scholarly journals Change in Admission Rates Among Patients Presenting to Emergency Departments with VTE and Low Risk of Complications: A Retrospective Cohort Study from 11 Community Hospitals

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4694-4694
Author(s):  
William Rhoades ◽  
Rasha Khatib ◽  
Kara Nitti ◽  
Marc McDowell ◽  
Rick Szymialis ◽  
...  

Background: Venous thromboembolism (VTE) is often diagnosed in the emergency department (ED), but adherence to clinical guidelines in the management of VTE in the ED may be low. The 2016 update of the American College of Chest Physicians (CHEST) guidelines has recommended home management or early discharge instead of in-hospital treatment for patients with low risk VTE. Gaps in clinical practice and clinical guideline recommendations need to be identified to improve VTE management in the ED. Objectives: To investigate changes in management of patients with low-risk VTE who received a diagnosis in the ED before and after the February 2016 update of CHEST guidelines on antithrombotic therapy for VTE. Methods: This retrospective analysis examined patient electronic medical records from January 1, 2013 to December 31, 2018 from a large healthcare system in Illinois. Data were collected on patients presenting in 11 EDs in community hospitals who were given a primary diagnosis or discharge diagnosis of VTE based on International Classification of Diseases, Ninth Revision or Tenth Revision. VTE was categorized as low-risk if diagnosis was either lower-extremity DVT or PE and a pulmonary embolism score index (PESI) lower than 85. A multivariable logistic regression model was constructed to measure the adjusted odds of hospital admissions among patients with low-risk VTE before and after the update of the CHEST guidelines. The model was adjusted for patient demographics and clinical characteristics, type of anticoagulant administered, preexisting comorbidities, and hospital characteristics. Results: Among 2,193,965 ED visits over the 6-year period, 15,543 visits representing 14,530 patients who received diagnoses of DVT (55%) or PE (45%) were included in the analysis. The mean age was 65.0 ± 17.4 years, with 46% being male and 63% Caucasian. A total of 83% of patients with DVT were considered low risk based on DVT location and 49% of patients with PE were low risk based on PESI. The rates of hospital admission for management of low-risk VTE declined from 81% in 2013 to 73% in 2018. In the adjusted model, patients visiting EDs between 2016 and 2018 (post-update of guidelines) were equally likely to be admitted compared with patients visiting EDs between 2013 and 2015 (pre-update of guidelines; odds ratio [OR]=0.91; 95% confidence interval [CI]: 0.81, 1.02). Patients who received a diagnosis of PE compared with DVT (OR=4.90; 95% CI: 4.26, 5.64) and patients who received vitamin K antagonists compared with direct oral anticoagulants (OR=1.74; 95% CI: 1.54, 1.96) had higher odds of hospital admission. However, the presence of a pharmacist was associated with lower odds of hospital admission (OR=0.68; 95% CI: 0.55, 0.85). Conclusions: Our study results indicate that most patients receiving a diagnosis of low-risk VTE in EDs were admitted for in-hospital management despite clinical guidelines recommending otherwise. The 2016 update of CHEST guidelines recommending outpatient management had minimal effects on decreasing the rate of admissions of patients with low-risk VTE. More effort in real-world practices is needed to adopt guideline recommendations and integrate clinical evidence on new and existing treatment advances. Disclosures Rhoades: Bristol-Meyers Squibb: Research Funding. Khatib:National Institutes of Health: Research Funding; Bristol-Meyers Squibb: Research Funding; Takeda: Research Funding. Nitti:Takeda: Research Funding; Bristol-Meyers Squibb: Research Funding. McDowell:Bristol-Meyers Squibb: Research Funding. Szymialis:Bristol-Meyers Squibb: Employment. Blair:Takeda: Research Funding; Bristol-Meyers Squibb: Research Funding; National Institutes of Health: Research Funding.

