Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates

2000 ◽  
Vol 11 (1) ◽  
pp. 57-91 ◽  
Author(s):  
Barry J. Sessle
Keyword(s):  
Future Research ◽  
Peripheral Sensitization ◽  
Nociceptive Transmission ◽  
Somatosensory Information ◽  
Peripheral Injury ◽  
Strategic Role ◽  
Therapeutic Procedures ◽  
The Face ◽  
Craniofacial Pain ◽  
Organizational Features

This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and output properties and intrinsic characteristics that are commensurate with its strategic role as the major brainstem relay of many types of somatosensory information derived from the face and mouth. The VBSNC plays a crucial role in craniofacial nociceptive transmission, as evidenced by clinical, behavioral, morphological, and electrophysiological data that have been especially derived from studies of the relay of cutaneous nociceptive afferent inputs through the subnucleus caudalis of the VBSNC. The recent literature, however, indicates that some fundamental differences exist in the processing of cutaneous vs. other craniofacial nociceptive inputs to the VBSNC, and that rostral components of the VBSNC may also play important roles in some of these processes. Modulatory mechanisms are also highlighted, including the neuro-chemical substrate by which nociceptive transmission in the VBSNC can be modulated. In addition, the long-term consequences of peripheral injury and inflammation and, in particular, the neuroplastic changes that can be induced in the VBSNC are emphasized in view of the likely role that central sensitization, as well as peripheral sensitization, can play in acute and chronic pain. The recent findings also provide new insights into craniofacial pain behavior and are particularly relevant to many approaches currently in use for the management of pain and to the development of new diagnostic and therapeutic procedures aimed at manipulating peripheral inputs and central processes underlying nociceptive transmission and its control within the VBSNC.

scholarly journals Effects of offloading devices on static and dynamic balance in patients with diabetic peripheral neuropathy: A systematic review

2021 ◽  
Author(s):  
Koen Andre Horstink ◽  
Lucas Henricus Vincentius van der Woude ◽  
Juha Markus Hijmans
Keyword(s):  
Systematic Review ◽  
Peripheral Neuropathy ◽  
Plantar Pressure ◽  
Diabetic Peripheral Neuropathy ◽  
Balance Control ◽  
Dynamic Balance ◽  
Movement Control ◽  
Future Research ◽  
Static Balance ◽  
Somatosensory Information

AbstractPatients with diabetic peripheral neuropathy (DPN) usually have reduced somatosensory information and altered perception in feet and ankles. Somatosensory information acts as feedback for movement control and loss of somatosensation leads to altered plantar pressure patterns during gait and stance. Offloading devices are used to reduce peak plantar pressure and prevent diabetic foot ulcers. However, offloading devices can unfortunately have negative effects on static and dynamic balance. It is important to investigate these unwanted effects, since patient with DPN already are at high risk of falling and offloading devices could potentially increase this risk. The aim of this systematic review is to investigate the effects of plantar offloading devices used for ulcer prevention on their role in static and dynamic balance control in patients with DPN. PubMed and Embase were systematically searched using relevant search terms. After title selection, abstract selection, and full-text selection only five articles could be included for further analysis. Two articles included static balance measurements, two articles included dynamic balance measurements, and one article included both. Results suggested that static balance control is reduced when rocker bottom shoes and different insole configurations are used, however, toe-only rockers showed less evidence for reduced static balance control. There was no evidence for reduced dynamic balance control in combination with offloading devices. However, these results should be interpreted with care, since the number of studies was very small and the quality of the studies was moderate. Future research should evaluate balance in combination with different offloading devices, so that clinicians subscribing them are more aware of their potential unwanted consequences.

