Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease

2021 ◽  
pp. 153537022098327
Author(s):  
Lisa Kobos ◽  
Jonathan Shannahan
Keyword(s):  
Metabolic Syndrome ◽  
Particulate Matter ◽  
Metabolic Diseases ◽  
The Elderly ◽  
The United States ◽  
Public Health Issue ◽  
Adverse Health Outcomes ◽  
Significant Public Health ◽  
Cardiovascular Systems ◽  
Vulnerable Subpopulations

Particulate matter is a significant public health issue in the United States and globally. Inhalation of particulate matter is associated with a number of systemic and organ-specific adverse health outcomes, with the pulmonary and cardiovascular systems being particularly vulnerable. Certain subpopulations are well-recognized as being more susceptible to inhalation exposures, such as the elderly and those with pre-existing respiratory disease. Metabolic syndrome is becoming increasingly prevalent in our society and has known adverse effects on the heart, lungs, and vascular systems. The limited evaluations of individuals with metabolic syndrome have demonstrated that they may compose a sensitive subpopulation to particulate exposures. However, the toxicological mechanisms responsible for this increased vulnerability are not fully understood. This review evaluates the currently available literature regarding how the response of an individual’s pulmonary and cardiovascular systems is influenced by metabolic syndrome and metabolic syndrome-associated conditions such as hypertension, dyslipidemia, and diabetes. Further, we will discuss potential therapeutic agents and targets for the alleviation and treatment of particulate-matter induced metabolic illness. The information reviewed here may contribute to the understanding of metabolic illness as a risk factor for particulate matter exposure and further the development of therapeutic approaches to treat vulnerable subpopulations, such as those with metabolic diseases.

scholarly journals The effects of assisted reproduction technologies on metabolic health and disease

2020 ◽  
Author(s):  
Maria Florencia Heber ◽  
Grażyna Ewa Ptak
Keyword(s):  
Metabolic Syndrome ◽  
Health Outcomes ◽  
Metabolic Diseases ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Postnatal Life ◽  
Metabolic Alterations ◽  
Adverse Health ◽  
Adverse Health Outcomes ◽  
The Individual

Abstract Background The increasing prevalence of metabolic diseases places a substantial burden on human health throughout the world. It is believed that predisposition to metabolic disease starts early in life, a period of great susceptibility to epigenetic reprogramming due to environmental insults. Assisted reproductive technologies (ART), i.e., treatments for infertility, may affect embryo development, resulting in multiple adverse health outcomes in postnatal life. The most frequently observed alteration in ART pregnancies is impaired placental nutrient transfer. Moreover, consequent intrauterine growth restriction and low birth weight followed by catch-up growth can all predict future obesity, insulin resistance, and chronic metabolic diseases. Scope of the review In this review, we have focused on evidence of adverse metabolic alterations associated with ART, which can contribute to the development of chronic adult-onset diseases, such as metabolic syndrome, type 2 diabetes, and cardiovascular disease. Due to high phenotypic plasticity, ART pregnancies can produce both offspring with adverse health outcomes, as well as healthy individuals. We further discuss the sex-specific and age-dependent metabolic alterations reflected in ART offspring, and how the degree of interference of a given ART procedure (from mild to more severe manipulation of the egg) affects the occurrence and degree of offspring alterations. Major conclusions Over the last few years, studies have reported signs of cardiometabolic alterations in ART offspring that are detectable at a young age but that do not appear to constitute a high risk of disease and morbidity per se. These abnormal phenotypes could be early indicators of the development of chronic diseases, including metabolic syndrome, in adulthood. The early detection of metabolic alterations could contribute to preventing the onset of disease in adulthood. Such early interventions may counteract the risk factors and improve the long-term health of the individual.

scholarly journals Association of Housing Stress With Child Maltreatment: A Systematic Review

2020 ◽  
pp. 152483802093913
Author(s):  
Caroline E. Chandler ◽  
Anna E. Austin ◽  
Meghan E. Shanahan
Keyword(s):  
Child Maltreatment ◽  
Child Protective Services ◽  
The United States ◽  
Public Health Issue ◽  
Material Hardship ◽  
Protective Services ◽  
Stress Indicators ◽  
Effective Prevention ◽  
Established Risk Factor ◽  
Significant Public Health

