scholarly journals The Bioactivities and Potential Clinical Values of Angelica Sinensis Polysaccharides

2021 ◽  
Vol 16 (3) ◽  
pp. 1934578X2199732
Author(s):  
Shi-Jie Bi ◽  
Rui-Jia Fu ◽  
Jia-Jia Li ◽  
Yan-Yan Chen ◽  
Yu-Ping Tang
Keyword(s):  
Biological Activities ◽  
Volatile Oil ◽  
Extraction Methods ◽  
Chemical Components ◽  
Angelica Sinensis ◽  
Chemical Compositions ◽  
Chronic Anemia ◽  
Angelica Sinensis Radix ◽  
Research Prospect ◽  
Further Development

Angelica sinensis Radix (ASR), one of the most commonly used traditional Chinese medicines, contains many chemical components such as polysaccharides, volatile oil, flavonoids, amino acids, and organic acids, among which polysaccharides play an indispensable role in the therapeutic effect of ASR. A. sinensis polysaccharide (ASP) has many biological activities, for instance, hematopoietic, anti-tumor, and liver protection, which are closely related to the treatment of human diseases such as chronic anemia, leukemia, and diabetes. In addition, there are excellent application prospects for drug delivery in nanoparticles. This paper reviews the chemical compositions, extraction methods, biological activity, action mechanism, potential clinical applications, nanoparticles, and research prospect of ASP from 2010 to 2020, so as to provide references for its further development.

scholarly journals The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Zhang ◽  
Yuewu Wang ◽  
Song Yang ◽  
Yunfeng Xiao ◽  
Haibin Guan ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Biological Activities ◽  
Biological Effects ◽  
Chinese Herb ◽  
Principal Component ◽  
Deficiency Syndrome ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Kidney Deficiency ◽  
Cistanche Deserticola

As a well-known Chinese herb medicine, the Cistanche deserticola has been used for the treatment of kidney deficiency syndrome in China for thousands of years. Both the raw product of Cistanche deserticola slices (RCD) and its Wine Steam-Processed Product (WSCD) are used clinically for different effects. In this study, the influences of steaming process with wine (SPW) from Cistanche deserticola on chemical compositions and biological effects were investigated. The principal component analysis (PCA) and quantitative analysis were used to study the differences of the chemical compositions. The effects of nourishing kidney were also investigated to compare the differences between the RCD and the WSCD. The PCA results indicated that the obvious separation was achieved in the RCD and WSCD. The results of quantitative analysis showed that the WSCD has higher amounts of total polysaccharides, total PhGs, isoacteoside, and osmanthuside B than RCD, while the content of 2′-acetylacteoside and acteoside decreased after the SPW. The comparison of RCD and WSCD on biological activities showed that both could restore the level of sex hormone in the model of kidney-yang deficiency and improve the antioxidant effect. The WSCD were much better in increasing the viscera weight of kidney and seminal vesicle. The results indicated that SPW changed its chemical components and enhanced its biological activities.

scholarly journals Chemical Compositions and Biological Activities of Scutellaria Genus Essential Oils (Lamiaceae)

2020 ◽  
Vol 15 (3) ◽  
Author(s):  
Jamal Kasaian ◽  
Peiman Alesheikh ◽  
Ameneh Mohammadi
Keyword(s):  
Essential Oils ◽  
Recent Literature ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Hexadecanoic Acid ◽  
Current Review ◽  
Germacrene D ◽  
Medicinal Properties

Context: Essential oils are secondary metabolites with versatile organic structures that, due to their compounds, have useful medicinal properties. There are about 250 species of the genus of Scutellaria perennial flowering plants from the Lamiaceae family. Its application for the treatment of allergy, inflammatory, hyperlipidemia, arteriosclerosis, hypertension, and hepatitis has a long history. Evidence Acquisition: Various studies on the chemical compounds of the Scutellaria genus have identified several ‎compounds, especially essentials oils. The current review is based on the evidence found in Chemical Abstract, Science Direct, Scopus, PubMed, Web of Knowledge, and Google Scholar databases. Results: Many studies on the chemical components of essential oils from the Scutellaria genus have identified several compounds. We summarized the chemical compositions and biological activities of Scutellaria essential oils. Hexadecanoic acid, germacrene D, β-caryophyllene, linalool, β-farnesene, and eugenol are the main compounds in essential oils of this genus. Despite many reports about essential oils of Scutellaria species (more than 38), a large number of species have not been studied yet. Therefore, several studies should be conducted on the chemical compounds and biological activities of unstudied Scutellaria essential oils. Conclusions: This review has summarized reports on the chemistry and biological activities of Scutellaria essential oils,‎ such as antioxidant, antimicrobial, antifeedant, phytotoxic, and acaricidal toxicities, based on the recent literature.

