Soyasaponins Lowered Plasma Cholesterol and Increased Fecal Bile Acids in Female Golden Syrian Hamsters

2005 ◽  
Vol 230 (7) ◽  
pp. 472-478 ◽  
Author(s):  
Sun-Ok Lee ◽  
Andrean L. Simons ◽  
Patricia A. Murphy ◽  
Suzanne Hendrich
Keyword(s):  
Total Cholesterol ◽  
Bile Acids ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Plasma Total Cholesterol ◽  
Fecal Bile Acids ◽  
Cholesterol Levels ◽  
Neutral Sterols ◽  
Group B ◽  
Cholesterol Status

A study was conducted in hamsters to determine if group B soyasaponins improve plasma cholesterol status by increasing the excretion of fecal bile acids and neutral sterols, to identify group B soyasaponin metabolites, and to investigate the relationship between a fecal group B soyasaponin metabolite and plasma lipids. Twenty female golden Syrian hamsters, 11–12 weeks old and 85–125 g, were randomly assigned to a control diet or a similar diet containing group B soyasaponins (containing no isoflavones), 2.2 mmol/kg, for 4 weeks. Hamsters fed group B soyasaponins had significantly lower plasma total cholesterol (by 20%), non–high-density lipoprotein (HDL) cholesterol (by 33%), and triglycerides (by 18%) compared with those fed casein (P < 0.05). The ratio of total cholesterol to HDL cholesterol was significantly lower (by 13%) in hamsters fed group B soyasaponins than in those fed casein (P < 0.05). The excretion of fecal bile acids and neutral sterols was significantly greater (by 105% and 85%, respectively) in soyasaponin-fed hamsters compared with those fed casein (P < 0.05). Compared with casein, group B soyasaponins lowered plasma total cholesterol levels and non-HDL cholesterol levels by a mechanism involving greater excretion of fecal bile acids and neutral sterols. Hamsters fed group B soyasaponins statistically clustered into two fecal soyasaponin metabolite–excretion phenotypes: high excreters (n = 3) and low excreters (n = 7). When high and low producers of this soyasaponin metabolite were compared for plasma cholesterol status, the high producers showed a significantly lower total-cholesterol-to-HDL-cholesterol ratio compared with the low producers (1.38 ± 0.7 vs. 1.59 ± 0.13; P < 0.03). Greater production of group B soyasaponin metabolite in hamsters was associated with better plasma cholesterol status, suggesting that gut microbial variation in soyasaponin metabolism may influence the health effects of group B soyasaponins.

scholarly journals Pengaruh propolis terhadap profil lipid plasma tikus model hiperkolesterolemia

2012 ◽  
Vol 8 (3) ◽  
pp. 106
Author(s):  
Krisnansari Diah ◽  
Ariadne Tiara Hapsari ◽  
Evy Sulistyoningrum ◽  
Agus Prastowo
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Sprague Dawley ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Group I ◽  
Before And After

Background: Nowadays, cardiovascular disease caused by hypercholesterolemia has become the main cause of death. Propolis has been used widely to reduce plasma cholesterol levels.Objective: The aims of this research was to study the effect of propolis on lipid profile of hypercholesterolemic Sprague Dawley rats.Method: This was an experimental study with pre-post test. Twenty four (24) male Sprague Dawley rats aged 12-16 week old, weighing 125-200 g were allocated into 4 groups. Group I received standard meal + aquadest-gavage; group II received high cholesterol meal + PTU 0,01 + aquadest gavage; group III received high cholesterol meal + PTU 0,01 + 0,027 g propolis gavage; group IV received high cholesterol meal + PTU 0,01 + 0,054 g propolis gavage. Total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol levels before and after treatment were measured. The data were then analyzed with One Way Anova.Results: The study showed that there were no significant differences in changes of body weight. There were significant differences in total cholesterol levels between all groups of treatment. Triglyceride levels were significantly different among all groups, except between group I and IV. Furthermore, the HDL cholesterol levels of group I vs III and group I vs IV were significantly different. However, there were no differences found in LDL cholesterol levels among all groups of treatment.Conclusion: Provision of 0,027 g and 0,054 g propolis improve lipid profile (total cholesterol, triglyceride and HDL cholesterol levels) of hypercholesterolemic rats.

Plasma and Red Cell Cholesterol

1961 ◽  
Vol 7 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Gordon Fels ◽  
Eugene Kanabrocki ◽  
Ervin Kaplan
Keyword(s):  
Total Cholesterol ◽  
Plasma Cholesterol ◽  
Tween 80 ◽  
Experimental Production ◽  
Red Cell ◽  
Elevated Plasma ◽  
Plasma Total Cholesterol ◽  
Cholesterol Levels ◽  
Cortisone Injection ◽  
Fat Feeding

Abstract The experimental production of hypercholesteremia in rabbits by three independent methods—namely, high-fat feeding, cortisone injection, and Tween-80 injection—results in an elevated plasma total cholesterol, whereas the total RBC cholesterol remains constant. Previous work on plasma and red cell cholesterol in humans has been substantiated. Normal total plasma and red cell cholesterol values are 187 ± 32 and 129 ± 20 mg.%, respectively. Elevated plasma total cholesterol occurring in coronary arteriosclerosis, diabetes, nephritis, hypothyroid, Hodgkin's disease, and obesity does not affect the erythrocyte levels. Elevated erythrocyte total cholesterol levels occur in sickle cell and pernicious anemia accompanied by slightly sub-normal plasma levels. A hypothesis is advanced to explain the variability of plasma cholesterol and the relative constancy of red cell cholesterol.