Child maltreatment is a significant public health issue in the United States. Understanding key risk factors for child maltreatment is critical to informing effective prevention. Poverty is an established risk factor for child maltreatment. However, recent research indicates that material hardship (i.e., difficulties meeting basic needs) may serve as a more direct measure of the way in which poverty affects daily life. One form of material hardship that is common among families is housing stress. Previous reviews have summarized the existing literature regarding the association of economic insecurity with child maltreatment, but no reviews have synthesized and critically evaluated the literature specific to the association of various types of housing stress with child maltreatment. We conducted a systematic search of multiple electronic databases to identify peer-reviewed studies conducted in the U.S. regarding the association of housing stress with child maltreatment. We identified 21 articles that used nine distinct measures of housing stress including homelessness or eviction, homeless or emergency shelter stays, foreclosure filing, housing instability, inadequate housing, physical housing risk, living doubled-up, housing unaffordability, and composite housing stress indicators. Overall, results from this body of literature indicate that housing stress is associated with an increased likelihood of caregiver or child self-reported maltreatment, child protective services (CPS) reports, investigated and substantiated CPS reports, out-of-home placements, and maltreatment death. Additional theory-driven research is needed to further our understanding of the contribution of specific types of housing stress to risk for specific types of maltreatment.

scholarly journals Shigella sonneiBacteremia Presenting with Profound Hepatic Dysfunction

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Oluwaseun Shogbesan ◽  
Andrew Rettew ◽  
Bilal Shaikh ◽  
Abdullateef Abdulkareem ◽  
Anthony Donato
Keyword(s):  
Laboratory Data ◽  
Abdominal Ultrasound ◽  
The United States ◽  
Shigella Sonnei ◽  
Public Health Issue ◽  
Watery Stool ◽  
Normal Limits ◽  
Significant Public Health ◽  
History Of

Worldwide, Shigellosis is a significant public health issue, associated with nearly one million deaths annually. About half a million cases ofShigellainfection are reported annually in the United States.Shigellabacteremia is uncommon and generally seen in children and immunocompromised adults. We present a case of aShigella sonneibacteremia with marked hepatic derangement in a 27-year-old previously healthy homosexual male with history of Roux-en-Y gastric bypass, who presented to the emergency room with a 4-day history of loose watery stool, abdominal cramps, nausea and vomiting, and yellow skin of 2-day duration. He reports similar diarrhea illness in two close contacts in preceding days. On examination, he was fully oriented but dehydrated, icteric, and febrile. Laboratory data revealed WBC of 2200/μL, elevated AST and ALT (201 IU/L, 73 IU/L resp.), normal alkaline phosphatase, elevated total and direct bilirubin of 8.2 mg/dL and 4.4 mg/dL, albumin of 3.2 g/dL, INR of 2.9, prothrombin time of 31.7, and platelet of 96,000/μL. Workup for infectious, autoimmune and medication-induced hepatitis, Wilson’s disease, and hemochromatosis was negative. Abdominal ultrasound and computed tomography of the abdomen showed hepatic steatosis and right-sided colitis. Stool and blood cultures were positive forShigella sonnei. He was treated with ciprofloxacin with improvement in liver function. Follow-up blood test 4 months later was within normal limits.

Pelvic Floor Dysfunction After Childbirth: Occupational Impact and Awareness of Available Treatment

2020 ◽  
pp. 153944922097088
Author(s):  
Rebecca Burkhart ◽  
Katlin Couchman ◽  
Katherine Crowell ◽  
Samantha Jeffries ◽  
Sarah Monvillers ◽  
...  
Keyword(s):  
Pelvic Floor ◽  
Daily Life ◽  
Pelvic Floor Dysfunction ◽  
The United States ◽  
Public Health Issue ◽  
Occupational Performance ◽  
Pelvic Floor Rehabilitation ◽  
Women's Lives ◽  
Significant Public Health ◽  
The Impact

Postpartum pelvic floor dysfunction (PFD) has been identified as a significant public health issue. The study aimed to (a) identify the impact of PFD on parous women’s occupations, (b) explore how PFD impacts daily life, and (c) determine the level of awareness regarding availability of PFD treatment. The preliminary study utilized a mixed-methods descriptive design. In total, 255 participants completed the Mothers and Children (MAC) survey, distributed electronically throughout the United States. Results indicated that PFD symptoms limit parous women’s occupational performance, specifically sexual activity and exercise. Despite results indicating PFD significantly detracted from participants’ daily life, 66.8% of participants reported having no awareness of pelvic floor rehabilitation to address PFD. Findings suggest that further research and increased advocacy within the field of occupational therapy are necessary to increase the awareness of PFD rehabilitation and mitigate the impact on women’s lives after childbirth.

