scholarly journals Secondary Metabolites from the Liverwort Ptilidium pulcherrimum

2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Dong-Xiao Guo ◽  
Yu Du ◽  
Yan-Yan Wang ◽  
Ling-Mei Sun ◽  
Jian-Bo Qu ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Hela Cells ◽  
Aromatic Compounds ◽  
Chemical Methods ◽  
Pentacyclic Triterpenoids ◽  
Nmr Data ◽  
Extensive Analysis ◽  
Pc3 Cells

A new trinortriterpenoid, diospyrolide acetate (1) and a new diphenylmethane derivative, pulcherrimumin (12), together with ten known pentacyclic triterpenoids (2–11) and four aromatic compounds (13–16), were isolated from the liverwort Ptilidium pulcherrimum. Their structures were established on the basis of extensive analysis of NMR data and by chemical methods. The cytotoxicity of compounds 1–16 was evaluated against the PC3, MDA-MB-231, and Hela cells lines. Ursane triterpenoids 8–10 exhibited moderate cytotoxicity against PC3 cells with IC50 values ranging from 10.1 to 39.7 μM.

scholarly journals New Hydroxydecanoic Acid Derivatives Produced by an Dndophytic Yeast Aureobasidium pullulans AJF1 from Flowers of Aconitum carmichaeli

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4051
Author(s):  
Choi ◽  
Kim ◽  
Choi ◽  
Kang ◽  
Shim
Keyword(s):  
Secondary Metabolites ◽  
Aureobasidium Pullulans ◽  
Large Scale ◽  
Biologically Active ◽  
Cytotoxic Activities ◽  
Chemical Methods ◽  
Nmr Data ◽  
Aconitum Carmichaeli ◽  
Modified Mosher’S Method ◽  
Mcf 7

Endophytes have been recognized as a source for structurally novel and biologically active secondary metabolites. Among the host plants for endophytes, some medicinal plants that produce pharmaceuticals have been reported to carry endophytes, which could also produce bioactive secondary metabolites. In this study, the medicinal plant Aconitum carmichaeli was selected as a potential source for endophytes. An endophytic microorganism, Aureobasidium pullulans AJF1, harbored in the flower of Aconitum carmichaeli, was cultured on a large scale and extracted with an organic solvent. Extensive chemical investigation of the extracts resulted in isolation of three lipid type compounds (1–3), which were identified to be (3R,5R)-3,5-dihydroxydecanoic acid (1), (3R,5R)-3-(((3R,5R)-3,5-dihydroxydecanoyl)oxy)-5-hydroxydecanoic acid (2), and (3R,5R)-3-(((3R,5R)-5-(((3R,5R)-3,5-dihydroxydecanoyl)oxy)-3-hydroxydecanoyl)oxy)-5-hydroxydecanoic acid (3) by chemical methods in combination with spectral analysis. Compounds 2 and 3 had new structures. Absolute configurations of the isolated compounds (1–3) were established using modified Mosher’s method together with analysis of NMR data for their acetonide derivatives. All the isolates (1–3) were evaluated for antibiotic activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and their cytotoxicities against MCF-7 cancer cells. Unfortunately, they showed low antibiotic activities and cytotoxic activities.

scholarly journals Scabiosa Genus: A Rich Source of Bioactive Metabolites

Medicines ◽  
2018 ◽  
Vol 5 (4) ◽  
pp. 110 ◽  
Author(s):  
Diana Pinto ◽  
Naima Rahmouni ◽  
Noureddine Beghidja ◽  
Artur Silva
Keyword(s):  
Secondary Metabolites ◽  
Liver Diseases ◽  
Mediterranean Region ◽  
Folk Medicine ◽  
In Vivo Studies ◽  
Bioactive Metabolites ◽  
Pentacyclic Triterpenoids ◽  
Medical Settings ◽  
Plant Names

The genus Scabiosa (family Caprifoliaceae) is considered large (618 scientific plant names of species) although only 62 have accepted Latin binominal names. The majority of the Scabiosa species are widely distributed in the Mediterranean region and some Scabiosa species are used in traditional medicine systems. For instance, Scabiosa columbaria L. is used traditionally against diphtheria while S. comosa Fisch. Ex Roem. and Schult. is used in Mongolian and Tibetan traditional medical settings to treat liver diseases. The richness of Scabiosa species in secondary metabolites such as iridoids, flavonoids and pentacyclic triterpenoids may contribute to its use in folk medicine. Details on the most recent and relevant pharmacological in vivo studies on the bioactive secondary metabolites isolated from Scabiosa species will be summarized and thoroughly discussed.

scholarly journals Volatilome and Essential Oil of Ulomoides dermestoides: A Broad-Spectrum Medical Insect

