scholarly journals Today's Adjuvant Therapy in Breast Cancer: Who Should Receive What?

1995 ◽  
Vol 2 (3) ◽  
pp. 107327489500200
Author(s):  
Anne E. Roberge ◽  
John K. Erban
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Randomized Trials ◽  
Public Health Problem ◽  
Treatment Recommendations ◽  
Current Therapy ◽  
Major Public Health Problem ◽  
Breast Cancer Patients ◽  
Treatment Plans ◽  
Available Information

Breast cancer remains a major public health problem. Prospective randomized trials comparing therapies are essential to improve current therapy but, for those women unable or unwilling to participate in clinical trials, treatment plans are needed. Treatment recommendations can be based on available information from individual trials and from a large collaborative overview. This information will be reviewed with treatment recommendations presented for subpopulations of breast cancer patients.

scholarly journals Basic study of a breast cancer epidemiology among the female patients using a regional data source: Case of Chlef region, Algeria

2021 ◽  
Author(s):  
MAAMAR BOUKABCHA
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Cancer Patients ◽  
Cancer Registry ◽  
Health Problem ◽  
Public Health Problem ◽  
Female Breast Cancer ◽  
Major Public Health Problem ◽  
Breast Cancer Patients ◽  
Female Breast

Abstract Purpose Breast cancer is a public health problem. It impact given several, important consequences for reducing this disease. We did this study to know the situation of breast cancer and the development of cancer registry. Methods Epidemiological, statistical and computer tools are used to collect, analysis and process of the data, we used the medical records to know the data information on female breast cancer patients, by collaboration with of Bedje Sisters Public Hospitalise of Chlef (BSPHC) and the Oran Cancer Registry. Results We collected approximately 177 cases of female breast cancer, and approximately 601595 female populations during the year 2016 for Chlef region. The incidence rate is more than 29 cases of female breast cancer patients per 100000 female populations for each year. Female breast cancer patients of Chlef region is a major public health problem according to the 2016 study. Incidence rates this disease are greatly increased between 55 years and 75 years old. Conclusion Prevention, early diagnostic and different care and treatment play an important role in reducing this chronic disease in this region and why not over the worldwide?

scholarly journals 3rd Etnean Occupational Medicine Workshop—Breast Cancer and Work

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1925
Author(s):  
Venerando Rapisarda ◽  
Caterina Ledda
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Health Problem ◽  
Occupational Medicine ◽  
Public Health Problem ◽  
Major Public Health Problem

Breast cancer, the most frequently occurring cancer in women, is a major public health problem, with over 1 million estimated new cases worldwide and nearly 459,000 related deaths every year [...]

scholarly journals Modern Aspects in the Diagnosis and Surgical Treatment of Breast Cancer in Early Stages

2021 ◽  
Vol 26 (1) ◽  
pp. 36-40
Author(s):  
Andrei Moisin ◽  
Ciprian Tănăsescu
Keyword(s):  
Public Health ◽  
Breast Cancer ◽  
Surgical Treatment ◽  
Early Detection ◽  
Early Diagnosis ◽  
Health Problem ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Early Stages ◽  
Common Cancer

Abstract Breast cancer is the most common cancer in women and a major public health problem, affecting 2.1 million women each year globally and causing the highest number of cancer-related deaths among women. In 2018, an estimated 627,000 women died from breast cancer (about 15% of all cancer deaths among women). To improve survival, early detection is essential. There are two strategies for early detection of breast cancer: early diagnosis and screening.(1) In Romania, the latest statistics show a higher incidence of breast cancer compared to the European average of 7929 new cases / year with a mortality of 3101 deaths / year.(2)

scholarly journals Molecular Targeted Therapy for Breast Cancer: A New Frontiers

2017 ◽  
Vol 14 (3) ◽  
pp. 953-959
Author(s):  
Osama Al-Amer ◽  
Atif Abdulwahab Oyouni ◽  
Shalini Saggu
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Breast Cancer Patients ◽  
Cancer Treatments ◽  
Cancer Disease ◽  
Postmenopausal Obesity ◽  
Hereditary Factors ◽  
Survival And Growth