scholarly journals Vacant Properties and Violence in Neighborhoods

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Charles C. Branas ◽  
David Rubin ◽  
Wensheng Guo
Keyword(s):  
Negative Binomial ◽  
Negative Binomial Regression ◽  
The United States ◽  
Public Health Issue ◽  
Negative Binomial Regression Model ◽  
Alcohol Outlets ◽  
Aggravated Assault ◽  
Increased Risk ◽  
Significant Public Health ◽  
Block Groups

Objectives. Violence remains a significant public health issue in the United States. To determine if urban vacant properties were associated with an increased risk of assaultive violence and if this association was modified by important neighborhood institutions (e.g., schools, parks/playgrounds, police stations, and alcohol outlets). Methods. Longitudinal ecologic study of all 1816 block groups in Philadelphia. Aggravated assault and vacant property data were compiled yearly from 2002 to 2006 and linked to block groups. A mixed effects negative binomial regression model examined the association of vacant properties and assaults between and within block groups. Results. Among all block groups, 84% experienced at least one vacant property, 89% at least one aggravated assault, and 64% at least one gun assault. Between block groups, the risk of aggravated assault increased 18% for every category shift of vacant properties (IRR 1.18, 95% CI: 1.12, 1.25, ). Parks/playgrounds and alcohol outlets potentially modified the association between vacant properties and aggravated assaults but only at low levels of vacancy. Conclusions. Increasing levels of vacancy were associated with increased risk of assaultive violence in urban block groups.

scholarly journals METABOLIC SYNDROME AMONG DOCTORS: A PILOT STUDY FROM ODISHA

2018 ◽  
Vol 11 (10) ◽  
pp. 294
Author(s):  
Magna Manjareeka ◽  
Soumya Mishra ◽  
Prakash K Nayak ◽  
Shubhransu Patro ◽  
Jayanti Mishra ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Male ◽  
Public Health Problem ◽  
The Elderly ◽  
High Density Lipoproteins ◽  
Cross Sectional ◽  
Standard Procedures ◽  
Significant Public Health Problem ◽  
Significant Public Health ◽  
Low Hdl

Objective: This study was planned to assess the prevalence of metabolic syndrome (MetS) among doctors of Bhubaneswar. Methods: A cross-sectional, single-centered observational study was conducted among doctors over a period of 8 months after clearance from Institutional Ethical Committee. All consented participants were subjected to anthropometric measurements and physical examination. Fasting plasma glucose and complete lipid profile were estimated using standard procedures after 12 h of overnight fast. MetS was defined according to the Modified National Cholesterol Education Program-Adult Treatment Panel III criteria for MetS screening. Results: Among 170 participants (males - 117 and females - 53), 64 (37.65%) were with MetS. Prevalence of same was higher in males (41.9%) than females (28.3%). The younger doctors (≤40 years) had more prevalence of MetS compared to the elderly (>40 years) doctors (41 [39.8%] vs. 23 [34.3%]). In the males, high blood pressure was the major contributor to the prevalence of MetS followed by low high-density lipoproteins-cholesterol (HDL-C) and high triglyceride values. However, in females, low HDL-C and greater waist circumference contributed the maximum to MetS. Conclusion: In the present study, the young male doctors have a greater prevalence of MetS than the older and the females. MetS is still a significant public health problem in the educated population including those of doctors, especially the younger ones. 

Neurocysticercosis

2010 ◽  
Vol 134 (10) ◽  
pp. 1560-1563
Author(s):  
Jack Moskowitz ◽  
Geoffrey Mendelsohn
Keyword(s):  
United States ◽  
Clinical Presentation ◽  
The United States ◽  
Public Health Issue ◽  
Laboratory Findings ◽  
Surgical Interventions ◽  
Clinical Symptomatology ◽  
Significant Public Health ◽  
The Central Nervous System ◽  
Available Information

Abstract Neurocysticercosis is a significant public health issue within the United States. Although cysticercosis was once thought to have been eradicated in the United States, the number of documented cases is rising and immigrants from endemic areas are at the highest risk for acquiring and developing this disease. The clinical presentation of neurocysticercosis is variable and vague neurologic symptoms or sudden unexplained death in individuals with risk factors may be the only available information warranting a consideration of neurocysticercosis. Radiologic and laboratory findings can help guide medical and surgical interventions, while histologic confirmation establishes a more definitive diagnosis. Encysted larvae can be found throughout the central nervous system and undergo progressive stages of decay. Degenerating vesicles elicit an inflammatory response, involving surrounding structures, and cause the major clinical symptomatology.

scholarly journals HPV Vaccination Champions: Evaluating a Technology-Mediated Intervention for Parents