Effect of age, sex, lactation and non-lactating stages on plasma total and HDL-cholesterol in Jaffarabadi buffaloes

2016 ◽  
Author(s):  
Ninan Jacob ◽  
J. S. Arya ◽  
P. U. Gajbhiye
Keyword(s):  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Plasma Total Cholesterol ◽  
Cattle Breeding ◽  
Male And Female ◽  
Cholesterol Levels ◽  
Effect Of Age

The study was conducted on male and female Jaffarabadi buffaloes (total 132) of various ages and physiological stages (lactating and non-lactating) maintained under standard feeding and managemental conditions followed at the Cattle Breeding Farm, Junagadh Agricultural University, Gujarat, to understand the variation in total cholesterol and HDL-cholesterol levels. Age significantly (P < 0.05) affected the plasma total cholesterol and HDL cholesterol levels in all the groups under study. Significant (P < 0.05) differences were also observed between the females and males at 1 week and 6 month age for total cholesterol and at 1 week, 1 month and 6 month age for HDL-cholesterol levels. Significant (P < 0.05) difference existed between different months of lactation for plasma total cholesterol and HDL-cholesterol. The levels of both the parameters were not significantly higher in pregnant than in non-pregnant Jaffarabadi buffaloes.

Evidence of age-dependent genetic influences on plasma total cholesterol

2005 ◽  
Vol 12 (4) ◽  
pp. 380-386 ◽  
Author(s):  
Rita Middelberg ◽  
Andrew C. Heath ◽  
Nicholas G. Martin ◽  
John B. Whitfield
Keyword(s):  
Environmental Factors ◽  
Total Cholesterol ◽  
Repeated Measures ◽  
Genetic Factor ◽  
Plasma Cholesterol ◽  
Long Term Effects ◽  
Plasma Total Cholesterol ◽  
Cholesterol Levels ◽  
Genetically Determined

Background Causes of variation in cardiovascular risk factors include biological variation within individuals, and more permanent differences between individuals, which are at least partly genetic in origin. We have compared the magnitude of genetic and non-genetic factors within and across occasions through repeated measures of plasma cholesterol in twin subjects, and have also determined how far the same genes affect cholesterol levels at different ages. Methods Data on plasma total cholesterol were extracted for 208 twin pairs who had provided blood on up to six occasions across a period of 17 years. They were aged 18–30 years at the time of first study and 30–47 at the time of the last. Multivariate models of variation due to genetic, shared environmental and unique environmental factors were fitted to the multi-occasion data and the proportions of variation due to these factors were estimated. Results One genetic factor influenced plasma cholesterol on all occasions and a second genetic factor only influenced cholesterol results on the fifth and sixth occasions 10–17 years after the first. Environmental factors did not have significant long-term effects. Conclusions We conclude that individuals’ long-term mean plasma cholesterol values are strongly genetically determined, but that some of these genes are age-specific in their effects.

Comparative effects on blood lipids and faecal steroids of five legume species incorporated into a semi-purified, hypercholesterolaemic rat diet

1996 ◽  
Vol 75 (4) ◽  
pp. 557-571 ◽  
Author(s):  
Fatima D Dabai ◽  
Ann F Walker ◽  
Ian E Sambrook ◽  
Vernon A Welch ◽  
Robert W Owen ◽  
...  
Keyword(s):  
Bile Acids ◽  
Plasma Cholesterol ◽  
Control Diet ◽  
Phaseolus Lunatus ◽  
Legume Species ◽  
Sprague Dawley ◽  
Faecal Excretion ◽  
Cholesterol Levels ◽  
Sprague Dawley Rats ◽  
Neutral Sterols

AbstractThe cholesterolaemic effects in rats of a diet (VS) containing Bambara groundnuts (Vignu subterrunea), a popular legume eaten in Nigeria, were compared with diets PV, PS, LC and PL, containing baked beans (Phaseolus vulgaris), marrowfat peas (Pisum sativum), lentils (Lens culinaris Medik.) and butter beans (Phaseolus lunatus) respectively. Sixty Sprague-Dawley rats were fed on hypercholesterolaemic semi-purified diets supplemented with 10 g cholesterol and 5 g cholic acid/kg and formulated to provide 40% of energy from fat, as in a typical Western-type human diet. Legumes were substituted for 330 g/kg of the semi-purified diet on a dry-matter basis, which was modified to maintain the same contribution of energy sources as the control diet C3. Another ten rats were fed on control diet C2, which was similar to diet C3 but with no added cholesterol. The rats were fed for 8 weeks and plasma cholesterol levels were measured at weeks 4 and 8. The diets incorporating the five different legume species produced very Merent cholesterolaemic effects. Diets PV and PL were more potent at lowering raised plasma cholesterol levels than diets PS and LC. Inclusion of the Bambara groundnut into the semi-purified diet resulted in an exaggeration of hypercholesterolaemia. Differences in cholesterol-lowering capacity of the various legume diets in this experiment could not be related to concentrations of faecal bile acids or neutral sterols. However, there was evidence that the inclusion of legumes in the diets reduced the faecal excretion of secondary bile acids

