scholarly journals The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Zhang ◽  
Yuewu Wang ◽  
Song Yang ◽  
Yunfeng Xiao ◽  
Haibin Guan ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Biological Activities ◽  
Biological Effects ◽  
Chinese Herb ◽  
Principal Component ◽  
Deficiency Syndrome ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Kidney Deficiency ◽  
Cistanche Deserticola

As a well-known Chinese herb medicine, the Cistanche deserticola has been used for the treatment of kidney deficiency syndrome in China for thousands of years. Both the raw product of Cistanche deserticola slices (RCD) and its Wine Steam-Processed Product (WSCD) are used clinically for different effects. In this study, the influences of steaming process with wine (SPW) from Cistanche deserticola on chemical compositions and biological effects were investigated. The principal component analysis (PCA) and quantitative analysis were used to study the differences of the chemical compositions. The effects of nourishing kidney were also investigated to compare the differences between the RCD and the WSCD. The PCA results indicated that the obvious separation was achieved in the RCD and WSCD. The results of quantitative analysis showed that the WSCD has higher amounts of total polysaccharides, total PhGs, isoacteoside, and osmanthuside B than RCD, while the content of 2′-acetylacteoside and acteoside decreased after the SPW. The comparison of RCD and WSCD on biological activities showed that both could restore the level of sex hormone in the model of kidney-yang deficiency and improve the antioxidant effect. The WSCD were much better in increasing the viscera weight of kidney and seminal vesicle. The results indicated that SPW changed its chemical components and enhanced its biological activities.

scholarly journals The Difference of Chemical Components and Biological Activities of the Crude Products and the Salt-Processed Product from Semen Cuscutae

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Song Yang ◽  
Hefang Xu ◽  
Baosheng Zhao ◽  
Shasha Li ◽  
Tingting Li ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Biological Activities ◽  
Biological Effects ◽  
Principal Component ◽  
Deficiency Syndrome ◽  
Antioxidant Effect ◽  
Chemical Components ◽  
Crude Product ◽  
Kidney Yang Deficiency ◽  
The Difference

Semen Cuscutae is a well-known Chinese medicine which has been used to nourish kidney in China for thousands of years. The crude product of semen Cuscutae (CP) and its salt-processed product (SPP) are separately used in clinic for their different effects. The study was designed to investigate the influence of processing from semen Cuscutae on chemical components and biological effects. The principal component analysis and quantitative analysis were used to study the differences of the chemical components. The effects of nourishing kidney were detected to compare the differences between the CP and SPP. The PCA results showed that the obvious separation was achieved in the CP and SPP samples. The results of quantitative analysis showed that quercetin and total flavonoids had significantly increased after salt processing while hyperoside had decreased. The comparison of CP and SPP on biological activities showed that both of them could ameliorate the kidney-yang deficiency syndrome by restoring the level of sex hormone, improving the immune function and antioxidant effect. However, SPP was better in increasing the level of T and the viscera weight of testicle and epididymis, improving the antioxidant effect. The results suggested that salt processing changed its chemical profile, which in turn enhanced its biological activities.

scholarly journals Correlation Between Quality and Geographical Origins of Leonuri Herba Revealed By the Qualitative Fingerprint Profiling and Quantitative Determination of Chemical Components

2021 ◽  
Author(s):  
Kelly Yinching Lam ◽  
Yinghao Wang ◽  
Tszking Lam ◽  
Chuenfai Ku ◽  
Wingping Yeung ◽  
...  
Keyword(s):  
Principal Component ◽  
Chinese Herbs ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Chemical Fingerprints ◽  
Chemical Discrimination ◽  
Chromatographic Peaks ◽  
And Cluster Analysis ◽  
Different Origins