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nhat Thanh Hoang Le ◽  
Nhan Thi Ho ◽  
Bryan Grenfell ◽  
Stephen Baker ◽  
Ronald B. Geskus

Abstract Background Infection with measles virus (MeV) causes immunosuppression and increased susceptibility to other infectious diseases. Only few studies reported a duration of immunosuppression, with varying results. We investigated the effect of immunosuppression on the incidence of hospital admissions for infectious diseases in Vietnamese children. Methods We used retrospective data (2005 to 2015; N = 4419) from the two pediatric hospitals in Ho Chi Minh City, Vietnam. We compared the age-specific incidence of hospital admission for infectious diseases before and after hospitalization for measles. We fitted a Poisson regression model that included gender, current age, and time since measles to obtain a multiplicative effect measure. Estimates were transformed to the additive scale. Results We observed two phases in the incidence of hospital admission after measles. The first phase started with a fourfold increased rate of admissions during the first month after measles, dropping to a level quite comparable to children of the same age before measles. In the second phase, lasting until at least 6 years after measles, the admission rate decreased further, with values up to 20 times lower than in children of the same age before measles. However, on the additive scale the effect size in the second phase was much smaller than in the first phase. Conclusion The first phase highlights the public health benefits of measles vaccination by preventing measles and immune amnesia. The beneficial second phase is interesting, but its strength strongly depends on the scale. It suggests a complicated interaction between MeV infection and the host immunity.


2020 ◽  
Vol 49 (4) ◽  
pp. 388-395
Author(s):  
Iris Q. Grunwald ◽  
Daniel J. Phillips ◽  
David Sexby ◽  
Viola Wagner ◽  
Martin Lesmeister ◽  
...  

Background: Acute stroke patients are usually transported to the nearest hospital regardless of their required level of care. This can lead to increased pressure on emergency departments and treatment delay. Objective: The aim of the study was to explore the benefit of a mobile stroke unit (MSU) in the UK National Health Service (NHS) for reduction of hospital admissions. Methods: Prospective cohort audit observation with dispatch of the MSU in the East of England Ambulance Service area in Southend-on-Sea was conducted. Emergency patients categorized as code stroke and headache were included from June 5, 2018, to December 18, 2018. Rate of avoided admission to the accident and emergency (A&E) department, rate of admission directly to target ward, and stroke management metrics were assessed. Results: In 116 MSU-treated patients, the following diagnoses were made: acute stroke, n = 33 (28.4%); transient ischaemic attacks, n = 13 (11.2%); stroke mimics, n = 32 (27.6%); and other conditions, n = 38 (32.8%). Pre-hospital thrombolysis was administered to 8 of 28 (28.6%) ischaemic stroke patients. Pre-hospital diagnosis avoided hospital admission for 29 (25.0%) patients. As hospital treatment was indicated, 35 (30.2%) patients were directly triaged to the stroke unit, 1 patient (0.9%) even directly to the catheter laboratory. Thus, only 50 (43.1%) patients required transfer to the A&E department. Moreover, the MSU enabled thrombolysis with a median dispatch-to-needle time of 42 min (interquartile range, 40–60). Conclusion: This first deployment of an MSU in the UK NHS demonstrated improved triage decision-making for or against hospital admission and admission to the appropriate target ward, thereby reducing pressure on strained A&E departments.


1998 ◽  
Vol 43 (2) ◽  
pp. 48-51 ◽  
Author(s):  
D.J. Godden ◽  
A. Robertson ◽  
N. Currie ◽  
J.S. Legge ◽  
J.A.R. Friend ◽  
...  

Domiciliary nebulisers are in widespread use for patients who have severe chronic airways disease, both asthma and chronic obstructive pulmonary disease (COPD). We report a study of the use of domiciliary nebulisers designed to assess practical problems and the value of such therapy in preventing hospital admissions. A total of 405 patients underwent a structured interview at home and their case records were reviewed. Technical performance of the nebuliser compressors was assessed The mean (SD) age of those interviewed was 64.5 (12) years. 185 patients had a physician diagnosis of asthma, and 208 had COPD. 87% patients used their nebuliser at least once daily. Side effects, reported by 54%, were related to frequency of use and commoner in younger patients. 29 subjects (7%) died within 2 years of receiving their nebuliser. Among the survivors, the 2 year periods before and after supply of the nebuliser were compared The percentage of patients requiring hospital admission for exacerbations of lung disease fell from 56% to 46% (p<0.01) but the number and duration of admissions was unchanged Those whose admission duration increased had more severely impaired spirometry when the nebuliser was supplied and had lower activity scores and higher breathlessness scores at the time of interview indicating more severe disease. Approximately half of the compressors were malfunctioning and patients' understanding of the principles of nebuliser treatment was poor. The provision of domiciliary nebuliser can influence hospital admission inpatients with obstructive airways disease. There is also a need for improved patient education and for technical support which may require the development of a nurse-run nebuliser service.