In the Face of Critique

2011 ◽  
Vol 34 (2) ◽  
pp. 241-282 ◽  
Author(s):  
Elyse Amend ◽  
David M. Secko
Keyword(s):  
The State ◽  
Future Research ◽  
Jigsaw Puzzle ◽  
Science Journalism ◽  
Data Set ◽  
Literature Searches ◽  
The Face ◽  
Qualitative Knowledge ◽  
Qualitative Literature

The qualitative literature related to health and science journalism often states that little is known about the perspectives of journalists. This is, in part, because of individual studies being like scattered pieces of a jigsaw puzzle. In this article, the authors report the results of a qualitative metasynthesis aimed at reassembling the qualitative literature involving health and science journalists. Comprehensive literature searches gave a data set of 21 studies whose synthesis produced 14 metathemes and four taxonomic groupings. This synthesis is used to show the state of qualitative knowledge and the potential for future research.

scholarly journals Mechanical challenges and cytoskeletal impairments in focal segmental glomerulosclerosis

2018 ◽  
Vol 314 (5) ◽  
pp. F921-F925 ◽  
Author(s):  
Di Feng ◽  
Clark DuMontier ◽  
Martin R. Pollak
Keyword(s):  
Blood Flow ◽  
Focal Segmental Glomerulosclerosis ◽  
Kidney Injury ◽  
Future Research ◽  
Disease States ◽  
Filtration Barrier ◽  
Segmental Glomerulosclerosis ◽  
The Face ◽  
Foot Process ◽  
Future Research Directions

Focal segmental glomerulosclerosis (FSGS) is a histologically defined form of kidney injury typically mediated by podocyte dysfunction. Podocytes rely on their intricate actin-based cytoskeleton to maintain the glomerular filtration barrier in the face of mechanical challenges resulting from pulsatile blood flow and filtration of this blood flow. This review summarizes the mechanical challenges faced by podocytes in the form of stretch and shear stress, both of which may play a role in the progression of podocyte dysfunction and detachment. It also reviews how podocytes respond to these mechanical challenges in dynamic fashion through rearranging their cytoskeleton, triggering various biochemical pathways, and, in some disease states, altering their morphology in the form of foot process effacement. Furthermore, this review highlights the growing body of evidence identifying several mutations of important cytoskeleton proteins as causes of FSGS. Lastly, it synthesizes the above evidence to show that a better understanding of how these mutations leave podocytes vulnerable to the mechanical challenges they face is essential to better understanding the mechanisms by which they lead to disease. The review concludes with future research directions to fill this gap and some novel techniques with which to pursue these directions.

Internal projects as strategic tools: an organisation-level perspective and a research agenda

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Torbjørn Bjorvatn
Keyword(s):  
Project Management ◽  
Theory Development ◽  
Future Research ◽  
Content Type ◽  
Theoretical Contribution ◽  
Research Areas ◽  
Linear Relationships ◽  
Strategic Role ◽  
And Performance

PurposeThe purpose of this conceptual paper is to describe and explain how organisations use internal projects to implement organisation-level strategy objectives.Design/methodology/approachTheory development with an emphasis on explaining key constructs and their mutual relationships. The theoretical contribution is represented in a diagram along with a detailed verbal account.FindingsThe paper develops a dynamic, cross-level framework to illustrate the organisational processes and outcomes that determine project-based strategy implementation within a single organisation. The interplay between the base organisation and the project, and benefits realisation were singled out as key future research areas. The proposed framework engages with central discourses in the fields of project management, strategic management, innovation studies, knowledge management and organisation studies.Research limitations/implicationsOnly the contours of an organisation-level theory of strategically motivated internal projects are outlined. Future research must elaborate on the complexities, the non-linear relationships and the boundary conditions that follow from the proposed framework.Practical implicationsManagers are alerted to the strategic role of internal projects, how these projects help connect strategy and performance and what the accompanying organisational processes and outcomes look like.Originality/valueThe paper constitutes an early conceptual treatment of strategy-driven internal projects as a distinct project category, thus addressing a major knowledge gap in project studies. Organisational project-management theory is extended with suggestions for future research.

Facework on Social Media in China

2021 ◽  
Author(s):  
Xiaoli Tian ◽  
Qian Li
Keyword(s):  
Social Media ◽  
Social Interactions ◽  
Future Research ◽  
Sociological Research ◽  
Interpersonal Interactions ◽  
The World ◽  
Online Spaces ◽  
The Face ◽  
Different Parts

With more social interactions shifting to online venues, the different attributes of major social media sites in China influence how interpersonal interactions are carried out. Despite the lack of physical co-presence online, face culture is extended to online spaces. On social media, Chinese users tend to protect their own face, give face to others, and avoid discrediting the face of others, especially when their online and offline networks overlap. This chapter also discusses the different methods used to study facework online and offline and how facework is studied in different parts of the world. It concludes with a brief discussion of how sociological research has contributed to the study of social media in China and directions for future research.