Abstract BackgroundLeonuri Herba (Yimucao) is a very commonly Chinese herbs for treating menstrual and maternal diseases for thousands of years in China. However, the herb collected in different origins was easily found in the markets which induce the unstable quality for clinic use. In this study, a comprehensive strategy of using multiple chromatographic analysis and chemometric analysis was firstly investigated for chemical discrimination of Leonuri Herba from different geographical origins.MethodsUHPLC-QTOF-MS/MS was applied to identify the peaks of Leonuri Herba and chemical fingerprints were established in 30 batches from different geographical origins. Meanwhile, dissimilarities of chemical compositions among different origins were further investigated by principal component analysis and cluster analysis.ResultsA total of 49 chromatographic peaks of Leonuri Herba were unequivocally or tentatively identified by UHPLC-QTOF-MS/MS. Leonuri Herba were classified into four categories, and eight major compounds detected could be used as chemical markers for discrimination. Also, the eight components, including leonurine, 4',5-dihydroxy-7-methoxyflavone, rutin, hyperoside, apigenin, quercetin, kaempferol and salicylic acid, were simultaneously quantified using the extracting ion mode of UHPLC-QTOF-MS/MS.ConclusionThis systematic information could ensure Leonuri Herba with well-controlled quality and safe use in clinic. This study could also provide a research model for further study of other Chinese Materia Medica.

scholarly journals Chemical Compositions and Biological Activities of Scutellaria Genus Essential Oils (Lamiaceae)

2020 ◽  
Vol 15 (3) ◽  
Author(s):  
Jamal Kasaian ◽  
Peiman Alesheikh ◽  
Ameneh Mohammadi
Keyword(s):  
Essential Oils ◽  
Recent Literature ◽  
Biological Activities ◽  
Chemical Compounds ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Hexadecanoic Acid ◽  
Current Review ◽  
Germacrene D ◽  
Medicinal Properties

Context: Essential oils are secondary metabolites with versatile organic structures that, due to their compounds, have useful medicinal properties. There are about 250 species of the genus of Scutellaria perennial flowering plants from the Lamiaceae family. Its application for the treatment of allergy, inflammatory, hyperlipidemia, arteriosclerosis, hypertension, and hepatitis has a long history. Evidence Acquisition: Various studies on the chemical compounds of the Scutellaria genus have identified several ‎compounds, especially essentials oils. The current review is based on the evidence found in Chemical Abstract, Science Direct, Scopus, PubMed, Web of Knowledge, and Google Scholar databases. Results: Many studies on the chemical components of essential oils from the Scutellaria genus have identified several compounds. We summarized the chemical compositions and biological activities of Scutellaria essential oils. Hexadecanoic acid, germacrene D, β-caryophyllene, linalool, β-farnesene, and eugenol are the main compounds in essential oils of this genus. Despite many reports about essential oils of Scutellaria species (more than 38), a large number of species have not been studied yet. Therefore, several studies should be conducted on the chemical compounds and biological activities of unstudied Scutellaria essential oils. Conclusions: This review has summarized reports on the chemistry and biological activities of Scutellaria essential oils,‎ such as antioxidant, antimicrobial, antifeedant, phytotoxic, and acaricidal toxicities, based on the recent literature.

scholarly journals Chemical Composition and Enzymatic Screening of Micromeria fruticosa serpyllifolia Volatile Oils Collected from Three Different Regions of West Bank, Palestine

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Nihaya Salameh ◽  
Naser Shraim ◽  
Nidal Jaradat
Keyword(s):  
Plant Extracts ◽  
Biological Activities ◽  
West Bank ◽  
Chemical Components ◽  
Chemical Compositions ◽  
Therapeutic Effects ◽  
Volatile Oils ◽  
Ic50 Values ◽  
Micromeria Fruticosa