ABSTRACT: Cancer has become a major public health problem worldwide. Researches focus on the new approaches for cancer treatments that involve the specific targets of the cancer disease. Breast cancer is the most frequent type of cancer among women, and it causes approximately 25% of the deaths in women below the age of 35. Multiple environmental and hereditary factors are responsible for breast cancer such as age, family history, postmenopausal obesity, early menarche, late menopause, alcohol consumption, pregnancy and the use of exogenous hormones. Treatment of breast cancer patients relies primarily on surgery followed by radiotherapy and systemic therapy. Several molecules expressed and secreted by breast cancer cells have been identified by their interactions, invasion and metastasis. These molecular interactions appear to maintain the cancer cells’ survival and growth. The improvement in understanding of the molecular basis of breast cancer will provide possible targets for novel therapies. Therefor, this review focuses on the molecular and cellular basis of the breast cancer treatment.

scholarly journals Assessment of prognostic factors in breast cancer in women in Senegal: a review of 288 cases

2021 ◽  
Vol 1 (1) ◽  
pp. 6-9
Author(s):  
Mamadou Ndiaye ◽  
Souleymane Dieng ◽  
Jaafar Thiam ◽  
Adja Coumba Diallo ◽  
Doudou Diouf ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Hormone Receptors ◽  
Ductal Carcinoma ◽  
Locally Advanced ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Advanced Stage ◽  
Breast Cancer Patients

INTRODUCTION: In Senegal, breast cancer is the second female cancer and poses a major public health problem. The aim of this work was to assess prognostic factors in the progression of breast cancer in women. PATIENTS AND METHODS: This is a retrospective study carried out over a period of one year from January 1, 2008 to December 31, 2008 on all the women followed for breast cancer in the oncology department at the Joliot Curie Institute. Thus, 288 breast cancer patients were collected. RESULTS: The average age of our patients was 47.32 years. The average parity was 4.9 children per woman. Twenty-two or 7% of patients had a history of cancer. Clinically, the tumor size was classified as T4 in 180 patients, ie 81%. Lymph node involvement in 188 patients (65.2%). The most frequent histological type was invasive ductal carcinoma with 90.3% of cases. A predominance of grades SBRII and SBRIII was observed (respectively 41% and 46%). Hormone receptors (RH) were positive in eight cases (24%). Overexpression of the HER2 gene was found in only four out of 30 patients. The limits of the surgery were specified in 48 patients with invaded margins in seven patients (14.5%). The presence of vascular emboli was noted in 18 patients among the 29 whose research was carried out in 179 patients, ie 62%. At the time of the initial diagnosis, 45 patients or 19.7% of patients presented at least one distant metastasis. The majority of patients were received at an advanced stage (89%, classified between stage III and IV). Only one patient was received at stage I. Overall survival for breast cancer was 72% at 3 years and 30% at 5 years. The 5-year overall survival of patients with localized disease was 85% compared to 5% for patients with advanced stage. CONCLUSION: The prognostic factors are multiple and often pejorative in our patients with a predominance of young women, locally advanced cancers and aggressive biological forms.

Substance Abuse and Drug-Related Death, Suicidal Ideation, and Suicide: A Review

Crisis ◽  
1999 ◽  
Vol 20 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Annie Mino ◽  
Arnaud Bousquet ◽  
Barbara Broers
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Substance Abuse ◽  
Suicidal Ideation ◽  
Family Support ◽  
Drug Users ◽  
Suicide Attempts ◽  
Public Health Problem ◽  
Major Public Health Problem ◽  
Hiv Epidemic

The high mortality rate among drug users, which is partly due to the HIV epidemic and partly due to drug-related accidental deaths and suicides, presents a major public health problem. Knowing more about prevalence, incidence, and risk factors is important for the development of rational preventive and therapeutic programs. This article attempts to give an overview of studies of the relations between substance abuse, suicidal ideation, suicide, and drug-related death. Research in this field is hampered by the absence of clear definitions, and results of studies are rarely comparable. There is, however, consensus about suicidal ideation being a risk factor for suicide attempts and suicide. Suicidal ideation is also a predictor of suicide, especially among drug users. It is correlated with an absence of family support, with the severity of the psychosocial dysfunctioning, and with multi-drug abuse, but also with requests for treatment. Every clinical examination of a drug user, not only of those who are depressed, should address the possible presence of suicidal ideation, as well as its intensity and duration.

