽  
Özgün Melike Gedar Totuk ◽  
Adriano Mollica ◽  
Kerem Kabadayı ◽  
Afsun Şahin
Keyword(s):  
Wound Healing ◽  
Mtt Assay ◽  
Corneal Epithelium ◽  
Healing Process ◽  
Wound Healing Process ◽  
Corneal Epithelial ◽  
Positive Effects ◽  
Study Results ◽  
Significant Difference ◽  
Epithelial Wound Healing

After physical or surgical damage of corneal epithelium, most of analgesic drugs, like non-selective opioid agonists and non-steroid anti-inflammatory drugs, cannot be used because of their negative effects on wound healing process. Biphalin is selective µ and Δ opioid receptor agonist which has proven analgesic effects on rodents. Our purpose of study is finding effects of biphalin on wound healing of corneal epithelium. We used primary culture of human corneal epithelial cells (HCECs) for examining effects of biphalin on wound healing. Firstly, we measured toxicity of Biphalin in various concentrations with MTT assay and we showed biphalin has no toxic effects on HCECs in lower concentrations than 100 µM in various incubation times. After MTT assay, we administered 1 µM and 10 µM biphalin at in vitro scratch assay of HCECs, biphalin increased wound closure process significantly at 1 µM concentration (p < 0.05). Then we tested effects of biphalin on cell migration and proliferation separately. Bifalin increased migration of HCECs significantly (p < 0.01) at transwell migration assay. But we did not observe any significant difference between groups in Ki67 proliferation assay. In all these experiments, we also used naloxone to inhibiting effects of biphalin. In biphalin plus naloxone groups, effects of biphalin decrease partially. Our study results suggest, biphalin has positive effects on epithelial wound healing via opioid receptors. This effect because of increased migration of HCECs under influence of biphalin. With these findings, we propose biphalin as a new analgesic agent for post-surgical and post-traumatic care of corneal epithelial wounds.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

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