Cross-cultural testing of face threats to predict apology and thanks intentions

2017 ◽  
Vol 45 (10) ◽  
pp. 1643-1654
Author(s):  
Hye Eun Lee ◽  
Hyunjin Park
Keyword(s):  
Future Research ◽  
North Americans ◽  
Face Threats ◽  
The Face ◽  
Future Research Directions ◽  
Face Threat ◽  
Korean College Students ◽  
Favor Asking ◽  
Negative Face

We examined whether Koreans intended to make an apology and North Americans intended to express thanks in a message asking for a favor. Because one reason for apologizing or thanking is to lessen the face threat occurred by favor asking, four face threats were empirically measured to predict participants' intentions. Participants were 104 North American and 90 Korean college students who took the role of an email sender making a favor request and selected from options for apologizing or thanking the receiver to lessen the four types of face threat. Results showed that North Americans intended to express thanks, and both North Americans and Koreans intended to make an apology when asking a favor; further, for Koreans, a speaker's positive face threat triggered intention to make an apology and, for North Americans, a receiver's negative face threat triggered an intention to express thanks. Implications and future research directions are discussed.

scholarly journals Alexithymia slows performance but preserves spontaneous semantic decoding of negative expressions in the emostroop task

2013 ◽  
Vol 6 ◽  
pp. 56-67 ◽  
Author(s):  
Courtney K. Hsing ◽  
Alicia J. HofelichMohr ◽  
R. Brent Stansfield ◽  
Stephanie D. Preston
Keyword(s):  
Emotion Processing ◽  
Facial Emotion ◽  
Future Research ◽  
Verbal Iq ◽  
The Face ◽  
Presentation Time ◽  
Early Processing ◽  
Iq Scores ◽  
Personality Construct

Alexithymia is a multifaceted personality construct related to deficits in the recognition and verbalization of emotions. It is uncertain what causes alexithymia or which stage of emotion processing is first affected. The current study was designed to determine if trait alexithymia was associated with impaired early semantic decoding of facial emotion. Participants performed the Emostroop task, which varied the presentation time of faces depicting neutral, angry, or sad expressions before the classification of angry or sad adjectives. The Emostroop effect was replicated, represented by slowed responses when the classified word was incongruent with the background facial emotion. Individuals with high alexithymia were slower overall across all trials, particularly when classifying sad adjectives; however, they did not differ on the basic Emostroop effect. Our results suggest that alexithymia does not stem from lower-level problems detecting and categorizing others’ facial emotions. Moreover, their impairment does not appear to extend uniformly across negative emotions and is not specific to angry or threatening stimuli as previously reported, at least during early processing. Almost in contrast to the expected impairment, individuals with high alexithymia and lower verbal IQ scores had even more pronounced Emostroop effects, especially when the face was displayed longer.To better understand the nature of alexithymia, future research needs to further disentangle the precise phase of emotion processing and forms of affect most affected in this relatively common condition

scholarly journals Methods Used to Evaluate mHealth Applications for Cardiovascular Disease: A Quasi-Systematic Scoping Review

2021 ◽  
Vol 18 (23) ◽  
pp. 12315
Author(s):  
Felix Holl ◽  
Jennifer Kircher ◽  
Walter J. Swoboda ◽  
Johannes Schobel
Keyword(s):  
Cardiovascular Disease ◽  
Health Care ◽  
Scoping Review ◽  
Evaluation Framework ◽  
Future Research ◽  
Laboratory Diagnostics ◽  
The Face ◽  
Mobile Health Applications ◽  
Study Designs ◽  
Mhealth Apps