Introduction. Volatile oils (VOs) have been commonly used in cosmetics and food as fragrances, flavoring, and preservative agents or in alternative medicine for their therapeutic effects. This necessitates investigating those plants and their VOs. This study was conducted to investigate the chemical compositions of the VOs of Micromeria fruticosa serpyllifolia growing widely in three regions in Palestine (i.e., Hebron, Ramallah, and Nablus districts representing south, middle, and north of West Bank). Afterwards, VOs were subjected to in vitro screening and their enzymatic properties were compared. Methods. The analysis of chemical components of VOs was performed by gas chromatography coupled with mass spectrometry (GC-MS). The antilipase activity was evaluated using porcine pancreatic lipase and p-nitrophenyl butyrate. The antiamylase activity was assessed using porcine pancreatic α-amylase, starch, and 3,5-dinitrosalicylic. Results. Plant extracts yield range was 0.67 to 0.99 w/w%. GC-MS analysis showed the high percentages of oxygenated components in the range of 86.1-89.88% and nonoxygenated components in the range of 4.38-4.71%. Seven components were observed, pulegone was the most abundant component in the three samples in the range of 74.43-86.04%, and isomenthone was the second most abundant component with the range of 3.16-14.41%. The sample collected from Nablus showed the most potent antilipase and antiamylase activity with IC50 values of 39.81 μg/mL and 3.31 μg/mL, respectively. Conclusions. The study showed that Micromeria fruticosa serpyllifolia volatile oils samples from different regions in Palestine contained different proportions of phytochemicals which provided different potential biological activities such as antiobesity and antidiabetes activities that were in line with traditional uses of the plant extracts. The plant extracts showed higher antilipase and antiamylase potency than that of the relative references and there were significant differences in these activities compared to each other.

scholarly journals The Bioactivities and Potential Clinical Values of Angelica Sinensis Polysaccharides

2021 ◽  
Vol 16 (3) ◽  
pp. 1934578X2199732
Author(s):  
Shi-Jie Bi ◽  
Rui-Jia Fu ◽  
Jia-Jia Li ◽  
Yan-Yan Chen ◽  
Yu-Ping Tang
Keyword(s):  
Biological Activities ◽  
Volatile Oil ◽  
Extraction Methods ◽  
Chemical Components ◽  
Angelica Sinensis ◽  
Chemical Compositions ◽  
Chronic Anemia ◽  
Angelica Sinensis Radix ◽  
Research Prospect ◽  
Further Development

Angelica sinensis Radix (ASR), one of the most commonly used traditional Chinese medicines, contains many chemical components such as polysaccharides, volatile oil, flavonoids, amino acids, and organic acids, among which polysaccharides play an indispensable role in the therapeutic effect of ASR. A. sinensis polysaccharide (ASP) has many biological activities, for instance, hematopoietic, anti-tumor, and liver protection, which are closely related to the treatment of human diseases such as chronic anemia, leukemia, and diabetes. In addition, there are excellent application prospects for drug delivery in nanoparticles. This paper reviews the chemical compositions, extraction methods, biological activity, action mechanism, potential clinical applications, nanoparticles, and research prospect of ASP from 2010 to 2020, so as to provide references for its further development.

scholarly journals Metabolomic Profiling and Biological Activities of Pleurotus columbinus Quél. Cultivated on Different Agri-Food Byproducts

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1245
Author(s):  
Paola Angelini ◽  
Roberto Maria Pellegrino ◽  
Bruno Tirillini ◽  
Giancarlo Angeles Flores ◽  
Husam B. R. Alabed ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Biological Activities ◽  
Biological Effects ◽  
Antioxidant Properties ◽  
Principal Component ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Ms Analysis ◽  
Quantitative Hplc ◽  
Mushroom Extracts