Comparison between different boost dose delivery techniques to the tumor bed of right sided breast cancer patients.

2017 ◽  
Vol 13 (1) ◽  
pp. 4605-4617
Author(s):  
Aly Mahmoud El-Hdidy
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Target Location ◽  
Breast Cancer Patients ◽  
Photon Beams ◽  
Lung Dose ◽  
Dose Volume Histograms ◽  
Tumor Bed ◽  
Boost Dose ◽  
Treatment Plans

Comparisons between three different techniques by which the boost dose was delivered to the tumor bed were carried out , aiming to present the best technique of treatment for right breast cancer patients.In this study, ten right sided breast cancer computed tomography (CT) scans were selected for ten early right breast cancer patients. We made three different treatment plans for each patient CT using three different irradiation techniques to deliver a prescribed boost dose of 10 Gy in 5 fractions to the boost PTV. In the first technique, two tangential photon beams were used, in the second technique we, two oblique photon beams were used and in the third technique, a single electron beam was used. The comparative analyses between the three techniques were performed by comparing the boost PTV- dose volume histograms (DVHs), the ipsilateral breast (right breast) DVHs, the ipsilateral lung (right lung) DVHs and the heart DVHs of the three techniques for each patient. Furthermore the dose that covering 100% , 95% of the volume (D100% , D95%) and the volume covered by 95% of the dose (V95%)of  the boost PTV of all techniques, were calculated for each patient to investigate the dose coverage of the target.Results showed that there were variations of the dose received by tumor bed, right breast and OARs depending on the technique used and the target location and size. A decrease of D100% than 90% of the prescribed dose was observed with the 3rd technique for patients 8, 9 and 10, and was observed with the 2nd technique for patient 5. A reduction of right breast dose was observed when the 3rd technique was use in comparison with the 1st and the 2nd techniques for patients 1, 2, 3, 4, 6 and 8.  Also reduction of right breast was observed when the 2nd technique used in comparison with 1st technique. An increase of lung dose was observed with the 3rd technique for patients 1, 2, 5 and 6, also was observed with 2nd technique in patient 3, 5 and 7. A decrease of lung dose was observed with the 1st technique for patients 2, 4, 5, 6, 7, 8 and 9An individualized treatment, several plans using different irradiation techniques should be developed for each patient individually to reach the best boost PTV dose coverage with minimal OARs’ dose. 

Crucial role of physiotherapy in treating COVID-19 patients

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 967-971
Author(s):  
Poonam Thakre ◽  
Waqar M. Naqvi ◽  
Trupti Deshmukh ◽  
Nikhil Ingole ◽  
Sourabh Deshmukh
Keyword(s):  
Public Health ◽  
Distress Syndrome ◽  
Public Health Problem ◽  
Public Health Emergency ◽  
High Rate ◽  
Major Public Health Problem ◽  
Front Line ◽  
The Many ◽  
Sixth International

The emergence in China of 2019 of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) previously provisionally names 2019-nCoV disease (COVID19) caused major global outbreak and is a major public health problem. On 30 January 2020, the WHO declared COVID19 to be the sixth international public health emergency. This present pandemic has engrossed the globe with a high rate of mortality. As a front line practitioner, physiotherapists are expected to be getting in direct contact with patients infected with the virus. That’s why it is necessary for understanding the many aspects of their role in the identification, contains, reduces and treats the symptoms of this disease. The main presentation is the involvement of respiratory system with symptoms like fever, cough, sore throat, sneezing and characteristics of pneumonia leads to ARDS(Acute respiratory distress syndrome) also land up in multiorgan dysfunction syndrome. This text describes and suggests physiotherapy management of acute COVID-19 patients. It also includes recommendations and guidelines for physiotherapy planning and management. It also covers the guidelines regarding personal care and equipment used for treatment which can be used in the treatment of acute adult patients with suspected or confirmed COVID-19.

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