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6311
Author(s):  
Paulina J. Cázares-Samaniego ◽  
Claudia G. Castillo ◽  
Miguel A. Ramos-López ◽  
Marco M. González-Chávez
Keyword(s):  
Secondary Metabolites ◽  
Essential Oil ◽  
Essential Oils ◽  
Traditional Medicine ◽  
Broad Spectrum ◽  
Alternative Treatment ◽  
Aromatic Compounds ◽  
Therapeutic Potential ◽  
Pharmacological Interest ◽  
Main Components

Ulomoides dermestoides are used as a broad-spectrum medical insect in the alternative treatment of various diseases. Preliminary volatilome studies carried out to date have shown, as the main components, methyl-1,4-benzoquinone, ethyl-1,4-benzoquinone, 1-tridecene, 1-pentadecene, and limonene. This work focused on the production of metabolites and their metabolic variations in U. dermestoides under stress conditions to provide additional valuable information to help better understand the broad-spectrum medical uses. To this end, VOCs were characterized by HS-SPME with PEG and CAR/PDMS fibers, and the first reported insect essential oils were obtained. In HS-SMPE, we found 17 terpenes, six quinones, five alkenes, and four aromatic compounds; in the essential oils, 53 terpenes, 54 carboxylic acids and derivatives, three alkynes, 12 alkenes (1-Pentadecene, EOT1: 77.6% and EOT2: 57.9%), 28 alkanes, nine alkyl disulfides, three aromatic compounds, 19 alcohols, three quinones, and 12 aldehydes were identified. Between both study approaches, a total of 171 secondary metabolites were identified with no previous report for U. dermestoides. A considerable number of the identified metabolites showed previous studies of the activity of pharmacological interest. Therefore, considering the wide variety of activities reported for these metabolites, this work allows a broader vision of the therapeutic potential of U. dermestoides in traditional medicine.

scholarly journals Malagasy Liverworts, Source of New and Biologically Active Compounds

2007 ◽  
Vol 2 (6) ◽  
pp. 1934578X0700200 ◽  
Author(s):  
Liva Harinantenaina ◽  
Yoshinori Asakawa
Keyword(s):  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Aromatic Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Raw 264.7 ◽  
Strong Inhibition ◽  
Phytochemical Investigation

The phytochemical investigation of eight Jungermaniales liverwort species: Bazzania decrescens, B. madagassa (Lepidoziaceae), Plagiochila barteri, P. terebrans (Plagiochilaceae), Isotachis aubertii (Isotachidaceae), Mastigophora diclados (Lepicoleaceae), Radula appressa (Radulaceae), and Thysananthus spathulistipus (Lejeuneaceae), collected from Madagascar, has been carried out to afford new and structurally interesting terpenoids and aromatic compounds. The biological activities of the isolated secondary metabolites were determined and the herbertene-type sesquiterpenoids were shown to have antibacterial activity. A new ent-clerodane diterpene from Thysananthus spathulistipus and bis-bibenzyls-type aromatic compounds exhibited strong inhibition of NO production in RAW 264.7 cells, while marchantin C produced moderate α-glucosidase inhibition. The chemosystematics of the studied species are discussed.

scholarly journals Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2577 ◽  
Author(s):  
Hongjing Dong ◽  
Yanling Geng ◽  
Xueyong Wang ◽  
Xiangyun Song ◽  
Xiao Wang ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
2D Nmr ◽  
No Production ◽  
Inhibitory Effects ◽  
Nmr Data ◽  
Extensive Analysis ◽  
Ic50 Values ◽  
Monoterpene Glycoside ◽  
Anti Inflammatory

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.

scholarly journals Quantum Chemical Investigation of Polychlorinated Dibenzodioxins, Dibenzofurans and Biphenyls: Relative Stability and Planarity Analysis

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5697
Author(s):  
Sopanant Datta ◽  
Taweetham Limpanuparb
Keyword(s):  
Aromatic Compounds ◽  
Relative Stability ◽  
Quantum Chemical ◽  
Prediction Models ◽  
Toxicity Prediction ◽  
Chemical Methods ◽  
Quantum Chemical Investigation ◽  
Polychlorinated Dibenzodioxins ◽  
Quantum Chemical Methods

All the possible polychlorinated aromatic compounds in the classes of dibenzodioxins (PCDDs), dibenzofurans (PCDFs), and biphenyls (PCBs) were studied by the quantum chemical methods of HF/6-311++G(d,p), B3LYP/6-311++G(d,p), and MP2/cc-pVTZ. The calculated stabilities and structures of these compounds were compared with the available data on their abundance and toxicity. Prediction models for trends in energy and planarity among these congeners were proposed. The results discussed here can help contribute to the understanding of the role of dioxin-like compounds (DLCs) in the environment.