The genus Pleurotus (Fr.) P. Kumm (Pleurotaceae, Basidiomycota) comprises a cosmopolitan group of mushrooms highly appreciated for their nutritional value and health-promoting benefits. Despite there being many studies about the phytochemical composition of Pleurotus spp., there are very few reports dealing with the phytochemistry, antioxidant and antimicrobial activities of P. columbinus Quél. In this study, a mass spectrometry ultra-performance liquid chromatography mass spectrometry (UHPLC)-QTOF method, coupled with principal component analysis (PCA), was applied to the P. columbinus metabolome in order to investigate the influence of different agri-food residues as growth substrates for P. columbinus cultivation, on the bioactive chemical profile of fruiting bodies and evaluated their potential as antioxidants and antimicrobials. Additionally, a quantitative HPLC-DAD-MS analysis was conducted on phenolic and flavonoid compounds, that could explain, albeit partially, the observed biological effects of P. columbinus extracts. The qualitative metabolic profile identified 97 metabolites, whereas the quantitative HPLC-DAD-MS analysis confirmed the presence of phenolic and flavonoids, in the mushroom extracts, which also showed intrinsic scavenging/reducing and antimicrobial effects. The antibacterial effects were particularly evident against Escherichia coli, whereas Tricophyton and Aspergillus were the dermatophytes more sensitive to the mushroom extracts. The present study supports more in-depth investigations, aimed at evaluating the influence of growth substrate on P. columbinus antimicrobial and antioxidant properties. The extracts from P. columbinus revealed valuable sources of primary and secondary metabolites, thus suggesting potential applications in the formulation of food supplements with biological properties, above all in terms of antioxidant and antimicrobial properties.

scholarly journals Quantitative Analysis of 7 Compounds in Diospyros lotus Leaf Extract and Its Biological Effects on Neuroprotection and Antineuroinflammation

2020 ◽  
Vol 15 (5) ◽  
pp. 1934578X2092485
Author(s):  
Yu Jin Kim ◽  
Hye-Sun Lim ◽  
Joo-Hwan Kim ◽  
MinKyun Na ◽  
Soo-Jin Jeong
Keyword(s):  
Quantitative Analysis ◽  
Biological Activities ◽  
Biological Effects ◽  
Amyloid Β ◽  
Neuronal Cell ◽  
Ethanol Extract ◽  
Prostaglandin E ◽  
Diospyros Lotus ◽  
Aβ Aggregation ◽  
Lotus Leaves

Diospyros lotus L. (Ebenaceae) is a deciduous plant that was traditionally used to treat various diseases such as sedation, constipation, and hypertension. However, its effects on Alzheimer’s diseases (AD) have not been reported. We investigated the potent biological effects of D. lotus on AD and performed quantitative analysis of 7 standard compounds in D. lotus leaves. First, two parts leaf and branch of D. lotus were compared to examine the effects on amyloid-β (Aβ) aggregation and oxidative stress. Ethanol extract of D. lotus leaves (EDLL) had higher activities on the Aβ disaggregation and antioxidation compared with ethanol extract of D. lotus branches (EDLB). Second, we have focused on the biological activities of EDLL for neurocellular analyses. In HT22 neuronal cells, EDLL reversed hydrogen peroxide (H2O2)-damaged cell death. In BV-2 microglia, EDLL suppressed lipopolysaccharide-stimulated productions of nitric oxide (NO) and prostaglandin E2. Third, we performed quantitative analyses of 7 standard compounds in D. lotus using high-performance liquid chromatography. Among 7 compounds, myricitrin (44.189 mg/g) was the most abundant compound in EDLL. Myricetin presented the marked inhibitory effect on Aβ aggregation, indicating its potential as a bioactive compound to control Aβ aggregation. Overall, this study suggests that EDLL may be a promising therapeutic agent for AD via Aβ disaggregation, and inhibition of neuronal cell damage and inflammation.

scholarly journals Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2590
Author(s):  
Dong-Kyu Lee ◽  
Seongoh Park ◽  
Nguyen Phuoc Long ◽  
Jung Eun Min ◽  
Hyung Min Kim ◽  
...  
Keyword(s):  
Biological Activities ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Principal Component ◽  
Research Quality ◽  
Pharmacological Effects ◽  
Multivariate Modeling ◽  
Linear Regression Models ◽  
Red Ginseng ◽  
Black Ginseng

Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the pharmacological effects of red ginseng and black ginseng. We searched reported studies on the pharmaceutical effects and composition of ginsenosides and assigned numeric scores using nonlinear principal component analysis, based on discretization measures for the included publications. Downstream weighted linear regression models were constructed to study the eight major biological activities that are generally known to be exhibited by red ginseng. Our statistical model, based on available ordinal information gathered from previous literature, helped in comparing the overlapping effects of black ginseng. Black ginseng showed antioxidant effects comparable to those of red ginseng; however, this variant was inferior to red ginseng in enhancing immunity, relieving fatigue, alleviating depression/anxiety, decreasing body fat, and reducing blood pressure. We have showed a cost-efficient method to indirectly evaluate the biological effects of ginseng products using data from published articles. This method can also be used to compare the nutritional and medicinal value of herbal medicines that share similar compositions of bioactive compounds.