Long-term Effect of Sotalol on Plasma Lipids

1979 ◽  
Vol 57 (s5) ◽  
pp. 405s-407s ◽  
Author(s):  
A. Lehtonen ◽  
J. Viikari
Keyword(s):  
Total Cholesterol ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Plasma Free Fatty Acid ◽  
Cholesterol Concentration ◽  
Plasma Total Cholesterol ◽  
Long Term Effect ◽  
The Difference

1. We studied the effect on plasma lipids of sotalol given orally over a 12 month period to patients with essential hypertension. 2. Plasma free fatty acid concentration was lower than initially at 1, 3, 6 and 12 months. The difference was significant (P &lt; 0·01) at 1 and 3 months. 3. Plasma cholesterol (VLDL + LDL-cholesterol) increased during treatment. Plasma total cholesterol increased from 5·49 ± sd 0·94 mmol/l at the beginning to 6·37 ± 1·10 mmol/l at 12 months (P &lt; 0·01). 4. HDL-cholesterol concentration and the ratio of HDL-cholesterol to total cholesterol decreased significantly. The ratios were 0·28 and 0·18 at the beginning and at 12 months respectively (P &lt; 0·001). 5. Plasma triglycerides increased simultaneously from 1·14 ± 0·31 to 1·89 ± 0·99 mmol/l (P &lt; 0·01).

THE EFFECTS OF NICOTINIC ACID ON BLOOD LIPIDS IN PATIENTS WITH LOW HDL-CHOLESTEROL AND NORMAL TOTAL CHOLESTEROL LEVELS

1989 ◽  
Vol 9 (10) ◽  
pp. 414 ◽  
Author(s):  
R. W. Squire ◽  
G. T. Gau ◽  
B. A. Kottke ◽  
T. D. Miller ◽  
T. G. Allison ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Total Cholesterol ◽  
Blood Lipids ◽  
Hdl Cholesterol ◽  
Cholesterol Levels ◽  
Low Hdl

Bile Acids: The Good, the Bad, and the Ugly

Physiology ◽  
1999 ◽  
Vol 14 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Alan F. Hofmann
Keyword(s):  
Bile Acids ◽  
Enterohepatic Circulation ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Absorption ◽  
Bile Acid Metabolism ◽  
Cholesterol Levels ◽  
Density Lipoprotein Receptor

Bile acids, amphipathic end products of cholesterol metabolism, are “good” in the infant because they enhance lipid absorption and thereby promote growth. Bile acids also induce bile flow and biliary lipid secretion. The enterohepatic circulation of bile acids is “bad” in the adult because it downregulates hepatocyte low-density lipoprotein receptor activity and thereby elevates plasma cholesterol levels. Defects in bile acid metabolism such as impaired biosynthesis or transport are “ugly” because they cause morbidity and death. New approaches for treating these defects are being developed.

scholarly journals Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia

2001 ◽  
Vol 86 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Robert Volpe ◽  
Leena Niittynen ◽  
Riitta Korpela ◽  
Cesare Sirtori ◽  
Antonello Bucci ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Plant Sterols ◽  
Dependent Manner ◽  
Low Fat ◽  
Treatment Groups ◽  
Cholesterol Levels ◽  
Dose Dependent

The objective of the present study was to assess the effect of consumption of a yoghurt-based drink enriched with 1–2 g plant sterols/d on serum lipids, transaminases, vitamins and hormone status in patients with primary moderate hypercholesterolaemia. Thirty patients were randomly assigned to one of two treatment groups: a low-fat low-lactose yoghurt-based drink enriched with 1 g plant sterol extracted from soyabean/dv.a low-fat low-lactose yoghurt, for a period of 4 weeks. After a 2-week wash-out period, patients were crossed over for an additional 4-week period. Second, after a 4-week wash-out period, eleven patients were treated with 2 g plant sterols/d in a second open part of the study for a period of 8 weeks. The yoghurt enriched with plant sterols significantly reduced, in a dose-dependent manner, serum total cholesterol and LDL-cholesterol levels and LDL-cholesterol:HDL-cholesterol (P<0·001), whereas no changes were observed in HDL-cholesterol and triacylglycerol levels, either in the first or the second part of the study. There were only slight, not statistically significant, differences in serum transaminase, vitamin and hormone levels. To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia.

scholarly journals Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet

2018 ◽  
Vol 54 (1) ◽  
pp. 16 ◽  
Author(s):  
Wiwik Werdiningsih ◽  
Suhartati Suhartati
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Fruit Peel ◽  
Cholesterol Levels ◽  
White Rats ◽  
Wistar Strain ◽  
Dragon Fruit ◽  
Pap Method

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.

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