scholarly journals Coconut inflorescence sap mediated synthesis of silver nanoparticles and its diverse antimicrobial properties

2019 ◽  
Author(s):  
M.K. Rajesh ◽  
K.S. Muralikrishna ◽  
Swapna S. Nair ◽  
B. Krishna Kumar ◽  
T.M. Subrahmanya ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Silver Nanoparticles ◽  
Secondary Metabolites ◽  
Hela Cells ◽  
Pathogenic Bacteria ◽  
Incubation Temperature ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Biological Origin ◽  
Synthesis Of Nanoparticles

ABSTRACTGreen synthesis of nanoparticles (NPs) involves the use of diverse extracts of biological origin as substrates to synthesize nanoparticles and can overcome the hazards associated with chemical methods. Coconut inflorescence sap, which is unfermented phloem sap obtained by tapping of coconut inflorescence, is a rich source of sugars and secondary metabolites. In this study, coconut inflorescence sap was used to synthesize silver nanoparticles (AgNPs). We have initially undertaken metabolomic profiling of coconut inflorescence sap from West Coast Tall cultivar to delineate its individual components. Secondary metabolites constituted the major portion of the inflorescence sap along with sugars, lipids and, peptides. The concentration of silver nitrate, inflorescence sap and incubation temperature for synthesis of AgNPs were optimized. Incubating the reaction mixture at 40°C was found to enhance AgNP synthesis. The AgNPs synthesized were characterized using UV-Visible spectrophotometry, X-Ray Diffraction (XRD), Fourier Transform Infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM) and Transmission Electron Microscopy (TEM). Antimicrobial property of AgNP was tested in tissue culture of arecanut (Areca catechu L.) where bacterial contamination (Bacillus pumilus) was a frequent occurrence. Significant reduction in the contamination was observed when plantlets were treated with aqueous solutions of 0.01, 0.02 and 0.03% of AgNPs for one hour. Notably, treatment with AgNPs did not affect growth and development of the arecanut plantlets. Cytotoxicity of AgNPs was quantified in HeLa cells. Viability (%) of HeLa cells declined significantly at 10 ppm concentration of AgNP and complete mortality was observed at 60 ppm. Antimicrobial properties of AgNPs synthesized from inflorescence sap were also evaluated and confirmed in human pathogenic bacteria viz., Salmonella sp., Vibrio parahaemolyticus, and Escherichia coli. The study concludes that unfermented inflorescence sap, with above neutral pH, serves as an excellent reducing agent to synthesize AgNPs from Ag+. Graphical abstract

scholarly journals Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 385 ◽  
Author(s):  
Holly Siddique ◽  
Barbara Pendry ◽  
M. Mukhlesur Rahman
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Mass Spectra ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Drug Resistant ◽  
Two Dimensional ◽  
Methicillin Resistant ◽  
One Dimensional ◽  
Nmr Data

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (1H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

scholarly journals Two Novel Diphenolic Metabolites from the Inedible Mushroom Thelephora palmata

2016 ◽  
Vol 11 (8) ◽  
pp. 1934578X1601100
Author(s):  
Ayako Nishio ◽  
Haruka Mikami ◽  
Hiroshi Imagawa ◽  
Toshihiro Hashimoto ◽  
Masami Tanaka ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bacillus Subtilis ◽  
Secondary Metabolites ◽  
Heteronuclear Nmr ◽  
Data Interpretation ◽  
Antimicrobial Activities ◽  
Fruiting Bodies ◽  
Nmr Data ◽  
Bioactive Secondary Metabolites

During the search for bioactive secondary metabolites, thelepalmatins A and B (1 and 2) were isolated from the fresh fruiting bodies of Thelephora palmata, together with four known compounds (3-6). Their structures were elucidated using MS analyses, and extensive 2D-heteronuclear NMR data interpretation. Compounds 3, 4 and 6 showed antimicrobial activities against Staphylococcus aureus and Bacillus subtilis with MIC values of 21.7-70.4 μM.

scholarly journals New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2

Marine Drugs ◽  
2019 ◽  
Vol 18 (1) ◽  
pp. 18 ◽  
Author(s):  
Yan Xu ◽  
Ruibao Huang ◽  
Hongwei Liu ◽  
Tingting Yan ◽  
Wanjing Ding ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Secondary Metabolites ◽  
Single Crystal ◽  
Nitric Oxide Production ◽  
Activated Macrophages ◽  
X Ray Diffraction ◽  
Chemical Methods ◽  
X Ray ◽  
Oxide Production ◽  
Ic50 Value

Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D–G (1–4) and letendronols A–C (5–7)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher’s method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 86 μM.

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