2021 ◽  
Vol 3 ◽  
Author(s):  
Beth Sundstrom ◽  
Kathleen B. Cartmell ◽  
Ashley A. White ◽  
Nicole Russo ◽  
Henry Well ◽  
...  
Keyword(s):  
Social Media ◽  
Feasibility Study ◽  
Hpv Vaccination ◽  
The United States ◽  
Vaccine Hesitancy ◽  
Public Health Issue ◽  
Significant Difference ◽  
Significant Public Health ◽  
Developed Nations

Human papillomavirus (HPV) vaccination prevents 6 HPV-related cancers in men and women. Yet, rates of HPV vaccination among adolescents in the United States lag behind other developed nations, revealing a significant public health issue. This feasibility study tested a collaborative online learning environment to cultivate HPV vaccination champions. A 3-month training program recruited parents to serve as proponents and social media influencers to identify solutions to overcome barriers to HPV vaccination. A mixed methods study design included a pretest survey, three online asynchronous focus groups, a posttest survey, as well as a longitudinal follow-up survey at 6 months. Participants included 22 parents who self-identified as female (95.4%) and white (90.9%). Overall, there was a statistically significant difference in knowledge of HPV and HPV vaccination between pretest and posttest (p = 0.0042). This technology-mediated intervention increased parents' confidence and motivated them to speak more freely about HPV vaccination in-person and online with others in their social networks. Participants identified prevalent misinformation about HPV vaccination and learned how to effectively craft messages to address concerns related to safety and side effects, gender, understanding of risk, and sexual activity. Objective measures and qualitative open-ended assessment showed high intervention engagement and treatment satisfaction. All participants (100%) indicated that they enjoyed participating in the intervention. The effectiveness of this feasibility study suggests that social media is an appropriate platform to empower parents to counter vaccine hesitancy and misinformation through HPV vaccination information that is simple and shareable in-person and online.

scholarly journals Opioid Prescribing Patterns by Drug Type: The Pennsylvania Experience

2021 ◽  
Author(s):  
Brock K. Bakewell ◽  
Chain Miller ◽  
Matthew Sherman ◽  
Asif M. Ilyas
Keyword(s):  
Monitoring Program ◽  
The United States ◽  
Prescribing Patterns ◽  
Public Health Issue ◽  
Cross Sectional ◽  
Opioid Prescribing ◽  
The Third ◽  
Department Of Health ◽  
Significant Public Health ◽  
Drug Type

Abstract Background: Opioid abuse persists as a significant public health issue in the United States; many states are implementing education and monitoring programs in response. This study examined opioid prescribing patterns and trends after implementing a prescription drug monitoring program in Pennsylvania from 2016 to 2020.Methods: A cross-sectional data analysis using de-identified data from Pennsylvania's PDMP delivered by the Pennsylvania Department of Health was undertaken.Results: In 2016, nearly 2 million opioid prescriptions were given to patients across the state. However, by the end of the study period in 2020, there was a 38% decrease in opioid prescriptions written. Specifically, over 700,000 fewer prescriptions in the first quarter of 2020 compared to the third quarter in 2016. The opioids that were most frequently prescribed were oxycodone, hydrocodone, and morphine.Conclusion: While fewer prescriptions were being prescribed overall, the breakdown of drug type being prescribed remained similar in 2020 compared to 2016. Fentanyl and hydrocodone saw the largest decrease between 2016 and 2020.

Preemption and the Obesity Epidemic: State and Local Menu Labeling Laws and the Nutrition Labeling and Education Act

2008 ◽  
Vol 36 (4) ◽  
pp. 772-789 ◽  
Author(s):  
Lainie Rutkow ◽  
Jon S. Vernick ◽  
James G. Hodge ◽  
Stephen P. Teret
Keyword(s):  
The United States ◽  
Public Health Issue ◽  
Nutrition Labeling ◽  
Menu Labeling ◽  
Obesity Epidemic ◽  
Significant Public Health ◽  
Control And Prevention ◽  
Education Act ◽  
State And Local ◽  
American Children

Worldwide, obesity has become a major cause of preventable death, disease, and disability. While the epidemic of obesity is a significant public health issue in many developed nations, the United States has the highest prevalence of obesity among adults and children internationally. The National Health and Nutrition Examination Survey (NHANES) estimates that over 60 percent of U.S. adults are overweight or obese. According to the Centers for Disease Control and Prevention, “overweight” refers to adults whose body mass index (BMI), a number calculated using weight and height measurements, is between 25 and 29.9. “Obese” refers to adults whose BMI is 30 or higher. Among American children and adolescents, approximately 17 percent are overweight.

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