scholarly journals Chemical Composition, Antioxidant and Anti-Inflammatory Activities of Clary Sage and Coriander Essential Oils Produced on Polluted and Amended Soils-Phytomanagement Approach

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5321
Author(s):  
Robin Raveau ◽  
Joël Fontaine ◽  
Anthony Verdin ◽  
Loris Mistrulli ◽  
Frédéric Laruelle ◽  
...  
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Biological Effects ◽  
Biological Properties ◽  
Chemical Compositions ◽  
Experimental Conditions ◽  
Aerial Parts ◽  
Mycorrhizal Inoculation ◽  
Anti Inflammatory

The potential of essential oils (EO), distilled from two aromatic plants—clary sage (Salvia sclarea L.) and coriander (Coriandrum sativum L.)—in view of applications as natural therapeutic agents was evaluated in vitro. These two were cultivated on a trace element (TE)-polluted soil, as part of a phytomanagement approach, with the addition of a mycorrhizal inoculant, evaluated for its contribution regarding plant establishment, growth, and biomass production. The evaluation of EO as an antioxidant and anti-inflammatory, with considerations regarding the potential influence of the TE-pollution and of the mycorrhizal inoculation on the EO chemical compositions, were the key focuses. Besides, to overcome EO bioavailability and target accession issues, the encapsulation of EO in β-cyclodextrin (β-CD) was also assessed. Firstly, clary sage EO was characterized by high proportions of linalyl acetate (51–63%) and linalool (10–17%), coriander seeds EO by a high proportion of linalool (75–83%) and lesser relative amounts of γ-terpinene (6–9%) and α-pinene (3–5%) and coriander aerial parts EO by 2-decenal (38–51%) and linalool (22–39%). EO chemical compositions were unaffected by both soil pollution and mycorrhizal inoculation. Of the three tested EO, the one from aerial parts of coriander displayed the most significant biological effects, especially regarding anti-inflammatory potential. Furthermore, all tested EO exerted promising antioxidant effects (IC50 values ranging from 9 to 38 g L−1). However, EO encapsulation in β-CD did not show a significant improvement of EO biological properties in these experimental conditions. These findings suggest that marginal lands polluted by TE could be used for the production of EO displaying faithful chemical compositions and valuable biological activities, with a non-food perspective.

scholarly journals Chemical Components and Biological Effects of Genus Origanum

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Li Zhou ◽  
Fatma Al-Zahra Kamal Kamel Attia ◽  
Lijun Meng ◽  
Sitan Chen ◽  
Zhenhua Liu ◽  
...  
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Biological Effects ◽  
Chinese Herbs ◽  
Chemical Components ◽  
Pharmacological Activities ◽  
Scientific Databases ◽  
Anticancer Properties ◽  
Growth Promoting ◽  
Inflammatory Growth

The plants from genus Origanum are common folk Chinese herbs used to treat a variety of diseases. They are also used as a spice, a seasoning, and an ornament. Origanum plants are rich in essential oils and also have other compounds including terpenoids, flavonoids, organic acids, and sterols. They have a variety of biological activities such as antispasmodic, anti-inflammatory, growth-promoting, antibacterial, antioxidant, and anticancer properties. The chemical components and biological effects of genus Origanum were summarized by different scientific databases such as Web of Science, SciFinder, Baidu Scholar, PubMed, ScienceDirect, and SpringerLink. In conclusion, recent studies were mainly focused on the activities of their essential oils. The research studies for nonvolatile constituents and their pharmacological activities are few. Therefore, research on compounds in genus Origanum plants can be strengthened and their application prospect can be explored so as to make better use of the resources of these plants.

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