2021 ◽  
Vol 5 (4) ◽  
pp. 64-64
Author(s):  
Daniel Phillips ◽  
Iris Q. Grunwald ◽  
Silke Walter ◽  
Klaus Faßbender

<sec id="s1"> Aims: The aim of the study was to explore the benefit of a mobile stroke unit (MSU) in the UK National Health Service (NHS) for reduction of hospital admissions. </sec> <sec id="s2"> Methods: Prospective cohort audit observation with dispatch of the MSU in the East of England Ambulance Service was conducted. Emergency patients categorised as code stroke and headache were included from 5 June to 18 December 2018. Rate of avoided admission to the accident and emergency (A&E) department, rate of admission directly to target ward and stroke management metrics were assessed. </sec> <sec id="s3"> Results: In 116 MSU-treated patients, the following diagnoses were made: acute stroke, n = 33 (28.4%); transient ischaemic attacks, n = 13 (11.2%); stroke mimics, n = 32 (27.6%); and other conditions, n = 38 (32.8%). Pre-hospital thrombolysis was administered to eight of 28 (28.6%) ischaemic stroke patients. Pre-hospital diagnosis avoided hospital admission for 29 (25.0%) patients. As hospital treatment was indicated, 35 (30.2%) patients were directly triaged to the stroke unit, one patient (0.9%) even directly to the catheter laboratory. Thus, only 50 (43.1%) patients required transfer to the A&E department. Moreover, the MSU enabled thrombolysis with a median dispatch-to-needle time of 42 mins (interquartile range, 40‐60). </sec> <sec id="s4"> Conclusion: This first deployment of an MSU in the UK NHS demonstrated improved triage decision-making for or against hospital admission and admission to the appropriate target ward, thereby reducing pressure on strained A&E departments. </sec>


1996 ◽  
Vol 36 (4) ◽  
pp. 328-330 ◽  
Author(s):  
Ajit Shah

This study compares the proportion of patients discharged to residential and nursing homes from a psychogeriatric unit and the length of hospital admissions before and after the introduction of the National Health Service and Community Care Act 1990. This Act appeared not to influence the proportion of patients discharged to residential and nursing homes and the length of hospital admission. A year after the introduction of this Act may be too soon to observe an effect as the actual implementation of the Act by the health and social services may take considerable time.


2021 ◽  
Author(s):  
Hsiu-Lan Li ◽  
Pei-Hui Tai ◽  
Yi-Ting Hwang ◽  
Shih-Wei Lin ◽  
Li-Ching Lan

Abstract Background:Compared with other diseases, end-stage kidney disease (ESKD) carries a greater risk of comorbidities including diabetes and anemia and has a higher hospital admission rate. The cause of hospital admission appears to be a common factor affecting the prognosis of patients with ESKD. Therefore, this study conducted a retrospective cohort analysis on all patients diagnosed with ESKD and receiving hemodialysis, investigating whether the type of their diagnosis for hospital admission changed before and after they started hemodialysis.Methods:This study recruited 592 patients with ESKD who received hemodialysis at any period between January 2005 and November 2017 and had been assigned the International Classification of Diseases Ninth Revision Clinical Modification (ICD-9-CM) code for ESKD. The patients’ demographic data and hospitalization status one year before and two years after they received hemodialysis were analyzed. A McNemar test was conducted to analyze the diagnostic changes from before to after hemodialysis in patients with ESKD.Results:The study’s sample of patients with ESKD comprised more women (51.86%) than men and had an average age of 67.15 years. The numbers of patients admitted to hospital for the following conditions all decreased significantly after they received hemodialysis: type 2 (non-insulin-dependent and adult-onset) diabetes; native atherosclerosis; urinary tract infection; gastric ulcer without mention of hemorrhage, perforation, or obstruction; pneumonia; reflux esophagitis; duodenal ulcer without mention of hemorrhage, perforation, or obstruction; and bacteremia. Most patients exhibited one or more of the following comorbidities: diabetes (n = 407, 68.75%), hypertension (n = 491, 82.94%), congestive heart failure (n = 161, 27.20%), ischemic heart disease (n = 125, 21.11%), cerebrovascular accident (n = 93, 15.71%), and gout (n = 96, 16.22%). An analysis of variance (ANOVA) indicated that changes in the ICD-9-CM codes for native atherosclerosis, urinary tract infection, pneumonia, and hyperkalemia were associated with age. Patients who developed pneumonia before or after they received hemodialysis tended to be older (range: 69–70 years old). Conclusions:This study investigated the causes of hospital admission among patients with ESKD one year before and two years after they received hemodialysis. This study results revealed hypertension to be the most common comorbidity. Regarding cause of admission, pneumonia was more prevalent in older than in younger patients. Moreover, changes in the ICD-9-CM codes of native atherosclerosis, urinary tract infection, pneumonia, and hyperkalemia were significantly correlated with age. Therefore, when administering comprehensive nursing care and treatment for ESKD, clinicians should not focus only on comorbidities but also consider factors (e.g., age) that can affect patient prognosis.