scholarly journals Chemical Composition and Enzymatic Screening of Micromeria fruticosa serpyllifolia Volatile Oils Collected from Three Different Regions of West Bank, Palestine

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nihaya Salameh ◽  
Naser Shraim ◽  
Nidal Jaradat
Keyword(s):  
Plant Extracts ◽  
Biological Activities ◽  
West Bank ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Therapeutic Effects ◽  
Volatile Oils ◽  
Ic50 Values ◽  
Micromeria Fruticosa

Introduction. Volatile oils (VOs) have been commonly used in cosmetics and food as fragrances, flavoring, and preservative agents or in alternative medicine for their therapeutic effects. This necessitates investigating those plants and their VOs. This study was conducted to investigate the chemical compositions of the VOs of Micromeria fruticosa serpyllifolia growing widely in three regions in Palestine (i.e., Hebron, Ramallah, and Nablus districts representing south, middle, and north of West Bank). Afterwards, VOs were subjected to in vitro screening and their enzymatic properties were compared. Methods. The analysis of chemical components of VOs was performed by gas chromatography coupled with mass spectrometry (GC-MS). The antilipase activity was evaluated using porcine pancreatic lipase and p-nitrophenyl butyrate. The antiamylase activity was assessed using porcine pancreatic α-amylase, starch, and 3,5-dinitrosalicylic. Results. Plant extracts yield range was 0.67 to 0.99 w/w%. GC-MS analysis showed the high percentages of oxygenated components in the range of 86.1-89.88% and nonoxygenated components in the range of 4.38-4.71%. Seven components were observed, pulegone was the most abundant component in the three samples in the range of 74.43-86.04%, and isomenthone was the second most abundant component with the range of 3.16-14.41%. The sample collected from Nablus showed the most potent antilipase and antiamylase activity with IC50 values of 39.81 μg/mL and 3.31 μg/mL, respectively. Conclusions. The study showed that Micromeria fruticosa serpyllifolia volatile oils samples from different regions in Palestine contained different proportions of phytochemicals which provided different potential biological activities such as antiobesity and antidiabetes activities that were in line with traditional uses of the plant extracts. The plant extracts showed higher antilipase and antiamylase potency than that of the relative references and there were significant differences in these activities compared to each other.

scholarly journals Relationship between the Chemical Composition and the Biological Functions of Coffee

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7634
Author(s):  
Shah Saud ◽  
Ahmad Mohammad Salamatullah
Keyword(s):  
Chemical Composition ◽  
Blood Sugar ◽  
Biological Function ◽  
Biological Activities ◽  
Chemical Components ◽  
Biological Functions ◽  
Coffee Plant ◽  
Theoretical Support ◽  
The World ◽  
Further Development

Coffee is a Rubiaceae coffee plant ranked as the first of the three most important beverages in the world, with effects including lowering blood sugar, protecting the liver, and protecting the nerves. Coffee contains many chemical components, including alkaloids, phenolic acids, flavonoids, terpenoids, and so on. Chemical components in coffee are the basis of its biological function and taste. The chemical components are the basis of biological activities and form the characteristic aroma of coffee. The main chemical components and biological activities of coffee have been extensively studied, which would provide a relevant basis and theoretical support for the further development of the coffee industry.

scholarly journals Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaiferaspp.)

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Deivid C. Soares ◽  
Nathalya A. Portella ◽  
Mônica Freiman de S. Ramos ◽  
Antonio C. Siani ◽  
Elvira M. Saraiva
Keyword(s):  
Biological Activities ◽  
Raw Material ◽  
Host Cells ◽  
Chemical Compositions ◽  
Chemical Marker ◽  
Leishmanicidal Activity ◽  
Copaiba Oil ◽  
Low Toxicity ◽  
Further Development ◽  
Dose Dependent

This study investigated the leishmanicidal activity againstLeishmania amazonensisof four commercial oils fromCopaiferaspp. named as C1, C2, C3, and C4, the sesquiterpene and diterpene pools obtained from distilling C4, and isolatedβ-caryophyllene (CAR). Copaiba oils chemical compositions were analyzed by gas chromatography and correlated with biological activities. Diterpenes-rich oils C2 and C3 showed antipromastigote activity. Sesquiterpenes-rich C1 and C4, and isolated CAR presented a dose-dependent activity against intracellular amastigotes, with IC50sof 2.9 µg/mL, 2.3 µg/mL, and 1.3 µg/mL (6.4 µM), respectively. Based on the highest antiamastigote activity and the low toxicity to the host cells, C4 was steamdistillated to separate pools of sesquiterpenes and diterpenes. Both pools were less active againstL. amazonensisand more toxic for the macrophages than the whole C4 oil. The leishmanicidal activity of C3 and C4 oils, as well as C4 fractions and CAR, appears to be independent of nitric oxide production by macrophages. This study pointed outβ-caryophyllene as an effective antileishmanial compound and also to its role as potential chemical marker in copaiba oils or fractions derived thereof, aiming further development of this rainforest raw material for leishmaniasis therapy.