In the face of demographic change and constantly increasing health care costs, health care system decision-makers face ever greater challenges. Mobile health applications (mHealth apps) have the potential to combat this trend. However, in order to integrate mHealth apps into care structures, an evaluation of such apps is needed. In this paper, we focus on the criteria and methods of evaluating mHealth apps for cardiovascular disease and the implications for developing a widely applicable evaluation framework for mHealth interventions. Our aim is to derive substantiated patterns and starting points for future research by conducting a quasi-systematic scoping review of relevant peer-reviewed literature published in English or German between 2000 and 2021. We screened 4066 articles and identified n = 38 studies that met our inclusion criteria. The results of the data derived from these studies show that usability, motivation, and user experience were evaluated primarily using standardized questionnaires. Usage protocols and clinical outcomes were assessed primarily via laboratory diagnostics and quality-of-life questionnaires, and cost effectiveness was tested primarily based on economic measures. Based on these findings, we propose important considerations and elements for the development of a common evaluation framework for professional mHealth apps, including study designs, data collection tools, and perspectives.

scholarly journals Conviction Narrative Theory: A Theory of Choice Under Radical Uncertainty

2020 ◽  
Author(s):  
Samuel Gregory Blane Johnson ◽  
Avri Bilovich ◽  
David Tuckett
Keyword(s):  
Decision Making ◽  
Narrative Theory ◽  
Future Research ◽  
Basic Model ◽  
The Face ◽  
Individual Cognition ◽  
Radical Uncertainty ◽  
Econometric Analyses ◽  
Interview Studies ◽  
Adaptive Decision Making

Real-world decisions often take place under radical uncertainty—where outcomes cannot be enumerated and probabilities cannot be assigned. Conviction Narrative Theory (CNT) is a theory of choice under radical uncertainty. Whereas most theories of choice assume that people rely on (potentially biased) probabilistic judgments, such theories cannot account for adaptive decision-making when probabilities cannot be assigned. CNT proposes that people use narratives—structured causal hypotheses—rather than probabilities, as the currency of thought that unifies our sense-making and decision-making faculties. According to CNT, narratives arise from the interplay between individual cognition and the social environment, with reasoners adopting a narrative to explain the available evidence; using that narrative to imagine plausible futures; and affectively evaluating those imagined futures to make a choice. Evidence from many different areas of the cognitive, behavioral, and social sciences supports this basic model, including lab experiments, interview studies, and econometric analyses. We describe several varieties of narratives that govern decisions, documenting the psychological mechanisms governing their evaluation and their use in decision-making. We suggest two ways in which narratives and affect work together to support adaptive decision-making—evaluating the compatibility of imagined futures and goals and maintaining conviction to act in the face of ambivalent reasons and changing information. We conclude by discussing practical implications of CNT and its generativity for future research.

scholarly journals Preference Falsification Revisited: How Psychological Science Can Offer Insight into Motivated Belief Misrepresentation and Collective Misunderstanding

2021 ◽  
Author(s):  
Jacob Elder ◽  
Yrian Derreumaux;Derreumaux ◽  
Brent Hughes
Keyword(s):  
Social Dynamics ◽  
Theoretical Framework ◽  
Political Polarization ◽  
Social Connections ◽  
Future Research ◽  
Group Norms ◽  
Political Climate ◽  
Psychological Science ◽  
The Face ◽  
Insight Into

Throughout life, people sometimes lie to curry favor or mitigate disharmony with others, a tendency that may be exacerbated under moments of elevated tension. This phenomenon is captured by the economic theoretical framework of Preference Falsification, which describes why people misrepresent their beliefs in the face of social pressures, and how misrepresentation accumulates to broader misunderstandings that can fuel political polarization. We describe why the current political climate may foster motivations to misrepresent beliefs, as individuals are increasingly siloed into like-minded communities with strong pressures to conform to group norms. Next, we adopt a psychological lens to understand and integrate three motivations that underlie individual misrepresentation – relating to an individual’s intrinsic preference, their reputational concern, and their desire for expression – and describe how individual acts of misrepresentation can propagate across social connections to establish misrepresented beliefs as public consensus. Finally, we outline inroads for examining Preference Falsification using psychological methods that may be uniquely suited to elucidate the different social dynamics and issues that elicit this behavior, with the goal of spurring future research. Ultimately, we argue that fostering a more ideologically pluralistic and socially interconnected society may offer one route to reducing misrepresentation and collective misunderstanding, and thereby attenuate polarization and intergroup antipathy.

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