2011 ◽  
Vol 9 (4) ◽  
pp. 518-522 ◽  
Author(s):  
Fernando Korkes ◽  
Jarques Lúcio da Silva II ◽  
Ita Pfeferman Heilberg

ABSTRACT Objective: To estimate costs associated to hospital treatment of urinary lithiasis in the Brazilian public health system as well as to evaluate demographic and epidemiological data referred to hospital admissions in the Brazilian public health system (or unified health care system). Methods: Data from the Informatic Department of Brazilian public health system were obtained as referred to costs in hospital admissions for urinary lithiasis during 2010 and also epidemiological data from 1996 through 2010. Results: There were 69,039 hospital admissions for urinary lithiasis, totaling 0.61% of all hospital admissions in the Brazilian public health system. The mean cost of each of these hospital admissions was US$ 240,23 or R$ 423.42 having as result an overall cost of US$ 16,240,378.00 or R$ 29.232.682,56. Hospital admissions for urinary lithiasis in the Brazilian public health system increased 69% from 1996 to 2010 (43,176 versus 69,309; p < 0.001; OR = 1.69). The number of hospital admissions was 5% greater between December and March as compared to the period between June and September (35,290 versus 33,749; p < 0.001; OR = 1.10). For Caucasian patients the hospital admission was 75% greater as compared to black patients (63.2% versus 35.8%; p = 0.02; OR = 1,75). Conclusion: Hospital admission for urinary liyhiasis has an elevated impact on the public health system with a cost of US$ 16,2 or R$ 29.2 million per year. The number of hospital admissions was greater in hotter months than in cold ones and also in the last decade, mainly in Caucasian population. These data may be helpful for the organization and optimization of health programs in the public health system as referred to prevention and treatment of urinary lithiasis in Brazil.


2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S332-S332
Author(s):  
Anisha Ganguly ◽  
Larry Brown ◽  
Deepak Agrawal ◽  
Kavita Bhavan

Abstract Background Self-administered outpatient parenteral antimicrobial therapy (S-OPAT) has been established as a clinically safe and effective alternative to inpatient or outpatient extended-course intravenous antibiotics while reducing healthcare resource utilization. However, previous research has not confirmed that transferring patients from the hospital to home for treatment does not cause a compensatory increase in emergency department (ED) visits. We sought to validate S-OPAT clinical safety and healthcare costs associated with S-OPAT by confirming that S-OPAT does not increase ED utilization during treatment. Methods We conducted a before-after study of ED utilization among S-OPAT patients. We compared ED visits, hospital admissions resulting from ED visits, hospital admissions due to OPAT-related causes, and hospital charges associated with all ED visits 60 days before and after initiation of S-OPAT. A 60-day time frame was selected to effectively encompass the maximum treatment duration (8 weeks) for S-OPAT. Paired t-tests were used to compare the change in ED utilization before and after initiation of S-OPAT. Results Among our cohort of 944 S-OPAT patients, 430 patients visited the ED 60 days before or after starting treatment. Of the patients with ED visits, 69 were admitted to the hospital for OPAT-related causes and 228 incurred hospital charges from their visit. Initiation of S-OPAT was associated with a statistically significant reduction in total ED visits, all-cause hospital admission, OPAT-related hospital admission, and hospital charges (see Table 1). Conclusion Our review of ED utilization among S-OPAT patients demonstrates a reduction in multiple parameters of ED utilization with the initiation of S-OPAT treatment. Our findings confirm that S-OPAT does not yield an increase, but rather a decrease, in ED visits with the transfer of patients from hospital to home. Disclosures All authors: No reported disclosures.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Sheetal Chaudhuri ◽  
Sophia Rosen ◽  
John Larkin ◽  
Len A Usvyat ◽  
David Sweet ◽  
...  