scholarly journals Application and Pharmacological Properties of Chinese Herb Danggui: A System Review

2020 ◽  
pp. 1-10
Author(s):  
Xi-jun Wang ◽  
Wen-xiu Li ◽  
Aihua Zhang ◽  
Jian-hua Miao ◽  
Hui Sun ◽  
...  
Keyword(s):  
Chinese Herb ◽  
Volatile Oil ◽  
Chemical Components ◽  
Angelica Sinensis ◽  
Pharmacological Activities ◽  
History Of ◽  
System Review ◽  
Cardioprotective Effects ◽  
The Relationship ◽  
Inflammatory Action

History of the usage of Angelica sinensis (Danggui in Chinese) is glorious, it often acts as monarch drug compatible in various classical formulations. Angelica sinensis can be widely used in treatment of gynecologic diseases and all kinds of blood-deficiency fever by tonifying blood and repairing vitality. It contains abundant volatile oil, organic acid and Angelica sinensis polysaccharide, coumarin, trace elements and amino acids, which possesses extensive pharmacological activities include resistant to cancer and tumour, regulation of blood system, hepatoprotective effects, anti-inflammatory action, antioxidant activity, protection of nervous system, as well as cardioprotective effects. Based on numerous reports and the published scientific literature recent years, an extensive review of research on chemical components, pharmacological activities and the compatibility application of Angelica sinensis were conducted. The relationship between active ingredients and the corresponding pharmacological effects, as well as commonly used couplet medicines and the utility in clinic were simultaneously summarized.

ANTICANCER EFFECT OF UVARIA GENUS

2014 ◽  
pp. 98-101
Author(s):  
Thi Bich Hien Le ◽  
Viet Duc Ho ◽  
Thi Hoai Nguyen
Keyword(s):  
Biological Activities ◽  
Current Trend ◽  
Healthcare Systems ◽  
Chemical Compositions ◽  
Cancer Therapies ◽  
Pharmacological Effects ◽  
Anticancer Effect ◽  
Anti Cancer ◽  
Tropical Areas ◽  
Cancer Activity

Nowadays, cancer treatment has been a big challenge to healthcare systems. Most of clinical anti-cancer therapies are toxic and cause adverse effects to human body. Therefore, current trend in science is seeking and screening of natural compounds which possess antineoplastic activities to utilize in treatment. Uvaria L. - Annonaceae includes approximately 175 species spreading over tropical areas of Asia, Australia, Africa and America. Studies on chemical compositions and pharmacological effects of Uvaria showed that several compound classes in this genus such as alkaloid, flavonoid, cyclohexen derivaties, acetogenin, steroid, terpenoid, etc. indicate considerable biological activities, for example anti-tumor, anti-cancer, antibacterial, antifungal, antioxidant, etc. Specifically, anti-cancer activity of fractions of extract and pure isolated compounds stands out for cytotoxicity against many cancer cell lines. This study provides an overview of anti-cancer activity of Uvaria and suggests a potential for further studies on seeking and developing novel anti-cancer compounds. Key words: Anti-cancer, Uvaria.

Novel Piperazine Amides of Cinnamic Acid Derivatives as Tyrosinase Inhibitors

2018 ◽  
Vol 16 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Zehra Tuğçe Gür ◽  
Fatma Sezer Şenol ◽  
Suhaib Shekfeh ◽  
İlkay Erdoğan Orhan ◽  
Erden Banoğlu ◽  
...  
Keyword(s):  
Cinnamic Acid ◽  
Active Site ◽  
Agaricus Bisporus ◽  
Biological Activities ◽  
Docking Simulation ◽  
Cinnamic Acid Derivatives ◽  
In Silico Docking ◽  
Amide Derivatives ◽  
Tyrosinase Inhibitors ◽  
Further Development

Background: A series of novel cinnamic acid piperazine amide derivatives has been designed and synthesized, and their biological activities were also evaluated as potential tyrosinase inhibitors. Methods: Compounds 9, 11 and 17 showed the most potent biological activity (IC50 = 66.5, 61.1 and 66 µM, respectively). In silico docking simulation was performed to position compound 11 into the Agaricus bisporus mushroom tyrosinase’s active site to determine the putative binding interactions. Results and Conclusion: The results indicated that compound 11 could serve as a promising lead compound for further development of potent tyrosinase inhibitors.

Sign in / Sign up

Export Citation Format

Share Document