Abstract Background and Aims End Stage Kidney Disease (ESKD) patients have high hospitalization rates. We have developed and deployed a predictive model to identify in-centre haemodialysis (HD) patients at an increased risk for all-cause hospitalization within the next 12 months. The model was used in a pilot called Dialysis Hospitalization Reduction Program (DHRP) to identify patients predicted to be at risk of &gt;=6 hospital admissions and provide additional interdisciplinary team intervention. We investigated the impact of the DHRP on hospitalization rates in HD patients. Method We used data from 45 clinics in South Alabama/Florida Panhandle regions of the United States who participated in DHRP pilot starting January 2016. The predictive model used more than 200 variables to stratify patients as high risk (&gt;=6 admissions), medium high risk (&gt;=3 admissions) and medium low risk (&gt;=1 admission) and low risk (&lt;1 admission). For patients identified at high risk of hospitalization, social workers assessed psychosocial barriers and offered additional psychosocial intervention to target those barriers. Dietitians utilized a high risk assessment looking at weight, nutrition, and access to food and supplements. Resident nurses assessed high risk patients focusing on anaemia, adequacy, access, blood pressure, fluid management, prior hospitalizations, glycaemic control and risk of skin ulcers and blood stream infection Data from patients at the participating clinics was collected and yearly hospital admission and day rates per patient year were calculated 2 years prior to (2014, 2015) and 3 years after (2016-2018) pilot start. Comparison clinics were chosen from neighbouring regions in South and North Florida (43 and 45 clinics respectively). Results Over the study period the number of patients ranged from 4661 to 5672 in the DHRP pilot clinics, 5416 to 5947 in South Florida control clinics, and 6087 to 7596 in North Florida control clinics. Hospitalization rates in pilot clinics during the first year of the DHRP remined similar to the rates during the two years preceding the pilot start. In the second and third years of the DHRP, pilot clinics showed reductions in hospital admission and day rates. At control clinics in both regions the hospital admissions and day rates showed increasing trends while DHRP clinics showed decreasing trends over the study period (Figures 1a and 1b). Conclusion These findings suggest predictive model risk directed interdisciplinary team interventions associate with lower hospitalization rates in HD patients, compared to controls. Further studies are needed to confirm these results.


BJPsych Open ◽  
2016 ◽  
Vol 2 (3) ◽  
pp. 233-243 ◽  
Author(s):  
Fenglian Xu ◽  
Elizabeth Sullivan ◽  
Colin Binns ◽  
Caroline S. E. Homer

BackgroundMental disorders of women during the postnatal period are a major public health problem. Compared with women's mental disorders, much less attention has been paid to men's mental disorders in the perinatal period. To date, there have been no reports in the literature describing secular changes of both maternal and paternal hospital admissions for mental disorders over the period covering the year before pregnancy (non-parents), during pregnancy (expectant parents) and up to the first year after birth (parents) based on linked parental data. The co-occurrences of couples' hospital admissions for mental disorders have not previously been investigated.AimsTo describe maternal and paternal hospital admissions for mental disorders before and after birth. To compare the co-occurrences of parents' hospital admissions for mental disorder in the perinatal period.MethodThis is a cohort study using paired parents' population data from the New South Wales (NSW) Perinatal Data Collection (PDC), Registry of Births, Deaths and Marriages (RBDM) and Admitted Patients Data Collection (APDC). The study included all parents (n=196 669 couples) who gave birth to their first child in NSW between 1 January 2003 and 31 December 2009.ResultsThe hospital admission rate for women with a principal mental disorder diagnosis in the period between the year before pregnancy and the first year after birth was significantly higher than that for men. Parents' mental disorders influenced each other. If a man was admitted to hospital with a principal mental disorder diagnosis, his wife or partner was more likely to be admitted to hospital with a principal mental disorder diagnosis compared with women whose partner had not had a hospital admission, andvice versa.ConclusionsMothers' mental disorders after birth increased more significantly than fathers. However, fathers' mental disorders significantly impacted the co-occurrence of mothers' mental disorders.


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